DK1981892T3 - Thienopyridinderivater som mek-inhibitorer - Google Patents

Thienopyridinderivater som mek-inhibitorer

Info

Publication number: DK1981892T3
Authority: DK; Denmark
Prior art keywords: mek inhibitors; thienopyridine derivatives; thienopyridine; derivatives; mek
Prior art date: 2006-01-31

Application number

DK07705076.3T

Other languages

English (en)

Inventor

Martin Clive Hutchings

Sarah Catherine Archibald

Daniel Christopher Brookings

Jeremy Martin Davis

James Andrew Johnson

Barry John Langham

Judi Charlotte Neuss

Original Assignee

Ucb Pharma Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-01-31

Filing date

2007-01-30

Publication date

2014-06-23

2007-01-30 Application filed by Ucb Pharma Sa filed Critical Ucb Pharma Sa

2014-06-23 Application granted granted Critical

2014-06-23 Publication of DK1981892T3 publication Critical patent/DK1981892T3/da

Links

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Pain & Pain Management (AREA)
Epidemiology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Transplantation (AREA)
Rheumatology (AREA)
Oncology (AREA)
Hematology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

DK07705076.3T 2006-01-31 2007-01-30 Thienopyridinderivater som mek-inhibitorer DK1981892T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB0601962.4A GB0601962D0 (en)	2006-01-31	2006-01-31	Therapeutic agents
PCT/GB2007/000310 WO2007088345A1 (en)	2006-01-31	2007-01-30	Thieno-pyridine derivatives as mek inhibitors

Publications (1)

Publication Number	Publication Date
DK1981892T3 true DK1981892T3 (da)	2014-06-23

Family

ID=36100789

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK07705076.3T DK1981892T3 (da)	2006-01-31	2007-01-30	Thienopyridinderivater som mek-inhibitorer

Country Status (27)

