EA200970263A1 - Полностью человеческая высокопродуктивная система получения усовершенствованных антител и белков - Google Patents
Полностью человеческая высокопродуктивная система получения усовершенствованных антител и белковInfo
- Publication number
- EA200970263A1 EA200970263A1 EA200970263A EA200970263A EA200970263A1 EA 200970263 A1 EA200970263 A1 EA 200970263A1 EA 200970263 A EA200970263 A EA 200970263A EA 200970263 A EA200970263 A EA 200970263A EA 200970263 A1 EA200970263 A1 EA 200970263A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- proteins
- fully human
- obtaining improved
- human high
- improved antibodies
- Prior art date
Links
- 102000004169 proteins and genes Human genes 0.000 title abstract 5
- 108090000623 proteins and genes Proteins 0.000 title abstract 5
- 239000000203 mixture Substances 0.000 abstract 3
- 210000004027 cell Anatomy 0.000 abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 2
- 210000000601 blood cell Anatomy 0.000 abstract 1
- 238000012258 culturing Methods 0.000 abstract 1
- 230000013595 glycosylation Effects 0.000 abstract 1
- 238000006206 glycosylation reaction Methods 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3076—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties
- C07K16/3092—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties against tumour-associated mucins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0006—Modification of the membrane of cells, e.g. cell decoration
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- A61K38/1735—Mucins, e.g. human intestinal mucin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
- A61K38/4846—Factor VII (3.4.21.21); Factor IX (3.4.21.22); Factor Xa (3.4.21.6); Factor XI (3.4.21.27); Factor XII (3.4.21.38)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/72—Increased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/734—Complement-dependent cytotoxicity [CDC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/55—Fusion polypeptide containing a fusion with a toxin, e.g. diphteria toxin
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
- Y02E60/00—Enabling technologies; Technologies with a potential or indirect contribution to GHG emissions mitigation
- Y02E60/10—Energy storage using batteries
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Cell Biology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Hematology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Mycology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
Настоящее изобретение относится к способу получения композиции молекулы белка, имеющей определенный характер гликозилирования, включающему: (а) введение в клетку-хозяин, которая представляет собой иммортализованную клетку крови человека, по меньшей мере одной нуклеиновой кислоты, кодирующей по меньшей мере часть указанного белка; (b) культивирование указанной клетки-хозяина в условиях, обеспечивающих продукцию указанной композиции молекулы белка; и (с) выделение указанной композиции молекулы белка.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP06090162 | 2006-09-10 | ||
EP06090171A EP1900750A1 (en) | 2006-09-18 | 2006-09-18 | Fully human high yield production system for improved antibodies |
