EA201300171A1 - Способы и композиции для терапии рака печени - Google Patents
Способы и композиции для терапии рака печениInfo
- Publication number
- EA201300171A1 EA201300171A1 EA201300171A EA201300171A EA201300171A1 EA 201300171 A1 EA201300171 A1 EA 201300171A1 EA 201300171 A EA201300171 A EA 201300171A EA 201300171 A EA201300171 A EA 201300171A EA 201300171 A1 EA201300171 A1 EA 201300171A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- liver cancer
- methods
- compositions
- cancer therapy
- antiproastrin
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/57438—Specifically defined cancers of liver, pancreas or kidney
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/575—Hormones
- G01N2333/595—Gastrins; Cholecystokinins [CCK]
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Biophysics (AREA)
- Endocrinology (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Hospice & Palliative Care (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Oncology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cell Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Abstract
Заявка обеспечивает способы лечения рака печени и предотвращения рецидива рака печени с помощью антипрогастриновых антител, способы мониторинга эффективности лечения рака печени при использовании антипрогастриновой терапии и композиции, которые применяются для этого.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US36785110P | 2010-07-26 | 2010-07-26 | |
US201161476204P | 2011-04-15 | 2011-04-15 | |
PCT/EP2011/062686 WO2012013609A1 (en) | 2010-07-26 | 2011-07-22 | Methods and compositions for liver cancer therapy |
Publications (2)
Publication Number | Publication Date |
---|---|
EA201300171A1 true EA201300171A1 (ru) | 2013-07-30 |
EA028515B1 EA028515B1 (ru) | 2017-11-30 |
Family
ID=45493809
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201790882A EA201790882A1 (ru) | 2010-07-26 | 2011-07-22 | Способы и композиции для терапии рака печени |
EA201300171A EA028515B1 (ru) | 2010-07-26 | 2011-07-22 | Способы и композиции для терапии рака печени |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201790882A EA201790882A1 (ru) | 2010-07-26 | 2011-07-22 | Способы и композиции для терапии рака печени |
Country Status (16)
Country | Link |
---|---|
US (1) | US10533050B2 (ru) |
EP (1) | EP2598531B1 (ru) |
JP (1) | JP5726305B2 (ru) |
KR (1) | KR101576174B1 (ru) |
CN (1) | CN103261224B (ru) |
AR (1) | AR082340A1 (ru) |
AU (1) | AU2011284908B2 (ru) |
BR (1) | BR112013002012A2 (ru) |
CA (1) | CA2806157C (ru) |
EA (2) | EA201790882A1 (ru) |
ES (1) | ES2871092T3 (ru) |
NZ (1) | NZ606195A (ru) |
PL (1) | PL2598531T3 (ru) |
SG (2) | SG10201703556YA (ru) |
WO (1) | WO2012013609A1 (ru) |
ZA (1) | ZA201300567B (ru) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5644110B2 (ja) | 2008-08-05 | 2014-12-24 | 東レ株式会社 | 癌の検出方法 |
KR101667319B1 (ko) | 2008-08-05 | 2016-10-18 | 도레이 카부시키가이샤 | 암의 치료 및 예방용 의약 조성물 |
US8900817B2 (en) | 2010-01-08 | 2014-12-02 | Les Laboratories Servier | Progastrin and liver pathologies |
EP2532743B1 (en) | 2010-02-04 | 2015-04-15 | Toray Industries, Inc. | Pharmaceutical composition for treatment and/or prevention of cancer |
BR112014002616B1 (pt) | 2011-08-04 | 2022-01-18 | Toray Industries, Inc | Método para detectar câncer pancreático |
