EA200800668A1 - Производные пиразина и их применение в качестве ингибиторов pi3k - Google Patents
Производные пиразина и их применение в качестве ингибиторов pi3kInfo
- Publication number
- EA200800668A1 EA200800668A1 EA200800668A EA200800668A EA200800668A1 EA 200800668 A1 EA200800668 A1 EA 200800668A1 EA 200800668 A EA200800668 A EA 200800668A EA 200800668 A EA200800668 A EA 200800668A EA 200800668 A1 EA200800668 A1 EA 200800668A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- pyrazine
- derivatives
- application
- diseases
- pi3k inhibitors
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
- C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
- C07D241/40—Benzopyrazines
- C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07—ORGANIC CHEMISTRY
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- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Cardiology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pulmonology (AREA)
- Neurosurgery (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Physical Education & Sports Medicine (AREA)
- Reproductive Health (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Communicable Diseases (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Endocrinology (AREA)
- Virology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Dermatology (AREA)
Abstract
Настоящее изобретение относится к производным пиразина формулы (I)в частности, для лечения и/или профилактики аутоиммунных нарушений и/или воспалительных заболеваний, сердечно-сосудистых заболеваний, нейродегенеративных заболеваний, бактериальных и вирусных инфекций, заболеваний почек, агрегации тромбоцитов, рака, нарушений при трансплантации, отторжения трансплантата или повреждений легких.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US71187305P | 2005-08-26 | 2005-08-26 | |
EP05107838 | 2005-08-26 | ||
PCT/EP2006/065688 WO2007023186A1 (en) | 2005-08-26 | 2006-08-25 | Pyrazine derivatives and use as pi3k inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
EA200800668A1 true EA200800668A1 (ru) | 2008-08-29 |
EA015937B1 EA015937B1 (ru) | 2011-12-30 |
Family
ID=35276409
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200800668A EA015937B1 (ru) | 2005-08-26 | 2006-08-25 | Производные пиразина и их применение в качестве ингибиторов pi3k |
Country Status (18)
Country | Link |
---|---|
US (3) | US8071597B2 (ru) |
EP (2) | EP1917252B1 (ru) |
JP (1) | JP5226513B2 (ru) |
KR (1) | KR20080049767A (ru) |
CN (1) | CN101296909B (ru) |
AU (1) | AU2006283846B2 (ru) |
BR (1) | BRPI0615233A2 (ru) |
CA (1) | CA2618479C (ru) |
EA (1) | EA015937B1 (ru) |
EC (1) | ECSP088215A (ru) |
ES (1) | ES2456000T3 (ru) |
HK (1) | HK1123296A1 (ru) |
IL (1) | IL189737A (ru) |
MX (1) | MX2008002723A (ru) |
NZ (1) | NZ565749A (ru) |
UA (1) | UA100358C2 (ru) |
WO (1) | WO2007023186A1 (ru) |
ZA (1) | ZA200801822B (ru) |
Families Citing this family (81)
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KR20140033237A (ko) * | 2005-10-07 | 2014-03-17 | 엑셀리시스, 인코포레이티드 | 포스파티딜이노시톨 3-키나아제 억제제 및 이의 사용 방법 |
US8217042B2 (en) | 2005-11-11 | 2012-07-10 | Zentaris Gmbh | Pyridopyrazines and their use as modulators of kinases |
