EA201390275A1 - Кристаллический (r)-(e)-2-(4-(2-(5-(1-(3,5-дихлорпиридин-4-ил)этокси)-1h-индазол-3-ил)винил)-1h-пиразол-1-ил)этанол - Google Patents

Кристаллический (r)-(e)-2-(4-(2-(5-(1-(3,5-дихлорпиридин-4-ил)этокси)-1h-индазол-3-ил)винил)-1h-пиразол-1-ил)этанол

Info

Publication number
EA201390275A1
EA201390275A1 EA201390275A EA201390275A EA201390275A1 EA 201390275 A1 EA201390275 A1 EA 201390275A1 EA 201390275 A EA201390275 A EA 201390275A EA 201390275 A EA201390275 A EA 201390275A EA 201390275 A1 EA201390275 A1 EA 201390275A1
Authority
EA
Eurasian Patent Office
Prior art keywords
indazol
pyrazol
ethanol
crystalline
dichlorpiridin
Prior art date
Application number
EA201390275A
Other languages
English (en)
Other versions
EA021817B1 (ru
Inventor
Бенджамин Алан Дисероад
Original Assignee
Эли Лилли Энд Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44999860&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201390275(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Эли Лилли Энд Компани filed Critical Эли Лилли Энд Компани
Publication of EA201390275A1 publication Critical patent/EA201390275A1/ru
Publication of EA021817B1 publication Critical patent/EA021817B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Abstract

В настоящем изобретении предложен кристаллический (R)-(E)-2-(4-(2-(5-(1-(3,5-дихлорпиридин-4-ил)этокси)-1Н-индазол-3-ил)винил)-1Н-пиразол-1-ил)этанол, подходящий для применения для лечения рака.
EA201390275A 2010-10-05 2011-09-29 Кристаллический (r)-(e)-2-(4-(2-(5-(1-(3,5-дихлорпиридин-4-ил)этокси)-1h-индазол-3-ил)винил)-1h-пиразол-1-ил)этанола моногидрат EA021817B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US38991110P 2010-10-05 2010-10-05
PCT/US2011/053798 WO2012047699A1 (en) 2010-10-05 2011-09-29 Crystalline (r) - (e) -2- (4- (2- (5- (1- (3, 5 -dichloropyridin-4 -yl) ethoxy) - 1h - indazol - 3 - yl) vinyl) -1 h- pyrazol- 1 -yl) ethanol and its use as fgfr inhibitor

Publications (2)

Publication Number Publication Date
EA201390275A1 true EA201390275A1 (ru) 2013-07-30
EA021817B1 EA021817B1 (ru) 2015-09-30

Family

ID=44999860

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201390275A EA021817B1 (ru) 2010-10-05 2011-09-29 Кристаллический (r)-(e)-2-(4-(2-(5-(1-(3,5-дихлорпиридин-4-ил)этокси)-1h-индазол-3-ил)винил)-1h-пиразол-1-ил)этанола моногидрат

Country Status (35)

