UA106724C2 - Спосіб отримання заміщених піримідинових похідних - Google Patents

Спосіб отримання заміщених піримідинових похідних

Info

Publication number
UA106724C2
UA106724C2 UAA201100983A UAA201100983A UA106724C2 UA 106724 C2 UA106724 C2 UA 106724C2 UA A201100983 A UAA201100983 A UA A201100983A UA A201100983 A UAA201100983 A UA A201100983A UA 106724 C2 UA106724 C2 UA 106724C2
Authority
UA
Ukraine
Prior art keywords
preparation
pyrimidine derivatives
substituted pyrimidine
intermediates
synthesis
Prior art date
Application number
UAA201100983A
Other languages
English (en)
Russian (ru)
Inventor
Серджіо Ческо-Канчіан
Хунфен Чень
Джеффрі С. Грімм
Неєлакандха С. Мані
Крістофер М. Мейпс
Девід К. Палмер
Деніел Дж. Піппел
Кірк Л. Соргі
Тун Сяо
Original Assignee
Янссен Фармацевтика Нв
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41464882&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UA106724(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Янссен Фармацевтика Нв filed Critical Янссен Фармацевтика Нв
Publication of UA106724C2 publication Critical patent/UA106724C2/uk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/20—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic unsaturated carbon skeleton
    • C07C211/22—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic unsaturated carbon skeleton containing at least two amino groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Даний винахід спрямований на створення способів одержання заміщених піримідинових похідних, що можуть знайти застосування як проміжні сполуки при синтезі модуляторів гістамінового рецептора H, а також на нові проміжні сполуки в синтезі модуляторів Н.
UAA201100983A 2008-06-30 2009-06-29 Спосіб отримання заміщених піримідинових похідних UA106724C2 (uk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7675208P 2008-06-30 2008-06-30
PCT/US2009/049027 WO2010002774A1 (en) 2008-06-30 2009-06-29 Process for the preparation of substituted pyrimidine derivatives

Publications (1)

Publication Number Publication Date
UA106724C2 true UA106724C2 (uk) 2014-10-10

Family

ID=41464882

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA201100983A UA106724C2 (uk) 2008-06-30 2009-06-29 Спосіб отримання заміщених піримідинових похідних

Country Status (36)

Country Link
US (6) US8309720B2 (uk)
EP (5) EP2924025A1 (uk)
JP (1) JP5416768B2 (uk)
KR (1) KR101675354B1 (uk)
CN (1) CN102137672B (uk)
AR (1) AR072396A1 (uk)
AU (1) AU2009267156B2 (uk)
BR (1) BRPI0913644A2 (uk)
CA (1) CA2729733C (uk)
CO (1) CO6341560A2 (uk)
CY (1) CY1116134T1 (uk)
DK (1) DK2310012T3 (uk)
EA (1) EA019361B1 (uk)
EC (1) ECSP11010745A (uk)
ES (1) ES2538135T3 (uk)
HK (4) HK1156857A1 (uk)
HR (1) HRP20150576T1 (uk)
HU (1) HUE024949T2 (uk)
IL (4) IL210214A (uk)
JO (1) JO3043B1 (uk)
ME (1) ME02154B (uk)
MX (1) MX2011000080A (uk)
MY (1) MY150601A (uk)
NI (1) NI201000232A (uk)
NZ (1) NZ590170A (uk)
PE (1) PE20110163A1 (uk)
PL (1) PL2310012T3 (uk)
PT (1) PT2310012E (uk)
RS (1) RS53985B1 (uk)
SI (1) SI2310012T1 (uk)
SV (1) SV2011003788A (uk)
TW (3) TWI498326B (uk)
UA (1) UA106724C2 (uk)
UY (1) UY31949A (uk)
WO (1) WO2010002774A1 (uk)
ZA (1) ZA201100759B (uk)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101054325B1 (ko) 2006-03-31 2011-08-04 얀센 파마슈티카 엔.브이. 히스타민 ｈ４ 수용체 조절제로서의 벤조이미다졸―２―일 피리미딘 및 피라진
PL2310012T3 (pl) * 2008-06-30 2015-08-31 Janssen Pharmaceutica Nv Sposób wytwarzania podstawionych pochodnych pirymidyny
US9371311B2 (en) 2008-06-30 2016-06-21 Janssen Pharmaceutica Nv Benzoimidazol-2-yl pyrimidine derivatives
JP5574294B2 (ja) * 2010-11-04 2014-08-20 独立行政法人科学技術振興機構 光磁気記録媒体及び光磁気記録方法
MY180726A (en) 2013-03-06 2020-12-08 Janssen Pharmaceutica Nv Benzoimidazol-2-yl pyrimidine modulators of the histamine h4 receptor
EP3124470B1 (en) * 2014-03-28 2020-01-08 Kaneka Corporation Method for producing tri-carbobenzoxy-arginine
ES2902527T3 (es) 2016-11-03 2022-03-28 Bristol Myers Squibb Co Derivados biciclo heterocíclicos sustituidos, útiles como inhibidores del canal ROMK

