DK172153B1 - N-(Pyridinyl)-1H-indol-1-aminer, fremgangsmåde til deres fremstilling, farmaceutisk præparat indeholdende dem samt deres anvendelse til fremstilling af et lægemiddel - Google Patents

N-(Pyridinyl)-1H-indol-1-aminer, fremgangsmåde til deres fremstilling, farmaceutisk præparat indeholdende dem samt deres anvendelse til fremstilling af et lægemiddel Download PDF

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Publication number
DK172153B1
DK172153B1 DK223488A DK223488A DK172153B1 DK 172153 B1 DK172153 B1 DK 172153B1 DK 223488 A DK223488 A DK 223488A DK 223488 A DK223488 A DK 223488A DK 172153 B1 DK172153 B1 DK 172153B1
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Prior art keywords
compound
formula
hydrogen
lower alkyl
give
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DK223488A
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Danish (da)
English (en)
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DK223488A (da
DK223488D0 (da
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Richard Charles Effland
Joseph Thomas Klein
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Hoechst Roussel Pharma
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Publication of DK223488D0 publication Critical patent/DK223488D0/da
Publication of DK223488A publication Critical patent/DK223488A/da
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, ***e
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK223488A 1987-04-24 1988-04-22 N-(Pyridinyl)-1H-indol-1-aminer, fremgangsmåde til deres fremstilling, farmaceutisk præparat indeholdende dem samt deres anvendelse til fremstilling af et lægemiddel DK172153B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4207987A 1987-04-24 1987-04-24
US4207987 1987-04-24

Publications (3)

Publication Number Publication Date
DK223488D0 DK223488D0 (da) 1988-04-22
DK223488A DK223488A (da) 1988-10-25
DK172153B1 true DK172153B1 (da) 1997-12-01

Family

ID=21919923

Family Applications (1)

Application Number Title Priority Date Filing Date
DK223488A DK172153B1 (da) 1987-04-24 1988-04-22 N-(Pyridinyl)-1H-indol-1-aminer, fremgangsmåde til deres fremstilling, farmaceutisk præparat indeholdende dem samt deres anvendelse til fremstilling af et lægemiddel

Country Status (17)

Country Link
EP (1) EP0287982B1 (de)
JP (1) JP2683360B2 (de)
KR (1) KR960015003B1 (de)
AT (1) ATE115143T1 (de)
AU (1) AU594876B2 (de)
CA (1) CA1330661C (de)
DE (1) DE3852335T2 (de)
DK (1) DK172153B1 (de)
ES (1) ES2065324T3 (de)
FI (1) FI90978C (de)
IE (1) IE65349B1 (de)
IL (1) IL86154A (de)
NO (1) NO168104C (de)
NZ (1) NZ224338A (de)
PH (1) PH26127A (de)
PT (1) PT87308B (de)
ZA (1) ZA882810B (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4868190A (en) * 1988-12-27 1989-09-19 Hoechst-Roussel Pharmaceuticals, Inc. N-pyridinyl-9H-carbazol-9-amines
US4983615A (en) * 1989-06-28 1991-01-08 Hoechst-Roussel Pharmaceuticals Inc. Heteroarylamino- and heteroaryloxypyridinamine compounds which are useful in treating skin disorders
US5179119A (en) * 1989-08-02 1993-01-12 Hoechst-Roussel Pharmaceuticals Incorporated 1,3-dihydro-1-(pyridinylamino)-2H-indol-1-ones and intermediates for the preparation thereof
ATE118002T1 (de) * 1989-08-02 1995-02-15 Hoechst Roussel Pharma 2,3-dihydro-1-(pyridinylamino)-indole, verfahren zu ihrer herstellung und ihre anwendung als arzneimittel.
US5006537A (en) * 1989-08-02 1991-04-09 Hoechst-Roussel Pharmaceuticals, Inc. 1,3-dihydro-1-(pyridinylamino)-2H-indol-2-ones
US5179099A (en) * 1989-08-02 1993-01-12 Hoechst-Roussel Pharmaceuticals Incorporated 2,3-dihydro-1-(pyridinylamino)-indoles
US4983608A (en) * 1989-09-05 1991-01-08 Hoechst-Roussell Pharmaceuticals, Inc. N-substituted-4-pyrimidinamines and pyrimidinediamines
US5102891A (en) * 1990-07-23 1992-04-07 Hoechst-Roussel Pharmaceuticals Inc. 1-(substituted pyridinylamino)-1H-indol-5-yl substituted carbamates
US5214038A (en) * 1991-04-15 1993-05-25 Hoechst-Roussel Pharmaceuticals Inc. 1-(pyrido[3,4-b]-1,4-oxazinyl-4-yl)-1H-indoles and intermediates for the preparation thereof
US5328920A (en) * 1991-04-17 1994-07-12 Hoechst-Roussel Pharmaceuticals Incorporated Substituted (pyridinylamino)-indoles
US5185350A (en) * 1991-09-23 1993-02-09 Hoechst-Roussel Pharmaceuticals Incorporated Substituted pyridinylamino-1h-indoles,1h-indazoles,2h-indazoles, benzo (b)thiophenes and 1,2-benzisothiazoles
US5356910A (en) 1993-07-19 1994-10-18 Hoechst-Roussel Pharmaceuticals Inc. Use of N-(pyridinyl)-1H-indol-1-amines for the treatment of obsessive-compulsive disorder
US5459274A (en) * 1994-05-13 1995-10-17 Hoechst-Roussel Pharmaceuticals Inc. Preparation of N-alkyl-N-pyridinyl-1H-indol-1-amines
HUP9802413A3 (en) * 1995-07-27 2002-02-28 Aventis Pharmaceuticals Inc Br Use of n-(pyrrol-1-yl)pyridinamines as anticonvulsant agents and for the preparation of a pharmaceutical composition for the treatment of convulsions
EP0840609B1 (de) * 1995-07-27 2002-06-05 Aventis Pharmaceuticals Inc. Verwendung von substituierten und nichtsubstituierten n-(pyrrol-1-yl)pyridinaminen als antikonvulsiva
WO1998029407A2 (en) * 1996-12-27 1998-07-09 Hoechst Marion Roussel, Inc. N-(pyridinylamino)isoindolines for treating alzheimer's and depression
EP1035114B1 (de) * 1999-03-10 2004-11-24 Tosoh Corporation Verfahren zur Herstellung Stickstoffheterocyclischer Verbindungen
JP4779185B2 (ja) * 1999-03-10 2011-09-28 東ソー株式会社 含窒素複素環化合物及びその製造方法
JP4683166B2 (ja) * 1999-03-10 2011-05-11 東ソー株式会社 含窒素複素環化合物の製造方法
GB0119435D0 (en) * 2001-02-15 2001-10-03 Aventis Pharm Prod Inc Method of treating of demyelinating diseases or conditions
US7538227B2 (en) 2004-01-13 2009-05-26 Sanofi-Aventis Deutschland Gmbh Process for stabilizing 4-halopyridines
GT200500063A (es) * 2004-04-01 2005-10-14 Metodo para tratar la esquizofrenia y/o anormalidades glucoregulatorias
FR2888238B1 (fr) * 2005-07-07 2007-09-07 Servier Lab Nouveaux derives 1h-indole-pyridinecarboxamides et 1h-indole-piperidinecarboxamide, leur procede de preparation et les compositions pharceumatiques qui les contiennent.
FR2911780A1 (fr) * 2007-01-26 2008-08-01 Urogene Traitement de l'incontinence fecale.
JP5412422B2 (ja) * 2007-04-13 2014-02-12 サノフイ Ｎ−アミノインドールの遷移金属触媒合成

