HK1184147A1 - Crystalline(r)-(e)-2-(4-(2-(5-(1-(3,5-dichloropyridin-4-yl)ethoxy)-1h- indazol-3-yl)vinyl)-1h-pyrazol-1-yl) ethanol and its use as fgfr inhibitor ((r)-(e)-2-(4-(2-(5-(1-(35--4-))-1h--3-) )-1h--1-) fgfr - Google Patents

Crystalline(r)-(e)-2-(4-(2-(5-(1-(3,5-dichloropyridin-4-yl)ethoxy)-1h- indazol-3-yl)vinyl)-1h-pyrazol-1-yl) ethanol and its use as fgfr inhibitor ((r)-(e)-2-(4-(2-(5-(1-(35--4-))-1h--3-) )-1h--1-) fgfr

Info

Publication number: HK1184147A1
Authority: HK; Hong Kong
Prior art keywords: fgfr; dichloropyridin; indazol; pyrazol; ethoxy
Prior art date: 2010-10-05

Application number

HK13111594.2A

Other languages

English (en)

Chinese (zh)

Inventor

Benjamin Alan Diseroad

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2010-10-05

Filing date

2013-10-15

Publication date

2014-01-17

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44999860&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1184147(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2013-10-15 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

2014-01-17 Publication of HK1184147A1 publication Critical patent/HK1184147A1/xx

Links

GKJCVYLDJWTWQU-CXLRFSCWSA-N 2-[4-[(e)-2-[5-[(1r)-1-(3,5-dichloropyridin-4-yl)ethoxy]-1h-indazol-3-yl]ethenyl]pyrazol-1-yl]ethanol Chemical compound O([C@H](C)C=1C(=CN=CC=1Cl)Cl)C(C=C12)=CC=C1NN=C2\C=C\C=1C=NN(CCO)C=1 GKJCVYLDJWTWQU-CXLRFSCWSA-N 0.000 title 1
229940125829 fibroblast growth factor receptor inhibitor Drugs 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

HK13111594.2A 2010-10-05 2013-10-15 Crystalline(r)-(e)-2-(4-(2-(5-(1-(3,5-dichloropyridin-4-yl)ethoxy)-1h- indazol-3-yl)vinyl)-1h-pyrazol-1-yl) ethanol and its use as fgfr inhibitor ((r)-(e)-2-(4-(2-(5-(1-(35--4-))-1h--3-) )-1h--1-) fgfr HK1184147A1 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US38991110P	2010-10-05	2010-10-05
PCT/US2011/053798 WO2012047699A1 (en)	2010-10-05	2011-09-29	Crystalline (r) - (e) -2- (4- (2- (5- (1- (3, 5 -dichloropyridin-4 -yl) ethoxy) - 1h - indazol - 3 - yl) vinyl) -1 h- pyrazol- 1 -yl) ethanol and its use as fgfr inhibitor

Publications (1)

Publication Number	Publication Date
HK1184147A1 true HK1184147A1 (en)	2014-01-17

Family

ID=44999860

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HK13111594.2A HK1184147A1 (en)	2010-10-05	2013-10-15	Crystalline(r)-(e)-2-(4-(2-(5-(1-(3,5-dichloropyridin-4-yl)ethoxy)-1h- indazol-3-yl)vinyl)-1h-pyrazol-1-yl) ethanol and its use as fgfr inhibitor ((r)-(e)-2-(4-(2-(5-(1-(35--4-))-1h--3-) )-1h--1-) fgfr

Country Status (35)

Country	Link
US (1)	US8530665B2 (xx)
EP (1)	EP2625175B1 (xx)
JP (1)	JP5940547B2 (xx)
KR (1)	KR101527661B1 (xx)
CN (1)	CN103153983B (xx)
AR (1)	AR083091A1 (xx)
AU (1)	AU2011312485B2 (xx)
BR (1)	BR112013006336A2 (xx)
CA (1)	CA2813329C (xx)
CL (1)	CL2013000884A1 (xx)
CO (1)	CO6710911A2 (xx)
DK (1)	DK2625175T3 (xx)
DO (1)	DOP2013000072A (xx)
EA (1)	EA021817B1 (xx)
EC (1)	ECSP13012539A (xx)
ES (1)	ES2558777T3 (xx)
HK (1)	HK1184147A1 (xx)
HR (1)	HRP20151299T1 (xx)
HU (1)	HUE026379T2 (xx)
IL (1)	IL224850A (xx)
JO (1)	JO3062B1 (xx)
MA (1)	MA34552B1 (xx)
ME (1)	ME02307B (xx)
MX (1)	MX2013003907A (xx)
NZ (1)	NZ608482A (xx)
PE (1)	PE20140252A1 (xx)
PL (1)	PL2625175T3 (xx)
PT (1)	PT2625175E (xx)
RS (1)	RS54457B1 (xx)
SG (1)	SG188286A1 (xx)
SI (1)	SI2625175T1 (xx)
TW (1)	TWI418554B (xx)
UA (1)	UA111725C2 (xx)
WO (1)	WO2012047699A1 (xx)
ZA (1)	ZA201301560B (xx)