EP06090190A EP1911766A1 (en) | 2006-10-13 | 2006-10-13 | Use of human cells of myeloid leukaemia origin for expression of antibodies |
EP07090094 | 2007-05-04 | ||
PCT/EP2007/007877 WO2008028686A2 (en) | 2006-09-10 | 2007-09-10 | Use of human cells of myeloid leukaemia origin for expression of antibodies |
Publications (2)
Publication Number | Publication Date |
---|---|
EA200970263A1 true EA200970263A1 (ru) | 2009-08-28 |
EA017622B1 EA017622B1 (ru) | 2013-01-30 |
Family
ID=39157600
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200970263A EA017622B1 (ru) | 2006-09-10 | 2007-09-10 | Полностью человеческая высокопродуктивная система получения усовершенствованных антител и белков |
Country Status (25)
Country | Link |
---|---|
US (3) | US9051356B2 (ru) |
EP (5) | EP3539981A1 (ru) |
JP (3) | JP5767779B2 (ru) |
KR (3) | KR101603632B1 (ru) |
CN (1) | CN103436574B (ru) |
AU (1) | AU2007294122B2 (ru) |
BR (1) | BRPI0716997B8 (ru) |
CA (1) | CA2662226C (ru) |
CU (1) | CU23791A3 (ru) |
CY (1) | CY1116279T1 (ru) |
DK (2) | DK2073842T4 (ru) |
EA (1) | EA017622B1 (ru) |
ES (2) | ES2533964T5 (ru) |
FI (1) | FI2073842T4 (ru) |
HR (1) | HRP20150307T1 (ru) |
IL (1) | IL197459A (ru) |
MX (1) | MX2009002388A (ru) |
NZ (1) | NZ575974A (ru) |
PL (1) | PL2073842T3 (ru) |
PT (1) | PT2073842E (ru) |
RS (1) | RS53861B1 (ru) |
SG (1) | SG174792A1 (ru) |
SI (1) | SI2073842T1 (ru) |
WO (1) | WO2008028686A2 (ru) |
ZA (1) | ZA201001903B (ru) |
Families Citing this family (75)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3528611B2 (ja) * | 1998-07-16 | 2004-05-17 | Jfeスチール株式会社 | 結束材の切断方法及びその装置 |
CA2662226C (en) | 2006-09-10 | 2020-08-04 | Glycotope Gmbh | Fully human high yield production system for improved antibodies and proteins |
EP1920781B1 (en) * | 2006-11-10 | 2015-03-04 | Glycotope GmbH | Compositions comprising a core-1 positive microorganism and their use for the treatment or prophylaxis of tumors |
WO2008135259A2 (en) * | 2007-05-04 | 2008-11-13 | Glycotope Gmbh | Antibody molecule composition |
GB0812277D0 (en) * | 2008-07-04 | 2008-08-13 | Fusion Antibodies Ltd | Antibody and uses thereof |
AU2009338190C1 (en) | 2009-01-22 | 2014-07-17 | Momenta Pharmaceuticals, Inc. | Galactose-alpha-1, 3-galactose-containing N-glycans in glycoprotein products derived from CHO cells |
US20120100576A1 (en) | 2009-07-08 | 2012-04-26 | Glycotope Gmbh | Perfusion bioreactor |
EP2281844A1 (en) | 2009-07-31 | 2011-02-09 | Glycotope GmbH | MUC 1 antibodies |
WO2012016576A1 (en) * | 2010-08-04 | 2012-02-09 | Glycotope Gmbh | Improved recombinant human follicle-stimulating hormone |
CN103119064B (zh) * | 2010-08-10 | 2018-09-04 | 葛莱高托普有限公司 | Fab糖基化抗体 |
US9051370B2 (en) | 2010-08-10 | 2015-06-09 | Glycotope Gmbh | Humanized EGFR antibodies |
BR112013003257A2 (pt) | 2010-08-10 | 2016-06-14 | Glycotope Gmbh | anticorpos egfr humanizados. |
WO2012085162A1 (en) | 2010-12-21 | 2012-06-28 | Glycotope Gmbh | Methods for culturing human myeloid leukaemia cells and cells derived therefrom |
CN103826661B (zh) | 2011-04-21 | 2019-03-05 | 西雅图基因公司 | 新的结合剂-药物缀合物(adc)及其用途 |
