DK3429603T3 - Fremgangsmåder og sammensætninger vedrørende ekspansion af hæmatopoietiske stamceller - Google Patents

Fremgangsmåder og sammensætninger vedrørende ekspansion af hæmatopoietiske stamceller Download PDF

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DK3429603T3
DK3429603T3 DK17767443.9T DK17767443T DK3429603T3 DK 3429603 T3 DK3429603 T3 DK 3429603T3 DK 17767443 T DK17767443 T DK 17767443T DK 3429603 T3 DK3429603 T3 DK 3429603T3
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procedures
compositions
expansion
stem cells
hematopoetic stem
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DK17767443.9T
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Derrick J Rossi
Wataru Ebina
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Childrens Medical Center
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DK17767443.9T 2016-03-15 2017-03-15 Fremgangsmåder og sammensætninger vedrørende ekspansion af hæmatopoietiske stamceller DK3429603T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662308324P 2016-03-15 2016-03-15
US201662309140P 2016-03-16 2016-03-16
PCT/US2017/022534 WO2017161001A1 (en) 2016-03-15 2017-03-15 Methods and compositions relating to hematopoietic stem cell expansion

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DK3429603T3 true DK3429603T3 (da) 2022-03-14

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US (1) US20190119642A1 (da)
EP (2) EP3429603B1 (da)
JP (2) JP7080179B2 (da)
AU (1) AU2017235461B2 (da)
DK (1) DK3429603T3 (da)
WO (1) WO2017161001A1 (da)
ZA (1) ZA201806132B (da)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112018013074A2 (pt) * 2015-12-30 2018-12-11 Novartis Ag terapias de célula efetora imune com eficácia real-çada
US20190119642A1 (en) * 2016-03-15 2019-04-25 Children's Medical Center Corporation Methods and compositions relating to hematopoietic stem cell expansion
JP7215994B2 (ja) 2016-09-06 2023-01-31 ザ チルドレンズ メディカル センター コーポレーション 人工多能性幹細胞由来の免疫細胞
GB201618106D0 (en) * 2016-10-26 2016-12-07 Lift Biosciences Ltd Cancer-killing cells
WO2018191476A1 (en) 2017-04-12 2018-10-18 Magenta Therapeutics, Inc. Aryl hydrocarbon receptor antagonists and uses thereof
WO2019018562A1 (en) 2017-07-19 2019-01-24 Ideaya Biosciences, Inc. AMIDO COMPOUND AS MODULATORS OF AHR
TWI793151B (zh) 2017-08-23 2023-02-21 瑞士商諾華公司 3-(1-氧異吲哚啉-2-基)之氫吡啶-2,6-二酮衍生物及其用途
CN111542597A (zh) * 2017-10-31 2020-08-14 美真达治疗公司 用于扩增造血干细胞和祖细胞的组合物和方法
JP2021510150A (ja) * 2018-01-03 2021-04-15 マジェンタ セラピューティクス インコーポレイテッドＭａｇｅｎｔａ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． 造血幹細胞および前駆細胞の増幅ならびに遺伝性代謝障害の処置のための組成物および方法
US20210254006A1 (en) 2018-06-06 2021-08-19 Ideaya Biosciences, Inc. Methods of culturing and/or expanding stem cells and/or lineage committed progenitor cells using lactam compounds
AR116109A1 (es) 2018-07-10 2021-03-31 Novartis Ag Derivados de 3-(5-amino-1-oxoisoindolin-2-il)piperidina-2,6-diona y usos de los mismos
EP3820573B1 (en) 2018-07-10 2023-08-09 Novartis AG 3-(5-hydroxy-1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and their use in the treatment of ikaros family zinc finger 2 (ikzf2)-dependent diseases
WO2020018848A1 (en) * 2018-07-19 2020-01-23 Ideaya Biosciences, Inc. Methods of culturing and/or expanding stem cells and/or lineage committed progenitor cells using amido compounds
WO2020077343A1 (en) * 2018-10-12 2020-04-16 Life Technologies Corporation Hematopoietic stem and progenitor cell expansion system
CN109536447A (zh) * 2018-12-28 2019-03-29 诺未科技（北京）有限公司 扩增造血干细胞的培养体系、方法及其用途
CN109468277A (zh) * 2018-12-28 2019-03-15 诺未科技（北京）有限公司 扩增造血干细胞的培养体系、方法及其用途
US20220315895A1 (en) * 2019-05-01 2022-10-06 Transfusion Health, Llc Methods of making oligopotent and unipotent precursors
CN110904038B (zh) * 2019-12-13 2023-09-12 深圳市蓝思人工智能医学研究院 一种间充质干细胞及其应用
AU2020409437A1 (en) * 2019-12-18 2022-07-14 Universite De Montreal Modulators of Cullin 3 adaptor KBTBD4 as anti-cancer compounds
JPWO2021149799A1 (da) * 2020-01-24 2021-07-29
CN118302519A (zh) * 2021-11-30 2024-07-05 特雷尔赫德生物***股份有限公司 用于维持和扩增造血干细胞的方法和组合物
IL312796A (en) * 2021-12-08 2024-07-01 Trailhead Biosystems Inc Methods and preparations for generating human erythroid progenitor cells

Family Cites Families (154)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH223191A (de) 1942-05-28 1942-08-31 Ramel Otto Vorrichtung zum Betätigen der Bremsen an Fahrrädern.