WO2013018894A1 (ja) | 2011-08-04 | 2013-02-07 | 東レ株式会社 | 癌の治療及び/又は予防用医薬組成物 |
BR112014002619A2 (pt) | 2011-08-04 | 2018-10-09 | Toray Industries, Inc | composição farmacêutica e método de tratamento e/ou prevenção de câncer pancreático e combinação farmacêutica |
CA2864999C (en) | 2012-02-21 | 2020-06-30 | Toray Industries, Inc. | Pharmaceutical composition for treatment and/or prevention of cancer |
PL2818483T3 (pl) | 2012-02-21 | 2018-01-31 | Toray Industries | Kompozycja lecznicza do leczenia i/lub zapobiegania nowotworowi |
PL2818482T3 (pl) | 2012-02-21 | 2019-11-29 | Toray Industries | Kompozycja farmaceutyczna do leczenia nowotworu |
IN2014KN01716A (ru) | 2012-02-21 | 2015-10-23 | Toray Industries | |
CN104203281B (zh) | 2012-03-30 | 2019-07-26 | 东丽株式会社 | 胆囊癌的治疗和/或预防用药物组合物 |
EP2832365B1 (en) * | 2012-03-30 | 2017-11-01 | Toray Industries, Inc. | Pharmaceutical composition for treatment and/or prevention of liver cancer |
KR102056654B1 (ko) | 2012-07-19 | 2019-12-17 | 도레이 카부시키가이샤 | 암의 검출 방법 |
CN104471404B (zh) | 2012-07-19 | 2017-03-01 | 东丽株式会社 | 癌的检测方法 |
TR201819812T4 (tr) | 2013-08-09 | 2019-01-21 | Toray Industries | Kanserin Tedavisi Ve/Veya Önlenmesi Amacına Yönelik Farmasötik Bileşim |
KR20170054459A (ko) * | 2014-09-10 | 2017-05-17 | 더블 본드 파마슈티컬스 에이비 | 친수성 약물의 표적 전달 방법 |
EP3023884A1 (en) * | 2014-11-21 | 2016-05-25 | Thomson Licensing | Method and apparatus for generating fingerprint of an audio signal |
CN114705858A (zh) | 2015-12-31 | 2022-07-05 | Syncerus有限责任公司 | 用于评估癌症发生的风险的组合物和方法 |
US20190011449A1 (en) | 2015-12-31 | 2019-01-10 | Progastrine Et Cancers S.À R.L. | Compositions and methods for detecting and treating gastric cancer |
JP7018885B2 (ja) | 2015-12-31 | 2022-02-14 | プロガストリン、エ、カンセル、エス、アー エル、エル | 食道癌の検出および治療のための組成物および方法 |
EA037015B1 (ru) | 2015-12-31 | 2021-01-27 | Прогастрин Э Кансер С.А Р.Л. | Применение и способ для профилактики или лечения рака яичников с использованием композиции, содержащей прогастринсвязывающее антитело |
KR102351556B1 (ko) | 2017-03-30 | 2022-01-14 | 프로가스트린 에 캔서스 에스.에이 알.엘. | 프로가스트린 결합 분자를 사용하는 전립선암의 검출 및 치료를 위한 조성물 및 방법 |
KR102616819B1 (ko) | 2017-03-30 | 2023-12-21 | 프로가스트린 에 캔서스 에스.에이 알.엘. | 폐암을 치료하기 위한 조성물 및 방법 |
WO2019110662A1 (en) * | 2017-12-05 | 2019-06-13 | Progastrine Et Cancers S.À R.L. | Combination therapy between anti-progastrin antibody and immunotherapy to treat cancer |
CN112004560A (zh) | 2017-12-08 | 2020-11-27 | Ecs生物识别***有限公司 | 癌症诊断中的放射性标记的前胃液素 |
TW201940881A (zh) | 2018-01-26 | 2019-10-16 | 瑞士商Ecs前胃泌激素公司 | 在癌症診斷中結合前胃泌激素檢測與其他癌症生物標記的技術 |
EP3759492A1 (en) * | 2018-02-27 | 2021-01-06 | ECS-Progastrin SA | Progastrin as a biomarker for immunotherapy |
AU2020358101A1 (en) * | 2019-10-02 | 2022-04-28 | Alamab Therapeutics, Inc. | Anto-connexin antibody formulations |
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DE69935977T2 (de) * | 1998-05-15 | 2008-01-10 | Receptor Biologix, Inc., Palo Alto | Vorbeugung und Behandlung von Hypergastrinämie |
CA2450898A1 (en) * | 2001-07-09 | 2003-01-23 | Aphton Corporation | Treatment and prevention of cancerous and pre-cancerous conditions of the liver, lung and esophagus |
US20080057519A1 (en) * | 2003-06-02 | 2008-03-06 | Mcwhirter John | Cell Surface Protein Associated with Human Chronic Lymphocytic Leukemia |
JP2008513536A (ja) * | 2004-09-22 | 2008-05-01 | レセプター バイオロジックス インコーポレイテッド | プロガストリンに対するモノクローナル抗体 |
