DE3852335T2 - N-(Pyridinyl)-1H-indol-1-amine, Verfahren zu deren Herstellung und ihre Verwendung als Arzneimittel. - Google Patents

N-(Pyridinyl)-1H-indol-1-amine, Verfahren zu deren Herstellung und ihre Verwendung als Arzneimittel.

Info

Publication number
DE3852335T2
DE3852335T2 DE3852335T DE3852335T DE3852335T2 DE 3852335 T2 DE3852335 T2 DE 3852335T2 DE 3852335 T DE3852335 T DE 3852335T DE 3852335 T DE3852335 T DE 3852335T DE 3852335 T2 DE3852335 T2 DE 3852335T2
Authority
DE
Germany
Prior art keywords
loweralkyl
arylloweralkyl
sec
aryl
halogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE3852335T
Other languages
English (en)
Other versions
DE3852335D1 (de
Inventor
Richard Charles Effland
Joseph Thomas Klein
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Hoechst Roussel Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Roussel Pharmaceuticals Inc filed Critical Hoechst Roussel Pharmaceuticals Inc
Publication of DE3852335D1 publication Critical patent/DE3852335D1/de
Application granted granted Critical
Publication of DE3852335T2 publication Critical patent/DE3852335T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, ***e
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE3852335T 1987-04-24 1988-04-18 N-(Pyridinyl)-1H-indol-1-amine, Verfahren zu deren Herstellung und ihre Verwendung als Arzneimittel. Expired - Lifetime DE3852335T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US4207987A 1987-04-24 1987-04-24

Publications (2)

Publication Number Publication Date
DE3852335D1 DE3852335D1 (de) 1995-01-19
DE3852335T2 true DE3852335T2 (de) 1995-05-11

Family

ID=21919923

Family Applications (1)

Application Number Title Priority Date Filing Date
DE3852335T Expired - Lifetime DE3852335T2 (de) 1987-04-24 1988-04-18 N-(Pyridinyl)-1H-indol-1-amine, Verfahren zu deren Herstellung und ihre Verwendung als Arzneimittel.

Country Status (17)

Country Link
EP (1) EP0287982B1 (de)
JP (1) JP2683360B2 (de)
KR (1) KR960015003B1 (de)
AT (1) ATE115143T1 (de)
AU (1) AU594876B2 (de)
CA (1) CA1330661C (de)
DE (1) DE3852335T2 (de)
DK (1) DK172153B1 (de)
ES (1) ES2065324T3 (de)
FI (1) FI90978C (de)
IE (1) IE65349B1 (de)
IL (1) IL86154A (de)
NO (1) NO168104C (de)
NZ (1) NZ224338A (de)
PH (1) PH26127A (de)
PT (1) PT87308B (de)
ZA (1) ZA882810B (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4868190A (en) * 1988-12-27 1989-09-19 Hoechst-Roussel Pharmaceuticals, Inc. N-pyridinyl-9H-carbazol-9-amines
US4983615A (en) * 1989-06-28 1991-01-08 Hoechst-Roussel Pharmaceuticals Inc. Heteroarylamino- and heteroaryloxypyridinamine compounds which are useful in treating skin disorders
DE69016531T2 (de) * 1989-08-02 1995-07-06 Hoechst Roussel Pharma 2,3-Dihydro-1-(pyridinylamino)-indole, Verfahren zu ihrer Herstellung und ihre Anwendung als Arzneimittel.
US5179099A (en) * 1989-08-02 1993-01-12 Hoechst-Roussel Pharmaceuticals Incorporated 2,3-dihydro-1-(pyridinylamino)-indoles
US5179119A (en) * 1989-08-02 1993-01-12 Hoechst-Roussel Pharmaceuticals Incorporated 1,3-dihydro-1-(pyridinylamino)-2H-indol-1-ones and intermediates for the preparation thereof
US5006537A (en) * 1989-08-02 1991-04-09 Hoechst-Roussel Pharmaceuticals, Inc. 1,3-dihydro-1-(pyridinylamino)-2H-indol-2-ones
US4983608A (en) * 1989-09-05 1991-01-08 Hoechst-Roussell Pharmaceuticals, Inc. N-substituted-4-pyrimidinamines and pyrimidinediamines
US5102891A (en) * 1990-07-23 1992-04-07 Hoechst-Roussel Pharmaceuticals Inc. 1-(substituted pyridinylamino)-1H-indol-5-yl substituted carbamates
US5214038A (en) * 1991-04-15 1993-05-25 Hoechst-Roussel Pharmaceuticals Inc. 1-(pyrido[3,4-b]-1,4-oxazinyl-4-yl)-1H-indoles and intermediates for the preparation thereof
US5328920A (en) * 1991-04-17 1994-07-12 Hoechst-Roussel Pharmaceuticals Incorporated Substituted (pyridinylamino)-indoles
US5185350A (en) * 1991-09-23 1993-02-09 Hoechst-Roussel Pharmaceuticals Incorporated Substituted pyridinylamino-1h-indoles,1h-indazoles,2h-indazoles, benzo (b)thiophenes and 1,2-benzisothiazoles
US5356910A (en) 1993-07-19 1994-10-18 Hoechst-Roussel Pharmaceuticals Inc. Use of N-(pyridinyl)-1H-indol-1-amines for the treatment of obsessive-compulsive disorder
US5459274A (en) * 1994-05-13 1995-10-17 Hoechst-Roussel Pharmaceuticals Inc. Preparation of N-alkyl-N-pyridinyl-1H-indol-1-amines
ES2174081T3 (es) * 1995-07-27 2002-11-01 Aventis Pharma Inc Uso de n-(pirrol-1-il)piridinaminas sustituidas y no sustituidas como agentes anticonvulsivos.
US5776955A (en) * 1995-07-27 1998-07-07 Hoechst Marion Roussel, Inc. Use of unsubstituted and substituted n-(pyrrol-1-yl)pyridinamines as anticonvulsant agents
HUP0000783A2 (hu) * 1996-12-27 2001-04-28 Hoechst Marion Roussel, Inc. N-(piridinil-amino)-izoindolinok és származékaik, eljárás előállításukra, e vegyületeket tartalmazó gyógyszerkészítmények és alkalmazásuk
JP4779185B2 (ja) * 1999-03-10 2011-09-28 東ソー株式会社 含窒素複素環化合物及びその製造方法
JP4683166B2 (ja) * 1999-03-10 2011-05-11 東ソー株式会社 含窒素複素環化合物の製造方法
DE60016068T2 (de) 1999-03-10 2005-11-03 Tosoh Corp., Shinnanyo Verfahren zur Herstellung Stickstoffheterocyclischer Verbindungen
GB0119435D0 (en) 2001-02-15 2001-10-03 Aventis Pharm Prod Inc Method of treating of demyelinating diseases or conditions
US7538227B2 (en) 2004-01-13 2009-05-26 Sanofi-Aventis Deutschland Gmbh Process for stabilizing 4-halopyridines
GT200500063A (es) * 2004-04-01 2005-10-14 Metodo para tratar la esquizofrenia y/o anormalidades glucoregulatorias
FR2888238B1 (fr) * 2005-07-07 2007-09-07 Servier Lab Nouveaux derives 1h-indole-pyridinecarboxamides et 1h-indole-piperidinecarboxamide, leur procede de preparation et les compositions pharceumatiques qui les contiennent.
FR2911780A1 (fr) * 2007-01-26 2008-08-01 Urogene Traitement de l'incontinence fecale.
BRPI0810199A2 (pt) * 2007-04-13 2014-10-14 Sanofi Aventis Síntese catalisada por metal de transição de n-aminoindóis