Country	Link
US (3)	US8283359B2 (da)
EP (1)	EP1981892B1 (da)
JP (1)	JP5249787B2 (da)
KR (1)	KR101446919B1 (da)
CN (1)	CN101379067B (da)
AU (1)	AU2007211377B2 (da)
BR (1)	BRPI0708016B1 (da)
CA (1)	CA2640594C (da)
CY (1)	CY1115404T1 (da)
DK (1)	DK1981892T3 (da)
EA (1)	EA016128B1 (da)
EC (1)	ECSP088704A (da)
ES (1)	ES2471970T3 (da)
GB (1)	GB0601962D0 (da)
HK (1)	HK1125924A1 (da)
HR (1)	HRP20140503T1 (da)
IL (1)	IL192603A (da)
MY (1)	MY146387A (da)
NO (1)	NO341064B1 (da)
NZ (1)	NZ569638A (da)
PL (1)	PL1981892T3 (da)
PT (1)	PT1981892E (da)
RS (1)	RS53342B (da)
SI (1)	SI1981892T1 (da)
UA (1)	UA95939C2 (da)
WO (1)	WO2007088345A1 (da)
ZA (1)	ZA200807447B (da)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB0601962D0 (en)	2006-01-31	2006-03-15	Ucb Sa	Therapeutic agents
GB0616214D0 (en) *	2006-08-15	2006-09-27	Ucb Sa	Therapeutic Agents
GB0714384D0 (en)	2007-07-23	2007-09-05	Ucb Pharma Sa	theraputic agents
CA2708176A1 (en) *	2007-12-21	2009-07-02	Genentech, Inc.	Azaindolizines and methods of use
WO2009093008A1 (en) *	2008-01-21	2009-07-30	Ucb Pharma S.A.	Thieno-pyridine derivatives as mek inhibitors
GB0811304D0 (en) *	2008-06-19	2008-07-30	Ucb Pharma Sa	Therapeutic agents
JP5503930B2 (ja) *	2009-09-18	2014-05-28	住友化学株式会社	３−アミノ−１−ｔｅｒｔ−ブトキシカルボニルピペリジンの精製方法およびそのクエン酸塩
EP2598661B1 (en)	2010-07-26	2017-09-27	Biomatrica, INC.	Compositions for stabilizing dna, rna and proteins in saliva and other biological samples during shipping and storage at ambient temperatures
US9376709B2 (en)	2010-07-26	2016-06-28	Biomatrica, Inc.	Compositions for stabilizing DNA and RNA in blood and other biological samples during shipping and storage at ambient temperatures
US9725703B2 (en)	2012-12-20	2017-08-08	Biomatrica, Inc.	Formulations and methods for stabilizing PCR reagents
ES2798899T3 (es)	2013-02-25	2020-12-14	Novartis Ag	Mutación novedosa del receptor de andrógenos
EA201690089A1 (ru)	2013-06-11	2017-04-28	Латвийский Институт Органического Синтеза	ТИЕНО[2,3-b]ПИРИДИНЫ КАК МОДУЛЯТОРЫ СОСТОЯНИЯ МНОЖЕСТВЕННОЙ ЛЕКАРСТВЕННОЙ УСТОЙЧИВОСТИ
EP3632208A1 (en)	2013-06-13	2020-04-08	Biomatrica, INC.	Cell stabilization
US10064404B2 (en)	2014-06-10	2018-09-04	Biomatrica, Inc.	Stabilization of thrombocytes at ambient temperatures
CN105384754B (zh) *	2014-09-02	2018-04-20	上海科州药物研发有限公司	作为蛋白激酶抑制剂的杂环类化合物及其制备方法和用途
WO2017033113A1 (en)	2015-08-21	2017-03-02	Acerta Pharma B.V.	Therapeutic combinations of a mek inhibitor and a btk inhibitor
ES2946184T3 (es)	2015-12-08	2023-07-13	Biomatrica Inc	Reducción de la velocidad de eritrosedimentación
EP3624796A1 (en) *	2017-05-19	2020-03-25	NFlection Therapeutics, Inc.	Pyrrolopyridine-aniline compounds for treatment of dermal disorders
MX2019013562A (es)	2017-05-19	2020-08-03	Nflection Therapeutics Inc	Compuestos de anilina heteroaromatica o fusionados para el tratamiento de trastornos dermicos.
CN109836434B (zh) *	2017-11-27	2020-09-25	上海宇耀生物科技有限公司	噻吩并环类化合物及其合成方法和应用
CA3120351A1 (en) *	2018-11-20	2020-05-28	Nflection Therapeutics, Inc.	Aryl-aniline and heteroaryl-aniline compounds for treatment of skin cancers
WO2020106306A1 (en)	2018-11-20	2020-05-28	Nflection Therapeutics, Inc.	Cyanoaryl-aniline compounds for treatment of dermal disorders
BR112021018168B1 (pt)	2019-03-21	2023-11-28	Onxeo	Composição farmacêutica, combinação e kit compreendendo uma molécula dbait e um inibidor de quinase para o tratamento de câncer
KR20220098759A (ko)	2019-11-08	2022-07-12	인쎄름 (엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔)	키나제 억제제에 대해 내성을 획득한 암의 치료 방법
CN111138449B (zh) *	2020-01-15	2022-11-29	四川大学华西医院	双靶向erk1和erk5抑制剂的制备及其抗肿瘤应用
WO2021148581A1 (en)	2020-01-22	2021-07-29	Onxeo	Novel dbait molecule and its use
GB202205203D0 (en)	2022-04-08	2022-05-25	UCB Biopharma SRL	Combination with inhibitor

