ATE413877T1 - Indol-derivate und ihre verwendung als kinase- hemmer, insbesondere ikk2-hemmer - Google Patents
Indol-derivate und ihre verwendung als kinase- hemmer, insbesondere ikk2-hemmerInfo
- Publication number
- ATE413877T1 ATE413877T1 AT05701855T AT05701855T ATE413877T1 AT E413877 T1 ATE413877 T1 AT E413877T1 AT 05701855 T AT05701855 T AT 05701855T AT 05701855 T AT05701855 T AT 05701855T AT E413877 T1 ATE413877 T1 AT E413877T1
- Authority
- AT
- Austria
- Prior art keywords
- inhibitors
- indole derivatives
- kinase inhibitors
- particular ikk2
- kinase
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Communicable Diseases (AREA)
- Dermatology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Oncology (AREA)
- Virology (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Obesity (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0400895.9A GB0400895D0 (en) | 2004-01-15 | 2004-01-15 | Chemical compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE413877T1 true ATE413877T1 (de) | 2008-11-15 |
Family
ID=31726240
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT05701855T ATE413877T1 (de) | 2004-01-15 | 2005-01-13 | Indol-derivate und ihre verwendung als kinase- hemmer, insbesondere ikk2-hemmer |
Country Status (24)
Country | Link |
---|---|
US (1) | US20080269200A1 (de) |
EP (1) | EP1703905B1 (de) |
JP (2) | JP4975447B2 (de) |
KR (1) | KR20070026357A (de) |
CN (1) | CN1933830A (de) |
AT (1) | ATE413877T1 (de) |
AU (1) | AU2005205090A1 (de) |
BR (1) | BRPI0506802A (de) |
CA (1) | CA2552953A1 (de) |
DE (1) | DE602005010970D1 (de) |
DK (1) | DK1703905T3 (de) |
ES (1) | ES2317184T3 (de) |
GB (1) | GB0400895D0 (de) |
HK (1) | HK1098047A1 (de) |
HR (1) | HRP20090071T3 (de) |
IL (1) | IL176739A0 (de) |
MA (1) | MA28279A1 (de) |
NO (1) | NO20063676L (de) |
PL (1) | PL1703905T3 (de) |
PT (1) | PT1703905E (de) |
RU (1) | RU2006129492A (de) |
SI (1) | SI1703905T1 (de) |
WO (1) | WO2005067923A1 (de) |
ZA (1) | ZA200604855B (de) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PE20060373A1 (es) | 2004-06-24 | 2006-04-29 | Smithkline Beecham Corp | Derivados 3-piperidinil-7-carboxamida-indazol como inhibidores de la actividad cinasa de ikk2 |
PE20060748A1 (es) * | 2004-09-21 | 2006-10-01 | Smithkline Beecham Corp | Derivados de indolcarboxamida como inhibidores de quinasa ikk2 |
US8063071B2 (en) | 2007-10-31 | 2011-11-22 | GlaxoSmithKline, LLC | Chemical compounds |
PE20070173A1 (es) * | 2005-06-30 | 2007-03-14 | Smithkline Beecham Corp | Compuestos de indol carboxamidas como inhibidores de ikk2 |
US20080242685A1 (en) * | 2005-10-25 | 2008-10-02 | Smithkline Beecham Corporation | Chemical Compounds |
US20080269291A1 (en) * | 2005-11-18 | 2008-10-30 | Kerns Jeffrey K | Chemical Compounds |
EP1959737A4 (de) * | 2005-12-16 | 2010-12-08 | Glaxosmithkline Llc | Chemische verbindungen |
WO2008087933A1 (ja) * | 2007-01-15 | 2008-07-24 | Santen Pharmaceutical Co., Ltd. | IκBキナーゼβ阻害活性を有する新規インドール誘導体 |
AR065804A1 (es) | 2007-03-23 | 2009-07-01 | Smithkline Beecham Corp | Compuesto de indol carboxamida, composicion farmaceutica que lo comprende y uso de dicho compuesto para preparar un medicamento |
EA019309B1 (ru) | 2008-02-04 | 2014-02-28 | Меркьюри Терапьютикс, Инк. | Модуляторы ampk (амф-активируемой протеинкиназы) |
EP2253618A1 (de) * | 2008-02-27 | 2010-11-24 | Takeda Pharmaceutical Company Limited | Verbindung mit 6-gliedrigem aromatischem ring |
WO2010007972A1 (ja) * | 2008-07-14 | 2010-01-21 | 参天製薬株式会社 | カルバモイル基、ウレイド基及び置換オキシ基を有する新規インドール誘導体 |
KR20110125258A (ko) * | 2009-03-05 | 2011-11-18 | 스미또모 가가꾸 가부시끼가이샤 | 할로겐 치환 벤젠디메탄올의 제조 방법 |
EP2406249A1 (de) | 2009-03-10 | 2012-01-18 | Glaxo Group Limited | Indolderivate als ikk2-inhibitoren |
EP2646020B1 (de) * | 2010-12-01 | 2016-09-21 | Glaxosmithkline LLC | Indole |
WO2014036268A2 (en) * | 2012-08-29 | 2014-03-06 | Mount Sinai School Of Medicine | Indole derivatives as sumo activators |
FR3001219A1 (fr) * | 2013-01-22 | 2014-07-25 | Centre Nat Rech Scient | Inhibiteurs de kinases |
WO2014121055A2 (en) | 2013-02-04 | 2014-08-07 | Janssen Pharmaceutica Nv | Flap modulators |
TWI644899B (zh) | 2013-02-04 | 2018-12-21 | 健生藥品公司 | Flap調節劑 |
UY35630A (es) * | 2013-06-26 | 2015-01-30 | Abbvie Inc | Carboxamidas primarias como inhibidores de btk |
WO2016096778A1 (en) * | 2014-12-18 | 2016-06-23 | F. Hoffmann-La Roche Ag | Benzazepine sulfonamide compounds |
WO2017096045A1 (en) * | 2015-12-02 | 2017-06-08 | Kyras Therapeutics, Inc. | Multivalent ras binding compounds |
WO2018013430A2 (en) | 2016-07-12 | 2018-01-18 | Arisan Therapeutics Inc. | Heterocyclic compounds for the treatment of arenavirus infection |
EP3636642A4 (de) | 2017-06-07 | 2021-03-24 | Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences | Indolessigsäurederivat und herstellungsverfahren sowie pharmazeutische verwendung davon |
WO2024059220A2 (en) * | 2022-09-15 | 2024-03-21 | Vanderbilt University | 6,5 southwestern core compounds as mglu5 negative allosteric modulators and methods of making and using the same |
Family Cites Families (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4775761A (en) * | 1983-08-22 | 1988-10-04 | Hoechst-Roussel Pharmaceuticals, Inc. | 3-(piperidinyl)- and 3-(pyrrolidinyl)-1H-indazoles |
US5256673A (en) * | 1983-11-25 | 1993-10-26 | Merck Patent Gesellschaft Mit Beschrankter Haftung | Indole-3-yl-A-tetrahydropyridyl or piperidyl compounds |
DE3342632A1 (de) * | 1983-11-25 | 1985-06-05 | Merck Patent Gmbh, 6100 Darmstadt | Indolderivate |
JPH0262875A (ja) * | 1988-05-23 | 1990-03-02 | Wakunaga Pharmaceut Co Ltd | 新規イソインドリン誘導体 |
US5254473A (en) * | 1990-03-16 | 1993-10-19 | Jp Laboratories | Solid state device for monitoring integral values of time and temperature of storage of perishables |
US5330986A (en) * | 1992-11-24 | 1994-07-19 | Hoechst-Roussel Pharmaceuticals Inc. | Indole-7-carboxamide derivatives |
ZA951822B (en) * | 1994-12-23 | 1996-09-26 | Glaxo Group Ltd | Chemical compounds |
DE19756036A1 (de) * | 1997-12-17 | 1999-06-24 | Merck Patent Gmbh | Amid- und Harnstoffderivate |
US6589954B1 (en) * | 1998-05-22 | 2003-07-08 | Scios, Inc. | Compounds and methods to treat cardiac failure and other disorders |
