MA28279A1 - Derives d'indole et utilisation de ceux-ci comme inhibiteurs de kinase, notamment des inhibiteurs de ikk2 - Google Patents
Derives d'indole et utilisation de ceux-ci comme inhibiteurs de kinase, notamment des inhibiteurs de ikk2Info
- Publication number
- MA28279A1 MA28279A1 MA29154A MA29154A MA28279A1 MA 28279 A1 MA28279 A1 MA 28279A1 MA 29154 A MA29154 A MA 29154A MA 29154 A MA29154 A MA 29154A MA 28279 A1 MA28279 A1 MA 28279A1
- Authority
- MA
- Morocco
- Prior art keywords
- inhibitors
- indole derivatives
- kinase inhibitors
- particular ikk2
- kinase
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P11/08—Bronchodilators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P17/04—Antipruritics
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- A—HUMAN NECESSITIES
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- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Dermatology (AREA)
- Neurosurgery (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Virology (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Transplantation (AREA)
- Endocrinology (AREA)
- Molecular Biology (AREA)
- AIDS & HIV (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
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Abstract
La présente invention se rapporte à un dispositif d'économie quantifiée de l'eau pour les toilettes utilisant un mécanisme de double chasse avec un seul bouton-poussoir (11) qui actionne, en déplaçant vers le haut, un tuyau de trop-5 plein (3), muni d'un flotteur (5) capable de maintenir le dispositif ouvert jusqu'à la chasse complète s'il n'y a pas d'autres forces agissant sur ledit tuyau sauf son propre poids, et il a aussi un poids additionnel variable (6) placé à une hauteur intermédiaire qui, dans une première pression instantanée, agit avec le poids de l'ensemble, fermant la vanne d'évacuation (4) avant la vidange complète, un volume préétabli d'eau demeurant dans le réservoir, alors qu'en exerçant une deuxième pression pendant le remplissage de ce dernier, le tuyau (3) demeure en position soulevée et la vanne d'évacuation (4) ouverte jusqu'à la vidange complète du réservoir comme le poids additionnel variable (6) disparaît; il suffit que la deuxième pression soit instantanée pour réaliser une chasse complète.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0400895.9A GB0400895D0 (en) | 2004-01-15 | 2004-01-15 | Chemical compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
MA28279A1 true MA28279A1 (fr) | 2006-11-01 |
Family
ID=31726240
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA29154A MA28279A1 (fr) | 2004-01-15 | 2006-07-03 | Derives d'indole et utilisation de ceux-ci comme inhibiteurs de kinase, notamment des inhibiteurs de ikk2 |
Country Status (24)
Country | Link |
---|---|
US (1) | US20080269200A1 (fr) |
EP (1) | EP1703905B1 (fr) |
JP (2) | JP4975447B2 (fr) |
KR (1) | KR20070026357A (fr) |
CN (1) | CN1933830A (fr) |
AT (1) | ATE413877T1 (fr) |
AU (1) | AU2005205090A1 (fr) |
BR (1) | BRPI0506802A (fr) |
