SG188286A1 - Crystalline (r) - (e) -2- (4- (2- (5- (1- (3, 5 -dichloropyridin-4 -yl) ethoxy) - 1h - indazol - 3 - yl) vinyl) -1 h- pyrazol- 1 -yl) ethanol and its use as fgfr inhibitor - Google Patents

Crystalline (r) - (e) -2- (4- (2- (5- (1- (3, 5 -dichloropyridin-4 -yl) ethoxy) - 1h - indazol - 3 - yl) vinyl) -1 h- pyrazol- 1 -yl) ethanol and its use as fgfr inhibitor Download PDF

Info

Publication number: SG188286A1
Authority: SG; Singapore
Prior art keywords: cancer; dichloropyridin; compound; vinyl; pyrazol
Prior art date: 2010-10-05

Application number

SG2013013743A

Other languages

English (en)

Inventor

Benjamin Alan Diseroad

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2010-10-05

Filing date

2011-09-29

Publication date

2013-04-30

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44999860&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG188286(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2011-09-29 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

2013-04-30 Publication of SG188286A1 publication Critical patent/SG188286A1/en

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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

SG2013013743A 2010-10-05 2011-09-29 Crystalline (r) - (e) -2- (4- (2- (5- (1- (3, 5 -dichloropyridin-4 -yl) ethoxy) - 1h - indazol - 3 - yl) vinyl) -1 h- pyrazol- 1 -yl) ethanol and its use as fgfr inhibitor SG188286A1 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US38991110P	2010-10-05	2010-10-05
PCT/US2011/053798 WO2012047699A1 (en)	2010-10-05	2011-09-29	Crystalline (r) - (e) -2- (4- (2- (5- (1- (3, 5 -dichloropyridin-4 -yl) ethoxy) - 1h - indazol - 3 - yl) vinyl) -1 h- pyrazol- 1 -yl) ethanol and its use as fgfr inhibitor

Publications (1)

Publication Number	Publication Date
SG188286A1 true SG188286A1 (en)	2013-04-30

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SG2013013743A SG188286A1 (en)	2010-10-05	2011-09-29	Crystalline (r) - (e) -2- (4- (2- (5- (1- (3, 5 -dichloropyridin-4 -yl) ethoxy) - 1h - indazol - 3 - yl) vinyl) -1 h- pyrazol- 1 -yl) ethanol and its use as fgfr inhibitor

Country Status (35)

Country	Link
US (1)	US8530665B2 (ru)
EP (1)	EP2625175B1 (ru)
JP (1)	JP5940547B2 (ru)
KR (1)	KR101527661B1 (ru)
CN (1)	CN103153983B (ru)
AR (1)	AR083091A1 (ru)
AU (1)	AU2011312485B2 (ru)
BR (1)	BR112013006336A2 (ru)
CA (1)	CA2813329C (ru)
CL (1)	CL2013000884A1 (ru)
CO (1)	CO6710911A2 (ru)
DK (1)	DK2625175T3 (ru)
DO (1)	DOP2013000072A (ru)
EA (1)	EA021817B1 (ru)
EC (1)	ECSP13012539A (ru)
ES (1)	ES2558777T3 (ru)
HK (1)	HK1184147A1 (ru)
HR (1)	HRP20151299T1 (ru)
HU (1)	HUE026379T2 (ru)
IL (1)	IL224850A (ru)
JO (1)	JO3062B1 (ru)
MA (1)	MA34552B1 (ru)
ME (1)	ME02307B (ru)
MX (1)	MX2013003907A (ru)
NZ (1)	NZ608482A (ru)
PE (1)	PE20140252A1 (ru)
PL (1)	PL2625175T3 (ru)
PT (1)	PT2625175E (ru)
RS (1)	RS54457B1 (ru)
SG (1)	SG188286A1 (ru)
SI (1)	SI2625175T1 (ru)
TW (1)	TWI418554B (ru)
UA (1)	UA111725C2 (ru)
WO (1)	WO2012047699A1 (ru)
ZA (1)	ZA201301560B (ru)

