DK3277681T3 - Imidazolonylquinoliner og deres anvendelse som atm-kinaseinhibitorer - Google Patents

Imidazolonylquinoliner og deres anvendelse som atm-kinaseinhibitorer Download PDF

Info

Publication number
DK3277681T3
DK3277681T3 DK16717560.3T DK16717560T DK3277681T3 DK 3277681 T3 DK3277681 T3 DK 3277681T3 DK 16717560 T DK16717560 T DK 16717560T DK 3277681 T3 DK3277681 T3 DK 3277681T3
Authority
DK
Denmark
Prior art keywords
imidazolonylquinolines
atm
kinase inhibitors
kinase
inhibitors
Prior art date
Application number
DK16717560.3T
Other languages
English (en)
Inventor
Thomas Fuchss
Kai Schiemann
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Application granted granted Critical
Publication of DK3277681T3 publication Critical patent/DK3277681T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
DK16717560.3T 2015-04-02 2016-03-31 Imidazolonylquinoliner og deres anvendelse som atm-kinaseinhibitorer DK3277681T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP15000968 2015-04-02
PCT/EP2016/000542 WO2016155884A1 (de) 2015-04-02 2016-03-31 Imidazolonylchinoline und deren verwendung als atm kinase inhibitoren

Publications (1)

Publication Number Publication Date
DK3277681T3 true DK3277681T3 (da) 2019-07-29

Family

ID=52814780

Family Applications (2)

Application Number Title Priority Date Filing Date
DK19172903.7T DK3560924T3 (da) 2015-04-02 2016-03-31 Imidazolonylquinoliner og deres anvendelse som atm-kinase-inhibitorer
DK16717560.3T DK3277681T3 (da) 2015-04-02 2016-03-31 Imidazolonylquinoliner og deres anvendelse som atm-kinaseinhibitorer

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK19172903.7T DK3560924T3 (da) 2015-04-02 2016-03-31 Imidazolonylquinoliner og deres anvendelse som atm-kinase-inhibitorer

Country Status (24)