EP1790342A1 (de) | 2005-11-11 | 2007-05-30 | Zentaris GmbH | Pyridopyrazin-Derivate und deren Verwendung als Modulatoren der Signaltransduktionswege |
JP2010500994A (ja) | 2006-08-16 | 2010-01-14 | エグゼリクシス, インコーポレイテッド | Pi3kおよびmekモジュレーターを使用する方法 |
EA200970783A1 (ru) * | 2007-02-22 | 2010-04-30 | Мерк Сероно С.А. | Соединения хиноксалина и их применение |
US7705018B2 (en) | 2007-03-23 | 2010-04-27 | Amgen Inc. | Substituted quinolines and their uses in treatment of inflammatory and related conditions |
US8481001B2 (en) * | 2007-04-11 | 2013-07-09 | Exelixis, Inc. | Combination therapies comprising quinoxaline inhibitors of P13K-alpha for use in the treatment of cancer |
WO2009017838A2 (en) * | 2007-08-01 | 2009-02-05 | Exelixis, Inc. | Combinations of jak-2 inhibitors and other agents |
CN101918531B (zh) | 2007-11-20 | 2013-06-12 | 3M创新有限公司 | 环境取样制品和方法 |
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WO2009155527A2 (en) * | 2008-06-19 | 2009-12-23 | Progenics Pharmaceuticals, Inc. | Phosphatidylinositol 3 kinase inhibitors |
ES2463676T3 (es) | 2008-11-10 | 2014-05-28 | Kyowa Hakko Kirin Co., Ltd. | Inhibidor de la producción de quinurenina |
US20120121515A1 (en) | 2009-03-13 | 2012-05-17 | Lenny Dang | Methods and compositions for cell-proliferation-related disorders |
CN102448951B (zh) | 2009-04-06 | 2017-05-10 | 安吉奥斯医药品有限公司 | 丙酮酸激酶m2调节剂、治疗组合物和相关使用方法 |
DK2427441T3 (en) | 2009-05-04 | 2017-03-20 | Agios Pharmaceuticals Inc | PKM2 Activators for use in the treatment of cancer |
EP2448581B1 (en) | 2009-06-29 | 2016-12-07 | Agios Pharmaceuticals, Inc. | Therapeutic compositions and related methods of use |
TWI649313B (zh) * | 2009-06-29 | 2019-02-01 | 阿吉歐斯製藥公司 | 治療化合物及組成物 |
US9649331B2 (en) | 2009-08-27 | 2017-05-16 | Ara Medical Llc | Sprayable polymers as adhesion barriers |
EP2473504B1 (en) | 2009-09-03 | 2015-02-25 | Bioenergenix | Heterocyclic compounds for the inhibition of pask |
DE102009049679A1 (de) | 2009-10-19 | 2011-04-21 | Merck Patent Gmbh | Pyrazolopyrimidinderivate |
WO2011050210A1 (en) | 2009-10-21 | 2011-04-28 | Agios Pharmaceuticals, Inc. | Methods and compositions for cell-proliferation-related disorders |
EP2525790B1 (en) | 2009-10-21 | 2020-05-27 | Agios Pharmaceuticals, Inc. | Methods and compositions for cell-proliferation-related disorders |
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US20110319410A1 (en) | 2011-12-29 |
CN101296909A (zh) | 2008-10-29 |
ZA200801822B (en) | 2009-09-30 |
US20110312960A1 (en) | 2011-12-22 |
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JP2009506015A (ja) | 2009-02-12 |
AU2006283846A1 (en) | 2007-03-01 |
ECSP088215A (es) | 2008-03-26 |
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CA2618479A1 (en) | 2007-03-01 |
EP1917252A1 (en) | 2008-05-07 |
HK1123296A1 (en) | 2009-06-12 |
CN101296909B (zh) | 2011-10-12 |
MX2008002723A (es) | 2008-03-26 |
NZ565749A (en) | 2010-12-24 |
IL189737A (en) | 2015-02-26 |
US8877757B2 (en) | 2014-11-04 |
JP5226513B2 (ja) | 2013-07-03 |
US8071597B2 (en) | 2011-12-06 |
EP2351745A1 (en) | 2011-08-03 |
UA100358C2 (xx) | 2012-12-25 |
CA2618479C (en) | 2014-12-30 |
EP1917252B1 (en) | 2014-01-01 |
AU2006283846B2 (en) | 2012-04-05 |
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