CA (1) | CA2552953A1 (fr) |
DE (1) | DE602005010970D1 (fr) |
DK (1) | DK1703905T3 (fr) |
ES (1) | ES2317184T3 (fr) |
GB (1) | GB0400895D0 (fr) |
HK (1) | HK1098047A1 (fr) |
HR (1) | HRP20090071T3 (fr) |
IL (1) | IL176739A0 (fr) |
MA (1) | MA28279A1 (fr) |
NO (1) | NO20063676L (fr) |
PL (1) | PL1703905T3 (fr) |
PT (1) | PT1703905E (fr) |
RU (1) | RU2006129492A (fr) |
SI (1) | SI1703905T1 (fr) |
WO (1) | WO2005067923A1 (fr) |
ZA (1) | ZA200604855B (fr) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR050253A1 (es) * | 2004-06-24 | 2006-10-11 | Smithkline Beecham Corp | Compuesto derivado de indazol carboxamida, composicion que lo comprende y su uso para la preparacion de un medicamento |
TW200626142A (en) * | 2004-09-21 | 2006-08-01 | Glaxo Group Ltd | Chemical compounds |
US8063071B2 (en) | 2007-10-31 | 2011-11-22 | GlaxoSmithKline, LLC | Chemical compounds |
UA99699C2 (ru) * | 2005-06-30 | 2012-09-25 | Смитклайн Бичам Корпорейшн | Производные индолкарбоксамида и фармацевтическая композиция, которая их содержит |
EP1940296A2 (fr) * | 2005-10-25 | 2008-07-09 | SmithKline Beecham Corporation | Composés chimiques |
JP2009516702A (ja) * | 2005-11-18 | 2009-04-23 | スミスクライン・ビーチャム・コーポレイション | 化合物 |
JP2009519968A (ja) * | 2005-12-16 | 2009-05-21 | スミスクライン・ビーチャム・コーポレイション | 化学物質 |
DK2119703T3 (da) * | 2007-01-15 | 2013-01-14 | Santen Pharmaceutical Co Ltd | Nyt indolderivat med inhiberende virkning på I-B-kinase. |
PE20081889A1 (es) * | 2007-03-23 | 2009-03-05 | Smithkline Beecham Corp | Indol carboxamidas como inhibidores de ikk2 |
US8273744B2 (en) * | 2008-02-04 | 2012-09-25 | Mercury Therapeutics, Inc. | AMPK modulators |
US20110009421A1 (en) * | 2008-02-27 | 2011-01-13 | Takeda Pharmaceutical Company Limited | Compound having 6-membered aromatic ring |
KR20110031481A (ko) * | 2008-07-14 | 2011-03-28 | 산텐 세이야꾸 가부시키가이샤 | 카르바모일기, 우레이드기 및 치환 옥시기를 갖는 신규 인돌 유도체 |
EP2404897A4 (fr) * | 2009-03-05 | 2014-02-26 | Sumitomo Chemical Co | Procédé de production de benzène diméthanol à substitution halogène |
US8354539B2 (en) | 2009-03-10 | 2013-01-15 | Glaxo Group Limited | Indole derivatives as IKK2 inhibitors |
US8765792B2 (en) | 2010-12-01 | 2014-07-01 | Glaxosmithkline Llc | Indoles |
WO2014036268A2 (fr) * | 2012-08-29 | 2014-03-06 | Mount Sinai School Of Medicine | Dérivés d'indole en tant qu'activateurs de la protéine sumo |
FR3001219A1 (fr) * | 2013-01-22 | 2014-07-25 | Centre Nat Rech Scient | Inhibiteurs de kinases |
US9079866B2 (en) | 2013-02-04 | 2015-07-14 | Janssen Pharmaceutica Nv | Flap modulators |
TWI644899B (zh) | 2013-02-04 | 2018-12-21 | 健生藥品公司 | Flap調節劑 |
ES2708998T3 (es) * | 2013-06-26 | 2019-04-12 | Abbvie Inc | Carboxamidas primarias como inhibidores de btk |
JP6644792B2 (ja) * | 2014-12-18 | 2020-02-12 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | ベンザゼピンスルホンアミド化合物 |
WO2017096045A1 (fr) * | 2015-12-02 | 2017-06-08 | Kyras Therapeutics, Inc. | Composés de liaison ras multivalents |
