DK1703905T3 - Indol-derivater og anvendelse deraf som kinaseinhibitorer, især IKK2-inhibitorer - Google Patents
Indol-derivater og anvendelse deraf som kinaseinhibitorer, især IKK2-inhibitorerInfo
- Publication number
- DK1703905T3 DK1703905T3 DK05701855T DK05701855T DK1703905T3 DK 1703905 T3 DK1703905 T3 DK 1703905T3 DK 05701855 T DK05701855 T DK 05701855T DK 05701855 T DK05701855 T DK 05701855T DK 1703905 T3 DK1703905 T3 DK 1703905T3
- Authority
- DK
- Denmark
- Prior art keywords
- inhibitors
- ikk2
- indole derivatives
- kinase inhibitors
- kinase
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Diabetes (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Virology (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Psychiatry (AREA)
- Transplantation (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Obesity (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0400895.9A GB0400895D0 (en) | 2004-01-15 | 2004-01-15 | Chemical compounds |
PCT/GB2005/000085 WO2005067923A1 (fr) | 2004-01-15 | 2005-01-13 | Derives d'indole et utilisation de ceux-ci comme inhibiteurs de kinase, notamment des inhibiteurs de ikk2 |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1703905T3 true DK1703905T3 (da) | 2009-02-16 |
Family
ID=31726240
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK05701855T DK1703905T3 (da) | 2004-01-15 | 2005-01-13 | Indol-derivater og anvendelse deraf som kinaseinhibitorer, især IKK2-inhibitorer |
Country Status (24)
Country | Link |
---|---|
US (1) | US20080269200A1 (fr) |
EP (1) | EP1703905B1 (fr) |
JP (2) | JP4975447B2 (fr) |
KR (1) | KR20070026357A (fr) |
CN (1) | CN1933830A (fr) |
AT (1) | ATE413877T1 (fr) |
AU (1) | AU2005205090A1 (fr) |
BR (1) | BRPI0506802A (fr) |
CA (1) | CA2552953A1 (fr) |
DE (1) | DE602005010970D1 (fr) |
DK (1) | DK1703905T3 (fr) |
ES (1) | ES2317184T3 (fr) |
GB (1) | GB0400895D0 (fr) |
HK (1) | HK1098047A1 (fr) |
HR (1) | HRP20090071T3 (fr) |
IL (1) | IL176739A0 (fr) |
MA (1) | MA28279A1 (fr) |
NO (1) | NO20063676L (fr) |
PL (1) | PL1703905T3 (fr) |
PT (1) | PT1703905E (fr) |
RU (1) | RU2006129492A (fr) |
SI (1) | SI1703905T1 (fr) |
WO (1) | WO2005067923A1 (fr) |
ZA (1) | ZA200604855B (fr) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW200616967A (en) * | 2004-06-24 | 2006-06-01 | Smithkline Beecham Corp | Novel indazole carboxamides and their use |
PE20060748A1 (es) * | 2004-09-21 | 2006-10-01 | Smithkline Beecham Corp | Derivados de indolcarboxamida como inhibidores de quinasa ikk2 |
US8063071B2 (en) | 2007-10-31 | 2011-11-22 | GlaxoSmithKline, LLC | Chemical compounds |
TWI380973B (zh) * | 2005-06-30 | 2013-01-01 | Smithkline Beecham Corp | 化合物 |
WO2007114848A2 (fr) * | 2005-10-25 | 2007-10-11 | Smithkline Beecham Corporation | Composés chimiques |
WO2007062318A2 (fr) * | 2005-11-18 | 2007-05-31 | Smithkline Beecham Corporation | Composes chimiques |
EP1959737A4 (fr) * | 2005-12-16 | 2010-12-08 | Glaxosmithkline Llc | Composes chimiques |
CN101583598B (zh) * | 2007-01-15 | 2012-09-12 | 参天制药株式会社 | 具有IκB激酶β抑制活性的新型吲哚衍生物 |
PE20081889A1 (es) * | 2007-03-23 | 2009-03-05 | Smithkline Beecham Corp | Indol carboxamidas como inhibidores de ikk2 |