CA2380373A1 (en) * | 1999-08-13 | 2001-02-22 | Seth Lederman | Cyclobenzaprine for treating generalized anxiety disorder and compositions thereof |
US6245799B1 (en) * | 1999-11-08 | 2001-06-12 | American Home Products Corp | [(Indol-3-yl)-cycloalkyl]-3-substituted azetidines for the treatment of central nervous system disorders |
AU2001255538B2 (en) * | 2000-04-24 | 2006-03-30 | Bristol-Myers Squibb Company | Heterocycles that are inhibitors of IMPDH enzyme |
US20050009876A1 (en) * | 2000-07-31 | 2005-01-13 | Bhagwat Shripad S. | Indazole compounds, compositions thereof and methods of treatment therewith |
US6897231B2 (en) * | 2000-07-31 | 2005-05-24 | Signal Pharmaceuticals, Inc. | Indazole derivatives as JNK inhibitors and compositions and methods related thereto |
AU2001288714A1 (en) * | 2000-09-06 | 2002-03-22 | Ortho-Mcneil Pharmaceutical, Inc. | A method for treating allergies |
US6869956B2 (en) * | 2000-10-03 | 2005-03-22 | Bristol-Myers Squibb Company | Methods of treating inflammatory and immune diseases using inhibitors of IκB kinase (IKK) |
MXPA03003599A (es) * | 2000-10-26 | 2003-08-01 | Tularik Inc | Agentes antiinflamatorios. |
JP4187642B2 (ja) * | 2001-06-07 | 2008-11-26 | エフ.ホフマン−ラ ロシュ アーゲー | 5−ht6受容体親和性を有する新規インドール誘導体 |
CA2460942A1 (en) * | 2001-09-19 | 2003-03-27 | Pharmacia Corporation | Substituted pyrazolyl compounds for the treatment of inflammation |
EP1444010A2 (de) * | 2001-10-30 | 2004-08-11 | Pharmacia Corporation | Heteroaromatische carbonsäureamid-derivate zur behandlung von entzündungen |
AU2003224257A1 (en) * | 2002-04-09 | 2003-10-27 | Astex Technology Limited | Heterocyclic compounds and their use as modulators of p38 map kinase |
AR039280A1 (es) * | 2002-04-11 | 2005-02-16 | Smithkline Beecham Corp | Compuesto de aminotiofeno y su uso para preparar una composicion farmaceutica |
EP1569911B1 (de) * | 2002-12-02 | 2008-07-02 | F. Hoffmann-La Roche Ag | Indazolderivate und ihre verwendung als crf antagonisten |
US20060116419A1 (en) * | 2002-12-06 | 2006-06-01 | Callahan James F | Nf-kb inhibitors |
JP2007514759A (ja) * | 2003-12-19 | 2007-06-07 | タケダ サン ディエゴ インコーポレイテッド | キナーゼ阻害剤 |
DE102004012069A1 (de) * | 2004-03-12 | 2005-09-29 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue aryl-haltige 5-Acylindolinone, deren Herstellung und deren Verwendung als Arzneimittel |
PE20060373A1 (es) * | 2004-06-24 | 2006-04-29 | Smithkline Beecham Corp | Derivados 3-piperidinil-7-carboxamida-indazol como inhibidores de la actividad cinasa de ikk2 |
PE20060748A1 (es) * | 2004-09-21 | 2006-10-01 | Smithkline Beecham Corp | Derivados de indolcarboxamida como inhibidores de quinasa ikk2 |
JP5833804B2 (ja) * | 2005-04-13 | 2015-12-16 | ニューラクソン,インコーポレーテッド | Nos阻害活性を有する置換インドール化合物 |
US8063071B2 (en) * | 2007-10-31 | 2011-11-22 | GlaxoSmithKline, LLC | Chemical compounds |
WO2007010964A1 (ja) * | 2005-07-22 | 2007-01-25 | Shionogi & Co., Ltd. | Pgd2受容体アンタゴニスト活性を有するインドール誘導体 |
WO2007102883A2 (en) * | 2005-10-25 | 2007-09-13 | Smithkline Beecham Corporation | Chemical compounds |
US20080242685A1 (en) * | 2005-10-25 | 2008-10-02 | Smithkline Beecham Corporation | Chemical Compounds |
US20080269291A1 (en) * | 2005-11-18 | 2008-10-30 | Kerns Jeffrey K | Chemical Compounds |
EP1959737A4 (de) * | 2005-12-16 | 2010-12-08 | Glaxosmithkline Llc | Chemische verbindungen |
MX2008012482A (es) * | 2006-03-31 | 2008-10-10 | Abbott Lab | Compuestos de indazol. |
ATE493411T1 (de) * | 2006-09-22 | 2011-01-15 | Glaxo Group Ltd | Pyrroloä2, 3-büpyridin-4-yl- benzolsulfonamidverbindungen als ikk2-hemmer |
AR065804A1 (es) * | 2007-03-23 | 2009-07-01 | Smithkline Beecham Corp | Compuesto de indol carboxamida, composicion farmaceutica que lo comprende y uso de dicho compuesto para preparar un medicamento |
GB0710528D0 (en) * | 2007-06-01 | 2007-07-11 | Glaxo Group Ltd | Novel compounds |
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2004
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- 2005-01-13 SI SI200530567T patent/SI1703905T1/sl unknown
- 2005-01-13 BR BRPI0506802-9A patent/BRPI0506802A/pt not_active IP Right Cessation
- 2005-01-13 DK DK05701855T patent/DK1703905T3/da active
- 2005-01-13 CN CNA2005800083624A patent/CN1933830A/zh active Pending
- 2005-01-13 RU RU2006129492/04A patent/RU2006129492A/ru not_active Application Discontinuation
- 2005-01-13 ES ES05701855T patent/ES2317184T3/es active Active
- 2005-01-13 WO PCT/GB2005/000085 patent/WO2005067923A1/en active Application Filing
- 2005-01-13 KR KR1020067014178A patent/KR20070026357A/ko not_active Application Discontinuation
- 2005-01-13 JP JP2006548393A patent/JP4975447B2/ja not_active Expired - Fee Related
- 2005-01-13 CA CA002552953A patent/CA2552953A1/en not_active Abandoned
- 2005-01-13 EP EP05701855A patent/EP1703905B1/de active Active
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- 2005-01-13 US US10/597,154 patent/US20080269200A1/en not_active Abandoned
- 2005-01-13 AU AU2005205090A patent/AU2005205090A1/en not_active Abandoned
- 2005-01-13 PT PT05701855T patent/PT1703905E/pt unknown
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- 2006-07-06 IL IL176739A patent/IL176739A0/en unknown
- 2006-08-15 NO NO20063676A patent/NO20063676L/no not_active Application Discontinuation
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Also Published As
Publication number | Publication date |
---|---|
HK1098047A1 (en) | 2007-07-13 |
KR20070026357A (ko) | 2007-03-08 |
WO2005067923A1 (en) | 2005-07-28 |
IL176739A0 (en) | 2006-10-31 |
PT1703905E (pt) | 2009-02-04 |
AU2005205090A1 (en) | 2005-07-28 |
EP1703905A1 (de) | 2006-09-27 |
JP2007517848A (ja) | 2007-07-05 |
HRP20090071T3 (en) | 2009-04-30 |
US20080269200A1 (en) | 2008-10-30 |
SI1703905T1 (sl) | 2009-04-30 |
DK1703905T3 (da) | 2009-02-16 |
JP2012025761A (ja) | 2012-02-09 |
JP4975447B2 (ja) | 2012-07-11 |
CA2552953A1 (en) | 2005-07-28 |
EP1703905B1 (de) | 2008-11-12 |
ES2317184T3 (es) | 2009-04-16 |
DE602005010970D1 (de) | 2008-12-24 |
BRPI0506802A (pt) | 2007-05-29 |
GB0400895D0 (en) | 2004-02-18 |
RU2006129492A (ru) | 2008-02-27 |
MA28279A1 (fr) | 2006-11-01 |
NO20063676L (no) | 2006-10-13 |
ZA200604855B (en) | 2007-11-28 |
PL1703905T3 (pl) | 2009-04-30 |
CN1933830A (zh) | 2007-03-21 |
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