EA201390465A1 - Двойные ингибиторы мэн и фрэс для лечения кастрационно-резистентного рака простаты и остеобластических метастазов в кости - Google Patents

Двойные ингибиторы мэн и фрэс для лечения кастрационно-резистентного рака простаты и остеобластических метастазов в кости

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Publication number
EA201390465A1
EA201390465A1 EA201390465A EA201390465A EA201390465A1 EA 201390465 A1 EA201390465 A1 EA 201390465A1 EA 201390465 A EA201390465 A EA 201390465A EA 201390465 A EA201390465 A EA 201390465A EA 201390465 A1 EA201390465 A1 EA 201390465A1
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EA
Eurasian Patent Office
Prior art keywords
treatment
castration
fres
prostate
man
Prior art date
Application number
EA201390465A
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English (en)
Other versions
EA027476B1 (ru
Inventor
Дэвид Смит
Маха Хуссейн
Original Assignee
Экселиксис, Инк.
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Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44741730&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201390465(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Экселиксис, Инк. filed Critical Экселиксис, Инк.
Publication of EA201390465A1 publication Critical patent/EA201390465A1/ru
Publication of EA027476B1 publication Critical patent/EA027476B1/ru

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C55/00—Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms
    • C07C55/02—Dicarboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Quinoline Compounds (AREA)
  • Steroid Compounds (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Настоящее изобретение направлено на лечение рака, в частности кастрационно-резистентного рака простаты и остеобластических метастазов в кости, с использованием двойного ингибитора МЭН и ФРЭС.
EA201390465A 2010-09-27 2011-09-26 Применение n-(4-{[6,7-бис-(метилокси)хинолин-4-ил]окси}фенил)-n'-(4-фторфенил)циклопропан-1,1-дикарбоксамида для лечения кастрационно-резистентного рака простаты и остеобластических метастазов в кости EA027476B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US38695910P 2010-09-27 2010-09-27
US201161481671P 2011-05-02 2011-05-02
PCT/US2011/053233 WO2012044572A1 (en) 2010-09-27 2011-09-26 Dual inhibitors of met and vegf for the treatment of castration- resistant prostate cancer and osteoblastic bone metastases

Publications (2)

Publication Number Publication Date
EA201390465A1 true EA201390465A1 (ru) 2013-08-30
EA027476B1 EA027476B1 (ru) 2017-07-31

Family

ID=44741730

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201390465A EA027476B1 (ru) 2010-09-27 2011-09-26 Применение n-(4-{[6,7-бис-(метилокси)хинолин-4-ил]окси}фенил)-n'-(4-фторфенил)циклопропан-1,1-дикарбоксамида для лечения кастрационно-резистентного рака простаты и остеобластических метастазов в кости

Country Status (22)

Country Link
US (5) US20140057943A1 (ru)
EP (1) EP2621481B2 (ru)
JP (2) JP6158705B2 (ru)
KR (1) KR101882328B1 (ru)
CN (1) CN103402505A (ru)
AR (1) AR085195A1 (ru)
AU (2) AU2011307304C1 (ru)
BR (1) BR112013007220A2 (ru)
CA (1) CA2812750C (ru)
DK (1) DK2621481T4 (ru)
EA (1) EA027476B1 (ru)
ES (1) ES2754973T5 (ru)
FI (1) FI2621481T4 (ru)
HU (1) HUE045810T2 (ru)
IL (1) IL225507B (ru)
MX (1) MX352926B (ru)
PL (1) PL2621481T5 (ru)
PT (1) PT2621481T (ru)
SI (1) SI2621481T2 (ru)
TW (2) TW201302709A (ru)
UA (1) UA114172C2 (ru)
WO (1) WO2012044572A1 (ru)

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HUE045810T2 (hu) 2020-01-28
US11612597B2 (en) 2023-03-28
UA114172C2 (uk) 2017-05-10
EP2621481B1 (en) 2019-08-14
MX2013003594A (es) 2013-08-01
AU2011307304A1 (en) 2013-05-02
MX352926B (es) 2017-12-14
FI2621481T4 (fi) 2023-01-13
US20240156803A1 (en) 2024-05-16
PL2621481T3 (pl) 2020-03-31
US20230301980A1 (en) 2023-09-28
DK2621481T3 (da) 2019-10-21
JP2017149714A (ja) 2017-08-31
US20140057943A1 (en) 2014-02-27
KR20140025304A (ko) 2014-03-04
KR101882328B1 (ko) 2018-07-27
WO2012044572A1 (en) 2012-04-05
US11969419B2 (en) 2024-04-30
DK2621481T4 (da) 2023-01-09
AU2011307304C1 (en) 2016-10-20
AR085195A1 (es) 2013-09-18
SI2621481T1 (sl) 2019-11-29
US20160220554A1 (en) 2016-08-04
PT2621481T (pt) 2019-11-19
ES2754973T5 (es) 2023-03-13
BR112013007220A2 (pt) 2017-08-08
PL2621481T5 (pl) 2023-03-13
TW201302709A (zh) 2013-01-16
SI2621481T2 (sl) 2023-02-28
IL225507B (en) 2019-08-29
JP6158705B2 (ja) 2017-07-05
EP2621481A1 (en) 2013-08-07
IL225507A0 (en) 2013-06-27
TW201738213A (zh) 2017-11-01
CA2812750C (en) 2020-10-06
CA2812750A1 (en) 2012-04-05
EA027476B1 (ru) 2017-07-31
JP2013537916A (ja) 2013-10-07
CN103402505A (zh) 2013-11-20
AU2016204747A1 (en) 2016-07-28
ES2754973T3 (es) 2020-04-21
AU2011307304B2 (en) 2016-04-14
US20200330450A1 (en) 2020-10-22
EP2621481B2 (en) 2022-10-19

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