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WO2012088266A2 (en)	2010-12-22	2012-06-28	Incyte Corporation	Substituted imidazopyridazines and benzimidazoles as inhibitors of fgfr3
PL3176170T3 (pl)	2012-06-13	2019-05-31	Incyte Holdings Corp	Podstawione związki tricykliczne jako inhibitory fgfr
US9388185B2 (en)	2012-08-10	2016-07-12	Incyte Holdings Corporation	Substituted pyrrolo[2,3-b]pyrazines as FGFR inhibitors
US9266892B2 (en)	2012-12-19	2016-02-23	Incyte Holdings Corporation	Fused pyrazoles as FGFR inhibitors
PT2986610T (pt)	2013-04-19	2018-03-09	Incyte Holdings Corp	Heterociclos bicíclicos como inibidores de fgfr
CN103819396B (zh) *	2014-02-26	2016-06-15	四川大学	一种手性的1-（3,5-二氯吡啶-4-基）-乙醇的合成方法
US10851105B2 (en)	2014-10-22	2020-12-01	Incyte Corporation	Bicyclic heterocycles as FGFR4 inhibitors
MA41551A (fr)	2015-02-20	2017-12-26	Incyte Corp	Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4
WO2016134294A1 (en)	2015-02-20	2016-08-25	Incyte Corporation	Bicyclic heterocycles as fgfr4 inhibitors
ES2751669T3 (es)	2015-02-20	2020-04-01	Incyte Corp	Heterociclos bicíclicos como inhibidores FGFR
AR111960A1 (es)	2017-05-26	2019-09-04	Incyte Corp	Formas cristalinas de un inhibidor de fgfr y procesos para su preparación
US11466004B2 (en)	2018-05-04	2022-10-11	Incyte Corporation	Solid forms of an FGFR inhibitor and processes for preparing the same
KR20210018264A (ko)	2018-05-04	2021-02-17	인사이트 코포레이션	Fgfr 억제제의 염
WO2020185532A1 (en)	2019-03-08	2020-09-17	Incyte Corporation	Methods of treating cancer with an fgfr inhibitor
KR20210142154A (ko)	2019-03-21	2021-11-24	옹쎄오	암 치료를 위한 키나제 억제제와 조합된 dbait 분자
US11591329B2 (en)	2019-07-09	2023-02-28	Incyte Corporation	Bicyclic heterocycles as FGFR inhibitors
PE20221085A1 (es)	2019-10-14	2022-07-05	Incyte Corp	Heterociclos biciclicos como inhibidores de fgfr
US11566028B2 (en)	2019-10-16	2023-01-31	Incyte Corporation	Bicyclic heterocycles as FGFR inhibitors
US20220401436A1 (en)	2019-11-08	2022-12-22	INSERM (Institute National de la Santé et de la Recherche Médicale)	Methods for the treatment of cancers that have acquired resistance to kinase inhibitors
CA3162010A1 (en)	2019-12-04	2021-06-10	Incyte Corporation	Derivatives of an fgfr inhibitor
CA3163875A1 (en)	2019-12-04	2021-06-10	Incyte Corporation	Tricyclic heterocycles as fgfr inhibitors
WO2021148581A1 (en)	2020-01-22	2021-07-29	Onxeo	Novel dbait molecule and its use
CN111705099B (zh) *	2020-07-01	2022-03-08	天津药明康德新药开发有限公司	一种(s)-1-(3,5-二氯吡啶-4-取代)乙醇的制备方法
JP2023553835A (ja) *	2020-12-17	2023-12-26	ブロッサムヒル・セラピューティクス・インコーポレイテッド	大環状化合物およびそれらの使用
EP4352059A1 (en)	2021-06-09	2024-04-17	Incyte Corporation	Tricyclic heterocycles as fgfr inhibitors

