DK3113772T3 - Trifluormethylsubstituerede pyrazoler som inhibitorer af kallikrein fra humant plasma - Google Patents

Trifluormethylsubstituerede pyrazoler som inhibitorer af kallikrein fra humant plasma Download PDF

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Publication number
DK3113772T3
DK3113772T3 DK15759254.4T DK15759254T DK3113772T3 DK 3113772 T3 DK3113772 T3 DK 3113772T3 DK 15759254 T DK15759254 T DK 15759254T DK 3113772 T3 DK3113772 T3 DK 3113772T3
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trifluoromethyls
human plasma
substituted pyrazoles
inhibitors
plasma calicrein
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DK15759254.4T
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English (en)
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Minwan Wu
Weihe Zhang
Yarlagadda S Babu
Venkat R Chintareddy
Pravin L Kotian
V Satish Kumar
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Biocryst Pharm Inc
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    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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DK15759254.4T 2014-03-07 2015-03-09 Trifluormethylsubstituerede pyrazoler som inhibitorer af kallikrein fra humant plasma DK3113772T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461949808P 2014-03-07 2014-03-07
US201461981515P 2014-04-18 2014-04-18
PCT/US2015/019535 WO2015134998A1 (en) 2014-03-07 2015-03-09 Human plasma kallikrein inhibitors

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DK3113772T3 true DK3113772T3 (da) 2020-12-07

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DK15759254.4T DK3113772T3 (da) 2014-03-07 2015-03-09 Trifluormethylsubstituerede pyrazoler som inhibitorer af kallikrein fra humant plasma
DK20191747.3T DK3828173T3 (da) 2014-03-07 2015-03-09 Substituerede pyrazoler som humant plasma-kallikreininhibitorer

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DK20191747.3T DK3828173T3 (da) 2014-03-07 2015-03-09 Substituerede pyrazoler som humant plasma-kallikreininhibitorer

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US (12) US10125102B2 (da)
EP (3) EP4180424A1 (da)
JP (4) JP6574435B2 (da)
KR (2) KR102510427B1 (da)
CN (2) CN113307772A (da)
AU (3) AU2015226855C1 (da)
BR (1) BR112016020199A8 (da)
CA (2) CA2941380C (da)
CY (1) CY1123810T1 (da)
DK (2) DK3113772T3 (da)
EA (1) EA036251B1 (da)
ES (2) ES2932406T3 (da)
FR (1) FR21C1048I2 (da)
HR (2) HRP20221373T1 (da)
HU (3) HUE060660T2 (da)
IL (2) IL280785B1 (da)
LT (3) LT3828173T (da)
MA (1) MA53399B1 (da)
MX (2) MX2020013059A (da)
NL (1) NL301142I2 (da)
NO (1) NO2022046I1 (da)
NZ (2) NZ762034A (da)
PH (1) PH12016501750A1 (da)
PL (2) PL3828173T3 (da)
PT (2) PT3828173T (da)
RS (2) RS61159B1 (da)
SG (2) SG10202001795XA (da)
SI (1) SI3113772T1 (da)
WO (1) WO2015134998A1 (da)

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MX2016009230A (es) 2014-01-31 2016-10-03 Bristol Myers Squibb Co Macrociclicos con grupos p2'heterociclicos como inhibidores del factor xia.
WO2015134998A1 (en) 2014-03-07 2015-09-11 Biocryst Pharmaceuticals, Inc. Human plasma kallikrein inhibitors
WO2016036893A1 (en) 2014-09-04 2016-03-10 Bristol-Myers Squibb Company Diamide macrocycles that are fxia inhibitors
US9453018B2 (en) 2014-10-01 2016-09-27 Bristol-Myers Squibb Company Pyrimidinones as factor XIa inhibitors
GB201421083D0 (en) 2014-11-27 2015-01-14 Kalvista Pharmaceuticals Ltd Enzyme inhibitors
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PT3355890T (pt) * 2015-10-01 2022-01-19 Biocryst Pharm Inc Inibidores de calicreína plasmática humana
IL293304A (en) 2016-05-31 2022-07-01 Kalvista Pharmaceuticals Ltd History of pyrazole as plasma kallikrein inhibitors
GB201609603D0 (en) 2016-06-01 2016-07-13 Kalvista Pharmaceuticals Ltd Polymorphs of N-[(6-cyano-2-fluoro-3-methoxyphenyl)Methyl]-3-(methoxymethyl)-1-({4-[(2-ox opyridin-1-YL)Methyl]phenyl}methyl)pyrazole-4-carboxamide
GB201609607D0 (en) 2016-06-01 2016-07-13 Kalvista Pharmaceuticals Ltd Polymorphs of N-(3-Fluoro-4-methoxypyridin-2-yl)methyl)-3-(methoxymethyl)-1-({4-((2-oxopy ridin-1-yl)methyl)phenyl}methyl)pyrazole-4-carboxamide and salts
HRP20220367T1 (hr) 2017-11-29 2022-05-27 Kalvista Pharmaceuticals Limited Oblici za doziranje koji sadrže plazmatski kalikrein inhibitor
GB201721515D0 (en) * 2017-12-21 2018-02-07 Kalvista Pharmaceuticals Ltd Dosage forms comprising a plasma kallikrein inhibtor
GB201719881D0 (en) 2017-11-29 2018-01-10 Kalvista Pharmaceuticals Ltd Solid forms of plasma kallikrein inhibitor and salts thereof
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UY38438A (es) 2018-11-02 2020-05-29 Biocryst Pharm Inc Sales cristalinas de un inhibidor de calicreína plasmática
CA3121202A1 (en) 2018-11-30 2020-06-04 Nuvation Bio Inc. Pyrrole and pyrazole compounds and methods of use thereof
EP3953395A4 (en) * 2019-04-08 2023-01-18 Biocryst Pharmaceuticals, Inc. PLASMACALLICREIN INHIBITORS AND METHODS OF USE THEM IN EYE DISEASES
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JP2022543419A (ja) * 2019-08-06 2022-10-12 バイオクリスト ファーマスーティカルズ，インコーポレイテッド 血漿カリクレイン阻害剤のプロセス規模合成
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WO2021032935A1 (en) * 2019-08-21 2021-02-25 Kalvista Pharmaceuticals Limited Enzyme inhibitors
TW202144331A (zh) * 2020-02-13 2021-12-01 德商百靈佳殷格翰國際股份有限公司 作為血漿激肽釋放酶抑制劑之雜芳族甲醯胺衍生物
EP4116299A4 (en) * 2020-03-04 2024-03-27 Medshine Discovery Inc HETEROCYCLIC COMPOUND
JP2023531411A (ja) * 2020-06-16 2023-07-24 メルク・シャープ・アンド・ドーム・エルエルシー 血漿カリクレイン阻害剤
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