DK3837256T3 - Ureaforbindelser og sammensætninger som smarca2/brm-atpase-hæmmere - Google Patents

Ureaforbindelser og sammensætninger som smarca2/brm-atpase-hæmmere Download PDF

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Publication number
DK3837256T3
DK3837256T3 DK19779145.2T DK19779145T DK3837256T3 DK 3837256 T3 DK3837256 T3 DK 3837256T3 DK 19779145 T DK19779145 T DK 19779145T DK 3837256 T3 DK3837256 T3 DK 3837256T3
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DK
Denmark
Prior art keywords
smarca2
compositions
urea compounds
atpase inhibitors
brm atpase
Prior art date
Application number
DK19779145.2T
Other languages
English (en)
Inventor
Christopher Adair
Julien Papillon
Katsumasa Nakajima
Troy Douglas Smith
Rukundo Ntaganda
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Application granted granted Critical
Publication of DK3837256T3 publication Critical patent/DK3837256T3/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
DK19779145.2T 2018-08-17 2019-08-12 Ureaforbindelser og sammensætninger som smarca2/brm-atpase-hæmmere DK3837256T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862765138P 2018-08-17 2018-08-17
PCT/IB2019/056847 WO2020035779A1 (en) 2018-08-17 2019-08-12 Urea compounds and compositions as smarca2/brm atpase inhibitors

Publications (1)

Publication Number Publication Date
DK3837256T3 true DK3837256T3 (da) 2023-05-30

Family

ID=68072895

Family Applications (1)

Application Number Title Priority Date Filing Date
DK19779145.2T DK3837256T3 (da) 2018-08-17 2019-08-12 Ureaforbindelser og sammensætninger som smarca2/brm-atpase-hæmmere

Country Status (21)

Country Link
US (1) US11958846B2 (da)
EP (2) EP4219488A1 (da)
JP (1) JP7328323B2 (da)
KR (1) KR20210047313A (da)
CN (1) CN112585136A (da)
AU (1) AU2019322325B2 (da)
BR (1) BR112021002632A2 (da)
CA (1) CA3107097A1 (da)
CY (1) CY1126039T1 (da)
DK (1) DK3837256T3 (da)
ES (1) ES2946060T3 (da)
FI (1) FI3837256T3 (da)
HR (1) HRP20230477T1 (da)
HU (1) HUE061963T2 (da)
LT (1) LT3837256T (da)
MX (1) MX2021001804A (da)
PL (1) PL3837256T3 (da)
PT (1) PT3837256T (da)
RS (1) RS64238B1 (da)
SI (1) SI3837256T1 (da)
WO (1) WO2020035779A1 (da)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3746124A4 (en) 2018-01-30 2021-10-27 Foghorn Therapeutics Inc. COMPOUNDS AND USES THEREOF
IL295100A (en) 2020-01-29 2022-09-01 Foghorn Therapeutics Inc materials and their use
CN112979646B (zh) * 2021-03-08 2022-01-14 北京富龙康泰生物技术有限公司 一种咪唑并吡啶类衍生物

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AUPP003197A0 (en) 1997-09-03 1997-11-20 Fujisawa Pharmaceutical Co., Ltd. New heterocyclic compounds
GB9823873D0 (en) * 1998-10-30 1998-12-30 Pharmacia & Upjohn Spa 2-ureido-thiazole derivatives,process for their preparation,and their use as antitumour agents
JP2002532415A (ja) 1998-12-16 2002-10-02 ワーナー−ランバート・カンパニー Ｍｅｋ阻害剤による関節炎の治療
US7217722B2 (en) * 2000-02-01 2007-05-15 Kirin Beer Kabushiki Kaisha Nitrogen-containing compounds having kinase inhibitory activity and drugs containing the same
CZ303815B6 (cs) 2000-07-19 2013-05-15 Warner-Lambert Company Derivát O-substituovaného esteru 4-jodfenylaminobenzhydroxamové kyseliny a farmaceutický prípravek s jeho obsahem
US20020173507A1 (en) 2000-08-15 2002-11-21 Vincent Santora Urea compounds and methods of uses
RU2292344C2 (ru) 2001-05-24 2007-01-27 Лео Фарма А/С Производные пиридилцианогуанидинов и фармацевтическая композиция на их основе
ES2555307T3 (es) 2002-03-08 2015-12-30 Eisai R&D Management Co., Ltd. Compuestos macrocíclicos útiles como agentes farmacéuticos
DOP2003000613A (es) 2002-03-13 2003-09-30 Array Biopharma Inc Derivados de bencimidazol n3 alquilado como inhibidores de mek (n3 alkylated benzimidazole derivatives as mek inhibitors)
US20030236287A1 (en) 2002-05-03 2003-12-25 Piotrowski David W. Positive allosteric modulators of the nicotinic acetylcholine receptor
MXPA05000130A (es) 2002-06-27 2005-02-17 Novo Nordisk As Derivados de aril-carbonilo como agentes terapeuticos.
CA2514733A1 (en) 2003-02-28 2004-09-16 Transform Pharmaceuticals, Inc. Pharmaceutical co-crystal compositions of drugs such as carbamazepine, celecoxib, olanzapine, itraconazole, topiramate, modafinil, 5-fluorouracil, hydrochlorothiazide, acetaminophen, aspirin, flurbiprofen, phenytoin and ibuprofen
MXPA05010496A (es) 2003-03-28 2005-11-16 Pharmacia & Upjohn Co Llc Moduladores alostericos positivos del receptor de acetilcolina nicotinico.
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JO2660B1 (en) 2006-01-20 2012-06-17 نوفارتيس ايه جي Pi-3 inhibitors and methods of use
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MX338504B (es) 2007-09-12 2016-04-20 Genentech Inc Combinaciones de compuestos inhibidores de fosfoinosituro 3-cinasa y agentes quimioterapeuticos, y metodos de uso.
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TWI436767B (zh) 2008-03-14 2014-05-11 Otsuka Pharma Co Ltd 基質金屬蛋白酶－２（ｍｍｐ－２）及／或基質金屬蛋白酶－９（ｍｍｐ－９）抑制劑
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WO2020126968A2 (en) 2018-12-20 2020-06-25 Bayer Aktiengesellschaft Urea derivatives

Also Published As

Publication number Publication date
AU2019322325A1 (en) 2021-02-18
JP2021534147A (ja) 2021-12-09
LT3837256T (lt) 2023-06-12
PL3837256T3 (pl) 2023-07-10
JP7328323B2 (ja) 2023-08-16
BR112021002632A2 (pt) 2021-05-11
CA3107097A1 (en) 2020-02-20
US20210323956A1 (en) 2021-10-21
ES2946060T3 (es) 2023-07-12
SI3837256T1 (sl) 2023-07-31
EP4219488A1 (en) 2023-08-02
HRP20230477T1 (hr) 2023-07-21
RS64238B1 (sr) 2023-06-30
KR20210047313A (ko) 2021-04-29
EP3837256B1 (en) 2023-03-08
US11958846B2 (en) 2024-04-16
WO2020035779A1 (en) 2020-02-20
EP3837256A1 (en) 2021-06-23
FI3837256T3 (fi) 2023-05-15
CY1126039T1 (el) 2023-11-15
MX2021001804A (es) 2021-04-19
AU2019322325B2 (en) 2022-01-20
PT3837256T (pt) 2023-05-23
HUE061963T2 (hu) 2023-09-28
CN112585136A (zh) 2021-03-30

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