BR0213464A - Derivados de 3-azabiciclo[3.1.0]hexano como antagonistas receptores de opióide - Google Patents

Derivados de 3-azabiciclo[3.1.0]hexano como antagonistas receptores de opióide

Info

Publication number
BR0213464A
BR0213464A BR0213464-0A BR0213464A BR0213464A BR 0213464 A BR0213464 A BR 0213464A BR 0213464 A BR0213464 A BR 0213464A BR 0213464 A BR0213464 A BR 0213464A
Authority
BR
Brazil
Prior art keywords
receptor antagonists
opioid receptor
azabicyclo
hexane derivatives
formula
Prior art date
Application number
BR0213464-0A
Other languages
English (en)
Inventor
Stanton Furst Mchardy
Spiros Liras
Steven Donald Heck
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of BR0213464A publication Critical patent/BR0213464A/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/04—Compounds containing oxirane rings containing only hydrogen and carbon atoms in addition to the ring oxygen atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Child & Adolescent Psychology (AREA)
  • Psychology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Nutrition Science (AREA)
  • Dermatology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

"DERIVADOS DE 3-AZABICICLO[3.1.O]HEXANO COMO ANTAGONISTAS RECEPTORES DE OPIóIDE". A presente invenção fornece um composto de fórmula I, em que X, Q, n, R^ 1^, R^ 2^, R^ 3^, R^ 4^, R^ 5^, R^ 6^, R^ 7^, R^ 8^, R^ 9^, e R^ 10^ são como definido. Os compostos de fórmula I têm atividade como antagonistas receptores oplóides. A presente invenção ainda fornece composições farmacêuticas e métodos terapêuticos compreendendo combinações da fórmula I.
BR0213464-0A 2001-10-22 2002-09-09 Derivados de 3-azabiciclo[3.1.0]hexano como antagonistas receptores de opióide BR0213464A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33851101P 2001-10-22 2001-10-22
PCT/IB2002/003668 WO2003035622A1 (en) 2001-10-22 2002-09-09 3-azabicyclo (3.1.0) hexane derivatives as opioid receptor antagonists

Publications (1)

Publication Number Publication Date
BR0213464A true BR0213464A (pt) 2004-11-09

Family

ID=23325099

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0213464-0A BR0213464A (pt) 2001-10-22 2002-09-09 Derivados de 3-azabiciclo[3.1.0]hexano como antagonistas receptores de opióide

Country Status (42)

Country Link
US (3) US7049335B2 (pt)
EP (1) EP1440059B1 (pt)
JP (2) JP4155522B2 (pt)
KR (1) KR100621292B1 (pt)
CN (1) CN100368398C (pt)
AP (1) AP1816A (pt)
AR (1) AR036905A1 (pt)
AT (1) ATE392415T1 (pt)
AU (1) AU2002329557B2 (pt)
BR (1) BR0213464A (pt)
CA (1) CA2463264C (pt)
CR (1) CR7317A (pt)
DE (1) DE60226161T2 (pt)
DK (1) DK1440059T3 (pt)
EA (1) EA006708B1 (pt)
EC (1) ECSP045077A (pt)
ES (1) ES2302839T3 (pt)
GE (1) GEP20084300B (pt)
GT (1) GT200200216A (pt)
HK (1) HK1072052A1 (pt)
HN (1) HN2002000299A (pt)
HR (1) HRP20040288A2 (pt)
HU (1) HUP0401884A2 (pt)
IL (2) IL161157A0 (pt)
IS (1) IS7187A (pt)
MA (1) MA27141A1 (pt)
MX (1) MXPA04003730A (pt)
MY (1) MY136580A (pt)
NO (1) NO329092B1 (pt)
NZ (1) NZ531807A (pt)
OA (1) OA12711A (pt)
PA (1) PA8556701A1 (pt)
PE (1) PE20030610A1 (pt)
PL (1) PL368919A1 (pt)
PT (1) PT1440059E (pt)
RS (1) RS25104A (pt)
SI (1) SI1440059T1 (pt)
SV (1) SV2004001363A (pt)
TN (1) TNSN04071A1 (pt)
UA (1) UA75714C2 (pt)
WO (1) WO2003035622A1 (pt)
ZA (1) ZA200402172B (pt)

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Also Published As

Publication number Publication date
MA27141A1 (fr) 2005-01-03
OA12711A (en) 2006-06-27
PA8556701A1 (es) 2003-07-28
WO2003035622A1 (en) 2003-05-01
NO20041626L (no) 2004-05-26
JP4155522B2 (ja) 2008-09-24
SV2004001363A (es) 2004-02-24
GEP20084300B (en) 2008-02-11
IL161157A0 (en) 2004-08-31
CR7317A (es) 2006-08-09
PT1440059E (pt) 2008-05-16
HRP20040288A2 (en) 2004-12-31
DK1440059T3 (da) 2008-07-14
IL161157A (en) 2009-09-01
JP2005511545A (ja) 2005-04-28
HN2002000299A (es) 2002-11-21
CA2463264A1 (en) 2003-05-01
AP2004003007A0 (en) 2004-06-30
CN1610664A (zh) 2005-04-27
CA2463264C (en) 2009-05-26
US20050171178A1 (en) 2005-08-04
PE20030610A1 (es) 2003-07-12
US20030087898A1 (en) 2003-05-08
EA006708B1 (ru) 2006-02-24
US7049335B2 (en) 2006-05-23
ATE392415T1 (de) 2008-05-15
ZA200402172B (en) 2006-09-27
GT200200216A (es) 2003-05-23
ES2302839T3 (es) 2008-08-01
MY136580A (en) 2008-10-31
AU2002329557B2 (en) 2008-07-31
ECSP045077A (es) 2004-05-28
KR100621292B1 (ko) 2006-09-13
HK1072052A1 (en) 2005-08-12
EP1440059B1 (en) 2008-04-16
IS7187A (is) 2004-03-18
NO329092B1 (no) 2010-08-23
NZ531807A (en) 2006-03-31
MXPA04003730A (es) 2004-07-23
EA200400467A1 (ru) 2004-08-26
AP1816A (en) 2008-01-04
KR20040048984A (ko) 2004-06-10
JP2008069169A (ja) 2008-03-27
HUP0401884A2 (hu) 2005-01-28
UA75714C2 (en) 2006-05-15
RS25104A (en) 2007-02-05
PL368919A1 (en) 2005-04-04
TNSN04071A1 (fr) 2006-06-01
CN100368398C (zh) 2008-02-13
SI1440059T1 (sl) 2008-08-31
US20070054950A1 (en) 2007-03-08
EP1440059A1 (en) 2004-07-28
DE60226161D1 (de) 2008-05-29
DE60226161T2 (de) 2009-07-02
AR036905A1 (es) 2004-10-13

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