CN101460196A (zh) * | 2006-05-22 | 2009-06-17 | 国立医学与健康研究所 | 在结肠癌治疗中的前胃泌素抑制剂 |
WO2008076454A1 (en) | 2006-12-19 | 2008-06-26 | The Board Of Regents Of The University Of Texas System | Immunogenic compositions comprising progastrin and uses thereof |
SG10201704933PA (en) * | 2009-10-16 | 2017-07-28 | Inst Nat De La Sante Et De La Rech Medicale (Inserm) | Monoclonal antibodies to progastrin and their uses |
US8900817B2 (en) * | 2010-01-08 | 2014-12-02 | Les Laboratories Servier | Progastrin and liver pathologies |
US9487582B2 (en) * | 2010-01-08 | 2016-11-08 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Methods for treating pancreatic cancer |
US9217032B2 (en) * | 2010-01-08 | 2015-12-22 | Les Laboratoires Servier | Methods for treating colorectal cancer |
KR101570404B1 (ko) * | 2010-03-24 | 2015-11-20 | 르 라보레또레 쎄르비에르 | 결장직장암 및 위창자암의 예방 |
-
2011
- 2011-07-22 KR KR1020137004701A patent/KR101576174B1/ko active IP Right Grant
- 2011-07-22 JP JP2013521088A patent/JP5726305B2/ja not_active Expired - Fee Related
- 2011-07-22 AU AU2011284908A patent/AU2011284908B2/en not_active Ceased
- 2011-07-22 ES ES11738200T patent/ES2871092T3/es active Active
- 2011-07-22 NZ NZ606195A patent/NZ606195A/en not_active IP Right Cessation
- 2011-07-22 US US13/189,403 patent/US10533050B2/en not_active Expired - Fee Related
- 2011-07-22 EP EP11738200.2A patent/EP2598531B1/en active Active
- 2011-07-22 BR BR112013002012A patent/BR112013002012A2/pt not_active Application Discontinuation
- 2011-07-22 CN CN201180046160.4A patent/CN103261224B/zh not_active Expired - Fee Related
- 2011-07-22 PL PL11738200T patent/PL2598531T3/pl unknown
- 2011-07-22 SG SG10201703556YA patent/SG10201703556YA/en unknown
- 2011-07-22 SG SG2013003512A patent/SG187544A1/en unknown
- 2011-07-22 EA EA201790882A patent/EA201790882A1/ru unknown
- 2011-07-22 CA CA2806157A patent/CA2806157C/en not_active Expired - Fee Related
- 2011-07-22 EA EA201300171A patent/EA028515B1/ru not_active IP Right Cessation
- 2011-07-22 WO PCT/EP2011/062686 patent/WO2012013609A1/en active Application Filing
- 2011-07-25 AR ARP110102679A patent/AR082340A1/es unknown
-
2013
- 2013-01-22 ZA ZA2013/00567A patent/ZA201300567B/en unknown
Also Published As
Publication number | Publication date |
---|---|
PL2598531T3 (pl) | 2021-08-30 |
ES2871092T3 (es) | 2021-10-28 |
NZ606195A (en) | 2015-02-27 |
EA028515B1 (ru) | 2017-11-30 |
SG10201703556YA (en) | 2017-06-29 |
EA201790882A1 (ru) | 2017-08-31 |
JP5726305B2 (ja) | 2015-05-27 |
ZA201300567B (en) | 2014-03-26 |
AR082340A1 (es) | 2012-11-28 |
SG187544A1 (en) | 2013-03-28 |
WO2012013609A1 (en) | 2012-02-02 |
EP2598531B1 (en) | 2020-12-30 |
CN103261224A (zh) | 2013-08-21 |
EP2598531A1 (en) | 2013-06-05 |
CN103261224B (zh) | 2015-10-07 |
KR101576174B1 (ko) | 2015-12-09 |
BR112013002012A2 (pt) | 2019-08-27 |
AU2011284908A1 (en) | 2013-02-07 |
JP2013533277A (ja) | 2013-08-22 |
US10533050B2 (en) | 2020-01-14 |
US20120020961A1 (en) | 2012-01-26 |
KR20130083438A (ko) | 2013-07-22 |
AU2011284908B2 (en) | 2015-05-21 |
CA2806157A1 (en) | 2012-02-02 |
CA2806157C (en) | 2016-11-22 |
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Legal Events
Date | Code | Title | Description |
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MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG MD TJ TM |