WO2018013430A2 (fr) | 2016-07-12 | 2018-01-18 | Arisan Therapeutics Inc. | Composés hétérocycliques pour le traitement d'une infection à arenavirus |
CN110418787B (zh) * | 2017-06-07 | 2022-09-13 | 中国中医科学院中药研究所 | 一种吲哚乙酸类衍生物及其制备方法和医药用途 |
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-
2004
- 2004-01-15 GB GBGB0400895.9A patent/GB0400895D0/en not_active Ceased
-
2005
- 2005-01-13 JP JP2006548393A patent/JP4975447B2/ja not_active Expired - Fee Related
- 2005-01-13 ES ES05701855T patent/ES2317184T3/es active Active
- 2005-01-13 KR KR1020067014178A patent/KR20070026357A/ko not_active Application Discontinuation
- 2005-01-13 CN CNA2005800083624A patent/CN1933830A/zh active Pending
- 2005-01-13 RU RU2006129492/04A patent/RU2006129492A/ru not_active Application Discontinuation
- 2005-01-13 CA CA002552953A patent/CA2552953A1/fr not_active Abandoned
- 2005-01-13 WO PCT/GB2005/000085 patent/WO2005067923A1/fr active Application Filing
- 2005-01-13 EP EP05701855A patent/EP1703905B1/fr active Active
- 2005-01-13 PL PL05701855T patent/PL1703905T3/pl unknown
- 2005-01-13 DK DK05701855T patent/DK1703905T3/da active
- 2005-01-13 PT PT05701855T patent/PT1703905E/pt unknown
- 2005-01-13 US US10/597,154 patent/US20080269200A1/en not_active Abandoned
- 2005-01-13 AT AT05701855T patent/ATE413877T1/de not_active IP Right Cessation
- 2005-01-13 DE DE602005010970T patent/DE602005010970D1/de active Active
- 2005-01-13 BR BRPI0506802-9A patent/BRPI0506802A/pt not_active IP Right Cessation
- 2005-01-13 SI SI200530567T patent/SI1703905T1/sl unknown
- 2005-01-13 AU AU2005205090A patent/AU2005205090A1/en not_active Abandoned
-
2006
- 2006-06-13 ZA ZA200604855A patent/ZA200604855B/xx unknown
- 2006-07-03 MA MA29154A patent/MA28279A1/fr unknown
- 2006-07-06 IL IL176739A patent/IL176739A0/en unknown
- 2006-08-15 NO NO20063676A patent/NO20063676L/no not_active Application Discontinuation
-
2007
- 2007-03-16 HK HK07102877.7A patent/HK1098047A1/xx not_active IP Right Cessation
-
2009
- 2009-02-05 HR HR20090071T patent/HRP20090071T3/xx unknown
-
2011
- 2011-09-01 JP JP2011190903A patent/JP2012025761A/ja not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
AU2005205090A1 (en) | 2005-07-28 |
ES2317184T3 (es) | 2009-04-16 |
NO20063676L (no) | 2006-10-13 |
SI1703905T1 (sl) | 2009-04-30 |
CN1933830A (zh) | 2007-03-21 |
JP4975447B2 (ja) | 2012-07-11 |
HK1098047A1 (en) | 2007-07-13 |
RU2006129492A (ru) | 2008-02-27 |
BRPI0506802A (pt) | 2007-05-29 |
GB0400895D0 (en) | 2004-02-18 |
KR20070026357A (ko) | 2007-03-08 |
IL176739A0 (en) | 2006-10-31 |
ATE413877T1 (de) | 2008-11-15 |
JP2007517848A (ja) | 2007-07-05 |
JP2012025761A (ja) | 2012-02-09 |
PT1703905E (pt) | 2009-02-04 |
PL1703905T3 (pl) | 2009-04-30 |
EP1703905B1 (fr) | 2008-11-12 |
EP1703905A1 (fr) | 2006-09-27 |
ZA200604855B (en) | 2007-11-28 |
WO2005067923A1 (fr) | 2005-07-28 |
DK1703905T3 (da) | 2009-02-16 |
US20080269200A1 (en) | 2008-10-30 |
CA2552953A1 (fr) | 2005-07-28 |
HRP20090071T3 (en) | 2009-04-30 |
DE602005010970D1 (de) | 2008-12-24 |
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