EA200200625A1 - Антипикорнавирусные соединения и композиции, их фармацевтическое применение и вещества для их синтеза - Google Patents

Антипикорнавирусные соединения и композиции, их фармацевтическое применение и вещества для их синтеза

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Publication number
EA200200625A1
EA200200625A1 EA200200625A EA200200625A EA200200625A1 EA 200200625 A1 EA200200625 A1 EA 200200625A1 EA 200200625 A EA200200625 A EA 200200625A EA 200200625 A EA200200625 A EA 200200625A EA 200200625 A1 EA200200625 A1 EA 200200625A1
Authority
EA
Eurasian Patent Office
Prior art keywords
compounds
formula
synthesis
substances
compositions
Prior art date
Application number
EA200200625A
Other languages
English (en)
Inventor
Питер С. Драгович
Томас Дж. Принс
Ру Зоу
Теодор О. мл. Джонсон
Original Assignee
Агурон Фармасьютикалз, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Агурон Фармасьютикалз, Инк. filed Critical Агурон Фармасьютикалз, Инк.
Publication of EA200200625A1 publication Critical patent/EA200200625A1/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Abstract

Описаны соединения формулы (I), где радикалы в указанной формуле являются такими, как они были определены в описании, и где указанные соединения преимущественно ингибируют или блокируют биологическую активность пикорнавирусной протеазы 3С. Также описаны соединения формулы (II), где радикалы в указанной формуле являются такими, как они были определены в описании, и где указанные соединения преимущественно ингибируют или блокируют биологическую активность пикорнавирусной протеазы 3С. Указанные соединения, а также фармацевтические композиции, содержащие указанные соединения, полезны для лечения пациентов или хозяев, инфицированных одним или несколькими пикорнавирусами, такими как риновирус. Кроме того, описаны промежуточные соединения и методы синтеза, используемые для получения таких соединений.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200200625A 1999-12-03 2000-12-01 Антипикорнавирусные соединения и композиции, их фармацевтическое применение и вещества для их синтеза EA200200625A1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US16898699P 1999-12-03 1999-12-03
US19205200P 2000-03-24 2000-03-24
PCT/US2000/032621 WO2001040189A1 (en) 1999-12-03 2000-12-01 Antipicornaviral compounds and compositions, their pharmaceutical uses, and materials for their synthesis

Publications (1)

Publication Number Publication Date
EA200200625A1 true EA200200625A1 (ru) 2002-12-26

Family

ID=26864652

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200200625A EA200200625A1 (ru) 1999-12-03 2000-12-01 Антипикорнавирусные соединения и композиции, их фармацевтическое применение и вещества для их синтеза

Country Status (31)

Country Link
US (1) US6514997B2 (ru)
EP (1) EP1252145A1 (ru)
JP (1) JP2003515591A (ru)
KR (1) KR20020058076A (ru)
CN (1) CN1402710A (ru)
AP (1) AP2002002510A0 (ru)
AR (1) AR030540A1 (ru)
AU (1) AU777943B2 (ru)
BG (1) BG106754A (ru)
BR (1) BR0016742A (ru)
CA (1) CA2392504A1 (ru)
CO (1) CO5261566A1 (ru)
CZ (1) CZ20021906A3 (ru)
DO (1) DOP2000000108A (ru)
EA (1) EA200200625A1 (ru)
EE (1) EE200200281A (ru)
HK (1) HK1052933A1 (ru)
HU (1) HUP0204006A3 (ru)
IL (1) IL149427A0 (ru)
IS (1) IS6378A (ru)
MX (1) MXPA02005124A (ru)
NO (1) NO20022589L (ru)
NZ (1) NZ518934A (ru)
OA (1) OA12101A (ru)
PA (1) PA8507801A1 (ru)
PE (1) PE20020157A1 (ru)
PL (1) PL356062A1 (ru)
SK (1) SK7602002A3 (ru)
UY (1) UY26465A1 (ru)
WO (1) WO2001040189A1 (ru)
YU (1) YU40002A (ru)

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WO2017197377A1 (en) * 2016-05-13 2017-11-16 Emory University Peptidomimetics for the treatment of norovirus infection

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PA8515201A1 (es) 2000-04-14 2002-10-24 Agouron Pharma Compuestos y composiciones antipicornavirales; sus usos farmaceuticos y los materiales para su sintesis
CA2412618A1 (en) * 2000-06-14 2001-12-20 Agouron Pharmaceuticals, Inc. Antipicornaviral compounds and compositions, their pharmaceutical uses, and materials for their synthesis
ATE438624T1 (de) * 2000-12-28 2009-08-15 Shionogi & Co 2-pyridonderivate mit affinität für den cannabinoid-typ-2-rezeptor
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EP1606019A1 (en) * 2003-03-07 2005-12-21 The University Court of The University of Aberdeen Cannabinoid receptor inverse agonists and neutral antagonists as therapeutic agents for the treatment of bone disorders
WO2004093860A1 (en) * 2003-04-21 2004-11-04 Pfizer Inc. Inhibitors of sars related coronavirus proteinase
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GB0702862D0 (en) * 2007-02-14 2007-03-28 Univ Aberdeen Therapeutic compounds
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EP2320891B1 (en) * 2008-08-29 2013-10-09 Treventis Corporation Butyrylcholinesterase ligands as diagnostic tools and treatment for deseases of the nervous system
KR101385855B1 (ko) * 2012-10-16 2014-04-22 이동익 카뎁신 검출용 다이아로마틱 아미노산 기질
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017197377A1 (en) * 2016-05-13 2017-11-16 Emory University Peptidomimetics for the treatment of norovirus infection
US11021513B2 (en) 2016-05-13 2021-06-01 Emory University Peptidomimetics for the treatment of norovirus infection

Also Published As

Publication number Publication date
NO20022589D0 (no) 2002-05-31
KR20020058076A (ko) 2002-07-12
US6514997B2 (en) 2003-02-04
HK1052933A1 (zh) 2003-10-03
EE200200281A (et) 2003-06-16
BG106754A (bg) 2003-07-31
BR0016742A (pt) 2002-09-03
US20010047006A1 (en) 2001-11-29
PE20020157A1 (es) 2002-02-22
SK7602002A3 (en) 2003-02-04
OA12101A (en) 2006-05-04
PA8507801A1 (es) 2002-08-26
AP2002002510A0 (en) 2002-06-30
PL356062A1 (en) 2004-06-14
AU1809401A (en) 2001-06-12
MXPA02005124A (es) 2003-01-28
NO20022589L (no) 2002-07-31
AU777943B2 (en) 2004-11-04
WO2001040189A1 (en) 2001-06-07
AR030540A1 (es) 2003-08-27
UY26465A1 (es) 2001-06-29
CN1402710A (zh) 2003-03-12
CA2392504A1 (en) 2001-06-07
NZ518934A (en) 2003-11-28
HUP0204006A2 (hu) 2003-03-28
IL149427A0 (en) 2002-11-10
CO5261566A1 (es) 2003-03-31
YU40002A (sh) 2006-01-16
CZ20021906A3 (cs) 2003-02-12
JP2003515591A (ja) 2003-05-07
DOP2000000108A (es) 2003-03-15
IS6378A (is) 2002-05-10
EP1252145A1 (en) 2002-10-30
HUP0204006A3 (en) 2004-11-29

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