US2993931A (en) 1958-12-26 1961-07-25 Texaco Inc Process for preparing urea and an aromatic amine
US2997422A (en) 1959-01-09 1961-08-22 Smith Kline French Lab Monoamine oxidase inhibition
US3011945A (en) 1960-03-07 1961-12-05 Smith Kline French Lab Phenylcyclopropylamine -10-(omega-aminoalkyl)-phenothiazine ataractic composition
US3079403A (en) 1960-09-19 1963-02-26 Smith Kline French Lab Process for preparing amines
US3134676A (en) 1961-06-21 1964-05-26 Smith Kline French Lab Animal feed compositions and methods for their administration
US3244596A (en) 1962-10-18 1966-04-05 Univ Iowa College Of Pharmacy Coated medicinal agents and coating compositions therefor
JPS60149520A (ja) 1984-01-13 1985-08-07 Ajinomoto Co Inc 抗腫瘍剤
JPS61176523A (ja) 1985-01-30 1986-08-08 Teruhiko Beppu 制癌剤
JPH01224381A (ja) 1988-03-04 1989-09-07 Japan Tobacco Inc トリコスタチン酸、トリコスタチンａの新規な合成中間体、及びトリコスタチン酸、トリコスタチンａの製造方法。
GB8817743D0 (en) 1988-07-26 1988-09-01 Fujisawa Pharmaceutical Co Fr901228 substance & preparation thereof
US5571714A (en) 1988-12-22 1996-11-05 Celtrix Pharmaceuticals, Inc. Monoclonal antibodies which bind both transforming growth factors β1 and β2 and methods of use
US6124449A (en) 1990-06-11 2000-09-26 Nexstar Pharmaceuticals, Inc. High affinity TGFβ nucleic acid ligands and inhibitors
US5731424A (en) 1990-06-11 1998-03-24 Nexstar Pharmaceuticals, Inc. High affinity TGFβ nucleic acid ligands and inhibitors
US5512421A (en) 1991-02-19 1996-04-30 The Regents Of The University Of California Generation, concentration and efficient transfer of VSV-G pseudotyped retroviral vectors
US5916891A (en) 1992-01-13 1999-06-29 Smithkline Beecham Corporation Pyrimidinyl imidazoles
IL104369A0 (en) 1992-01-13 1993-05-13 Smithkline Beecham Corp Novel compounds and compositions
DK0669836T3 (da) 1992-11-13 1996-10-14 Idec Pharma Corp Terapeutisk anvendelse af kimære og radioaktivt mærkede antistoffer og humant B-lymfocytbegrænset differentieringsantigen til behandling af B-cellelymfom
ZA945363B (en) 1993-07-21 1995-03-14 Smithkline Beecham Corp Novel compounds
ES2140561T3 (es) 1993-09-17 2000-03-01 Smithkline Beecham Corp Proteina de union de farmacos.
US5426196A (en) 1993-12-22 1995-06-20 Glaxo Inc. Synthesis of diaryl methanes
JPH07206670A (ja) 1994-01-14 1995-08-08 Kyowa Hakko Kogyo Co Ltd 免疫抑制剤
US5486534A (en) 1994-07-21 1996-01-23 G. D. Searle & Co. 3,4-substituted pyrazoles for the treatment of inflammation
US5547892A (en) 1995-04-27 1996-08-20 Taiwan Semiconductor Manufacturing Company Process for forming stacked contacts and metal contacts on static random access memory having thin film transistors
US5801030A (en) 1995-09-01 1998-09-01 Genvec, Inc. Methods and vectors for site-specific recombination
CA2232090A1 (en) 1995-09-21 1997-03-27 Eli Lilly And Company Selective .beta.3 adrenergic agonists
ZA967892B (en) 1995-09-21 1998-03-18 Lilly Co Eli Selective β3 adrenergic agonists.
GB2306108A (en) 1995-10-13 1997-04-30 Merck & Co Inc Treatment of Raf-mediated cancers with imidazole derivatives
JP2000506532A (ja) 1996-03-13 2000-05-30 スミスクライン・ビーチャム・コーポレイション サイトカイン介在疾患の治療にて有用な新規ピリミジン化合物
JP2000507545A (ja) 1996-03-25 2000-06-20 スミスクライン・ビーチャム・コーポレイション Ｃｎｓ損傷についての新規な治療
US6281230B1 (en) 1996-07-24 2001-08-28 Celgene Corporation Isoindolines, method of use, and pharmaceutical compositions
US5798368A (en) 1996-08-22 1998-08-25 Celgene Corporation Tetrasubstituted 2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolines and method of reducing TNFα levels
EP0827946A1 (en) 1996-09-04 1998-03-11 Vrije Universiteit Brussel Inhibitors for the differentiation of cells, in particular hepatic stellate cells
DE69711519T2 (de) 1996-09-05 2002-10-31 Eli Lilly And Co., Indianapolis Carbazolanaloge als selektive beta3-adrenergische Agonisten
TW589189B (en) 1997-08-04 2004-06-01 Scras Kit containing at least one double-stranded RNA combined with at least one anti-viral agent for therapeutic use in the treatment of a viral disease, notably of viral hepatitis
US5955476A (en) 1997-11-18 1999-09-21 Celgene Corporation Substituted 2-(2,6-dioxo-3-fluoropiperidin-3-yl)-isoindolines and method of reducing inflammatory cytokine levels
US6806358B1 (en) 1997-12-16 2004-10-19 University Of California San Diego Peptide inhibitor of TGF-β growth factors
US6506559B1 (en) 1997-12-23 2003-01-14 Carnegie Institute Of Washington Genetic inhibition by double-stranded RNA
CA2321307A1 (en) 1998-02-27 1999-09-02 Venkatachala L. Narayanan Disubstituted lavendustin a analogs and pharmaceutical compositions comprising the analogs
FR2778337B1 (fr) 1998-05-05 2001-08-31 Inst Nat Sante Rech Med Antagonistes des ligands du recepteur des arylhydrocarbures
GB9809869D0 (en) 1998-05-09 1998-07-08 Medical Res Council Inhibition of protein kinases
US7045519B2 (en) 1998-06-19 2006-05-16 Chiron Corporation Inhibitors of glycogen synthase kinase 3
US6489344B1 (en) 1998-06-19 2002-12-03 Chiron Corporation Inhibitors of glycogen synthase kinase 3
GB9827152D0 (en) 1998-07-03 1999-02-03 Devgen Nv Characterisation of gene function using double stranded rna inhibition
US6184226B1 (en) 1998-08-28 2001-02-06 Scios Inc. Quinazoline derivatives as inhibitors of P-38 α
ES2146552B1 (es) 1998-11-24 2001-04-16 Inst Cientifico Tecnol Navarra Peptidos inhibidores de tgf/31
CA2361201A1 (en) 1999-01-28 2000-08-03 Medical College Of Georgia Research Institute, Inc. Composition and method for in vivo and in vitro attenuation of gene expression using double stranded rna
DE19956568A1 (de) 1999-01-30 2000-08-17 Roland Kreutzer Verfahren und Medikament zur Hemmung der Expression eines vorgegebenen Gens
WO2000059900A1 (en) 1999-04-01 2000-10-12 The Board Of Trustees Of The University Of Arkansas P38mapk inhibitor and uses thereof
MXPA01011499A (es) 1999-05-13 2002-06-04 American Cyanamid Co Formulaciones de combinacion de adyuvantes.
AU1086501A (en) 1999-10-15 2001-04-30 Carnegie Institution Of Washington Rna interference pathway genes as tools for targeted genetic interference
GB9927444D0 (en) 1999-11-19 2000-01-19 Cancer Res Campaign Tech Inhibiting gene expression
EP1276889B1 (de) 2000-04-27 2005-10-19 Max-Delbrück-Centrum Für Molekulare Medizin Sleeping beauty, ein transposonvektor mit breitem wirtsbereich für die genetische transformation bei wirbeltieren
EP1313872A1 (en) 2000-09-01 2003-05-28 Fujisawa Pharmaceutical Co., Ltd. A method of producing fr901228
WO2002020495A2 (en) 2000-09-06 2002-03-14 Chiron Corporation Inhibitors of glycogen synthase kinase 3
US6509318B1 (en) 2000-09-29 2003-01-21 The Regents Of The University Of California TGF-B inhibitors and methods
US7399633B2 (en) 2000-10-27 2008-07-15 Fred Hutchinson Cancer Research Center Methods for immortalizing cells
GB0102672D0 (en) 2001-02-02 2001-03-21 Glaxo Group Ltd Compounds
US20050287128A1 (en) 2001-05-18 2005-12-29 Sirna Therapeutics, Inc. RNA interference mediated inhibition of TGF-beta and TGF-beta receptor gene expression using short interfering nucleic acid (siNA)
US20050227936A1 (en) 2001-05-18 2005-10-13 Sirna Therapeutics, Inc. RNA interference mediated inhibition of TGF-beta and TGF-beta receptor gene expression using short interfering nucleic acid (siNA)
CA2446820C (en) 2001-05-24 2010-07-13 Eli Lilly And Company Novel pyrrole derivatives as pharmaceutical agents
US20030028905A1 (en) 2001-07-31 2003-02-06 Petra Knaus Mutant forms of the TGF-beta type II receptor which bind all TGF-beta isoforms
JP5170934B2 (ja) 2001-08-16 2013-03-27 ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア 改良ｄｎａリポフェクションならびに／または徐放性プロドラッグおよび薬物療法のための試薬の合成と使用
JP2005504770A (ja) 2001-08-17 2005-02-17 メルク　エンド　カムパニー　インコーポレーテッド ５−スルホンアミド−８−ヒドロキシ−１，６−ナフチリジン−７−カルボキサミドの製造方法
US20040006030A1 (en) 2002-07-02 2004-01-08 Isis Pharmaceuticals Inc. Antisense modulation of TGF-beta 2 expression
JP2005530800A (ja) 2002-05-15 2005-10-13 スミスクライン・ビーチャム・コーポレイション ベンゾオキサジンおよびベンゾオキサジノン置換トリアゾール
US7190468B2 (en) 2002-07-17 2007-03-13 Hewlett-Packard Development Company, L.P. Background document rendering system and method
US20050245520A1 (en) 2002-07-31 2005-11-03 Nerina Dodic 2-Phenylpyridin-4-yl derivatives as alk5 inhibitors
AP2005003262A0 (en) 2002-09-18 2005-03-31 Pfizer Prod Inc Novel isothiazole and isoxazole compounds as tranforming growth factor (TGF) inhibitors.
DE60330362D1 (de) 2002-09-18 2010-01-14 Pfizer Prod Inc Neue pyrazol-verbindungen als hemmer des transformierenden wachstumsfaktors (tgf)
AU2003268155A1 (en) 2002-09-19 2004-04-08 Eli Lilly And Company Methods of inhibiting tgf beta with substituted pyrazoles
EP1418164A1 (en) 2002-11-07 2004-05-12 Institut National De La Sante Et De La Recherche Medicale (Inserm) New stilbene derivatives and their use as aryl hydrocarbon receptor ligand antagonists
US20040138188A1 (en) 2002-11-22 2004-07-15 Higgins Linda S. Use of TGF-beta inhibitors to counteract pathologic changes in the level or function of steroid/thyroid receptors
WO2004067530A1 (en) 2003-01-27 2004-08-12 Pfizer Products Inc. Isothiazole derivatives
CL2004000234A1 (es) 2003-02-12 2005-04-15 Biogen Idec Inc Compuestos derivados 3-(piridin-2-il)-4-heteroaril-pirazol sustituidos, antagonistas de aik5 y/o aik4; composicion farmaceutica y uso del compuesto en el tratamiento de desordenes fibroticos como esclerodermia, lupus nefritico, cicatrizacion de herid
ES2305744T3 (es) 2003-03-12 2008-11-01 Millennium Pharmaceuticals, Inc. Derivados de quinazolina como inhibidores e tgf-beta.
WO2004087056A2 (en) 2003-03-28 2004-10-14 Scios Inc. BI-CYCLIC PYRIMIDINE INHIBITORS OF TGFβ
WO2004087646A2 (de) 2003-04-03 2004-10-14 Merck Patent Gmbh Pyrrolidin -1,2-dicarbonsäure-1-(phenylamid) -2- (4-(3-oxo-morpholin-4-yl)-phenylamid) derivate und verwandte verbindungen als inhibitoren des koagulationsfaktors xa zur behandlung von thromboembolischen erkrankungen
US7575822B2 (en) 2003-04-09 2009-08-18 Bloom Energy Corporation Method of optimizing operating efficiency of fuel cells
US7314939B2 (en) 2003-06-17 2008-01-01 Millennium Pharmaceuticals, Inc. Compositions and methods for inhibiting TGF-β
JP4723799B2 (ja) 2003-07-08 2011-07-13 株式会社ソニー・コンピュータエンタテインメント 制御システムおよび制御方法
US20060229266A1 (en) 2003-08-13 2006-10-12 Kumar Nalin M Silencing of tgf-beta receptor type II expression by sirna
FR2860514A1 (fr) 2003-10-03 2005-04-08 Sanofi Synthelabo Derives d'arylalkylcarbamates, leur preparation et leur application en therapeutique
JP4688680B2 (ja) 2003-10-28 2011-05-25 独立行政法人理化学研究所 ＴＧＦ−β情報伝達経路阻害剤
US7368445B2 (en) 2004-03-01 2008-05-06 Eli Lilly And Company Fused pyrazole derivatives as TGF-β signal transduction inhibitors for the treatment of fibrosis and neoplasms
FR2873498B1 (fr) 2004-07-20 2007-08-10 Conception & Dev Michelin Sa Arret d'une pile a combustible alimentee en oxygene pur
JP2007176795A (ja) 2004-08-18 2007-07-12 Univ Nihon ＴＧＦ−β遺伝子発現抑制剤
DE102004047254A1 (de) 2004-09-29 2006-04-13 Merck Patent Gmbh Carbonylverbindungen
US7850960B2 (en) 2004-12-30 2010-12-14 University Of Washington Methods for regulation of stem cells
CN101189234B (zh) 2005-03-25 2011-08-17 泰博特克药品有限公司 Hcv的杂二环抑制剂
US20080207594A1 (en) 2005-05-04 2008-08-28 Davelogen Aktiengesellschaft Use of Gsk-3 Inhibitors for Preventing and Treating Pancreatic Autoimmune Disorders
PT1910370E (pt) 2005-07-22 2015-06-30 Lilly Co Eli Um pirrolo[1,2-b]pirazole mono-hidratado substituído com piridina e quinolina como inibidor do tgf-beta
US20080194021A1 (en) 2005-07-29 2008-08-14 Mays Robert W Use of a Gsk-3 Inhibitor to Maintain Potency of Culture Cells
WO2007039151A1 (en) 2005-09-28 2007-04-12 Universität Zürich Blockers of transforming growth factor beta and its receptors for the treatment of infectious diseases
EP2341135A3 (en) 2005-10-18 2011-10-12 Precision Biosciences Rationally-designed meganucleases with altered sequence specificity and DNA-binding affinity
CN101340927A (zh) 2005-10-24 2009-01-07 西玛生物医学信息公司 TGF-β1抑制性多肽在制备免疫反应调节剂上的用途
KR100998816B1 (ko) 2005-10-31 2010-12-06 주식회사 대웅제약 신규한 항진균성 트리아졸 유도체
EP1801098A1 (en) 2005-12-16 2007-06-27 Merck Sante 2-Adamantylurea derivatives as selective 11B-HSD1 inhibitors
KR20080082618A (ko) 2005-12-16 2008-09-11 알콘, 인코퍼레이티드 Ａｌｋ5 조절제를 사용한 안압의 조절
WO2007075911A2 (en) 2005-12-22 2007-07-05 Yale University Inhibition of glycogen synthase kinase and methods of treating autoimmune or immune inflammatory disease
KR20070077468A (ko) 2006-01-23 2007-07-26 크리스탈지노믹스(주) 단백질 키나아제 활성을 저해하는 이미다조피리딘 유도체,이의 제조방법 및 이를 함유하는 약학 조성물
US20090186076A1 (en) 2006-02-01 2009-07-23 Kazunori Kataoka Combined Use of TGF-Beta Signaling Inhibitor and Antitumor Agent
ITMI20060181A1 (it) 2006-02-03 2007-08-04 Univ Padova Modulatori del tgf-b e loro uso
WO2007109097A2 (en) 2006-03-16 2007-09-27 Alnylam Pharmaceuticals, Inc. RNAi MODULATION OF TGF-BETA AND THERAPEUTIC USES THEREOF
AU2007230902B2 (en) 2006-03-24 2013-03-14 Children's Medical Center Corporation Method to modulate hematopoietic stem cell growth
WO2008022182A1 (en) 2006-08-16 2008-02-21 The Uab Research Foundation Methods for promoting coupling between bone formation and resorption
EP1995316A1 (de) 2007-05-25 2008-11-26 Qiagen GmbH Verfahren zur schonenden Zellaufreinigung, Zellgewinnung und Transfektion von Zellen
EP2009095A1 (en) 2007-06-28 2008-12-31 Innovalor AG Method of generating glucose-responsive cells
US20110190280A1 (en) 2007-08-29 2011-08-04 George Adjabeng Thiazole And Oxazole Kinase Inhibitors
CA2704383A1 (en) 2007-10-31 2009-05-07 James Jefferson Smith Rationally-designed single-chain meganucleases with non-palindromic recognition sequences
GB0805312D0 (en) 2008-03-20 2008-04-30 Medical Res Council Modulation of the immune response
FR2932180B1 (fr) 2008-06-04 2012-08-10 Centre Nat Rech Scient Dihydro iso ca-4 et analogues : puissants cytotoxiques, inhibiteurs de la polymerisation de la tubuline
US8298825B1 (en) 2008-08-25 2012-10-30 The General Hospital Corporation TGF-beta receptor inhibitors to enhance direct reprogramming
GB0818907D0 (en) 2008-10-15 2008-11-19 Isis Innovation Histone lysine demethylase inhibitors
WO2010065917A1 (en) 2008-12-05 2010-06-10 The Regents Of The University Of California Methods of treating neurological disorders
SG172160A1 (en) 2008-12-17 2011-07-28 Scripps Research Inst Generation and maintenance of stem cells
WO2010085699A2 (en) 2009-01-23 2010-07-29 The Johns Hopkins University Mammalian piggybac transposon and methods of use
US20120122212A1 (en) 2009-03-06 2012-05-17 Marica Grskovic Tgf-beta pathway inhibitors for enhancement of cellular reprogramming of human cells
US8822684B1 (en) 2009-08-06 2014-09-02 Vanderbilt University Compounds and methods useful for directing stem cell differentiation
WO2011106573A2 (en) 2010-02-24 2011-09-01 Oryzon Genomics, S.A. Lysine demethylase inhibitors for diseases and disorders associated with hepadnaviridae
CA2804795A1 (en) 2010-07-12 2012-01-19 Nicholas Vrolijk Romidepsin solid forms and uses thereof
WO2012107499A1 (en) 2011-02-08 2012-08-16 Oryzon Genomics S.A. Lysine demethylase inhibitors for myeloproliferative or lymphoproliferative diseases or disorders
WO2012109429A2 (en) 2011-02-09 2012-08-16 Glaxosmithkline Llc Lyophilized formulations
WO2012115120A1 (ja) 2011-02-21 2012-08-30 国立大学法人 大阪大学 ５－ｈｔ神経細胞の製造方法
WO2012122405A2 (en) 2011-03-08 2012-09-13 The Trustees Of Columbia University In The City Of New York Screening assays using stem cells and stem cell-derived neurons from mouse models of alzheimer's disease
RU2456356C1 (ru) 2011-04-29 2012-07-20 Борис Сергеевич Кустов Коллоидный раствор наносеребра и способ его получения
US9505763B2 (en) 2011-07-25 2016-11-29 Vanderbilt University Cancer treatment using BMP inhibitor
EP2763670B1 (en) 2011-10-03 2018-12-05 Universite Libre De Bruxelles Reactivation of hiv-1 gene expression to treat persistent hiv infection
US8735622B2 (en) 2011-11-30 2014-05-27 The Regents Of The University Of Colorado, A Body Corporate Histone demethylase inhibitors and methods for using the same
US9834755B2 (en) 2011-12-08 2017-12-05 Fred Hutchinson Cancer Research Center Compositions and methods for enhanced generation of hematopoietic stem/progenitor cells
US20130178520A1 (en) 2011-12-23 2013-07-11 Duke University Methods of treatment using arylcyclopropylamine compounds
MX2014008390A (es) 2012-01-12 2014-09-22 Celgene Corp Formulaciones de romidepsina y sus usos.