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3005852A (en) 1959-12-22 1961-10-24 Gen Aniline & Film Corp Production of sulfoxides and sulfones
US3931195A (en) * 1971-03-03 1976-01-06 Mead Johnson & Company Substituted piperidines
US4191828A (en) * 1976-04-14 1980-03-04 Richardson-Merrell Inc. Process for preparing 2-(2,2-dicyclohexylethyl)piperidine
US4190601A (en) * 1978-05-31 1980-02-26 Union Carbide Corporation Production of tertiary amines by reductive alkylation
JPS5942396A (ja) * 1982-09-02 1984-03-08 Ishihara Sangyo Kaisha Ltd リン酸アミド誘導体およびそれらを含有する殺虫、殺ダニ、殺線虫剤
JPS6130576A (ja) 1984-07-24 1986-02-12 Ube Ind Ltd ２−アミノ−５−シアノピリミジンの製法
CA2144762A1 (en) * 1992-10-14 1994-04-28 George D. Hartman Fibrinogen receptor antagonists
GB9422391D0 (en) 1994-11-05 1995-01-04 Solvay Interox Ltd Oxidation of organosulphur compounds
EA200000840A1 (ru) * 1998-02-17 2001-02-26 Туларик, Инк. Антивирусные производные пиримидина
GB9914258D0 (en) * 1999-06-18 1999-08-18 Celltech Therapeutics Ltd Chemical compounds
HUP0202678A3 (en) * 1999-09-30 2004-06-28 Pfizer Certain alkylene diamine-substituted pyrazolo[1,5,-a]-1,5-pyrimidines and pyrazolo[1,5-a]-1,3,5-triazines, pharmaceutical compositions containing them and their use
PL362686A1 (en) 2000-07-21 2004-11-02 Syngenta Participations Ag Process for the preparation of 4,6-dimethoxy-2-(methylsulfonyl)-1,3-pyrimidine
PE20020506A1 (es) * 2000-08-22 2002-07-09 Glaxo Group Ltd Derivados de pirazol fusionados como inhibidores de la proteina cinasa
US20030130264A1 (en) 2001-02-16 2003-07-10 Tularik Inc. Methods of using pyrimidine-based antiviral agents
JP2004525150A (ja) * 2001-03-30 2004-08-19 スミスクライン ビーチャム コーポレーション 治療用化合物としてのピラゾロピリジン類の使用
ATE323706T1 (de) * 2001-12-17 2006-05-15 Smithkline Beecham Corp Pyrazolopyridazinderivate
TWI270542B (en) 2002-02-07 2007-01-11 Sumitomo Chemical Co Method for preparing sulfone or sulfoxide compound
ATE440827T1 (de) * 2002-12-04 2009-09-15 Ore Pharmaceuticals Inc Melanocortin-rezeptormodulatoren
JP2006525261A (ja) * 2003-05-05 2006-11-09 エフ．ホフマン−ラ　ロシュ　アーゲー Ｃｒｆ活性を有する縮合ピリミジン誘導体
US7786291B2 (en) 2004-10-27 2010-08-31 Schering Corporation Compositions and methods for short interfering nucleic acid inhibition of Nav1.8
US20060281712A1 (en) 2005-06-14 2006-12-14 Chi-Feng Yen Pyrimidine compounds
BRPI0612720B1 (pt) * 2005-07-06 2016-02-10 Ge Healthcare Bio Sciences Ab método de preparação de uma matriz de separação
TW200800201A (en) * 2005-11-18 2008-01-01 Lilly Co Eli Pyrimidinyl benzothiophene compounds
CN101032483B (zh) * 2006-03-09 2011-05-04 陈德桂 调节雄激素受体活性的乙内酰脲衍生物及其应用
JP2009532367A (ja) * 2006-03-31 2009-09-10 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ヒスタミンｈ４受容体のモジュレーターとしてのベンゾイミダゾール−２−イルピリジン
KR101054325B1 (ko) * 2006-03-31 2011-08-04 얀센 파마슈티카 엔.브이. 히스타민 ｈ４ 수용체 조절제로서의 벤조이미다졸―２―일 피리미딘 및 피라진
PL2310012T3 (pl) 2008-06-30 2015-08-31 Janssen Pharmaceutica Nv Sposób wytwarzania podstawionych pochodnych pirymidyny
US20100029942A1 (en) * 2008-06-30 2010-02-04 Sergio Cesco-Cancian Process for the preparation of benzoimidazol-2-yl pyrimidine derivatives