US9062106B2 (en) | 2011-04-27 | 2015-06-23 | Abbvie Inc. | Methods for controlling the galactosylation profile of recombinantly-expressed proteins |
US20140296490A1 (en) * | 2011-08-10 | 2014-10-02 | Laboratoire Français Du Fractionnement Et Des Biotechnologies | Highly galactosylated antibodies |
BR112014004065A2 (pt) | 2011-08-22 | 2017-03-14 | Glycotope Gmbh | micro-organismos carregando um antígeno de tumor |
US9181572B2 (en) | 2012-04-20 | 2015-11-10 | Abbvie, Inc. | Methods to modulate lysine variant distribution |
US9150645B2 (en) | 2012-04-20 | 2015-10-06 | Abbvie, Inc. | Cell culture methods to reduce acidic species |
US9067990B2 (en) | 2013-03-14 | 2015-06-30 | Abbvie, Inc. | Protein purification using displacement chromatography |
JP2015528802A (ja) * | 2012-07-18 | 2015-10-01 | グリコトープ ゲーエムベーハー | フコシル化が低い抗her2抗体を用いた新規治療処置 |
US9512214B2 (en) | 2012-09-02 | 2016-12-06 | Abbvie, Inc. | Methods to control protein heterogeneity |
AU2014206792A1 (en) | 2013-01-18 | 2015-07-23 | Glycotope Gmbh | Fusion peptides for enhancing protein expression |
TW201444871A (zh) * | 2013-02-13 | 2014-12-01 | Lab Francais Du Fractionnement | 具有修飾的糖化作用之西妥昔單抗及其用途 |
CN105308071A (zh) * | 2013-02-13 | 2016-02-03 | 法国化学与生物科技实验室 | 高度半乳糖基化的抗her2抗体及其用途 |
US10034921B2 (en) | 2013-02-13 | 2018-07-31 | Laboratoire Français Du Fractionnement Et Des Biotechnologies | Proteins with modified glycosylation and methods of production thereof |
WO2014125374A2 (en) | 2013-02-13 | 2014-08-21 | Laboratoire Français Du Fractionnement Et Des Biotechnologies | Highly galactosylated anti-tnf-alpha antibodies and uses thereof |
CA2905010A1 (en) | 2013-03-12 | 2014-09-18 | Abbvie Inc. | Human antibodies that bind human tnf-alpha and methods of preparing the same |
WO2014158272A1 (en) | 2013-03-14 | 2014-10-02 | Abbott Laboratories | Hcv antigen-antibody combination assay and methods and compositions for use therein |
US9499614B2 (en) | 2013-03-14 | 2016-11-22 | Abbvie Inc. | Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosaccharides |
EP3564384A1 (en) | 2013-03-14 | 2019-11-06 | Abbott Laboratories | Hcv core lipid binding domain monoclonal antibodies |
JP2016512241A (ja) | 2013-03-14 | 2016-04-25 | アボット・ラボラトリーズAbbott Laboratories | 改良された抗体検出のためのhcvns3組換え抗原およびこの突然変異体 |
US9017687B1 (en) | 2013-10-18 | 2015-04-28 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same using displacement chromatography |
US9217168B2 (en) | 2013-03-14 | 2015-12-22 | Momenta Pharmaceuticals, Inc. | Methods of cell culture |
TW201940691A (zh) | 2013-03-15 | 2019-10-16 | 美商艾爾德生物製藥股份有限公司 | 抗體純化及純度監測 |
EA201591977A1 (ru) | 2013-04-22 | 2016-06-30 | Гликотоп Гмбх | Противораковая терапия анти-egfr антителами, имеющими низкое фукозилирование |
US10208125B2 (en) * | 2013-07-15 | 2019-02-19 | University of Pittsburgh—of the Commonwealth System of Higher Education | Anti-mucin 1 binding agents and uses thereof |
EP3052640A2 (en) | 2013-10-04 | 2016-08-10 | AbbVie Inc. | Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins |
US9181337B2 (en) | 2013-10-18 | 2015-11-10 | Abbvie, Inc. | Modulated lysine variant species compositions and methods for producing and using the same |
US9085618B2 (en) | 2013-10-18 | 2015-07-21 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same |