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3242185A (en) * 1963-10-07 1966-03-22 Merck & Co Inc Lower aliphatic acids, salts and derivatives thereof
DE1670184A1 (de) * 1967-01-20 1971-01-21 Boehringer Sohn Ingelheim Verfahren zur Herstellung heterocyclisch substituierter Hydrazino-imidazoline-(2)
CH603581A5 (de) * 1974-03-29 1978-08-31 Siegfried Ag
US4260767A (en) * 1979-12-26 1981-04-07 American Cyanamid Company 2-Pyridylhydrazides
JPS60142955A (ja) * 1983-12-28 1985-07-29 Fuji Photo Film Co Ltd インド−ル誘導体の製造方法
US4792562A (en) * 1985-12-04 1988-12-20 Hoechst-Roussel Pharmaceuticals, Inc. N-(pyrrol-1-yl)pyridinamines having memory enhancing activity

Also Published As

Publication number Publication date
EP0287982A2 (de) 1988-10-26
NO168104B (no) 1991-10-07
ES2065324T3 (es) 1995-02-16
PT87308B (pt) 1992-08-31
NO881776L (no) 1988-10-25
KR880012591A (ko) 1988-11-28
JPS63280079A (ja) 1988-11-17
AU594876B2 (en) 1990-03-15
JP2683360B2 (ja) 1997-11-26
DK223488A (da) 1988-10-25
NO881776D0 (no) 1988-04-22
CA1330661C (en) 1994-07-12
IE881213L (en) 1988-10-24
IL86154A (en) 1992-03-29
KR960015003B1 (ko) 1996-10-23
NZ224338A (en) 1991-07-26
DK223488D0 (da) 1988-04-22
NO168104C (no) 1992-01-15
FI881874A0 (fi) 1988-04-21
FI90978B (fi) 1994-01-14
DE3852335T2 (de) 1995-05-11
IE65349B1 (en) 1995-10-18
FI881874A (fi) 1988-10-25
AU1510088A (en) 1988-10-27
PT87308A (pt) 1988-05-01
ATE115143T1 (de) 1994-12-15
PH26127A (en) 1992-02-24
EP0287982A3 (de) 1991-03-27
FI90978C (fi) 1994-04-25
ZA882810B (en) 1988-10-20
IL86154A0 (en) 1988-11-15
DE3852335D1 (de) 1995-01-19
EP0287982B1 (de) 1994-12-07

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B1 Patent granted (law 1993)
PUP Patent expired