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATE344791T1 (de)	1997-07-01	2006-11-15	Warner Lambert Co	2-(4-brom or 4-iod phenylamino)benzoesäurederivate und ihre anwendung als mek-inhibitoren
US6232320B1 (en)	1998-06-04	2001-05-15	Abbott Laboratories	Cell adhesion-inhibiting antiinflammatory compounds
EP1150950A2 (en)	1999-01-13	2001-11-07	Warner-Lambert Company	Anthranilic acid derivatives
OA11746A (en)	1999-01-13	2005-05-13	Warner Lambert Co	Benzoheterocycles and their use as MEK inhibitors.
DK1301472T3 (da)	2000-07-19	2014-04-07	Warner Lambert Co	Oxygenerede estere af 4-iod-phenylamino-benzhydroxamsyrer
US7235537B2 (en)	2002-03-13	2007-06-26	Array Biopharma, Inc.	N3 alkylated benzimidazole derivatives as MEK inhibitors
AU2003220202A1 (en)	2002-03-13	2003-09-29	Array Biopharma, Inc	N3 alkylated benzimidazole derivatives as mek inhibitors
KR100984613B1 (ko)	2002-03-13	2010-09-30	어레이 바이오파마 인크.	Ｍｅｋ 억제제로서의 ｎ3 알킬화 벤즈이미다졸 유도체
US20030225273A1 (en)	2002-03-21	2003-12-04	Michaelides Michael R.	Thiopyrimidine and isothiazolopyrimidine kinase inhibitors
GB0214268D0 (en) *	2002-06-20	2002-07-31	Celltech R&D Ltd	Chemical compounds
CL2003002287A1 (es) *	2002-11-25	2005-01-14	Wyeth Corp	COMPUESTOS DERIVADOS DE TIENO[3,2-b]-PIRIDINA-6-CARBONITRILOS Y TIENEO[2,3-b]-PIRIDINA-5-CARBONITRILOS, COMPOSICION FARMACEUTICA, PROCEDIMIENTO DE PREPARACION Y COMPUESTOS INTERMEDIARIOS, Y SU USO EN EL TRATAMIENTO DEL CANCER, APOPLEJIA, OSTEOPOROSIS
JP2006512338A (ja) *	2002-12-12	2006-04-13	ファルマシア・コーポレーション	マイトジェン活性化プロテインキナーゼ−活性化プロテインキナーゼ−２阻害剤としてのアミノシアノピリジンの使用法
AU2004249495A1 (en)	2003-06-20	2004-12-29	Ucb Pharma S.A.	Thienopyridone derivatives as kinase inhibitors
AU2004249498B2 (en) *	2003-06-20	2009-11-19	Ucb Pharma S.A.	Thienopyridone derivatives as kinase inhibitors
US20050049276A1 (en)	2003-07-23	2005-03-03	Warner-Lambert Company, Llc	Imidazopyridines and triazolopyridines
DE602004023207D1 (de)	2003-07-24	2009-10-29	Warner Lambert Co	Benzimidazol-derivate als mek-hemmer
US7144907B2 (en)	2003-09-03	2006-12-05	Array Biopharma Inc.	Heterocyclic inhibitors of MEK and methods of use thereof
AU2004270394A1 (en) *	2003-09-10	2005-03-17	Gpc Biotech Ag	Heterobicyclic compounds as pharmaceutically active agents
EP1689387B1 (en)	2003-11-19	2011-09-14	Array Biopharma, Inc.	Bicyclic inhibitors of mek and methods of synthesis thereof
US7217723B2 (en)	2004-02-02	2007-05-15	Eisai Co., Ltd.	Heterocyclic compound having oxime group
WO2007027855A2 (en)	2005-09-01	2007-03-08	Array Biopharma Inc.	Raf inhibitor compounds and methods of use thereof
BRPI0617165B1 (pt)	2005-10-07	2023-10-03	Exelixis Inc	Compostos inibidores mek, composições farmacêuticas que os contem e métodos de uso dos mesmos
GB0601962D0 (en)	2006-01-31	2006-03-15	Ucb Sa	Therapeutic agents
TW200808769A (en)	2006-04-18	2008-02-16	Astrazeneca Ab	Therapeutic compounds
GB0616214D0 (en)	2006-08-15	2006-09-27	Ucb Sa	Therapeutic Agents
EP2056829B9 (en)	2006-08-16	2012-09-26	Exelixis, Inc.	Using pi3k and mek modulators in treatments of cancer
CA2671982C (en)	2006-12-14	2016-01-26	Exelixis, Inc.	Methods of using mek inhibitors
GB0714384D0 (en)	2007-07-23	2007-09-05	Ucb Pharma Sa	theraputic agents
WO2009093008A1 (en)	2008-01-21	2009-07-30	Ucb Pharma S.A.	Thieno-pyridine derivatives as mek inhibitors
GB0811304D0 (en)	2008-06-19	2008-07-30	Ucb Pharma Sa	Therapeutic agents

