CY1115404T1 - Παραγωγα θειενο-πυριδινης ως αναστολεις μεκ - Google Patents

Παραγωγα θειενο-πυριδινης ως αναστολεις μεκ

Info

Publication number
CY1115404T1
CY1115404T1 CY20141100415T CY141100415T CY1115404T1 CY 1115404 T1 CY1115404 T1 CY 1115404T1 CY 20141100415 T CY20141100415 T CY 20141100415T CY 141100415 T CY141100415 T CY 141100415T CY 1115404 T1 CY1115404 T1 CY 1115404T1
Authority
CY
Cyprus
Prior art keywords
mek
antolosis
thieno
pyridines
production
Prior art date
Application number
CY20141100415T
Other languages
English (en)
Inventor
Martin Clive Hutchings
Sarah Catherine Archibald
Daniel Christopher Brookings
Jeremy Martin Davis
James Andrew Johnson
Barry John Langham
Judi Charlotte Neuss
Original Assignee
Ucb Pharma S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ucb Pharma S.A. filed Critical Ucb Pharma S.A.
Publication of CY1115404T1 publication Critical patent/CY1115404T1/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Transplantation (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Μια σειρά παραγώγων θειενο[2,3-b]πυριδίνης που είναι υποκατεστημένα στη θέση 2 από ένα υποκατεστημένο τμήμα ανιλίνης, που είναι επιλεκτικοί αναστολείς ανθρώπινων ενζύμων ΜΕΚ (ΜΑΡΚΚ), είναι συνεπώς ωφέλιμα για την ιατρική, για παράδειγμα στην αντιμετώπιση φλεγμονωδών, αυτοάνοσων, καρδιαγγειακών, πολλαπλασιαστικών (συμπεριλαμβανομένων των ογκολογικών) και αλγαισθητικών καταστάσεων.
CY20141100415T 2006-01-31 2014-06-11 Παραγωγα θειενο-πυριδινης ως αναστολεις μεκ CY1115404T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0601962.4A GB0601962D0 (en) 2006-01-31 2006-01-31 Therapeutic agents
EP07705076.3A EP1981892B1 (en) 2006-01-31 2007-01-30 Thieno-pyridine derivatives as mek inhibitors

Publications (1)

Publication Number Publication Date
CY1115404T1 true CY1115404T1 (el) 2017-01-04

Family

ID=36100789

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20141100415T CY1115404T1 (el) 2006-01-31 2014-06-11 Παραγωγα θειενο-πυριδινης ως αναστολεις μεκ

Country Status (27)

Country Link
US (3) US8283359B2 (el)
EP (1) EP1981892B1 (el)
JP (1) JP5249787B2 (el)
KR (1) KR101446919B1 (el)
CN (1) CN101379067B (el)
AU (1) AU2007211377B2 (el)
BR (1) BRPI0708016B1 (el)
CA (1) CA2640594C (el)
CY (1) CY1115404T1 (el)
DK (1) DK1981892T3 (el)
EA (1) EA016128B1 (el)
EC (1) ECSP088704A (el)
ES (1) ES2471970T3 (el)
GB (1) GB0601962D0 (el)
HK (1) HK1125924A1 (el)
HR (1) HRP20140503T1 (el)
IL (1) IL192603A (el)
MY (1) MY146387A (el)
NO (1) NO341064B1 (el)
NZ (1) NZ569638A (el)
PL (1) PL1981892T3 (el)
PT (1) PT1981892E (el)
RS (1) RS53342B (el)
SI (1) SI1981892T1 (el)
UA (1) UA95939C2 (el)
WO (1) WO2007088345A1 (el)
ZA (1) ZA200807447B (el)