Country Link
US (1) US8530665B2 (ru)
EP (1) EP2625175B1 (ru)
JP (1) JP5940547B2 (ru)
KR (1) KR101527661B1 (ru)
CN (1) CN103153983B (ru)
AR (1) AR083091A1 (ru)
AU (1) AU2011312485B2 (ru)
BR (1) BR112013006336A2 (ru)
CA (1) CA2813329C (ru)
CL (1) CL2013000884A1 (ru)
CO (1) CO6710911A2 (ru)
DK (1) DK2625175T3 (ru)
DO (1) DOP2013000072A (ru)
EA (1) EA021817B1 (ru)
EC (1) ECSP13012539A (ru)
ES (1) ES2558777T3 (ru)
HK (1) HK1184147A1 (ru)
HR (1) HRP20151299T1 (ru)
HU (1) HUE026379T2 (ru)
IL (1) IL224850A (ru)
JO (1) JO3062B1 (ru)
MA (1) MA34552B1 (ru)
ME (1) ME02307B (ru)
MX (1) MX2013003907A (ru)
NZ (1) NZ608482A (ru)
PE (1) PE20140252A1 (ru)
PL (1) PL2625175T3 (ru)
PT (1) PT2625175E (ru)
RS (1) RS54457B1 (ru)
SG (1) SG188286A1 (ru)
SI (1) SI2625175T1 (ru)
TW (1) TWI418554B (ru)
UA (1) UA111725C2 (ru)
WO (1) WO2012047699A1 (ru)
ZA (1) ZA201301560B (ru)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19945982A1 (de) * 1999-09-24 2001-03-29 Knoll Ag Geschwindigkeitsbestimmte Partikel
US8754114B2 (en) 2010-12-22 2014-06-17 Incyte Corporation Substituted imidazopyridazines and benzimidazoles as inhibitors of FGFR3
LT3176170T (lt) 2012-06-13 2019-04-25 Incyte Holdings Corporation Pakeisti tricikliniai junginiai, kaip fgfr inhibitoriai
WO2014026125A1 (en) 2012-08-10 2014-02-13 Incyte Corporation Pyrazine derivatives as fgfr inhibitors
US9266892B2 (en) 2012-12-19 2016-02-23 Incyte Holdings Corporation Fused pyrazoles as FGFR inhibitors
DK2986610T5 (en) 2013-04-19 2018-12-10 Incyte Holdings Corp BICYCLIC HETEROCYCLES AS FGFR INHIBITORS
CN103819396B (zh) * 2014-02-26 2016-06-15 四川大学 一种手性的1-（3,5-二氯吡啶-4-基）-乙醇的合成方法
US10851105B2 (en) 2014-10-22 2020-12-01 Incyte Corporation Bicyclic heterocycles as FGFR4 inhibitors
CN107438607B (zh) 2015-02-20 2021-02-05 因赛特公司 作为fgfr抑制剂的双环杂环
MA41551A (fr) 2015-02-20 2017-12-26 Incyte Corp Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4
WO2016134294A1 (en) 2015-02-20 2016-08-25 Incyte Corporation Bicyclic heterocycles as fgfr4 inhibitors
AR111960A1 (es) 2017-05-26 2019-09-04 Incyte Corp Formas cristalinas de un inhibidor de fgfr y procesos para su preparación
WO2019213506A1 (en) 2018-05-04 2019-11-07 Incyte Corporation Salts of an fgfr inhibitor
PE20210920A1 (es) 2018-05-04 2021-05-19 Incyte Corp Formas solidas de un inhibidor de fgfr y procesos para prepararlas
WO2020185532A1 (en) 2019-03-08 2020-09-17 Incyte Corporation Methods of treating cancer with an fgfr inhibitor
KR20210142154A (ko) 2019-03-21 2021-11-24 옹쎄오 암 치료를 위한 키나제 억제제와 조합된 dbait 분자
WO2021007269A1 (en) 2019-07-09 2021-01-14 Incyte Corporation Bicyclic heterocycles as fgfr inhibitors
KR20220100879A (ko) 2019-10-14 2022-07-18 인사이트 코포레이션 Fgfr 저해제로서의 이환식 헤테로사이클
WO2021076728A1 (en) 2019-10-16 2021-04-22 Incyte Corporation Bicyclic heterocycles as fgfr inhibitors
CA3159348A1 (en) 2019-11-08 2021-05-14 Inserm (Institut National De La Sante Et De La Recherche Medicale) Methods for the treatment of cancers that have acquired resistance to kinase inhibitors
JP2023505258A (ja) 2019-12-04 2023-02-08 インサイト・コーポレイション Ｆｇｆｒ阻害剤としての三環式複素環
PE20221504A1 (es) 2019-12-04 2022-09-30 Incyte Corp Derivados de un inhibidor de fgfr
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use
CN111705099B (zh) * 2020-07-01 2022-03-08 天津药明康德新药开发有限公司 一种(s)-1-(3,5-二氯吡啶-4-取代)乙醇的制备方法
JP2023553835A (ja) * 2020-12-17 2023-12-26 ブロッサムヒル・セラピューティクス・インコーポレイテッド 大環状化合物およびそれらの使用
US11939331B2 (en) 2021-06-09 2024-03-26 Incyte Corporation Tricyclic heterocycles as FGFR inhibitors