Country Link
US (5) US10457677B2 (da)
EP (3) EP3277681B1 (da)
JP (2) JP6791873B2 (da)
KR (2) KR102652052B1 (da)
CN (3) CN107889488B (da)
AU (3) AU2016239270B2 (da)
BR (1) BR122019005502B1 (da)
CA (1) CA2981365A1 (da)
DK (2) DK3560924T3 (da)
ES (3) ES2880626T3 (da)
HR (2) HRP20191396T1 (da)
HU (2) HUE045477T2 (da)
IL (3) IL254714B (da)
LT (2) LT3560924T (da)
MX (2) MX2020011558A (da)
PL (2) PL3277681T3 (da)
PT (2) PT3560924T (da)
RS (2) RS59139B1 (da)
RU (1) RU2743343C2 (da)
SG (2) SG10202002181UA (da)
SI (2) SI3277681T1 (da)
TR (1) TR201911244T4 (da)
WO (1) WO2016155884A1 (da)
ZA (1) ZA201707423B (da)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2880626T3 (es) * 2015-04-02 2021-11-25 Merck Patent Gmbh Imidazolonilquinolinas
GB201516504D0 (en) * 2015-09-17 2015-11-04 Astrazeneca Ab Imadazo(4,5-c)quinolin-2-one Compounds and their use in treating cancer
GB201519406D0 (en) * 2015-11-03 2015-12-16 Astrazeneca Ab Imidazo[4,5-c]quinolin-2-one compounds and their use in treating cancer
WO2018153365A1 (zh) * 2017-02-27 2018-08-30 上海瑛派药业有限公司 取代的稠合杂芳三环化合物作为激酶抑制剂及其应用
JOP20190209A1 (ar) * 2017-03-16 2019-09-12 Astrazeneca Ab مركبات إيميدازو [ 4، 5-c ] كينولين-2-أون ديوترومية واستخدامها في علاج السرطان
AU2019206623A1 (en) 2018-01-12 2020-07-16 Prolynx Llc Synergistic cancer treatment
US20210353614A1 (en) * 2018-03-14 2021-11-18 Merck Patent Gmbh Compounds and uses thereof to treat tumors in a subject
CN111989323A (zh) 2018-04-12 2020-11-24 拜耳公司 作为农药的n-(环丙基甲基)-5-(甲基磺酰基)-n-{1-[1-(嘧啶-2-基)-1h-1，2，4-***-5-基]乙基}苯甲酰胺衍生物及相应的吡啶甲酰胺衍生物
WO2019201283A1 (en) * 2018-04-20 2019-10-24 Xrad Therapeutics, Inc. Dual atm and dna-pk inhibitors for use in anti-tumor therapy
CN110386932A (zh) * 2018-04-20 2019-10-29 艾科思莱德制药公司 用于抗肿瘤疗法中的双重atm和dna-pk抑制剂
GB201814487D0 (en) * 2018-09-06 2018-10-24 Cycle Pharmaceuticals Ltd Cancer
CN109045042A (zh) * 2018-09-21 2018-12-21 上海交通大学医学院附属上海儿童医学中心 Atm抑制剂在制备抑制急性淋巴细胞性白血病复发的药物中的应用
BR112021005989A2 (pt) * 2018-09-30 2021-06-29 Medshine Discovery Inc. derivados de quinolino-pirrolidin-2-ona e aplicação dos mesmos
EP3947375B1 (en) 2019-03-27 2024-04-03 Merck Patent GmbH Imidazolonylquinoline compounds and therapeutic uses thereof
CN114258301A (zh) * 2019-07-30 2022-03-29 艾科思莱德制药公司 用于抗肿瘤疗法中的双重atm和dna-pk抑制剂
IL292613A (en) 2019-11-01 2022-07-01 Ares Trading Sa Combined inhibition of pd-1, tgf-beta and atm along with radiotherapy for cancer treatment
EP4069366A1 (en) 2019-12-04 2022-10-12 CHDI Foundation, Inc. Atm kinase inhibitors and compositions and methods of use thereof
CN115003672A (zh) * 2020-01-09 2022-09-02 南京明德新药研发有限公司 喹啉并咪唑类化合物及其应用
CN115380031A (zh) * 2020-03-30 2022-11-22 南京明德新药研发有限公司 作为atm抑制剂的喹啉并吡咯烷-2-酮类化合物的晶型及其应用
JP2023530004A (ja) * 2020-06-18 2023-07-12 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング ウイルス感染症の処置のための化合物
TW202216209A (zh) 2020-06-24 2022-05-01 英商阿斯特捷利康英國股份有限公司 抗體-藥物結合物及atm抑制劑之組合
BR112023002078A2 (pt) 2020-09-18 2023-03-28 Merck Patent Gmbh Preparação farmacêutica
KR20230026478A (ko) 2020-09-21 2023-02-24 웨이 중 혈액-뇌 장벽 투과능을 가진 치환된 1-(3,3-디플루오로피페리딘-4-일)-이미다조[4,5-c] 퀴놀린-2-온 화합물
EP3992191A1 (en) 2020-11-03 2022-05-04 Deutsches Krebsforschungszentrum Imidazo[4,5-c]quinoline compounds and their use as atm kinase inhibitors
CN115232122A (zh) * 2021-04-23 2022-10-25 石药集团中奇制药技术（石家庄）有限公司 炔类化合物及其制备和应用
CN115716829A (zh) * 2022-11-13 2023-02-28 药康众拓(江苏)医药科技有限公司 一种喹啉并咪唑酮联氘代吡唑类化合物及其应用

