BR112015030918A2 - método para produção de células progenitoras renais, e fármacos contendo células progenitoras renais - Google Patents
método para produção de células progenitoras renais, e fármacos contendo células progenitoras renaisInfo
- Publication number
- BR112015030918A2 BR112015030918A2 BR112015030918A BR112015030918A BR112015030918A2 BR 112015030918 A2 BR112015030918 A2 BR 112015030918A2 BR 112015030918 A BR112015030918 A BR 112015030918A BR 112015030918 A BR112015030918 A BR 112015030918A BR 112015030918 A2 BR112015030918 A2 BR 112015030918A2
- Authority
- BR
- Brazil
- Prior art keywords
- progenitor cells
- renal progenitor
- cells
- producing
- drugs containing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0684—Cells of the urinary tract or kidneys
- C12N5/0687—Renal stem cells; Renal progenitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/22—Urine; Urinary tract, e.g. kidney or bladder; Intraglomerular mesangial cells; Renal mesenchymal cells; Adrenal gland
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1841—Transforming growth factor [TGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0684—Cells of the urinary tract or kidneys
- C12N5/0686—Kidney cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/48—Reproductive organs
- A61K35/54—Ovaries; Ova; Ovules; Embryos; Foetal cells; Germ cells
- A61K35/545—Embryonic stem cells; Pluripotent stem cells; Induced pluripotent stem cells; Uncharacterised stem cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/15—Transforming growth factor beta (TGF-β)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/999—Small molecules not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/45—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from artificially induced pluripotent stem cells
Abstract
a presente invenção fornece: um método para produção de células progenitoras renais a partir de células mesodérmicas intermediárias, o método incluindo uma etapa para cultivo de células meso-dérmicas intermediárias em um meio de cultura que contém um ativador de sinalização de tgfss e um inibidor de bmp; as células progenitoras renais produzidas pelo método; uma composição farmacêutica contendo as células; e um agente terapêutico para doenças renais que compreendem as células.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2013123072 | 2013-06-11 | ||
JP2014092108 | 2014-04-25 | ||
PCT/JP2014/066081 WO2014200115A1 (ja) | 2013-06-11 | 2014-06-11 | 腎前駆細胞の製造方法及び腎前駆細胞を含む医薬 |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112015030918A2 true BR112015030918A2 (pt) | 2017-12-05 |
Family
ID=52022399
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112015030918A BR112015030918A2 (pt) | 2013-06-11 | 2014-06-11 | método para produção de células progenitoras renais, e fármacos contendo células progenitoras renais |
Country Status (15)
Country | Link |
---|---|
US (1) | US11225642B2 (pt) |
EP (1) | EP3020803B1 (pt) |
JP (1) | JP6450311B2 (pt) |
KR (1) | KR102145967B1 (pt) |
CN (1) | CN105283542A (pt) |
AU (1) | AU2014279065B2 (pt) |
BR (1) | BR112015030918A2 (pt) |
CA (1) | CA2915085C (pt) |
ES (1) | ES2794074T3 (pt) |
IL (1) | IL243023B (pt) |
MX (1) | MX2015017036A (pt) |
RU (1) | RU2696315C2 (pt) |
SG (1) | SG11201510201PA (pt) |
TW (1) | TWI629360B (pt) |
WO (1) | WO2014200115A1 (pt) |
Families Citing this family (21)
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EP2794860B1 (en) * | 2011-12-19 | 2017-05-03 | Kyoto University | Method for inducing differentiation of human pluripotent stem cells into intermediate mesoderm cells |
NZ715302A (en) * | 2013-06-14 | 2021-12-24 | Univ Queensland | Renal progenitor cells |
EP3027737B1 (en) * | 2013-07-29 | 2018-12-26 | F.Hoffmann-La Roche Ag | Method for differentiation of pluripotent stem cells into multi-competent renal precursors |
KR101853477B1 (ko) * | 2015-06-24 | 2018-04-30 | 전북대학교산학협력단 | Sirt1 발현 조절을 통한 배아줄기세포로부터 신장전구세포로의 분화 조절 방법 |
EP3313420B1 (en) | 2015-06-25 | 2024-03-13 | The Children's Medical Center Corporation | Methods and compositions relating to hematopoietic stem cell expansion, enrichment, and maintenance |
AU2016321015B2 (en) | 2015-09-11 | 2021-09-30 | Astellas Pharma Inc. | Method for producing renal progenitor cells |
WO2017049243A1 (en) * | 2015-09-17 | 2017-03-23 | Bonventre Joseph V | Methods of generating nephrons from human pluripotent stem cells |
EP3429603B1 (en) | 2016-03-15 | 2021-12-29 | Children's Medical Center Corporation | Methods and compositions relating to hematopoietic stem cell expansion |
JP7201223B2 (ja) * | 2016-04-08 | 2023-01-10 | 国立大学法人京都大学 | 多能性幹細胞から、内胚葉系細胞を選択的に誘導する方法 |
JP2019537729A (ja) | 2016-09-28 | 2019-12-26 | オルガノボ インコーポレイテッド | アッセイにおける人工腎臓組織の使用 |
EP3527655A4 (en) | 2016-10-11 | 2020-05-06 | Tokushima University | METHOD FOR PRODUCING RENAL-LIKE BIOLOGICAL TISSUE |
JP7274683B2 (ja) * | 2017-04-25 | 2023-05-17 | 国立大学法人 熊本大学 | 多能性幹細胞から樹状分岐した集合管を伴う腎臓構造を作製する方法 |
BR112019024637A2 (pt) | 2017-05-25 | 2020-06-16 | Kyoto University | Método para produzir células progenitoras renais, célula progenitora renal, organoide renal, composição farmacêutica, e, agente terapêutico para uma doença renal. |
JP2021500929A (ja) * | 2017-10-31 | 2021-01-14 | マードック チルドレンズ リサーチ インスティテュート | 組成物および方法 |
US11859209B2 (en) | 2017-12-19 | 2024-01-02 | Kyoto University | Method for inducing osteogenic differentiation |
EP3828262A4 (en) * | 2018-07-23 | 2022-03-30 | Kyoto University | NOVEL RENAL PROGENITOR CELL MARKER AND METHOD OF RENAL PROGENITOR CELL CONCENTRATION USING THE SAME |
WO2022149616A1 (ja) | 2021-01-08 | 2022-07-14 | 国立大学法人京都大学 | ネフロン前駆細胞を拡大培養するための培地、ネフロン前駆細胞を拡大培養する方法、腎臓オルガノイドの製造方法 |
WO2023017848A1 (ja) | 2021-08-11 | 2023-02-16 | 国立大学法人京都大学 | 腎間質前駆細胞の製造方法並びにエリスロポエチン産生細胞、およびレニン産生細胞の製造方法 |
CN114457006B (zh) * | 2022-02-21 | 2023-07-28 | 广州华越肾科再生医学科技有限公司 | 一种通过不连续分化制备肾脏足细胞的方法 |
CN114702591B (zh) * | 2022-05-17 | 2022-09-23 | 诺赛联合(北京)生物医学科技有限公司 | 成体细胞衍生的类器官制备技术 |
CN117305222B (zh) * | 2023-11-28 | 2024-02-20 | 广州华越肾科再生医学科技有限公司 | 多能干细胞分化为肾祖细胞的方法 |
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-
2014
- 2014-06-11 AU AU2014279065A patent/AU2014279065B2/en active Active
- 2014-06-11 EP EP14811223.8A patent/EP3020803B1/en active Active
- 2014-06-11 CN CN201480033367.1A patent/CN105283542A/zh active Pending
- 2014-06-11 SG SG11201510201PA patent/SG11201510201PA/en unknown
- 2014-06-11 US US14/897,319 patent/US11225642B2/en active Active
- 2014-06-11 BR BR112015030918A patent/BR112015030918A2/pt not_active IP Right Cessation
- 2014-06-11 WO PCT/JP2014/066081 patent/WO2014200115A1/ja active Application Filing
- 2014-06-11 CA CA2915085A patent/CA2915085C/en active Active
- 2014-06-11 MX MX2015017036A patent/MX2015017036A/es unknown
- 2014-06-11 ES ES14811223T patent/ES2794074T3/es active Active
- 2014-06-11 KR KR1020167000639A patent/KR102145967B1/ko active IP Right Grant
- 2014-06-11 RU RU2015156492A patent/RU2696315C2/ru active
- 2014-06-11 TW TW103120163A patent/TWI629360B/zh not_active IP Right Cessation
- 2014-06-11 JP JP2015522946A patent/JP6450311B2/ja active Active
-
2015
- 2015-12-10 IL IL243023A patent/IL243023B/en active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
CN105283542A (zh) | 2016-01-27 |
KR20160019509A (ko) | 2016-02-19 |
RU2015156492A (ru) | 2017-07-14 |
TW201536917A (zh) | 2015-10-01 |
US11225642B2 (en) | 2022-01-18 |
CA2915085C (en) | 2021-04-27 |
AU2014279065B2 (en) | 2020-04-09 |
IL243023B (en) | 2019-05-30 |
JPWO2014200115A1 (ja) | 2017-02-23 |
RU2015156492A3 (pt) | 2018-04-02 |
RU2696315C2 (ru) | 2019-08-01 |
TWI629360B (zh) | 2018-07-11 |
CA2915085A1 (en) | 2014-12-18 |
MX2015017036A (es) | 2016-07-21 |
KR102145967B1 (ko) | 2020-08-19 |
EP3020803A1 (en) | 2016-05-18 |
JP6450311B2 (ja) | 2019-01-09 |
EP3020803A4 (en) | 2017-02-22 |
AU2014279065A1 (en) | 2016-01-21 |
US20160137985A1 (en) | 2016-05-19 |
WO2014200115A1 (ja) | 2014-12-18 |
SG11201510201PA (en) | 2016-01-28 |
EP3020803B1 (en) | 2020-03-11 |
ES2794074T3 (es) | 2020-11-17 |
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