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6897231B2 (en) * 2000-07-31 2005-05-24 Signal Pharmaceuticals, Inc. Indazole derivatives as JNK inhibitors and compositions and methods related thereto
AP1666A (en) * 2000-09-11 2006-09-29 Chiron Corp Quinolinone derivatives as tyrosine kinase inhibitors.
TW200406385A (en) 2002-05-31 2004-05-01 Eisai Co Ltd Pyrazole compound and pharmaceutical composition containing the same
BRPI0508895A (pt) * 2004-03-17 2007-09-11 Pfizer formas polimorficas e amorfa de {2-flúor-5-[3-((e)-2-piridn-2-il-vinil)-1h-indazol-6-ilamin]- fenil}-amida de ácido 2,5-dimetil-2h-pirazol-3-carboxìlico
JP4746299B2 (ja) * 2004-07-16 2011-08-10 ジュズ インターナショナル ピーティーイー エルティーディー 金属酸化物粉末の製造方法
JP2006163651A (ja) 2004-12-03 2006-06-22 Sony Computer Entertainment Inc 表示装置、表示装置の制御方法、プログラム及びフォントデータ
US20060160863A1 (en) * 2005-01-05 2006-07-20 Agouron Pharmaceuticals, Inc. Polymorphic and amorphous forms of 2-{3-[(E)-2-(4,6-dimethyl-pyridin-2-yl)-vinyl]-1H-indazol-6-ylamino}-N-(4-hydroxy-but-2-ynyl)benzamide
WO2007058626A1 (en) 2005-11-16 2007-05-24 S*Bio Pte Ltd Indazole compounds
MX2009010761A (es) * 2007-04-05 2009-10-28 Pfizer Prod Inc Formas cristalinas de 6-[2-(metilcarbamoil)fenilsulfanil]-3-e-[2-( piridin-2-il)etenil]indzol adecuadas para el tratamiento del crecimiento celular anormal en mamiferos.
JO2860B1 (en) * 2009-05-07 2015-03-15 ايلي ليلي اند كومباني Phenylendazolyl compounds

Also Published As

Publication number Publication date
CN103153983B (zh) 2014-11-05
PE20140252A1 (es) 2014-03-12
CA2813329C (en) 2015-05-26
RS54457B1 (en) 2016-06-30
CO6710911A2 (es) 2013-07-15
US20120083511A1 (en) 2012-04-05
EP2625175A1 (en) 2013-08-14
CN103153983A (zh) 2013-06-12
KR20130052680A (ko) 2013-05-22
EP2625175B1 (en) 2015-11-18
SG188286A1 (en) 2013-04-30
AU2011312485A1 (en) 2013-03-07
AR083091A1 (es) 2013-01-30
JP5940547B2 (ja) 2016-06-29
AU2011312485B2 (en) 2014-09-04
ES2558777T3 (es) 2016-02-08
MX2013003907A (es) 2013-06-03
HK1184147A1 (en) 2014-01-17
SI2625175T1 (sl) 2016-01-29
DK2625175T3 (en) 2016-02-01
UA111725C2 (uk) 2016-06-10
EA021817B1 (ru) 2015-09-30
PT2625175E (pt) 2016-01-22
CL2013000884A1 (es) 2013-10-18
HRP20151299T1 (hr) 2016-01-01
DOP2013000072A (es) 2013-08-15
JO3062B1 (ar) 2017-03-15
WO2012047699A1 (en) 2012-04-12
JP2013538875A (ja) 2013-10-17
KR101527661B1 (ko) 2015-06-09
PL2625175T3 (pl) 2016-04-29
ECSP13012539A (es) 2013-06-28
HUE026379T2 (en) 2016-06-28
IL224850A (en) 2016-09-29
US8530665B2 (en) 2013-09-10
BR112013006336A2 (pt) 2019-09-24
NZ608482A (en) 2014-03-28
ME02307B (me) 2016-06-20
TWI418554B (zh) 2013-12-11
CA2813329A1 (en) 2012-04-12
TW201249826A (en) 2012-12-16
MA34552B1 (fr) 2013-09-02
ZA201301560B (en) 2014-08-27

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU