EA201291181A1 - Композиции и способы применения терапевтических поливалентных антител против белка, родственного рецептору липопротеинов низкой плотности 6 (lrp6) - Google Patents

Композиции и способы применения терапевтических поливалентных антител против белка, родственного рецептору липопротеинов низкой плотности 6 (lrp6)

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EA201291181A1
EA201291181A1 EA201291181A EA201291181A EA201291181A1 EA 201291181 A1 EA201291181 A1 EA 201291181A1 EA 201291181 A EA201291181 A EA 201291181A EA 201291181 A EA201291181 A EA 201291181A EA 201291181 A1 EA201291181 A1 EA 201291181A1
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EA
Eurasian Patent Office
Prior art keywords
compositions
methods
lrp6
application
low density
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EA201291181A
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English (en)
Inventor
Фэн Цун
Сет Эттенберг
Дэвид Дженкинс
Мин Лэй
Андреас Лоэв
Карен Винсен
Ли Чжоу
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Новартис Аг
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Application filed by Новартис Аг filed Critical Новартис Аг
Publication of EA201291181A1 publication Critical patent/EA201291181A1/ru

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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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Abstract

Изобретение относится к антителу или антигенсвязывающему фрагменту, имеющим по меньшей мере два связывающих рецептор домена для двух различных участков связывания LRP6, и к их композициям и способам их применения.
EA201291181A 2010-05-06 2011-05-05 Композиции и способы применения терапевтических поливалентных антител против белка, родственного рецептору липопротеинов низкой плотности 6 (lrp6) EA201291181A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33199310P 2010-05-06 2010-05-06
PCT/EP2011/057200 WO2011138391A1 (en) 2010-05-06 2011-05-05 Compositions and methods of use for therapeutic low density lipoprotein - related protein 6 (lrp6) multivalent antibodies

Publications (1)

Publication Number Publication Date
EA201291181A1 true EA201291181A1 (ru) 2013-05-30

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EA201291181A EA201291181A1 (ru) 2010-05-06 2011-05-05 Композиции и способы применения терапевтических поливалентных антител против белка, родственного рецептору липопротеинов низкой плотности 6 (lrp6)

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US (1) US9290573B2 (ru)
EP (1) EP2566894A1 (ru)
JP (4) JP2013527761A (ru)
KR (1) KR20130066631A (ru)
CN (1) CN103237811A (ru)
AU (1) AU2011249782B2 (ru)
BR (1) BR112012028326A2 (ru)
CA (1) CA2798390A1 (ru)
CL (2) CL2012003093A1 (ru)
CO (1) CO6630180A2 (ru)
EA (1) EA201291181A1 (ru)
GT (1) GT201200298A (ru)
IL (1) IL222814A0 (ru)
MA (1) MA34287B1 (ru)
MX (1) MX2012012927A (ru)
PE (1) PE20130206A1 (ru)
SG (1) SG185415A1 (ru)
TN (1) TN2012000512A1 (ru)
WO (1) WO2011138391A1 (ru)
ZA (1) ZA201208050B (ru)

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