2006
- 2006-01-31 GB GBGB0601962.4A patent/GB0601962D0/en not_active Ceased
2007
- 2007-01-30 BR BRPI0708016-6A patent/BRPI0708016B1/pt active IP Right Grant
- 2007-01-30 UA UAA200809945A patent/UA95939C2/ru unknown
- 2007-01-30 JP JP2008552878A patent/JP5249787B2/ja active Active
- 2007-01-30 KR KR1020087018972A patent/KR101446919B1/ko active IP Right Grant
- 2007-01-30 CN CN2007800040774A patent/CN101379067B/zh active Active
- 2007-01-30 PT PT77050763T patent/PT1981892E/pt unknown
- 2007-01-30 CA CA2640594A patent/CA2640594C/en active Active
- 2007-01-30 WO PCT/GB2007/000310 patent/WO2007088345A1/en active Application Filing
- 2007-01-30 DK DK07705076.3T patent/DK1981892T3/da active
- 2007-01-30 RS RS20140304A patent/RS53342B/en unknown
- 2007-01-30 EA EA200801684A patent/EA016128B1/ru not_active IP Right Cessation
- 2007-01-30 MY MYPI20082765A patent/MY146387A/en unknown
- 2007-01-30 ES ES07705076.3T patent/ES2471970T3/es active Active
- 2007-01-30 ZA ZA200807447A patent/ZA200807447B/xx unknown
- 2007-01-30 EP EP07705076.3A patent/EP1981892B1/en active Active
- 2007-01-30 PL PL07705076T patent/PL1981892T3/pl unknown
- 2007-01-30 NZ NZ569638A patent/NZ569638A/en unknown
- 2007-01-30 AU AU2007211377A patent/AU2007211377B2/en active Active
- 2007-01-30 SI SI200731467T patent/SI1981892T1/sl unknown
2008
- 2008-07-03 IL IL192603A patent/IL192603A/en active IP Right Grant
- 2008-07-30 US US12/182,931 patent/US8283359B2/en active Active
- 2008-08-28 EC EC2008008704A patent/ECSP088704A/es unknown
- 2008-08-29 NO NO20083739A patent/NO341064B1/no unknown
2009
- 2009-04-20 HK HK09103590.9A patent/HK1125924A1/xx unknown
2012
- 2012-09-05 US US13/604,282 patent/US8394822B2/en active Active
2013
- 2013-02-06 US US13/760,788 patent/US8604051B2/en active Active
2014
- 2014-06-02 HR HRP20140503TT patent/HRP20140503T1/hr unknown
- 2014-06-11 CY CY20141100415T patent/CY1115404T1/el unknown