ES2733946T3 (es) 2012-01-27 2019-12-03 Univ Montreal Derivados de pirimido[4,5-b]indol y su uso en la expansión de células madre hematopoyéticas
CN104379732B (zh) 2012-04-24 2018-08-17 国际干细胞公司 由人多能干细胞衍生神经干细胞和多巴胺能神经元
WO2013166488A1 (en) 2012-05-04 2013-11-07 Indiana University Research & Technology Corporation Methods for generating the inner ear and other cranial placode-derived tissues using pluripotent stem cells
WO2014018375A1 (en) 2012-07-23 2014-01-30 Xenon Pharmaceuticals Inc. Cyp8b1 and uses thereof in therapeutic and diagnostic methods
CN103577266B (zh) 2012-07-31 2017-06-23 国际商业机器公司 用于对现场可编程门阵列资源进行分配的方法及***
EP2907870A4 (en) 2012-10-09 2016-04-06 Hayashi Nakanobu REPROGRAMMING PEPTIDE AND USE THEREOF
WO2014062138A1 (en) 2012-10-19 2014-04-24 Agency For Science, Technology And Research Methods of differentiating stem cells into one or more cell lineages
US20140127231A1 (en) 2012-11-02 2014-05-08 University Of Vermont p38 MAPK Pathway Inhibitors as Female-Specific Therapeutics
US8697359B1 (en) 2012-12-12 2014-04-15 The Broad Institute, Inc. CRISPR-Cas systems and methods for altering expression of gene products
WO2014102731A1 (en) 2012-12-31 2014-07-03 Leiutis Pharmaceuticals Pvt. Ltd Novel pharmaceutical compositions of romidepsin
US20140248696A1 (en) 2013-03-01 2014-09-04 Wisconsin Alumni Research Foundation Methods of maintaining, expanding, and diffrentiating neuronal subtype specific progenitors
EP2964651A4 (en) 2013-03-04 2016-11-30 Brigham & Womens Hospital BMP HEMMER AND METHOD OF USE THEREOF
CA2903081A1 (en) 2013-03-14 2014-09-25 Quanticel Pharmaceuticals, Inc. Histone demethylase inhibitors
CA2906752A1 (en) * 2013-03-14 2014-09-25 Children's Medical Center Corporation Compositions and methods for reprogramming hematopoietic stem cell lineages
AU2014256876B2 (en) 2013-04-26 2020-11-12 Cornell, University Cortical interneurons and other neuronal cells produced by the directed differentiation of pluripotent and multipotent cells
EP3003301B1 (en) 2013-05-30 2021-02-24 Board Of Regents Of The Nevada System Of Higher Education On Behalf Of The University Of Nevada, Las Vegas Novel suicidal lsd1 inhibitors targeting sox2-expressing cancer cells
BR112015030918A2 (pt) 2013-06-11 2017-12-05 Astellas Pharma Inc método para produção de células progenitoras renais, e fármacos contendo células progenitoras renais
US20160116474A1 (en) 2013-06-20 2016-04-28 The Broad Institute, Inc. Compositions and methods for detecting and treating glioblastoma
CN104278008B (zh) 2013-07-12 2020-08-21 北京宏冠再生医学科技有限公司 一种通过小分子化合物处理来制备多潜能干细胞的方法、试剂盒和用途
WO2015148716A1 (en) * 2014-03-26 2015-10-01 The Brigham And Women's Hospital, Inc. Compositions and methods for ex vivo expansion of human hematopoietic stem/progenitor cells
US10669528B2 (en) * 2015-06-25 2020-06-02 Children's Medical Center Corporation Methods and compositions relating to hematopoietic stem cell expansion, enrichment, and maintenance
US20190119642A1 (en) * 2016-03-15 2019-04-25 Children's Medical Center Corporation Methods and compositions relating to hematopoietic stem cell expansion

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