MX2010008376A (es) * | 2008-02-04 | 2011-02-22 | Mercury Therapeutics Inc | Moduladores ampk. |
EP2253618A1 (fr) * | 2008-02-27 | 2010-11-24 | Takeda Pharmaceutical Company Limited | Composé contenant un cycle aromatique à 6 chaînons |
US8445529B2 (en) * | 2008-07-14 | 2013-05-21 | Santen Pharmaceutical Co., Ltd. | Indole derivative having, carbamoyl group, ureido group and substituted oxy group |
CN102341367B (zh) * | 2009-03-05 | 2014-05-07 | 住友化学株式会社 | 卤素取代苯二甲醇的制造方法 |
US8354539B2 (en) | 2009-03-10 | 2013-01-15 | Glaxo Group Limited | Indole derivatives as IKK2 inhibitors |
ES2607064T3 (es) * | 2010-12-01 | 2017-03-29 | Glaxosmithkline Llc | Indoles |
WO2014036268A2 (fr) * | 2012-08-29 | 2014-03-06 | Mount Sinai School Of Medicine | Dérivés d'indole en tant qu'activateurs de la protéine sumo |
FR3001219A1 (fr) * | 2013-01-22 | 2014-07-25 | Centre Nat Rech Scient | Inhibiteurs de kinases |
TWI644899B (zh) | 2013-02-04 | 2018-12-21 | 健生藥品公司 | Flap調節劑 |
US9079866B2 (en) | 2013-02-04 | 2015-07-14 | Janssen Pharmaceutica Nv | Flap modulators |
ES2708998T3 (es) * | 2013-06-26 | 2019-04-12 | Abbvie Inc | Carboxamidas primarias como inhibidores de btk |
WO2016096778A1 (fr) * | 2014-12-18 | 2016-06-23 | F. Hoffmann-La Roche Ag | Composés sulfonamide de benzazépine |
US20170158702A1 (en) * | 2015-12-02 | 2017-06-08 | Kyras Therapeutics, Inc. | Multivalent ras binding compounds |
WO2018013430A2 (fr) | 2016-07-12 | 2018-01-18 | Arisan Therapeutics Inc. | Composés hétérocycliques pour le traitement d'une infection à arenavirus |
CN110418787B (zh) * | 2017-06-07 | 2022-09-13 | 中国中医科学院中药研究所 | 一种吲哚乙酸类衍生物及其制备方法和医药用途 |
WO2024059220A2 (fr) * | 2022-09-15 | 2024-03-21 | Vanderbilt University | Composés à noyau 6,5 southwestern utilisés en tant que modulateurs allostériques négatifs du mglu5 et leurs méthodes de production et d'utilisation |
Family Cites Families (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4775761A (en) * | 1983-08-22 | 1988-10-04 | Hoechst-Roussel Pharmaceuticals, Inc. | 3-(piperidinyl)- and 3-(pyrrolidinyl)-1H-indazoles |
DE3342632A1 (de) * | 1983-11-25 | 1985-06-05 | Merck Patent Gmbh, 6100 Darmstadt | Indolderivate |
US5256673A (en) * | 1983-11-25 | 1993-10-26 | Merck Patent Gesellschaft Mit Beschrankter Haftung | Indole-3-yl-A-tetrahydropyridyl or piperidyl compounds |
JPH0262875A (ja) * | 1988-05-23 | 1990-03-02 | Wakunaga Pharmaceut Co Ltd | 新規イソインドリン誘導体 |
US5254473A (en) * | 1990-03-16 | 1993-10-19 | Jp Laboratories | Solid state device for monitoring integral values of time and temperature of storage of perishables |
US5330986A (en) * | 1992-11-24 | 1994-07-19 | Hoechst-Roussel Pharmaceuticals Inc. | Indole-7-carboxamide derivatives |
ZA951822B (en) * | 1994-12-23 | 1996-09-26 | Glaxo Group Ltd | Chemical compounds |
DE19756036A1 (de) * | 1997-12-17 | 1999-06-24 | Merck Patent Gmbh | Amid- und Harnstoffderivate |
US6589954B1 (en) * | 1998-05-22 | 2003-07-08 | Scios, Inc. | Compounds and methods to treat cardiac failure and other disorders |
AU6634000A (en) * | 1999-08-13 | 2001-03-13 | Vela Pharmaceuticals Inc. | Cyclobenzaprine for treating generalized anxiety disorder and compositions thereof |