WO2015073884A2 (en) * | 2013-11-15 | 2015-05-21 | Abbvie, Inc. | Glycoengineered binding protein compositions |
NZ720736A (en) | 2013-12-23 | 2020-08-28 | Bayer Pharma AG | Antibody drug conjugates (adcs) with kinesin spindel protein (ksp) |
RU2689119C2 (ru) * | 2014-03-05 | 2019-05-24 | Ультраджиникс Фармасьютикал Инк. | Композиции на основе сиалированных гликопротеинов и их применение |
US20150307546A1 (en) * | 2014-04-29 | 2015-10-29 | Georgia Tech Research Corporation | Thermo-responsive lectin-elp fusion binding ligands for glycoprotein purification by affinity precipitation |
CN105820248A (zh) * | 2015-01-07 | 2016-08-03 | 上海张江生物技术有限公司 | 一种新型抗egfr单克隆抗体的制备方法及应用 |
LU92659B1 (en) * | 2015-02-23 | 2016-08-24 | Glycotope Gmbh | Glycooptimized antibody drug conjugates |
CN108012545B (zh) | 2015-03-31 | 2022-08-30 | 葛莱高托普有限公司 | 包含珠蛋白基因簇的调控元件的真核表达载体 |
FR3034420A1 (fr) | 2015-03-31 | 2016-10-07 | Lab Francais Du Fractionnement | Anticorps monoclonaux anti-cd303 |
WO2016198499A1 (en) | 2015-06-09 | 2016-12-15 | Glycotope Gmbh | IMPROVED METHOD FOR PRODUCTION OF γ-CARBOXYLATED POLYPEPTIDES |
CA2990076A1 (en) | 2015-06-22 | 2016-12-29 | Bayer Pharma Aktiengesellschaft | Antibody drug conjugates (adcs) and antibody prodrug conjugates (apdcs) with enzymatically cleavable groups |
PE20180452A1 (es) | 2015-06-23 | 2018-03-05 | Bayer Pharma AG | Conjugados homogeneos especificos de sitio con inhibidores de ksp |
WO2016207328A1 (en) | 2015-06-24 | 2016-12-29 | Glycotope Gmbh | PROCESS FOR THE PURIFICATION OF γ-CARBOXYLATED POLYPEPTIDES |
WO2017060322A2 (en) | 2015-10-10 | 2017-04-13 | Bayer Pharma Aktiengesellschaft | Ptefb-inhibitor-adc |
WO2017070460A1 (en) | 2015-10-22 | 2017-04-27 | Massachusetts Institute Of Technology | Vegf-a-binding proteins and her2-binding proteins with enhanced stability against aggregation |
WO2017162733A1 (en) * | 2016-03-22 | 2017-09-28 | Glycotope Gmbh | Iga antibodies with enhanced stability |
MX2018011627A (es) | 2016-03-24 | 2019-01-10 | Bayer Pharma AG | Profarmacos de farmacos citotoxicos que tienen grupos enzimaticamente escindibles. |
EP3471776B1 (en) | 2016-06-15 | 2022-05-04 | Bayer Pharma Aktiengesellschaft | Specific antibody-drug-conjugates with ksp inhibitors and anti-cd123-antibodies |
EP3472338B1 (en) | 2016-06-20 | 2024-05-22 | Octapharma AG | Means and methods for modifying multiple alleles |
FR3060394B1 (fr) | 2016-12-16 | 2019-05-24 | Laboratoire Francais Du Fractionnement Et Des Biotechnologies | Combinaison d'anticorps anti-cd303 et anti-amhrii |
FR3060395B1 (fr) | 2016-12-16 | 2019-05-24 | Laboratoire Francais Du Fractionnement Et Des Biotechnologies | Combinaison d'anticorps anti-cd303 et anti-her2 |
JP7030811B2 (ja) | 2016-12-21 | 2022-03-07 | バイエル・ファルマ・アクティエンゲゼルシャフト | Ksp阻害剤を有する特異的抗体-薬物コンジュゲート(adc) |
AU2017380871A1 (en) | 2016-12-21 | 2019-07-11 | Bayer Aktiengesellschaft | Antibody drug conjugates (ADCs) having enzymatically cleavable groups |
CA3047491A1 (en) | 2016-12-21 | 2018-06-28 | Bayer Aktiengesellschaft | Prodrugs of cytotoxic active agents having enzymatically cleavable groups |
