DK2310012T3 - Fremgangsmåde til fremstilling af substituerede pyrimidinderivater - Google Patents

Fremgangsmåde til fremstilling af substituerede pyrimidinderivater Download PDF

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Publication number
DK2310012T3
DK2310012T3 DK09774225T DK09774225T DK2310012T3 DK 2310012 T3 DK2310012 T3 DK 2310012T3 DK 09774225 T DK09774225 T DK 09774225T DK 09774225 T DK09774225 T DK 09774225T DK 2310012 T3 DK2310012 T3 DK 2310012T3
Authority
DK
Denmark
Prior art keywords
procedure
pyrimidine derivatives
substituted pyrimidine
preparing substituted
preparing
Prior art date
Application number
DK09774225T
Other languages
English (en)
Inventor
Sergio Cesco-Cancian
Hongfeng Chen
Jeffrey S Grimm
Neelakandha S Mani
Christopher M Mapes
David C Palmer
Daniel J Pippel
Kirk L Sorgi
Tong Xiao
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41464882&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK2310012(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Application granted granted Critical
Publication of DK2310012T3 publication Critical patent/DK2310012T3/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/20—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic unsaturated carbon skeleton
    • C07C211/22—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic unsaturated carbon skeleton containing at least two amino groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
DK09774225T 2008-06-30 2009-06-29 Fremgangsmåde til fremstilling af substituerede pyrimidinderivater DK2310012T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7675208P 2008-06-30 2008-06-30
PCT/US2009/049027 WO2010002774A1 (en) 2008-06-30 2009-06-29 Process for the preparation of substituted pyrimidine derivatives

Publications (1)

Publication Number Publication Date
DK2310012T3 true DK2310012T3 (da) 2015-03-30

Family

ID=41464882

Family Applications (1)

Application Number Title Priority Date Filing Date
DK09774225T DK2310012T3 (da) 2008-06-30 2009-06-29 Fremgangsmåde til fremstilling af substituerede pyrimidinderivater

Country Status (36)

Country Link
US (6) US8309720B2 (da)
EP (5) EP2924035A1 (da)
JP (1) JP5416768B2 (da)
KR (1) KR101675354B1 (da)
CN (1) CN102137672B (da)
AR (1) AR072396A1 (da)
AU (1) AU2009267156B2 (da)
BR (1) BRPI0913644A2 (da)
CA (1) CA2729733C (da)
CO (1) CO6341560A2 (da)
CY (1) CY1116134T1 (da)
DK (1) DK2310012T3 (da)
EA (1) EA019361B1 (da)
EC (1) ECSP11010745A (da)
ES (1) ES2538135T3 (da)
HK (4) HK1156857A1 (da)
HR (1) HRP20150576T1 (da)
HU (1) HUE024949T2 (da)
IL (4) IL210214A (da)
JO (1) JO3043B1 (da)
ME (1) ME02154B (da)
MX (1) MX2011000080A (da)
MY (1) MY150601A (da)
NI (1) NI201000232A (da)
NZ (1) NZ590170A (da)
PE (1) PE20110163A1 (da)
PL (1) PL2310012T3 (da)
PT (1) PT2310012E (da)
RS (1) RS53985B1 (da)
SI (1) SI2310012T1 (da)
SV (1) SV2011003788A (da)
TW (3) TWI481603B (da)
UA (1) UA106724C2 (da)
UY (1) UY31949A (da)
WO (1) WO2010002774A1 (da)
ZA (1) ZA201100759B (da)

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* Cited by examiner, † Cited by third party
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PT2007752E (pt) 2006-03-31 2010-10-18 Janssen Pharmaceutica Nv Benzoimidazol-2-il pirimidinas e pirazinas como moduladores do receptor de histamina h4
HUE024949T2 (en) 2008-06-30 2016-02-29 Janssen Pharmaceutica Nv Process for the preparation of substituted pyrimidine derivatives
US9371311B2 (en) 2008-06-30 2016-06-21 Janssen Pharmaceutica Nv Benzoimidazol-2-yl pyrimidine derivatives
JP5574294B2 (ja) * 2010-11-04 2014-08-20 独立行政法人科学技術振興機構 光磁気記録媒体及び光磁気記録方法
TWI617554B (zh) 2013-03-06 2018-03-11 健生藥品公司 組織胺ｈ受體之苯并咪唑－２－基嘧啶調控劑
JP6484220B2 (ja) * 2014-03-28 2019-03-13 株式会社カネカ トリ−カルボベンゾキシ−アルギニンの製造方法
AU2017362870A1 (en) 2016-11-03 2019-06-20 Bristol-Myers Squibb Company Substituted bicycle heterocyclic derivatives useful as ROMK channel inhibitors