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GB0714384D0 (en) 2007-07-23 2007-09-05 Ucb Pharma Sa theraputic agents
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WO2009093008A1 (en) * 2008-01-21 2009-07-30 Ucb Pharma S.A. Thieno-pyridine derivatives as mek inhibitors
GB0811304D0 (en) * 2008-06-19 2008-07-30 Ucb Pharma Sa Therapeutic agents
JP5503930B2 (ja) * 2009-09-18 2014-05-28 住友化学株式会社 ３−アミノ−１−ｔｅｒｔ−ブトキシカルボニルピペリジンの精製方法およびそのクエン酸塩
EP2598661B1 (en) 2010-07-26 2017-09-27 Biomatrica, INC. Compositions for stabilizing dna, rna and proteins in saliva and other biological samples during shipping and storage at ambient temperatures
US9376709B2 (en) 2010-07-26 2016-06-28 Biomatrica, Inc. Compositions for stabilizing DNA and RNA in blood and other biological samples during shipping and storage at ambient temperatures
US9725703B2 (en) 2012-12-20 2017-08-08 Biomatrica, Inc. Formulations and methods for stabilizing PCR reagents
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WO2017033113A1 (en) 2015-08-21 2017-03-02 Acerta Pharma B.V. Therapeutic combinations of a mek inhibitor and a btk inhibitor
ES2946184T3 (es) 2015-12-08 2023-07-13 Biomatrica Inc Reducción de la velocidad de eritrosedimentación
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CN109836434B (zh) * 2017-11-27 2020-09-25 上海宇耀生物科技有限公司 噻吩并环类化合物及其合成方法和应用
CA3120351A1 (en) * 2018-11-20 2020-05-28 Nflection Therapeutics, Inc. Aryl-aniline and heteroaryl-aniline compounds for treatment of skin cancers
WO2020106306A1 (en) 2018-11-20 2020-05-28 Nflection Therapeutics, Inc. Cyanoaryl-aniline compounds for treatment of dermal disorders
BR112021018168B1 (pt) 2019-03-21 2023-11-28 Onxeo Composição farmacêutica, combinação e kit compreendendo uma molécula dbait e um inibidor de quinase para o tratamento de câncer
KR20220098759A (ko) 2019-11-08 2022-07-12 인쎄름 (엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔) 키나제 억제제에 대해 내성을 획득한 암의 치료 방법
CN111138449B (zh) * 2020-01-15 2022-11-29 四川大学华西医院 双靶向erk1和erk5抑制剂的制备及其抗肿瘤应用
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use
GB202205203D0 (en) 2022-04-08 2022-05-25 UCB Biopharma SRL Combination with inhibitor

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Also Published As

Publication number Publication date
IL192603A0 (en) 2009-02-11
US8283359B2 (en) 2012-10-09
RS53342B (en) 2014-10-31
US20120329774A1 (en) 2012-12-27
UA95939C2 (en) 2011-09-26
CA2640594A1 (en) 2007-08-09
SI1981892T1 (sl) 2014-07-31
CN101379067A (zh) 2009-03-04
ES2471970T3 (es) 2014-06-27
KR20080095870A (ko) 2008-10-29
BRPI0708016B1 (pt) 2021-07-06
US20130150573A1 (en) 2013-06-13
PL1981892T3 (pl) 2014-08-29
NO20083739L (no) 2008-08-29
JP5249787B2 (ja) 2013-07-31
IL192603A (en) 2013-12-31
EP1981892B1 (en) 2014-03-12
KR101446919B1 (ko) 2014-10-07
ECSP088704A (es) 2008-09-29
US8394822B2 (en) 2013-03-12
NO341064B1 (no) 2017-08-14
HK1125924A1 (en) 2009-08-21
WO2007088345A1 (en) 2007-08-09
DK1981892T3 (da) 2014-06-23
ZA200807447B (en) 2009-11-25
EP1981892A1 (en) 2008-10-22
AU2007211377A1 (en) 2007-08-09
GB0601962D0 (en) 2006-03-15
CA2640594C (en) 2014-12-23
HRP20140503T1 (hr) 2014-07-04
EA200801684A1 (ru) 2009-04-28
JP2009525317A (ja) 2009-07-09
NZ569638A (en) 2010-08-27
AU2007211377B2 (en) 2012-03-01
EA016128B1 (ru) 2012-02-28
US8604051B2 (en) 2013-12-10
BRPI0708016A2 (pt) 2011-05-17
PT1981892E (pt) 2014-06-23
MY146387A (en) 2012-08-15
CN101379067B (zh) 2011-03-23
US20090149437A1 (en) 2009-06-11

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