WO2018138113A1 (en) | 2017-01-27 | 2018-08-02 | Glycotope Gmbh | Anti-cancer treatments with an anti-muc1 antibody and an erbb inhibitor |
JP6829357B2 (ja) * | 2017-03-17 | 2021-02-10 | 住友ベークライト株式会社 | 抗体の糖鎖検出法 |
JP2020515532A (ja) | 2017-03-29 | 2020-05-28 | グリコトープ ゲーエムベーハー | Muc1およびcd3に結合する多重特異的抗体構築物 |
JP2020512382A (ja) * | 2017-03-29 | 2020-04-23 | グリコトープ ゲーエムベーハー | Pd−l1抗体およびta−muc1抗体 |
CA3055433A1 (en) | 2017-03-29 | 2018-10-04 | Glycotope Gmbh | Humanized anti-cd40 antibodies |
MX2020002551A (es) * | 2017-09-06 | 2020-08-20 | Airway Therapeutics Inc | Metodos, composiciones y celulas para preparar proteina surfactante d (sp-d). |
KR20200044955A (ko) | 2017-09-06 | 2020-04-29 | 에어웨이 테라퓨틱스, 아이엔씨. | 계면활성제 단백질 d (sp-d)를 제조하는 방법 및 조성물 |
WO2019166617A1 (en) | 2018-03-01 | 2019-09-06 | Glycotope Gmbh | Fusion protein constructs comprising an anti-muc1 antibody and il-15 |
RS65580B1 (sr) | 2018-05-18 | 2024-06-28 | Daiichi Sankyo Co Ltd | Anti-muc1-eksatekan antitelo-lek konjugat |
PE20221790A1 (es) | 2019-12-06 | 2022-11-25 | Regeneron Pharma | Composiciones de proteina anti-vegf y metodos para producir la misma |
WO2022002887A1 (en) | 2020-06-30 | 2022-01-06 | Glycotope Gmbh | Humanized antibodies against lewis y |
WO2023175117A1 (en) | 2022-03-16 | 2023-09-21 | Glycotope Gmbh | Antibodies against lypd3 |
Family Cites Families (60)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4966843A (en) * | 1982-11-01 | 1990-10-30 | Cetus Corporation | Expression of interferon genes in Chinese hamster ovary cells |
AU2353384A (en) * | 1983-01-19 | 1984-07-26 | Genentech Inc. | Amplification in eukaryotic host cells |
KR850004274A (ko) * | 1983-12-13 | 1985-07-11 | 원본미기재 | 에리트로포이에틴의 제조방법 |
US4931275A (en) * | 1985-12-02 | 1990-06-05 | Yeda Research & Development Co., Ltd. | Anti-tumor vaccines and their preparation |
US5683674A (en) * | 1987-01-07 | 1997-11-04 | Imperial Cancer Research Technology Ltd. | Antibody against human mucin core protein and method of preparing and using same |
AU664030B2 (en) | 1991-02-27 | 1995-11-02 | Micromet Ag | Serine-rich peptide linkers |
JP3698370B2 (ja) * | 1992-04-13 | 2005-09-21 | ダナ−ファーバー キャンサー インスティチュート インク | 癌腫抗原用抗体 |
US5804187A (en) * | 1992-11-16 | 1998-09-08 | Cancer Research Fund Of Contra Costa | Modified antibodies with human milk fat globule specificity |
US5910488A (en) | 1993-06-07 | 1999-06-08 | Vical Incorporated | Plasmids suitable for gene therapy |
DE4329004A1 (de) | 1993-08-28 | 1995-03-09 | Max Delbrueck Centrum | Monoklonale Antikörper gegen das Thomsen-Friedenreich-Antigen, ihre Herstellung und ihre Verwendung zum Tumornachweis |
WO1995010538A1 (en) * | 1993-10-15 | 1995-04-20 | The University Of North Carolina At Chapel Hill | Dna encoding the human p2u receptor and null cells expressing p2u receptors |
US5997873A (en) * | 1994-01-13 | 1999-12-07 | Mount Sinai School Of Medicine Of The City University Of New York | Method of preparation of heat shock protein 70-peptide complexes |
US5961979A (en) * | 1994-03-16 | 1999-10-05 | Mount Sinai School Of Medicine Of The City University Of New York | Stress protein-peptide complexes as prophylactic and therapeutic vaccines against intracellular pathogens |