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PL3176170T3 (pl)	2012-06-13	2019-05-31	Incyte Holdings Corp	Podstawione związki tricykliczne jako inhibitory fgfr
US9388185B2 (en)	2012-08-10	2016-07-12	Incyte Holdings Corporation	Substituted pyrrolo[2,3-b]pyrazines as FGFR inhibitors
US9266892B2 (en)	2012-12-19	2016-02-23	Incyte Holdings Corporation	Fused pyrazoles as FGFR inhibitors
PT2986610T (pt)	2013-04-19	2018-03-09	Incyte Holdings Corp	Heterociclos bicíclicos como inibidores de fgfr
CN103819396B (zh) *	2014-02-26	2016-06-15	四川大学	一种手性的1-（3,5-二氯吡啶-4-基）-乙醇的合成方法
US10851105B2 (en)	2014-10-22	2020-12-01	Incyte Corporation	Bicyclic heterocycles as FGFR4 inhibitors
MA41551A (fr)	2015-02-20	2017-12-26	Incyte Corp	Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4
WO2016134294A1 (en)	2015-02-20	2016-08-25	Incyte Corporation	Bicyclic heterocycles as fgfr4 inhibitors
ES2751669T3 (es)	2015-02-20	2020-04-01	Incyte Corp	Heterociclos bicíclicos como inhibidores FGFR
AR111960A1 (es)	2017-05-26	2019-09-04	Incyte Corp	Formas cristalinas de un inhibidor de fgfr y procesos para su preparación
US11466004B2 (en)	2018-05-04	2022-10-11	Incyte Corporation	Solid forms of an FGFR inhibitor and processes for preparing the same
KR20210018264A (ko)	2018-05-04	2021-02-17	인사이트 코포레이션	Fgfr 억제제의 염
WO2020185532A1 (en)	2019-03-08	2020-09-17	Incyte Corporation	Methods of treating cancer with an fgfr inhibitor
KR20210142154A (ko)	2019-03-21	2021-11-24	옹쎄오	암 치료를 위한 키나제 억제제와 조합된 dbait 분자
US11591329B2 (en)	2019-07-09	2023-02-28	Incyte Corporation	Bicyclic heterocycles as FGFR inhibitors
PE20221085A1 (es)	2019-10-14	2022-07-05	Incyte Corp	Heterociclos biciclicos como inhibidores de fgfr
US11566028B2 (en)	2019-10-16	2023-01-31	Incyte Corporation	Bicyclic heterocycles as FGFR inhibitors
US20220401436A1 (en)	2019-11-08	2022-12-22	INSERM (Institute National de la Santé et de la Recherche Médicale)	Methods for the treatment of cancers that have acquired resistance to kinase inhibitors
CA3162010A1 (en)	2019-12-04	2021-06-10	Incyte Corporation	Derivatives of an fgfr inhibitor
CA3163875A1 (en)	2019-12-04	2021-06-10	Incyte Corporation	Tricyclic heterocycles as fgfr inhibitors
WO2021148581A1 (en)	2020-01-22	2021-07-29	Onxeo	Novel dbait molecule and its use
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JP2023553835A (ja) *	2020-12-17	2023-12-26	ブロッサムヒル・セラピューティクス・インコーポレイテッド	大環状化合物およびそれらの使用
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2011
- 2011-09-22 JO JOP/2011/0294A patent/JO3062B1/ar active
- 2011-09-23 AR ARP110103482A patent/AR083091A1/es unknown
- 2011-09-23 TW TW100134428A patent/TWI418554B/zh not_active IP Right Cessation
- 2011-09-29 NZ NZ608482A patent/NZ608482A/en not_active IP Right Cessation
- 2011-09-29 PT PT117713123T patent/PT2625175E/pt unknown
- 2011-09-29 WO PCT/US2011/053798 patent/WO2012047699A1/en active Application Filing
- 2011-09-29 ME MEP-2015-198A patent/ME02307B/me unknown
- 2011-09-29 DK DK11771312.3T patent/DK2625175T3/en active
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- 2011-09-29 EA EA201390275A patent/EA021817B1/ru not_active IP Right Cessation
- 2011-09-29 EP EP11771312.3A patent/EP2625175B1/en active Active
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- 2011-09-29 MX MX2013003907A patent/MX2013003907A/es active IP Right Grant
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- 2011-09-29 JP JP2013532838A patent/JP5940547B2/ja not_active Expired - Fee Related
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- 2011-09-29 CA CA2813329A patent/CA2813329C/en not_active Expired - Fee Related
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- 2011-09-29 MA MA35780A patent/MA34552B1/fr unknown
- 2011-09-29 BR BR112013006336A patent/BR112013006336A2/pt not_active IP Right Cessation
- 2011-09-29 HU HUE11771312A patent/HUE026379T2/en unknown
- 2011-09-29 SG SG2013013743A patent/SG188286A1/en unknown
- 2011-09-29 US US13/248,055 patent/US8530665B2/en not_active Expired - Fee Related
- 2011-09-29 SI SI201130673T patent/SI2625175T1/sl unknown
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- 2011-09-29 PL PL11771312T patent/PL2625175T3/pl unknown
- 2011-09-29 UA UAA201303378A patent/UA111725C2/uk unknown
2013
- 2013-02-21 IL IL224850A patent/IL224850A/en not_active IP Right Cessation
- 2013-02-28 ZA ZA2013/01560A patent/ZA201301560B/en unknown
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- 2013-04-03 EC ECSP13012539 patent/ECSP13012539A/es unknown
- 2013-04-08 CO CO13090555A patent/CO6710911A2/es unknown
- 2013-10-15 HK HK13111594.2A patent/HK1184147A1/xx not_active IP Right Cessation
2015
- 2015-11-30 HR HRP20151299TT patent/HRP20151299T1/hr unknown

