EA201690952A1 - Пиразол для лечения аутоиммунных расстройств - Google Patents

Пиразол для лечения аутоиммунных расстройств

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Publication number
EA201690952A1
EA201690952A1 EA201690952A EA201690952A EA201690952A1 EA 201690952 A1 EA201690952 A1 EA 201690952A1 EA 201690952 A EA201690952 A EA 201690952A EA 201690952 A EA201690952 A EA 201690952A EA 201690952 A1 EA201690952 A1 EA 201690952A1
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EA
Eurasian Patent Office
Prior art keywords
pyrazol
treatment
disease
autoimmune disorders
present
Prior art date
Application number
EA201690952A
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English (en)
Inventor
Масато Йосида
Кадзуаки Таками
Юсуке Томинари
Дзениу Сиокава
Акито Сибуя
Юсуке Сасаки
Тони Гибсон
Теруфуми Такаги
Original Assignee
Такеда Фармасьютикал Компани Лимитед
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Publication of EA201690952A1 publication Critical patent/EA201690952A1/ru

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
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    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
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    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
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    • A61P37/00—Drugs for immunological or allergic disorders
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    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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    • C07D495/10—Spiro-condensed systems

Abstract

Настоящее изобретение обеспечивает гетероциклическое соединение, обладающее действием ингибирования IRAK-4, которое является полезным для профилактики или лечения воспалительного заболевания, аутоиммунного заболевания, костно-суставного дегенеративного заболевания, неопластического заболевания и т.п., и содержащее его лекарственное средство. Настоящее изобретение относится к соединению, представленному формулой (I)где каждый символ определен в описании изобретения, или его соли.
EA201690952A 2013-11-08 2014-11-05 Пиразол для лечения аутоиммунных расстройств EA201690952A1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2013232571 2013-11-08
JP2014128562 2014-06-23
PCT/JP2014/080005 WO2015068856A1 (en) 2013-11-08 2014-11-05 Pyrazole for the treatment autoimmune disorders

Publications (1)

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EA201690952A1 true EA201690952A1 (ru) 2016-08-31

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ID=51999482

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US (2) US9321757B2 (ru)
EP (1) EP3066094B1 (ru)
JP (1) JP6412148B2 (ru)
CN (1) CN105899505B (ru)
BR (1) BR112016010041B1 (ru)
CA (1) CA2929316C (ru)
EA (1) EA201690952A1 (ru)
ES (1) ES2777123T3 (ru)
TW (1) TW201605847A (ru)
UY (1) UY35821A (ru)
WO (1) WO2015068856A1 (ru)

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CA2929316A1 (en) 2015-05-14
CA2929316C (en) 2021-12-28
EP3066094A1 (en) 2016-09-14
BR112016010041A2 (pt) 2020-10-27
US9321757B2 (en) 2016-04-26
BR112016010041B1 (pt) 2023-04-18
TW201605847A (zh) 2016-02-16
US9890145B2 (en) 2018-02-13
CN105899505B (zh) 2018-08-28
US20150133451A1 (en) 2015-05-14
UY35821A (es) 2015-06-30
JP2016535772A (ja) 2016-11-17
EP3066094B1 (en) 2020-01-08
JP6412148B2 (ja) 2018-10-24
WO2015068856A1 (en) 2015-05-14
US20160311811A1 (en) 2016-10-27
CN105899505A (zh) 2016-08-24
ES2777123T3 (es) 2020-08-03

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