Also Published As

Publication number Publication date
HK1156857A1 (en) 2012-06-22
US20130053561A1 (en) 2013-02-28
US8309720B2 (en) 2012-11-13
US20130225816A1 (en) 2013-08-29
PT2310012E (pt) 2015-04-02
AU2009267156A1 (en) 2010-01-07
TW201012810A (en) 2010-04-01
TWI498326B (zh) 2015-09-01
EP2924025A1 (en) 2015-09-30
HK1201441A1 (en) 2015-09-04
AU2009267156B2 (en) 2015-05-28
PL2310012T3 (pl) 2015-08-31
MY150601A (en) 2014-01-30
NI201000232A (es) 2011-09-07
EP2310012A1 (en) 2011-04-20
US20140066624A1 (en) 2014-03-06
US9359327B2 (en) 2016-06-07
US20100004450A1 (en) 2010-01-07
BRPI0913644A2 (pt) 2015-11-24
AR072396A1 (es) 2010-08-25
CN102137672A (zh) 2011-07-27
SI2310012T1 (sl) 2015-06-30
DK2310012T3 (da) 2015-03-30
EP2310012A4 (en) 2012-06-20
IL235570A (en) 2016-08-31
TW201420583A (zh) 2014-06-01
CO6341560A2 (es) 2011-11-21
CN102137672B (zh) 2014-03-26
HK1214590A1 (zh) 2016-07-29
CA2729733A1 (en) 2010-01-07
MX2011000080A (es) 2011-03-02
CY1116134T1 (el) 2017-02-08
HUE024949T2 (en) 2016-02-29
EP2310012B1 (en) 2015-03-04
HK1215434A1 (zh) 2016-08-26
JO3043B1 (ar) 2016-09-05
US9079883B2 (en) 2015-07-14
NZ590170A (en) 2012-04-27
RS53985B1 (en) 2015-10-30
JP2011526910A (ja) 2011-10-20
SV2011003788A (es) 2011-02-08
IL210214A (en) 2016-07-31
US9079882B2 (en) 2015-07-14
ZA201100759B (en) 2012-07-25
HRP20150576T1 (hr) 2015-09-11
US9006432B2 (en) 2015-04-14
EP2769721A3 (en) 2015-04-01
ES2538135T3 (es) 2015-06-17
CA2729733C (en) 2016-10-25
WO2010002774A1 (en) 2010-01-07
US9079884B2 (en) 2015-07-14
UY31949A (es) 2010-01-29
EP2769721A2 (en) 2014-08-27
EP2924023A1 (en) 2015-09-30
JP5416768B2 (ja) 2014-02-12
IL235572A (en) 2016-09-29
TWI481603B (zh) 2015-04-21
PE20110163A1 (es) 2011-03-28
EA201170113A1 (ru) 2011-08-30
US20140073795A1 (en) 2014-03-13
EA019361B1 (ru) 2014-03-31
ECSP11010745A (es) 2011-02-28
ME02154B (me) 2015-10-20
IL210214A0 (en) 2011-03-31
KR20110023901A (ko) 2011-03-08
US20140121374A1 (en) 2014-05-01
TW201433568A (zh) 2014-09-01
IL235571A (en) 2016-09-29
EP2924035A1 (en) 2015-09-30
KR101675354B1 (ko) 2016-11-11

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