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0211649D0 (en) 2002-05-21 2002-07-03 Novartis Ag Organic compounds
DK1879893T3 (da) 2005-03-21 2010-09-13 Ferrer Int Fremgangsmåde til fremstilling af 1-substituerede 1H-imidazo[4,5-c]quinolin-4-aminforbindelser og mellemprodukter dertil
GB0510390D0 (en) 2005-05-20 2005-06-29 Novartis Ag Organic compounds
CN101616672A (zh) 2007-02-20 2009-12-30 诺瓦提斯公司 作为脂质激酶和mTOR双重抑制剂的咪唑并喹啉类
BRPI0909082A2 (pt) 2008-03-26 2019-02-26 Novartis Ag imidazoquinolinas e derivados de pirimidina como moduladores potentes de processos angiogênicos acionados por vegf
PE20140407A1 (es) * 2008-06-10 2014-04-25 Abbott Lab Nuevos compuestos triciclicos
MX340304B (es) 2008-10-01 2016-07-05 Novartis Ag * Antagonismo de smoothened para el tratamiento de los trastornos relacionados con la senda de hedgehog.
EP2438064A1 (en) * 2009-06-04 2012-04-11 Novartis AG 1H-IMIDAZO[4,5-c]QUINOLINONE DERIVATIVES
EP2438063A1 (en) 2009-06-04 2012-04-11 Novartis AG 1h-imidazo[4,5-c]quinolinone compounds, useful for the treatment of proliferative diseases
GB0919423D0 (en) * 2009-11-05 2009-12-23 Glaxosmithkline Llc Novel compounds
BR112012022868A2 (pt) * 2010-03-16 2018-06-05 Merck Patent Gmbh morfolinilquinazolinas
PE20130376A1 (es) * 2010-06-28 2013-03-30 Merck Patent Gmbh [1,8]naftiridinas sustituidas por 2,4-diarilo como inhibidores de quinasas para uso contra el cancer
CN102372711B (zh) 2010-08-18 2014-09-17 山东轩竹医药科技有限公司 咪唑并喹啉类PI3K和mTOR双重抑制剂
DE102010035744A1 (de) 2010-08-28 2012-03-01 Merck Patent Gmbh Imidazolonylchinoline
CN102399218A (zh) * 2010-09-16 2012-04-04 和记黄埔医药（上海）有限公司 一类并合三杂环及其作为pi3k抑制剂的用途
PE20140792A1 (es) 2010-12-03 2014-07-09 Novartis Ag Composiciones farmaceuticas
CN103012398B (zh) 2011-09-19 2015-10-14 上海恒瑞医药有限公司 咪唑并喹啉类衍生物及其可药用盐、其制备方法及其在医药上的应用
US9879003B2 (en) 2012-04-11 2018-01-30 Dana-Farber Cancer Institute, Inc. Host targeted inhibitors of dengue virus and other viruses
CN104349771A (zh) 2012-06-06 2015-02-11 诺华股份有限公司 用于***疾病的17α-羟化酶(C17,20-裂解酶)抑制剂和特定PI-3K抑制剂的组合
NO2714752T3 (da) * 2014-05-08 2018-04-21
ES2880626T3 (es) * 2015-04-02 2021-11-25 Merck Patent Gmbh Imidazolonilquinolinas