Also Published As

Publication number	Publication date
IL192603A0 (en)	2009-02-11
US8283359B2 (en)	2012-10-09
RS53342B (en)	2014-10-31
US20120329774A1 (en)	2012-12-27
UA95939C2 (en)	2011-09-26
CA2640594A1 (en)	2007-08-09
SI1981892T1 (sl)	2014-07-31
CN101379067A (zh)	2009-03-04
ES2471970T3 (es)	2014-06-27
KR20080095870A (ko)	2008-10-29
BRPI0708016B1 (pt)	2021-07-06
US20130150573A1 (en)	2013-06-13
PL1981892T3 (pl)	2014-08-29
NO20083739L (no)	2008-08-29
JP5249787B2 (ja)	2013-07-31
IL192603A (en)	2013-12-31
EP1981892B1 (en)	2014-03-12
KR101446919B1 (ko)	2014-10-07
ECSP088704A (es)	2008-09-29
US8394822B2 (en)	2013-03-12
NO341064B1 (no)	2017-08-14
HK1125924A1 (en)	2009-08-21
WO2007088345A1 (en)	2007-08-09
ZA200807447B (en)	2009-11-25
EP1981892A1 (en)	2008-10-22
AU2007211377A1 (en)	2007-08-09
GB0601962D0 (en)	2006-03-15
CA2640594C (en)	2014-12-23
HRP20140503T1 (hr)	2014-07-04
EA200801684A1 (ru)	2009-04-28
JP2009525317A (ja)	2009-07-09
NZ569638A (en)	2010-08-27
AU2007211377B2 (en)	2012-03-01
EA016128B1 (ru)	2012-02-28
US8604051B2 (en)	2013-12-10
BRPI0708016A2 (pt)	2011-05-17
PT1981892E (pt)	2014-06-23
CY1115404T1 (el)	2017-01-04
MY146387A (en)	2012-08-15
CN101379067B (zh)	2011-03-23
US20090149437A1 (en)	2009-06-11

Publication	Publication Date	Title
DK1981892T3 (da)	2014-06-23	Thienopyridinderivater som mek-inhibitorer
DK2086939T3 (da)	2010-10-11	Pyridiacarboxamid som II-beta-HSDI-inhibitorer
DK2125748T3 (da)	2011-08-01	Acylaminopyrazol som FGFR inhibitorer
DK2094263T3 (da)	2013-12-02	2-adamantyl-butyramidderivater som selektive 11 beta-hsd1-inhibitorer
DK1789041T3 (da)	2008-09-08	Aryl-pyridinderivater som 11-beta-HSD1-inhibitorer
DK2078001T3 (da)	2010-07-19	Diazepan-acetamidderivater som selektive 11-HSD1-inhibitorer
DK2178840T3 (da)	2012-03-26	Azabiphenylaminobenzoesyre-derivater som dhodh-hæmmere
DK2041138T3 (da)	2014-08-11	Pyrroltriazinkinase-inhibitorer
DK1797042T3 (da)	2009-03-02	Indozolonderivater som 11B-HSD1-inhibitorer
DK2024375T3 (da)	2011-06-27	Cyclopropyl-kondenserede indolobenzazepin-HCV-NS5B-hæmmere
DK2402317T3 (da)	2013-10-07	DGAT-inhibitor
DK2318389T3 (da)	2013-09-30	Pyridazinderivater som SMO-inhibitorer
DK2220070T3 (da)	2011-07-04	2-benzylpyridazinonderivater som Met-kinaseinhibitorer
BRPI0806898A2 (pt)	2015-07-14	Inibidores de mek
DK2016080T3 (da)	2010-11-22	Dihydropyrazolopyrimidinon-derivater
ATE483711T1 (de)	2010-10-15	Spiroindolinonderivate
CR10831A (es)	2009-06-18	INHIBIDORES ESPIRO CETONA DE ACETIL-CoA CARBOXILASA
DK2160389T3 (da)	2014-06-23	Thioxoquinazolinonderivater som glutaminylcyclaseinhibitorer
DK2099447T3 (da)	2013-02-18	Imidazotriaziner og imidazopyrimidiner som kinaseinhibitorer
ATE469905T1 (de)	2010-06-15	Pyridopyrimidinonderivate
DK2125792T3 (da)	2011-03-07	Purinderivater som immunomodulatorer
ATE512135T1 (de)	2011-06-15	Spiroindolinonderivate
DK1959951T3 (da)	2010-03-01	Heteroaryl-substituerede piperidinderivater som L-CPT1-inhibitorer
DK2383271T3 (da)	2013-10-07	Aminoquinoloner som GSK-3-inhibitorer
BRPI0811212A2 (pt)	2014-10-29	Inibidores de p70 quinase