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GB9914258D0 (en) * 1999-06-18 1999-08-18 Celltech Therapeutics Ltd Chemical compounds
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JP3507483B1 (ja) 2000-07-21 2004-03-15 シンジェンタ パーティシペーションズ アクチェンゲゼルシャフト ４，６−ジメトキシ−２−（メチルスルホニル）−１，３−ピリミジンの製造方法
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JP2004525150A (ja) * 2001-03-30 2004-08-19 スミスクライン ビーチャム コーポレーション 治療用化合物としてのピラゾロピリジン類の使用
AU2002357164A1 (en) * 2001-12-17 2003-06-30 Smithkline Beecham Corporation Pyrazolopyridazine derivatives
TWI270542B (en) 2002-02-07 2007-01-11 Sumitomo Chemical Co Method for preparing sulfone or sulfoxide compound
WO2004050610A2 (en) * 2002-12-04 2004-06-17 Gene Logic Inc. Modulators of melanocortin receptor
BRPI0409986A (pt) * 2003-05-05 2006-05-09 Hoffmann La Roche derivados de pirimidina fundida com atividade de crf
AR051829A1 (es) 2004-10-27 2007-02-14 Schering Corp Composiciones y metodos para inhibicion de nav 1 mediante arn corto de interferencia
JP5118029B2 (ja) 2005-06-14 2013-01-16 タイゲン バイオテクノロジー カンパニー，リミテッド ピリミジン化合物
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PT2007752E (pt) * 2006-03-31 2010-10-18 Janssen Pharmaceutica Nv Benzoimidazol-2-il pirimidinas e pirazinas como moduladores do receptor de histamina h4
HUE024949T2 (en) 2008-06-30 2016-02-29 Janssen Pharmaceutica Nv Process for the preparation of substituted pyrimidine derivatives
CN103319459A (zh) * 2008-06-30 2013-09-25 詹森药业有限公司 用于制备苯并咪唑-2-基嘧啶衍生物的方法

Also Published As

Publication number Publication date
MY150601A (en) 2014-01-30
TWI481603B (zh) 2015-04-21
US9359327B2 (en) 2016-06-07
US9079882B2 (en) 2015-07-14
ZA201100759B (en) 2012-07-25
PE20110163A1 (es) 2011-03-28
SI2310012T1 (sl) 2015-06-30
HK1201441A1 (en) 2015-09-04
US20130225816A1 (en) 2013-08-29
IL235571A (en) 2016-09-29
EP2310012B1 (en) 2015-03-04
PT2310012E (pt) 2015-04-02
JP2011526910A (ja) 2011-10-20
US20140073795A1 (en) 2014-03-13
US8309720B2 (en) 2012-11-13
TW201420583A (zh) 2014-06-01
HUE024949T2 (en) 2016-02-29
US9079883B2 (en) 2015-07-14
NZ590170A (en) 2012-04-27
IL210214A (en) 2016-07-31
US9006432B2 (en) 2015-04-14
UY31949A (es) 2010-01-29
ME02154B (me) 2015-10-20
CA2729733A1 (en) 2010-01-07
EP2924023A1 (en) 2015-09-30
KR20110023901A (ko) 2011-03-08
EP2924035A1 (en) 2015-09-30
HK1214590A1 (zh) 2016-07-29
US9079884B2 (en) 2015-07-14
TWI498326B (zh) 2015-09-01
TW201433568A (zh) 2014-09-01
CN102137672A (zh) 2011-07-27
UA106724C2 (uk) 2014-10-10
CY1116134T1 (el) 2017-02-08
HK1156857A1 (en) 2012-06-22
PL2310012T3 (pl) 2015-08-31
EP2769721A2 (en) 2014-08-27
WO2010002774A1 (en) 2010-01-07
TW201012810A (en) 2010-04-01
US20130053561A1 (en) 2013-02-28
IL235570A (en) 2016-08-31
KR101675354B1 (ko) 2016-11-11
US20100004450A1 (en) 2010-01-07
AU2009267156A1 (en) 2010-01-07
US20140121374A1 (en) 2014-05-01
RS53985B1 (en) 2015-10-30
SV2011003788A (es) 2011-02-08
ES2538135T3 (es) 2015-06-17
HK1215434A1 (zh) 2016-08-26
EA019361B1 (ru) 2014-03-31
US20140066624A1 (en) 2014-03-06
CN102137672B (zh) 2014-03-26
EP2769721A3 (en) 2015-04-01
EP2924025A1 (en) 2015-09-30
AU2009267156B2 (en) 2015-05-28
CA2729733C (en) 2016-10-25
CO6341560A2 (es) 2011-11-21
HRP20150576T1 (hr) 2015-09-11
IL210214A0 (en) 2011-03-31
EP2310012A1 (en) 2011-04-20
AR072396A1 (es) 2010-08-25
IL235572A (en) 2016-09-29
BRPI0913644A2 (pt) 2015-11-24
EA201170113A1 (ru) 2011-08-30
NI201000232A (es) 2011-09-07
EP2310012A4 (en) 2012-06-20
MX2011000080A (es) 2011-03-02
JO3043B1 (ar) 2016-09-05
ECSP11010745A (es) 2011-02-28
JP5416768B2 (ja) 2014-02-12

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