US5888773A (en) * | 1994-08-17 | 1999-03-30 | The United States Of America As Represented By The Department Of Health And Human Services | Method of producing single-chain Fv molecules |
US5739277A (en) * | 1995-04-14 | 1998-04-14 | Genentech Inc. | Altered polypeptides with increased half-life |
EP0833907A1 (en) | 1995-06-23 | 1998-04-08 | President And Fellows Of Harvard College | Transcriptional regulation of genes encoding vascular endothelial growth factor receptors |
GB9603256D0 (en) * | 1996-02-16 | 1996-04-17 | Wellcome Found | Antibodies |
WO1997040182A1 (de) | 1996-04-19 | 1997-10-30 | Gabriele Pecher | Gentransfizierte humane dendritische zellen, ihre herstellung und ihre verwendung, bevorzugt als vakzine |
ATE550042T1 (de) * | 1997-11-20 | 2012-04-15 | Vical Inc | Behandlung von krebs mithilfe cytokin- exprimierender polynukleotide und zusammensetzungen dafür |
US5948646A (en) * | 1997-12-11 | 1999-09-07 | Fordham University | Methods for preparation of vaccines against cancer comprising heat shock protein-peptide complexes |
EP2180007B2 (en) | 1998-04-20 | 2017-08-30 | Roche Glycart AG | Glycosylation engineering of antibodies for improving antibody-dependent cellular cytotoxicity |
AUPP816899A0 (en) | 1999-01-14 | 1999-02-11 | Food Technology Innovations Pty Limited | Improved microbial products |
EP1399538A2 (en) | 1999-03-02 | 2004-03-24 | Human Genome Sciences, Inc. | Engineering intracellular sialylation pathways |
CA2368734C (en) | 1999-03-30 | 2005-08-23 | Japan Tobacco Inc. | Method for preparing monoclonal antibody |
JP4488579B2 (ja) * | 1999-03-30 | 2010-06-23 | 日本たばこ産業株式会社 | モノクローナル抗体の製造方法 |
EP2275540B1 (en) | 1999-04-09 | 2016-03-23 | Kyowa Hakko Kirin Co., Ltd. | Method for controlling the activity of immunologically functional molecule |
US7147850B2 (en) * | 1999-08-18 | 2006-12-12 | Altarex Medical Corp. | Therapeutic binding agents against MUC-1 antigen and methods for their use |
AU782569B2 (en) | 1999-08-18 | 2005-08-11 | Oncoquest Inc. | Therapeutic binding agents against MUC-1 antigen and methods of their use |
WO2001023421A2 (en) * | 1999-09-30 | 2001-04-05 | Corixa Corporation | Stress protein compositions and methods for prevention and treatment of cancer and infectious disease |
FR2809312B1 (fr) | 2000-05-25 | 2002-07-12 | Gervais Danone Sa | Utilisation de l. casei dans des compositions immunostimulantes |
US6946292B2 (en) | 2000-10-06 | 2005-09-20 | Kyowa Hakko Kogyo Co., Ltd. | Cells producing antibody compositions with increased antibody dependent cytotoxic activity |
JPWO2002030954A1 (ja) * | 2000-10-06 | 2004-02-19 | 協和醗酵工業株式会社 | 抗体を精製する方法 |
GB0029360D0 (en) | 2000-12-01 | 2001-01-17 | Univ Nottingham | Humanised antibodies and uses thereof |
JPWO2002061118A1 (ja) | 2001-02-01 | 2004-06-03 | 株式会社ヤクルト本社 | 発酵乳飲食品中のビフィドバクテリウム属細菌の腸内到達度評価方法 |
DE10139428A1 (de) * | 2001-08-17 | 2003-03-27 | Nemod Immuntherapie Ag | Herstellung und Verwendung von humanen CD124 und CD116 positiven Tumorzelllinien zur Herstellung von allogenen oder semi-allogenen Immuntherapeutika |
WO2003016329A2 (en) * | 2001-08-17 | 2003-02-27 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Glycoconjugates of sialic acid derivates, methods for their production and use thereof |
