EA201591176A1 - Композиции и способы с использованием пептидной метки, связывающейся с гиалуронаном - Google Patents

Композиции и способы с использованием пептидной метки, связывающейся с гиалуронаном

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Publication number
EA201591176A1
EA201591176A1 EA201591176A EA201591176A EA201591176A1 EA 201591176 A1 EA201591176 A1 EA 201591176A1 EA 201591176 A EA201591176 A EA 201591176A EA 201591176 A EA201591176 A EA 201591176A EA 201591176 A1 EA201591176 A1 EA 201591176A1
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Eurasian Patent Office
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methods
eye
compositions
protein
nucleic acid
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EA201591176A
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English (en)
Inventor
Джой Гхош
Майкл Рогуска
Эндрю Анх Нгуен
Андрей Голосов
Томас Пицонка
Маттиас Машасек
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Новартис Аг
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Publication of EA201591176A1 publication Critical patent/EA201591176A1/ru

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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4718—Cytokine-induced proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
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    • A—HUMAN NECESSITIES
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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
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    • A61P27/00—Drugs for disorders of the senses
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    • A61P27/10—Ophthalmic agents for accommodation disorders, e.g. myopia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
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    • C07K2319/00—Fusion polypeptide
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Abstract

Изобретение относится, частично, к композициям и способам с использованием пептидной метки, связывающей гиалуронан (НА). НА-метку можно присоединять к молекуле, такой как белок или нуклеиновая кислота, которая при введении в глаз приводит к увеличению времени полужизни в глазу, и/или среднего времени удержания в глазу, и/или к уменьшению выведения из глаза белка или нуклеиновой кислоты. Изобретение относится также к способам лечения глазного заболевания, включая сосудистое заболевание сетчатки, посредством введения белка или нуклеиновой кислоты с присоединенной пептидной меткой для НА.
EA201591176A 2012-12-18 2013-12-17 Композиции и способы с использованием пептидной метки, связывающейся с гиалуронаном EA201591176A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261738488P 2012-12-18 2012-12-18
PCT/US2013/075795 WO2014099997A1 (en) 2012-12-18 2013-12-17 Compositions and methods that utilize a peptide tag that binds to hyaluronan

Publications (1)

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EA201591176A1 true EA201591176A1 (ru) 2016-02-29

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Country Status (17)

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US (2) US20140186350A1 (ru)
EP (1) EP2935589A1 (ru)
JP (1) JP2016502850A (ru)
KR (1) KR20150095684A (ru)
CN (1) CN104995303A (ru)
AR (1) AR094141A1 (ru)
AU (1) AU2013362909A1 (ru)
BR (1) BR112015013861A2 (ru)
CA (1) CA2891686A1 (ru)
CL (1) CL2015001709A1 (ru)
EA (1) EA201591176A1 (ru)
MX (1) MX2015007931A (ru)
PH (1) PH12015501352A1 (ru)
SG (1) SG11201503566QA (ru)
TW (1) TW201427989A (ru)
UY (1) UY35195A (ru)
WO (1) WO2014099997A1 (ru)

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