EA201170031A1 - СВЯЗЫВАЮЩИЕ НЕСКОЛЬКО МИШЕНЕЙ БЕЛКИ, ОБЛАДАЮЩИЕ АНТАГОНИСТИЧЕСКИМ ДЕЙСТВИЕМ ПО ОТНОШЕНИЮ К TGF-β - Google Patents

СВЯЗЫВАЮЩИЕ НЕСКОЛЬКО МИШЕНЕЙ БЕЛКИ, ОБЛАДАЮЩИЕ АНТАГОНИСТИЧЕСКИМ ДЕЙСТВИЕМ ПО ОТНОШЕНИЮ К TGF-β

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EA201170031A1
EA201170031A1 EA201170031A EA201170031A EA201170031A1 EA 201170031 A1 EA201170031 A1 EA 201170031A1 EA 201170031 A EA201170031 A EA 201170031A EA 201170031 A EA201170031 A EA 201170031A EA 201170031 A1 EA201170031 A1 EA 201170031A1
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Prior art keywords
tgf
multiple targets
antagonistic action
fusion proteins
multispecific fusion
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EA201170031A
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English (en)
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Алан Кейт Лофквист
Питер Роберт Баум
Питер Армстронг Томпсон
Линда Мишер
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Эмерджент Продакт Дивелопмент Сиэтл, Ллс
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Publication of EA201170031A1 publication Critical patent/EA201170031A1/ru

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Abstract

Согласно настоящему изобретению предложен мультиспецифичный гибридный белок, состоящий из домена антагониста TGF-β, и другого связывающего домена, обладающего свойствами антагониста по отношению к гетрологичной мишени (например, к IL-6, IL-10, ФРЭС, ФНО, ФРГ, TWEAK, ИФР) свойствами агониста по отношению к гетрологичной мишени (например, к GITR). Указаный мультиспецифичный гибридный белок также может содержать промежуточный домен, разделяющий указанные связывающие домены и способствующий димеризации. Также согласно настоящему изобретению предложены полинуклеотиды, кодирующие указанные мультиспецифичные гибридные белки, композиции указанных гибридных белков и способы применения указанных мультиспецифичных гибридных белков и композиций.
EA201170031A 2008-07-02 2009-07-02 СВЯЗЫВАЮЩИЕ НЕСКОЛЬКО МИШЕНЕЙ БЕЛКИ, ОБЛАДАЮЩИЕ АНТАГОНИСТИЧЕСКИМ ДЕЙСТВИЕМ ПО ОТНОШЕНИЮ К TGF-β EA201170031A1 (ru)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US13408808P 2008-07-02 2008-07-02
US13408908P 2008-07-02 2008-07-02
US13408508P 2008-07-02 2008-07-02
US13408608P 2008-07-02 2008-07-02
US13409008P 2008-07-02 2008-07-02
US13409108P 2008-07-02 2008-07-02
US13408708P 2008-07-02 2008-07-02
US18123209P 2009-05-26 2009-05-26
PCT/US2009/049616 WO2010003118A1 (en) 2008-07-02 2009-07-02 Tgf-b antagonist multi-target binding proteins

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EA201170031A1 true EA201170031A1 (ru) 2011-08-30

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US (1) US20110177070A1 (ru)
EP (1) EP2310508A1 (ru)
JP (1) JP2011526794A (ru)
KR (1) KR20110044992A (ru)
CN (1) CN102203258A (ru)
AU (1) AU2009266873A1 (ru)
CA (1) CA2729810A1 (ru)
EA (1) EA201170031A1 (ru)
IL (1) IL210268A0 (ru)
MX (1) MX2011000039A (ru)
NZ (1) NZ590667A (ru)
WO (1) WO2010003118A1 (ru)

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MX2011000039A (es) 2011-05-31
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JP2011526794A (ja) 2011-10-20
CN102203258A (zh) 2011-09-28
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WO2010003118A1 (en) 2010-01-07
AU2009266873A1 (en) 2010-01-07

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