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Publication number	Publication date
CL2013000884A1 (es)	2013-10-18
KR101527661B1 (ko)	2015-06-09
PT2625175E (pt)	2016-01-22
ME02307B (me)	2016-06-20
EP2625175B1 (en)	2015-11-18
HUE026379T2 (en)	2016-06-28
PE20140252A1 (es)	2014-03-12
CO6710911A2 (es)	2013-07-15
US20120083511A1 (en)	2012-04-05
CN103153983A (zh)	2013-06-12
IL224850A (en)	2016-09-29
JP5940547B2 (ja)	2016-06-29
NZ608482A (en)	2014-03-28
CA2813329C (en)	2015-05-26
EA201390275A1 (ru)	2013-07-30
JP2013538875A (ja)	2013-10-17
PL2625175T3 (pl)	2016-04-29
AU2011312485B2 (en)	2014-09-04
ZA201301560B (en)	2014-08-27
AR083091A1 (es)	2013-01-30
HRP20151299T1 (hr)	2016-01-01
WO2012047699A1 (en)	2012-04-12
DK2625175T3 (en)	2016-02-01
HK1184147A1 (en)	2014-01-17
AU2011312485A1 (en)	2013-03-07
CA2813329A1 (en)	2012-04-12
JO3062B1 (ar)	2017-03-15
RS54457B1 (en)	2016-06-30
BR112013006336A2 (pt)	2019-09-24
TW201249826A (en)	2012-12-16
EP2625175A1 (en)	2013-08-14
DOP2013000072A (es)	2013-08-15
TWI418554B (zh)	2013-12-11
ECSP13012539A (es)	2013-06-28
ES2558777T3 (es)	2016-02-08
KR20130052680A (ko)	2013-05-22
EA021817B1 (ru)	2015-09-30
SI2625175T1 (sl)	2016-01-29
UA111725C2 (uk)	2016-06-10
MX2013003907A (es)	2013-06-03
CN103153983B (zh)	2014-11-05
MA34552B1 (fr)	2013-09-02
US8530665B2 (en)	2013-09-10

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