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CA2421120C (en)	2000-09-11	2008-07-15	Chiron Corporation	Quinolinone derivatives as tyrosine kinase inhibitors
KR20050004214A (ko)	2002-05-31	2005-01-12	에자이 가부시키가이샤	피라졸 화합물 및 이것을 포함하여 이루어지는 의약 조성물
BRPI0508895A (pt) *	2004-03-17	2007-09-11	Pfizer	formas polimorficas e amorfa de {2-flúor-5-[3-((e)-2-piridn-2-il-vinil)-1h-indazol-6-ilamin]- fenil}-amida de ácido 2,5-dimetil-2h-pirazol-3-carboxìlico
JP4746299B2 (ja) *	2004-07-16	2011-08-10	ジュズインターナショナルピーティーイーエルティーディー	金属酸化物粉末の製造方法
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2011
- 2011-09-22 JO JOP/2011/0294A patent/JO3062B1/ar active
- 2011-09-23 AR ARP110103482A patent/AR083091A1/es unknown
- 2011-09-23 TW TW100134428A patent/TWI418554B/zh not_active IP Right Cessation
- 2011-09-29 NZ NZ608482A patent/NZ608482A/en not_active IP Right Cessation
- 2011-09-29 PT PT117713123T patent/PT2625175E/pt unknown
- 2011-09-29 WO PCT/US2011/053798 patent/WO2012047699A1/en active Application Filing
- 2011-09-29 ME MEP-2015-198A patent/ME02307B/me unknown
- 2011-09-29 DK DK11771312.3T patent/DK2625175T3/en active
- 2011-09-29 KR KR1020137008655A patent/KR101527661B1/ko not_active IP Right Cessation
- 2011-09-29 EA EA201390275A patent/EA021817B1/ru not_active IP Right Cessation
- 2011-09-29 EP EP11771312.3A patent/EP2625175B1/en active Active
- 2011-09-29 CN CN201180048148.7A patent/CN103153983B/zh not_active Expired - Fee Related
- 2011-09-29 MX MX2013003907A patent/MX2013003907A/es active IP Right Grant
- 2011-09-29 ES ES11771312.3T patent/ES2558777T3/es active Active
- 2011-09-29 JP JP2013532838A patent/JP5940547B2/ja not_active Expired - Fee Related
- 2011-09-29 PE PE2013000789A patent/PE20140252A1/es not_active Application Discontinuation
- 2011-09-29 CA CA2813329A patent/CA2813329C/en not_active Expired - Fee Related
- 2011-09-29 AU AU2011312485A patent/AU2011312485B2/en not_active Ceased
- 2011-09-29 MA MA35780A patent/MA34552B1/fr unknown
- 2011-09-29 BR BR112013006336A patent/BR112013006336A2/pt not_active IP Right Cessation
- 2011-09-29 HU HUE11771312A patent/HUE026379T2/en unknown
- 2011-09-29 SG SG2013013743A patent/SG188286A1/en unknown
- 2011-09-29 US US13/248,055 patent/US8530665B2/en not_active Expired - Fee Related
- 2011-09-29 SI SI201130673T patent/SI2625175T1/sl unknown
- 2011-09-29 RS RS20150828A patent/RS54457B1/en unknown
- 2011-09-29 PL PL11771312T patent/PL2625175T3/pl unknown
- 2011-09-29 UA UAA201303378A patent/UA111725C2/uk unknown
2013
- 2013-02-21 IL IL224850A patent/IL224850A/en not_active IP Right Cessation
- 2013-02-28 ZA ZA2013/01560A patent/ZA201301560B/en unknown
- 2013-04-02 DO DO2013000072A patent/DOP2013000072A/es unknown
- 2013-04-02 CL CL2013000884A patent/CL2013000884A1/es unknown
- 2013-04-03 EC ECSP13012539 patent/ECSP13012539A/es unknown
- 2013-04-08 CO CO13090555A patent/CO6710911A2/es unknown
- 2013-10-15 HK HK13111594.2A patent/HK1184147A1/xx not_active IP Right Cessation
2015
- 2015-11-30 HR HRP20151299TT patent/HRP20151299T1/hr unknown

Also Published As

Publication number	Publication date
CL2013000884A1 (es)	2013-10-18
KR101527661B1 (ko)	2015-06-09
PT2625175E (pt)	2016-01-22
ME02307B (me)	2016-06-20
EP2625175B1 (en)	2015-11-18
HUE026379T2 (en)	2016-06-28
PE20140252A1 (es)	2014-03-12
CO6710911A2 (es)	2013-07-15
US20120083511A1 (en)	2012-04-05
CN103153983A (zh)	2013-06-12
IL224850A (en)	2016-09-29
JP5940547B2 (ja)	2016-06-29
NZ608482A (en)	2014-03-28
CA2813329C (en)	2015-05-26
EA201390275A1 (ru)	2013-07-30
JP2013538875A (ja)	2013-10-17
PL2625175T3 (pl)	2016-04-29
AU2011312485B2 (en)	2014-09-04
ZA201301560B (en)	2014-08-27
AR083091A1 (es)	2013-01-30
HRP20151299T1 (hr)	2016-01-01
WO2012047699A1 (en)	2012-04-12
DK2625175T3 (en)	2016-02-01
AU2011312485A1 (en)	2013-03-07
CA2813329A1 (en)	2012-04-12
JO3062B1 (ar)	2017-03-15
RS54457B1 (en)	2016-06-30
BR112013006336A2 (pt)	2019-09-24
TW201249826A (en)	2012-12-16
EP2625175A1 (en)	2013-08-14
DOP2013000072A (es)	2013-08-15
TWI418554B (zh)	2013-12-11
ECSP13012539A (es)	2013-06-28
SG188286A1 (en)	2013-04-30
ES2558777T3 (es)	2016-02-08
KR20130052680A (ko)	2013-05-22
EA021817B1 (ru)	2015-09-30
SI2625175T1 (sl)	2016-01-29
UA111725C2 (uk)	2016-06-10
MX2013003907A (es)	2013-06-03
CN103153983B (zh)	2014-11-05
MA34552B1 (fr)	2013-09-02
US8530665B2 (en)	2013-09-10