US6245799B1 (en) * | 1999-11-08 | 2001-06-12 | American Home Products Corp | [(Indol-3-yl)-cycloalkyl]-3-substituted azetidines for the treatment of central nervous system disorders |
JP2003531205A (ja) * | 2000-04-24 | 2003-10-21 | ブリストル−マイヤーズ スクイブ カンパニー | Impdh酵素の阻害剤である複素環化合物 |
US20050009876A1 (en) * | 2000-07-31 | 2005-01-13 | Bhagwat Shripad S. | Indazole compounds, compositions thereof and methods of treatment therewith |
US6897231B2 (en) * | 2000-07-31 | 2005-05-24 | Signal Pharmaceuticals, Inc. | Indazole derivatives as JNK inhibitors and compositions and methods related thereto |
US6369032B1 (en) * | 2000-09-06 | 2002-04-09 | Ortho-Mcneil Pharmaceutical, Inc. | Method for treating allergies |
US6869956B2 (en) * | 2000-10-03 | 2005-03-22 | Bristol-Myers Squibb Company | Methods of treating inflammatory and immune diseases using inhibitors of IκB kinase (IKK) |
BR0114978A (pt) * | 2000-10-26 | 2004-04-20 | Tularik Inc | Composições e métodos que são úteis no tratamento de condições ou doenças inflamatórias, metabólicas, e proliferativas celulares |
EP1401813B1 (fr) * | 2001-06-07 | 2007-02-07 | F. Hoffman-la Roche AG | Nouveaux derives de l'indole a affinite pour le recepteur 5-ht6 |
US6956052B2 (en) * | 2001-09-19 | 2005-10-18 | Pharmacia Corporation | Substituted pyrazolyl compounds for the treatment of inflammation |
MXPA04004064A (es) * | 2001-10-30 | 2004-09-06 | Pharmacia Corp | Derivados heteroaromaticos de carboxamida para el tratramiento de la inflamacion. |
JP2005526831A (ja) * | 2002-04-09 | 2005-09-08 | アステックス テクノロジー リミテッド | 医薬化合物 |
AR039280A1 (es) * | 2002-04-11 | 2005-02-16 | Smithkline Beecham Corp | Compuesto de aminotiofeno y su uso para preparar una composicion farmaceutica |
AU2003286180B2 (en) * | 2002-12-02 | 2009-11-12 | F. Hoffmann-La Roche Ag | Indazole derivatives as CRF antagonists |
EP1569924A4 (fr) * | 2002-12-06 | 2007-02-21 | Smithkline Beecham Corp | Inhibiteurs du facteur nf-kb |
JP2007514759A (ja) * | 2003-12-19 | 2007-06-07 | タケダ サン ディエゴ インコーポレイテッド | キナーゼ阻害剤 |
DE102004012069A1 (de) * | 2004-03-12 | 2005-09-29 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue aryl-haltige 5-Acylindolinone, deren Herstellung und deren Verwendung als Arzneimittel |
TW200616967A (en) * | 2004-06-24 | 2006-06-01 | Smithkline Beecham Corp | Novel indazole carboxamides and their use |
PE20060748A1 (es) * | 2004-09-21 | 2006-10-01 | Smithkline Beecham Corp | Derivados de indolcarboxamida como inhibidores de quinasa ikk2 |
TWI466879B (zh) * | 2005-04-13 | 2015-01-01 | Neuraxon Inc | 具有一氧化氮合成酶抑制活性之取代的吲哚化合物 |
US8063071B2 (en) * | 2007-10-31 | 2011-11-22 | GlaxoSmithKline, LLC | Chemical compounds |
JP5072594B2 (ja) * | 2005-07-22 | 2012-11-14 | 塩野義製薬株式会社 | Pgd2受容体アンタゴニスト活性を有するインドール誘導体 |
WO2007102883A2 (fr) * | 2005-10-25 | 2007-09-13 | Smithkline Beecham Corporation | Composés chimiques |
WO2007114848A2 (fr) * | 2005-10-25 | 2007-10-11 | Smithkline Beecham Corporation | Composés chimiques |
WO2007062318A2 (fr) * | 2005-11-18 | 2007-05-31 | Smithkline Beecham Corporation | Composes chimiques |
EP1959737A4 (fr) * | 2005-12-16 | 2010-12-08 | Glaxosmithkline Llc | Composes chimiques |
