HK1156857A1 - Process for the preparation of substituted pyrimidine derivatives - Google Patents

Process for the preparation of substituted pyrimidine derivatives

Info

Publication number
HK1156857A1
HK1156857A1 HK11111216.2A HK11111216A HK1156857A1 HK 1156857 A1 HK1156857 A1 HK 1156857A1 HK 11111216 A HK11111216 A HK 11111216A HK 1156857 A1 HK1156857 A1 HK 1156857A1
Authority
HK
Hong Kong
Prior art keywords
preparation
pyrimidine derivatives
substituted pyrimidine
substituted
derivatives
Prior art date
Application number
HK11111216.2A
Other languages
English (en)
Chinese (zh)
Inventor
Sergio Cesco-Cancian
Hongfeng Chen
Jeffrey S Grimm
Neelakandha S Mani
Christopher M Mapes
David C Palmer
Daniel J Pippel
Kirk L Sorgi
Tong Xiao
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41464882&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1156857(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of HK1156857A1 publication Critical patent/HK1156857A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/20—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic unsaturated carbon skeleton
    • C07C211/22—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic unsaturated carbon skeleton containing at least two amino groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
HK11111216.2A 2008-06-30 2011-10-19 Process for the preparation of substituted pyrimidine derivatives HK1156857A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7675208P 2008-06-30 2008-06-30
PCT/US2009/049027 WO2010002774A1 (en) 2008-06-30 2009-06-29 Process for the preparation of substituted pyrimidine derivatives

Publications (1)

Publication Number Publication Date
HK1156857A1 true HK1156857A1 (en) 2012-06-22

Family

ID=41464882

Family Applications (4)

Application Number Title Priority Date Filing Date
HK11111216.2A HK1156857A1 (en) 2008-06-30 2011-10-19 Process for the preparation of substituted pyrimidine derivatives
HK15101911.7A HK1201441A1 (en) 2008-06-30 2015-02-26 Process for the preparation of substituted pyrimidine derivatives
HK16102449.5A HK1214590A1 (zh) 2008-06-30 2016-03-03 哌啶和哌嗪衍生物
HK16103405.5A HK1215434A1 (zh) 2008-06-30 2016-03-23 取代的嘧啶衍生物

Family Applications After (3)

Application Number Title Priority Date Filing Date
HK15101911.7A HK1201441A1 (en) 2008-06-30 2015-02-26 Process for the preparation of substituted pyrimidine derivatives
HK16102449.5A HK1214590A1 (zh) 2008-06-30 2016-03-03 哌啶和哌嗪衍生物
HK16103405.5A HK1215434A1 (zh) 2008-06-30 2016-03-23 取代的嘧啶衍生物

Country Status (36)

Country Link
US (6) US8309720B2 (da)
EP (5) EP2924023A1 (da)
JP (1) JP5416768B2 (da)
KR (1) KR101675354B1 (da)
CN (1) CN102137672B (da)
AR (1) AR072396A1 (da)
AU (1) AU2009267156B2 (da)
BR (1) BRPI0913644A2 (da)
CA (1) CA2729733C (da)
CO (1) CO6341560A2 (da)
CY (1) CY1116134T1 (da)
DK (1) DK2310012T3 (da)
EA (1) EA019361B1 (da)
EC (1) ECSP11010745A (da)
ES (1) ES2538135T3 (da)
HK (4) HK1156857A1 (da)
HR (1) HRP20150576T1 (da)
HU (1) HUE024949T2 (da)
IL (4) IL210214A (da)
JO (1) JO3043B1 (da)
ME (1) ME02154B (da)
MX (1) MX2011000080A (da)
MY (1) MY150601A (da)
NI (1) NI201000232A (da)
NZ (1) NZ590170A (da)
PE (1) PE20110163A1 (da)
PL (1) PL2310012T3 (da)
PT (1) PT2310012E (da)
RS (1) RS53985B1 (da)
SI (1) SI2310012T1 (da)
SV (1) SV2011003788A (da)
TW (3) TWI498326B (da)
UA (1) UA106724C2 (da)
UY (1) UY31949A (da)
WO (1) WO2010002774A1 (da)
ZA (1) ZA201100759B (da)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101460483B (zh) 2006-03-31 2013-05-08 詹森药业有限公司 作为组胺h4受体调节剂的苯并咪唑-2-基嘧啶和吡嗪
WO2010002774A1 (en) * 2008-06-30 2010-01-07 Janssen Pharmaceutica Nv Process for the preparation of substituted pyrimidine derivatives
US9371311B2 (en) 2008-06-30 2016-06-21 Janssen Pharmaceutica Nv Benzoimidazol-2-yl pyrimidine derivatives
JP5574294B2 (ja) * 2010-11-04 2014-08-20 独立行政法人科学技術振興機構 光磁気記録媒体及び光磁気記録方法
SI2964229T1 (sl) 2013-03-06 2020-02-28 Janssen Pharmaceutica Nv Benzoimidazol-2-il pirimidin modulatorji receptorja histamina H4
CN106132926B (zh) * 2014-03-28 2019-05-21 株式会社钟化 三苄氧羰基精氨酸的制造方法
AU2017362870A1 (en) 2016-11-03 2019-06-20 Bristol-Myers Squibb Company Substituted bicycle heterocyclic derivatives useful as ROMK channel inhibitors