Legal Events

Date	Code	Title	Description
2020-05-15	PC	Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)	Effective date: 20191001

Publication	Publication Date	Title
HK1184147A1 (en)	2014-01-17	Crystalline(r)-(e)-2-(4-(2-(5-(1-(3,5-dichloropyridin-4-yl)ethoxy)-1h- indazol-3-yl)vinyl)-1h-pyrazol-1-yl) ethanol and its use as fgfr inhibitor ((r)-(e)-2-(4-(2-(5-(1-(35--4-))-1h--3-) )-1h--1-) fgfr
HUS2000049I1 (hu)	2021-01-28	Kináz aktivitással rendelkezõ helyettesített imidazol származékok
HK1203959A1 (en)	2015-11-06	Method for the preparation of 4-[3-(4-cyclopropanecarbonyl- piperazine-1-carbonyl)-4-fluoro-benzyl -2h-phthalazin-1-one 1-()-4-[5-[(34--4--1-) -2-
RS52795B (en)	2013-10-31	VINYL INDAZOLIL UNITS
ZA201001513B (en)	2010-10-27	5-(4-(Haloalkoxy) phenyl) pyrimidine-2-amine compounds and compositions as kinase inhibitors
IL209122A0 (en)	2011-01-31	Phenyl or pyridinyl substituted indazoles derivatives
ZA201100026B (en)	2012-04-25	4-(pyridin-4-yl)-1h-(1,3,5)triazin-2-one derivatives as gsk3-beta inhibitors for the treatment of neurodegenerative diseases
IL208467A0 (en)	2010-12-30	3,4-substituted piperidine derivatives as renin inhibitors
EP2300453A4 (en)	2012-03-21	3,4-SUBSTITUTED PIPERIDINE DERIVATIVES AS INHIBITORS OF THE REINE
IL199389A (en)	2014-01-30	2-Oxide salt ((4 - (1-methyl-4-pyridine-4-yl) -h1-pyrrolysis-3-yl) phenoxy) quinoline
PL2943488T3 (pl)	2018-09-28	Postacie soli megluminowej kwasu 2-((1r,4r)-4-(4-(5-(benzoksazol-2-iloamino)pirydyn-2-ylo)fenylo)cykloheksylo)octowego i ich zastosowania jako inhibitory dgat1
TN2013000142A1 (en)	2014-06-25	Crystalline (r) - (e) -2- (4- (2- (5- (1- (3, 5 -dichloropyridin-4 -yl) ethoxy) - 1h - indazol - 3 - yl) vinyl) -1 h- pyrazol- 1 -yl) ethanol and its use as fgfr inhibitor
WO2011084652A3 (en)	2011-09-09	Crystalline salts of a factor xa inhibitor
BRPI0816757A2 (pt)	2015-03-17	Formas polimorfas de (s) -2- ((4-benzofuranil) carbonilaminometil)-1-((4-(2-metil-5-(4-fluorofenil))tia zolil)carbonil) piperidina
TH115254B (th)	2012-07-31	สารประกอบไวนิลอินดาโซลอิล
TH132151A (th)	2014-03-28	((r)-(e)-2-(4-(2-(5-(1-(3,5-ไดคลอโรไพริดิน-4-อิล)เอทธอกซี)-1h-อินดาซอล-3-อิล)ไวนิล)-1h-ไพราซอล-1-อิล)เอทธานอลเชิงผลึก
CY1117146T1 (el)	2017-04-05	Κρυσταλλικη (r)-(ε)-2-(4-(2-(5-(1-(3,5-διχλωροπυριδινο-4-υλ)αιθοξυ)-1 η-ινδαζολο-3-υλ)βινυλο)-1 η-πυραζολο-1-υλ)αιθανολη και η χρηση της ως αναστολεα του fgfr
ZA201007486B (en)	2011-12-28	3,4- substituted piperidine derivatives as renin inhibitors