MX2008012482A (es) * | 2006-03-31 | 2008-10-10 | Abbott Lab | Compuestos de indazol. |
US20080176891A1 (en) * | 2006-09-22 | 2008-07-24 | Paul Bamborough | Novel compounds |
PE20081889A1 (es) * | 2007-03-23 | 2009-03-05 | Smithkline Beecham Corp | Indol carboxamidas como inhibidores de ikk2 |
GB0710528D0 (en) * | 2007-06-01 | 2007-07-11 | Glaxo Group Ltd | Novel compounds |
-
2004
- 2004-01-15 GB GBGB0400895.9A patent/GB0400895D0/en not_active Ceased
-
2005
- 2005-01-13 WO PCT/GB2005/000085 patent/WO2005067923A1/fr active Application Filing
- 2005-01-13 AT AT05701855T patent/ATE413877T1/de not_active IP Right Cessation
- 2005-01-13 SI SI200530567T patent/SI1703905T1/sl unknown
- 2005-01-13 JP JP2006548393A patent/JP4975447B2/ja not_active Expired - Fee Related
- 2005-01-13 AU AU2005205090A patent/AU2005205090A1/en not_active Abandoned
- 2005-01-13 BR BRPI0506802-9A patent/BRPI0506802A/pt not_active IP Right Cessation
- 2005-01-13 DE DE602005010970T patent/DE602005010970D1/de active Active
- 2005-01-13 CA CA002552953A patent/CA2552953A1/fr not_active Abandoned
- 2005-01-13 PL PL05701855T patent/PL1703905T3/pl unknown
- 2005-01-13 US US10/597,154 patent/US20080269200A1/en not_active Abandoned
- 2005-01-13 RU RU2006129492/04A patent/RU2006129492A/ru not_active Application Discontinuation
- 2005-01-13 DK DK05701855T patent/DK1703905T3/da active
- 2005-01-13 PT PT05701855T patent/PT1703905E/pt unknown
- 2005-01-13 ES ES05701855T patent/ES2317184T3/es active Active
- 2005-01-13 CN CNA2005800083624A patent/CN1933830A/zh active Pending
- 2005-01-13 EP EP05701855A patent/EP1703905B1/fr active Active
- 2005-01-13 KR KR1020067014178A patent/KR20070026357A/ko not_active Application Discontinuation
-
2006
- 2006-06-13 ZA ZA200604855A patent/ZA200604855B/xx unknown
- 2006-07-03 MA MA29154A patent/MA28279A1/fr unknown
- 2006-07-06 IL IL176739A patent/IL176739A0/en unknown
- 2006-08-15 NO NO20063676A patent/NO20063676L/no not_active Application Discontinuation
-
2007
- 2007-03-16 HK HK07102877.7A patent/HK1098047A1/xx not_active IP Right Cessation
-
2009
- 2009-02-05 HR HR20090071T patent/HRP20090071T3/xx unknown
-
2011
- 2011-09-01 JP JP2011190903A patent/JP2012025761A/ja not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
DE602005010970D1 (de) | 2008-12-24 |
CN1933830A (zh) | 2007-03-21 |
JP4975447B2 (ja) | 2012-07-11 |
PT1703905E (pt) | 2009-02-04 |
EP1703905A1 (fr) | 2006-09-27 |
JP2012025761A (ja) | 2012-02-09 |
US20080269200A1 (en) | 2008-10-30 |
IL176739A0 (en) | 2006-10-31 |
ES2317184T3 (es) | 2009-04-16 |
RU2006129492A (ru) | 2008-02-27 |
ATE413877T1 (de) | 2008-11-15 |
SI1703905T1 (sl) | 2009-04-30 |
CA2552953A1 (fr) | 2005-07-28 |
HRP20090071T3 (en) | 2009-04-30 |
NO20063676L (no) | 2006-10-13 |
ZA200604855B (en) | 2007-11-28 |
HK1098047A1 (en) | 2007-07-13 |
JP2007517848A (ja) | 2007-07-05 |
PL1703905T3 (pl) | 2009-04-30 |
BRPI0506802A (pt) | 2007-05-29 |
KR20070026357A (ko) | 2007-03-08 |
MA28279A1 (fr) | 2006-11-01 |
AU2005205090A1 (en) | 2005-07-28 |
EP1703905B1 (fr) | 2008-11-12 |
WO2005067923A1 (fr) | 2005-07-28 |
GB0400895D0 (en) | 2004-02-18 |
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