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US5786373A (en) * 1992-10-14 1998-07-28 Merck & Co., Inc. Fibrinogen receptor antagonists
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CA2321153A1 (en) * 1998-02-17 1999-08-19 Timothy D. Cushing Anti-viral pyrimidine derivatives
GB9914258D0 (en) * 1999-06-18 1999-08-18 Celltech Therapeutics Ltd Chemical compounds
KR20020047198A (ko) * 1999-09-30 2002-06-21 해피 페너 ; 해리 에이치. 페너 2세 특정 알킬렌 디아민-치환된피라졸로[1,5-ａ]-1,5-피리미딘 및피라졸로[1,5-ａ]-1,3,5-트리아진
IL153662A0 (en) 2000-07-21 2003-07-06 Syngenta Participations Ag Process for the preparation of 4,6-dimethoxy-2- (methylsulfonyl)-1,3-pyrimidine
PE20020506A1 (es) * 2000-08-22 2002-07-09 Glaxo Group Ltd Derivados de pirazol fusionados como inhibidores de la proteina cinasa
AU2002258400A1 (en) 2001-02-16 2002-08-28 Tularik Inc. Methods of using pyrimidine-based antiviral agents
JP2004525150A (ja) * 2001-03-30 2004-08-19 スミスクライン ビーチャム コーポレーション 治療用化合物としてのピラゾロピリジン類の使用
JP2005524609A (ja) * 2001-12-17 2005-08-18 スミスクライン ビーチャム コーポレーション ピラゾロピリダジン誘導体
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CA2508914A1 (en) * 2002-12-04 2004-06-17 Gene Logic Inc. Modulators of melanocortin receptor
AU2004235907B2 (en) * 2003-05-05 2007-08-30 F. Hoffmann La-Roche Ag Fused pyrimidine derivatives with CRF activity
US7786291B2 (en) 2004-10-27 2010-08-31 Schering Corporation Compositions and methods for short interfering nucleic acid inhibition of Nav1.8
JP5118029B2 (ja) 2005-06-14 2013-01-16 タイゲン バイオテクノロジー カンパニー，リミテッド ピリミジン化合物
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CN101460483B (zh) * 2006-03-31 2013-05-08 詹森药业有限公司 作为组胺h4受体调节剂的苯并咪唑-2-基嘧啶和吡嗪
JP2009532367A (ja) * 2006-03-31 2009-09-10 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ヒスタミンｈ４受容体のモジュレーターとしてのベンゾイミダゾール−２−イルピリジン
WO2010002774A1 (en) 2008-06-30 2010-01-07 Janssen Pharmaceutica Nv Process for the preparation of substituted pyrimidine derivatives
CN102137857A (zh) * 2008-06-30 2011-07-27 詹森药业有限公司 用于制备苯并咪唑-2-基嘧啶衍生物的方法

Also Published As

Publication number Publication date
BRPI0913644A2 (pt) 2015-11-24
ECSP11010745A (es) 2011-02-28
KR20110023901A (ko) 2011-03-08
MX2011000080A (es) 2011-03-02
HRP20150576T1 (hr) 2015-09-11
CA2729733C (en) 2016-10-25
EP2769721A2 (en) 2014-08-27
US20140066624A1 (en) 2014-03-06
US9079883B2 (en) 2015-07-14
US9006432B2 (en) 2015-04-14
US9359327B2 (en) 2016-06-07
AU2009267156A1 (en) 2010-01-07
HK1201441A1 (en) 2015-09-04
RS53985B1 (en) 2015-10-30
DK2310012T3 (da) 2015-03-30
NI201000232A (es) 2011-09-07
HK1214590A1 (zh) 2016-07-29
IL210214A (en) 2016-07-31
US20130225816A1 (en) 2013-08-29
CN102137672B (zh) 2014-03-26
HK1215434A1 (zh) 2016-08-26
AU2009267156B2 (en) 2015-05-28
HUE024949T2 (en) 2016-02-29
AR072396A1 (es) 2010-08-25
EP2924025A1 (en) 2015-09-30
US20130053561A1 (en) 2013-02-28
TW201012810A (en) 2010-04-01
US9079884B2 (en) 2015-07-14
EA019361B1 (ru) 2014-03-31
ES2538135T3 (es) 2015-06-17
UY31949A (es) 2010-01-29
PE20110163A1 (es) 2011-03-28
JP5416768B2 (ja) 2014-02-12
TWI498326B (zh) 2015-09-01
PT2310012E (pt) 2015-04-02
IL235571A (en) 2016-09-29
IL210214A0 (en) 2011-03-31
PL2310012T3 (pl) 2015-08-31
US9079882B2 (en) 2015-07-14
UA106724C2 (uk) 2014-10-10
CO6341560A2 (es) 2011-11-21
EP2924035A1 (en) 2015-09-30
TW201420583A (zh) 2014-06-01
CN102137672A (zh) 2011-07-27
ZA201100759B (en) 2012-07-25
TWI481603B (zh) 2015-04-21
CY1116134T1 (el) 2017-02-08
ME02154B (me) 2015-10-20
US20140073795A1 (en) 2014-03-13
NZ590170A (en) 2012-04-27
US20100004450A1 (en) 2010-01-07
EP2310012A4 (en) 2012-06-20
EP2310012B1 (en) 2015-03-04
EA201170113A1 (ru) 2011-08-30
TW201433568A (zh) 2014-09-01
IL235572A (en) 2016-09-29
JO3043B1 (ar) 2016-09-05
MY150601A (en) 2014-01-30
WO2010002774A1 (en) 2010-01-07
EP2310012A1 (en) 2011-04-20
IL235570A (en) 2016-08-31
SI2310012T1 (sl) 2015-06-30
KR101675354B1 (ko) 2016-11-11
SV2011003788A (es) 2011-02-08
EP2769721A3 (en) 2015-04-01
EP2924023A1 (en) 2015-09-30
CA2729733A1 (en) 2010-01-07
JP2011526910A (ja) 2011-10-20
US8309720B2 (en) 2012-11-13
US20140121374A1 (en) 2014-05-01

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20210629