WO2003035686A2 (en) * | 2001-10-22 | 2003-05-01 | Applied Research Systems Ars Holding N.V. | Compositions of fsh with high sialylation degree and their use for the preparation of medicaments |
GB0125473D0 (en) | 2001-10-24 | 2001-12-12 | Syngenta Ltd | Chemical process |
KR100506766B1 (ko) | 2001-11-20 | 2005-08-05 | (주)에이티젠 | 환경 스트레스에 내성을 부여하는 신규한 펩타이드 및이를 포함하는 융합단백질 |
WO2004009632A2 (de) | 2002-07-22 | 2004-01-29 | Nemod Immuntherapie Ag | Verfahren zur herstellung eines immunstimulatorischen muzins (muc1) |
US7595192B2 (en) * | 2002-08-16 | 2009-09-29 | Glycotype Gmbh | Process for the production of temperature-induced tumor cell lysates for use as immunogenic compounds |
DE10256900A1 (de) | 2002-11-29 | 2004-06-24 | Nemod Immuntherapie Ag | Tumorspezifische Erkennungsmoleküle |
DE10303664A1 (de) | 2003-01-23 | 2004-08-12 | Nemod Immuntherapie Ag | Erkennungsmoleküle zur Behandlung und Detektion von Tumoren |
WO2005019258A2 (en) | 2003-08-11 | 2005-03-03 | Genentech, Inc. | Compositions and methods for the treatment of immune related diseases |
WO2005017130A2 (en) | 2003-08-18 | 2005-02-24 | Glycotope Gmbh | Tumour cell lines nm-f9 (dsm acc2606) and nm-d4 (dsm acc2605), uses thereof |
FR2861080B1 (fr) * | 2003-10-20 | 2006-02-17 | Lab Francais Du Fractionnement | Anticorps presentant un taux de fucose et de galactose optimise |
US20050203010A1 (en) * | 2003-11-14 | 2005-09-15 | Atgen Co., Ltd. | Novel peptides conferring environmental stress resistance and fusion proteins including said peptides |
JP4913604B2 (ja) * | 2004-02-13 | 2012-04-11 | グリコトープ ゲーエムベーハー | 高活性糖タンパク質−製造条件、及びその効率的製造方法 |
JP4904266B2 (ja) | 2004-07-26 | 2012-03-28 | ザ リサーチ ファウンデイション オブ ステイト ユニバーシティー オブ ニューヨーク | 抗−tf−抗原抗体の治療的使用 |
WO2007093922A1 (en) * | 2006-02-14 | 2007-08-23 | Koninklijke Philips Electronics N.V. | Bit detection for optical disc reading |
WO2007124992A1 (en) | 2006-04-28 | 2007-11-08 | Unilever N.V. | Method of manufacturing a cultured edible product comprising omega-3 polyunsaturated fatty acids |
EP1900750A1 (en) | 2006-09-18 | 2008-03-19 | Glycotope Gmbh | Fully human high yield production system for improved antibodies |
EP1911766A1 (en) | 2006-10-13 | 2008-04-16 | Glycotope Gmbh | Use of human cells of myeloid leukaemia origin for expression of antibodies |
CA2662226C (en) | 2006-09-10 | 2020-08-04 | Glycotope Gmbh | Fully human high yield production system for improved antibodies and proteins |
EP1920781B1 (en) * | 2006-11-10 | 2015-03-04 | Glycotope GmbH | Compositions comprising a core-1 positive microorganism and their use for the treatment or prophylaxis of tumors |
EP2291086A1 (en) | 2008-05-13 | 2011-03-09 | Glycotope GmbH | Fermentation process |
WO2010119691A1 (ja) | 2009-04-16 | 2010-10-21 | 国立大学法人東京大学 | 抗tmprss11e抗体を用いた癌の診断と治療 |
EP2281844A1 (en) | 2009-07-31 | 2011-02-09 | Glycotope GmbH | MUC 1 antibodies |
AU2014206792A1 (en) | 2013-01-18 | 2015-07-23 | Glycotope Gmbh | Fusion peptides for enhancing protein expression |
JP2015138634A (ja) | 2014-01-22 | 2015-07-30 | 株式会社オートネットワーク技術研究所 | 端子金具付き電線及びその製造方法 |
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