Also Published As

Publication number Publication date
HRP20191396T1 (hr) 2019-11-01
IL271494B (en) 2021-05-31
DK3560924T3 (da) 2021-06-28
CN111747952A (zh) 2020-10-09
ES2880626T3 (es) 2021-11-25
EP3560924A1 (de) 2019-10-30
CA2981365A1 (en) 2016-10-06
AU2020204241B2 (en) 2022-11-17
TR201911244T4 (tr) 2019-08-21
US10975075B2 (en) 2021-04-13
JP7111790B2 (ja) 2022-08-02
SI3277681T1 (sl) 2019-09-30
JP2021046403A (ja) 2021-03-25
EP3868761B1 (de) 2023-03-01
AU2020204241A1 (en) 2020-07-16
EP3277681A1 (de) 2018-02-07
ES2946507T3 (es) 2023-07-20
SI3560924T1 (sl) 2021-08-31
BR122019005502B1 (pt) 2024-02-27
RU2743343C2 (ru) 2021-02-17
AU2022256215A1 (en) 2022-11-24
IL282584B (en) 2021-12-01
BR112017020941A2 (pt) 2018-07-10
US20190211013A1 (en) 2019-07-11
LT3560924T (lt) 2021-08-25
EP3560924B1 (de) 2021-03-31
US10457677B2 (en) 2019-10-29
SG10202002181UA (en) 2020-05-28
IL254714A0 (en) 2017-11-30
EP3277681B1 (de) 2019-05-08
HUE054745T2 (hu) 2021-09-28
US20230203034A1 (en) 2023-06-29
ES2741853T3 (es) 2020-02-12
EP3868761A1 (de) 2021-08-25
RU2017138100A3 (da) 2019-10-04
IL254714B (en) 2020-01-30
KR102652052B1 (ko) 2024-03-27
JP6791873B2 (ja) 2020-11-25
MX2020011558A (es) 2022-03-09
RS62082B1 (sr) 2021-08-31
US20200325137A1 (en) 2020-10-15
PL3560924T3 (pl) 2021-10-11
PT3277681T (pt) 2019-08-20
KR20240044525A (ko) 2024-04-04
SG11201708065QA (en) 2017-10-30
AU2016239270B2 (en) 2020-03-26
ZA201707423B (en) 2021-05-26
MX2017012613A (es) 2018-01-24
US10745399B2 (en) 2020-08-18
LT3277681T (lt) 2019-08-12
PL3277681T3 (pl) 2019-10-31
US11608338B2 (en) 2023-03-21
KR20170132323A (ko) 2017-12-01
HUE045477T2 (hu) 2019-12-30
AU2016239270A1 (en) 2017-11-16
HRP20210981T1 (hr) 2021-09-17
US20210198257A1 (en) 2021-07-01
IL271494A (en) 2020-02-27
WO2016155884A1 (de) 2016-10-06
RU2017138100A (ru) 2019-05-08
JP2018510191A (ja) 2018-04-12
US20180072715A1 (en) 2018-03-15
CN111689963A (zh) 2020-09-22
IL282584A (en) 2021-06-30
PT3560924T (pt) 2021-07-02
RS59139B1 (sr) 2019-09-30
CN107889488B (zh) 2020-08-11
CN107889488A (zh) 2018-04-06

Similar Documents

Publication Publication Date Title
DK3277681T3 (da) Imidazolonylquinoliner og deres anvendelse som atm-kinaseinhibitorer
DK3149001T3 (da) Hidtil ukendte pyrazolopyrimidinderivater og deres anvendelse som MALT1-hæmmere
DK3389658T3 (da) Glycosidasehæmmere og anvendelser deraf
DK3307707T3 (da) Halogensubstituerede phenoxyphenylamidiner og anvendelsen deraf som fungicider
DK3221306T3 (da) Heteroarylforbindelser som irak-inhibitorer og anvendelser deraf
DK3105218T3 (da) Cyclopropylaminer som lsd1-inhibitorer
DK3105226T3 (da) Cyclopropylaminer som lsd1-inhibitorer
DK3442972T3 (da) Bromdomænehæmmere
BR112016030697A2 (pt) inibidores da desmetilase-1 específica da lisina
DK3015526T3 (da) Hydrofluorolefinbaseret sammensætning og anvendelse deraf
DK3557998T3 (da) Sammensætninger, kompositioner og anvendelsesmetoder
DK3663290T3 (da) Polymethinforbindelser og anvendelse deraf som fluorescerende markører
DK3538528T3 (da) Pyrrolamider som alpha v-integrinhæmmere
DK3274430T3 (da) Mikroalgesammensætninger og deres anvendelser
DK3347353T3 (da) Pyrazolyl-substituerede heteroaryler og deres anvendelse som lægemidler
DK3288944T3 (da) Imidazopyrazinoner som pde1-inhibitorer
DK3341379T3 (da) EZH2-hæmmere
DK3137168T3 (da) Substituerede 4-phenylpiperidiner, deres fremstilling og anvendelse
DK3313833T3 (da) Forbindelser og anvendelse deraf som inhibitorer af n-myristoyl-transferase
DK3571192T3 (da) Jak1-selektive inhibitorer
DK3186242T3 (da) Alfa-amino-beta-carboxymuconsyre-semialdehyd-decarboxylasehæmmere
DK3214079T3 (da) Seks-leddede benzodiazepinderivater som dpp-4-inhibitorer og hvordan de bruges
DK3630744T3 (da) Pyrazol-magl-inhibitorer
DK3240821T3 (da) Lavdosis gashydrathæmmersammensætning og tilhørende fremgangsmåde
DK3310784T3 (da) Tricykliske forbindelser og deres anvendelse som phosphodiesterasehæmmere