EA033198B1 - Оксадиазольные производные, пригодные в качестве ингибиторов hdac - Google Patents

Оксадиазольные производные, пригодные в качестве ингибиторов hdac

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Publication number
EA033198B1
EA033198B1 EA201890338A EA201890338A EA033198B1 EA 033198 B1 EA033198 B1 EA 033198B1 EA 201890338 A EA201890338 A EA 201890338A EA 201890338 A EA201890338 A EA 201890338A EA 033198 B1 EA033198 B1 EA 033198B1
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EA
Eurasian Patent Office
Prior art keywords
hdac inhibitors
oxadiazole derivatives
derivatives useful
diseases
compound
Prior art date
Application number
EA201890338A
Other languages
English (en)
Other versions
EA201890338A1 (ru
Inventor
Акира Каиеда
Масаси Тоефуку
Масаки Даини
Хироси Нара
Масато Йосикава
Наоки Исии
Коусуке Хидака
Original Assignee
Такеда Фармасьютикал Компани Лимитед
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Application filed by Такеда Фармасьютикал Компани Лимитед filed Critical Такеда Фармасьютикал Компани Лимитед
Publication of EA201890338A1 publication Critical patent/EA201890338A1/ru
Publication of EA033198B1 publication Critical patent/EA033198B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems

Abstract

Изобретение относится к гетероциклическому соединению, обладающему ингибирующим HDAC действием и являющемуся пригодным для лечения аутоиммунных заболеваний и/или воспалительных заболеваний, реакции "трансплантат против хозяина", рака, заболеваний центральной нервной системы, включая нейродегенеративные заболевания, болезни Шарко-Мари-Тута и подобных, и фармацевтической композиции, содержащей данное соединение. Настоящее изобретение относится к соединению, представленному формулой (I)где каждый символ представляет собой, как определено в описании, или его соли.
EA201890338A 2015-07-17 2016-07-15 Оксадиазольные производные, пригодные в качестве ингибиторов hdac EA033198B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2015143354 2015-07-17
JP2016029020 2016-02-18
PCT/JP2016/071655 WO2017014321A1 (en) 2015-07-17 2016-07-15 Oxadiazole derivatives useful as hdac inhibitors

Publications (2)

Publication Number Publication Date
EA201890338A1 EA201890338A1 (ru) 2018-07-31
EA033198B1 true EA033198B1 (ru) 2019-09-30

Family

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Family Applications (1)

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EA201890338A EA033198B1 (ru) 2015-07-17 2016-07-15 Оксадиазольные производные, пригодные в качестве ингибиторов hdac

Country Status (11)

Country Link
US (1) US10308643B2 (ru)
EP (1) EP3325475B1 (ru)
JP (1) JP6671456B2 (ru)
CN (1) CN108026088B (ru)
AU (1) AU2016297362B2 (ru)
BR (1) BR112018000906A2 (ru)
CA (1) CA2992700A1 (ru)
EA (1) EA033198B1 (ru)
ES (1) ES2793014T3 (ru)
TW (1) TW201713649A (ru)
WO (1) WO2017014321A1 (ru)

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EP4046688A4 (en) * 2019-10-18 2023-09-27 Takeda Pharmaceutical Company Limited HETEROCYCLIC COMPOUND
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Also Published As

Publication number Publication date
JP6671456B2 (ja) 2020-03-25
WO2017014321A1 (en) 2017-01-26
CA2992700A1 (en) 2017-01-26
AU2016297362A1 (en) 2018-02-22
ES2793014T3 (es) 2020-11-12
CN108026088B (zh) 2021-02-12
EP3325475B1 (en) 2020-03-18
TW201713649A (zh) 2017-04-16
US10308643B2 (en) 2019-06-04
EP3325475A1 (en) 2018-05-30
CN108026088A (zh) 2018-05-11
AU2016297362B2 (en) 2020-04-16
JP2018524378A (ja) 2018-08-30
EA201890338A1 (ru) 2018-07-31
US20170015655A1 (en) 2017-01-19
BR112018000906A2 (pt) 2018-09-11

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