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3242185A (en) * 1963-10-07 1966-03-22 Merck & Co Inc Lower aliphatic acids, salts and derivatives thereof
DE1670184A1 (de) * 1967-01-20 1971-01-21 Boehringer Sohn Ingelheim Verfahren zur Herstellung heterocyclisch substituierter Hydrazino-imidazoline-(2)
CH603581A5 (de) * 1974-03-29 1978-08-31 Siegfried Ag
US4260767A (en) * 1979-12-26 1981-04-07 American Cyanamid Company 2-Pyridylhydrazides
JPS60142955A (ja) * 1983-12-28 1985-07-29 Fuji Photo Film Co Ltd インド−ル誘導体の製造方法
US4792562A (en) * 1985-12-04 1988-12-20 Hoechst-Roussel Pharmaceuticals, Inc. N-(pyrrol-1-yl)pyridinamines having memory enhancing activity

Also Published As

Publication number Publication date
PT87308B (pt) 1992-08-31
IL86154A0 (en) 1988-11-15
DK223488A (da) 1988-10-25
IE881213L (en) 1988-10-24
DK223488D0 (da) 1988-04-22
EP0287982A2 (de) 1988-10-26
EP0287982A3 (de) 1991-03-27
AU594876B2 (en) 1990-03-15
NO168104B (no) 1991-10-07
IE65349B1 (en) 1995-10-18
FI881874A0 (fi) 1988-04-21
NO881776D0 (no) 1988-04-22
ZA882810B (en) 1988-10-20
IL86154A (en) 1992-03-29
JPS63280079A (ja) 1988-11-17
NO168104C (no) 1992-01-15
FI90978B (fi) 1994-01-14
DE3852335D1 (de) 1995-01-19
AU1510088A (en) 1988-10-27
KR960015003B1 (ko) 1996-10-23
KR880012591A (ko) 1988-11-28
CA1330661C (en) 1994-07-12
NZ224338A (en) 1991-07-26
JP2683360B2 (ja) 1997-11-26
ATE115143T1 (de) 1994-12-15
DK172153B1 (da) 1997-12-01
PT87308A (pt) 1988-05-01
ES2065324T3 (es) 1995-02-16
FI90978C (fi) 1994-04-25
EP0287982B1 (de) 1994-12-07
FI881874A (fi) 1988-10-25
PH26127A (en) 1992-02-24
NO881776L (no) 1988-10-25

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DE3852335D1 (de) N-(Pyridinyl)-1H-indol-1-amine, Verfahren zu deren Herstellung und ihre Verwendung als Arzneimittel.
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Legal Events

Date Code Title Description
8364 No opposition during term of opposition