DK1529044T5 - Dehydrophenylahistiner og analoger deraf og syntesen af dehydrophenylahistiner og analoger deraf - Google Patents
Dehydrophenylahistiner og analoger deraf og syntesen af dehydrophenylahistiner og analoger derafInfo
- Publication number
- DK1529044T5 DK1529044T5 DK03811651T DK03811651T DK1529044T5 DK 1529044 T5 DK1529044 T5 DK 1529044T5 DK 03811651 T DK03811651 T DK 03811651T DK 03811651 T DK03811651 T DK 03811651T DK 1529044 T5 DK1529044 T5 DK 1529044T5
- Authority
- DK
- Denmark
- Prior art keywords
- sub
- dehydrophenylahistins
- analogs
- aldehyde
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/14—Ectoparasiticides, e.g. scabicides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Oncology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Catalysts (AREA)
- Plural Heterocyclic Compounds (AREA)
- Steroid Compounds (AREA)
- Epoxy Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US40107402P | 2002-08-02 | 2002-08-02 | |
US41112802P | 2002-09-16 | 2002-09-16 | |
US45006303P | 2003-02-24 | 2003-02-24 | |
PCT/US2003/024232 WO2004054498A2 (en) | 2002-08-02 | 2003-08-01 | Dehydrophenylahistins and analogs thereof and the synthesis of dehydrophenylahistins and analogs thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
DK1529044T3 DK1529044T3 (da) | 2008-02-04 |
DK1529044T5 true DK1529044T5 (da) | 2008-04-21 |
Family
ID=32600863
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK03811651T DK1529044T5 (da) | 2002-08-02 | 2003-08-01 | Dehydrophenylahistiner og analoger deraf og syntesen af dehydrophenylahistiner og analoger deraf |
Country Status (20)
Country | Link |
---|---|
US (4) | US7064201B2 (da) |
EP (1) | EP1529044B1 (da) |
JP (1) | JP4616649B2 (da) |
KR (2) | KR101049100B1 (da) |
CN (1) | CN100540548C (da) |
AT (1) | ATE374767T1 (da) |
AU (1) | AU2003302721B2 (da) |
BR (2) | BR0313363A (da) |
CA (1) | CA2494049C (da) |
CO (1) | CO5721010A2 (da) |
DE (1) | DE60316688T2 (da) |
DK (1) | DK1529044T5 (da) |
ES (1) | ES2295695T3 (da) |
HK (2) | HK1078080A1 (da) |
IL (2) | IL166628A0 (da) |
MX (1) | MXPA05001217A (da) |
NZ (1) | NZ538433A (da) |
PT (1) | PT1529044E (da) |
WO (1) | WO2004054498A2 (da) |
ZA (1) | ZA200501616B (da) |
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US7026322B2 (en) * | 1998-11-12 | 2006-04-11 | Nereus Pharmaceuticals, Inc. | Phenylahistin and the phenylahistin analogs, a new class of anti-tumor compounds |
BRPI0017067B8 (pt) * | 2000-01-18 | 2021-05-25 | Beyondspring Pharmaceuticals Inc | inibidor de divisão de célula, desidrogenase, método para a produção de um inibidor de divisão de célula e composto |
ES2381775T3 (es) | 2000-08-04 | 2012-05-31 | Dmi Biosciences, Inc. | Procedimiento del uso de dicetopiperazinas y composición que las contiene |
US7935704B2 (en) * | 2003-08-01 | 2011-05-03 | Nereus Pharmaceuticals, Inc. | Dehydrophenylahistins and analogs thereof and the synthesis of dehydrophenylahistins and analogs thereof |
KR101049100B1 (ko) | 2002-08-02 | 2011-07-15 | 니리어스 파마슈티컬즈, 인코퍼레이션 | 데하이드로페닐아히스틴 및 그의 동족체, 및 이들의 합성방법 |
US7919497B2 (en) | 2002-08-02 | 2011-04-05 | Nereus Pharmaceuticals, Inc. | Analogs of dehydrophenylahistins and their therapeutic use |
AU2004241101B2 (en) | 2003-05-15 | 2010-05-13 | Ampio Pharmaceuticals, Inc. | Treatment of T-cell mediated diseases |
KR101228104B1 (ko) * | 2004-02-04 | 2013-02-01 | 니리어스 파마슈티컬즈, 인코퍼레이션 | 데하이드로페닐아히스틴 및 그의 동족체, 및 이들의합성방법 |
CN101111248A (zh) * | 2004-12-06 | 2008-01-23 | 新南部创新有限公司 | 癌症的治疗 |
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US8129527B2 (en) | 2006-11-03 | 2012-03-06 | Nereus Pharmacuticals, Inc. | Analogs of dehydrophenylahistins and their therapeutic use |
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CN107778297B (zh) * | 2016-08-12 | 2021-11-19 | 深圳华大海洋科技有限公司 | 氘代脱氢苯基阿夕斯丁类化合物的多晶型及其制备方法和应用 |
CN106565686B (zh) * | 2016-10-11 | 2019-03-01 | 深圳海王医药科技研究院有限公司 | 微管蛋白抑制剂 |
CN106565685B (zh) * | 2016-10-11 | 2019-03-01 | 深圳海王医药科技研究院有限公司 | 微管蛋白抑制剂 |
CN110431135A (zh) | 2017-01-06 | 2019-11-08 | 大连万春布林医药有限公司 | 微管蛋白结合化合物及其治疗用途 |
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CN108658945B (zh) * | 2017-03-31 | 2020-11-20 | 深圳海王医药科技研究院有限公司 | 一种微管蛋白抑制剂(vda-1)的a晶型 |
US11434225B2 (en) | 2017-08-03 | 2022-09-06 | Pliva Hrvatska D.O.O. | Salts and solid state forms of plinabulin |
CN109498627B (zh) * | 2017-09-15 | 2021-06-04 | 深圳华大海洋科技有限公司 | 一种***的药物组合物及其应用 |
CN111018840B (zh) * | 2017-10-25 | 2022-09-09 | 西南大学 | 3-咪唑取代的靛红唑醇类化合物及其制备方法和医药应用 |
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CN108299399A (zh) * | 2018-02-01 | 2018-07-20 | 深圳海王医药科技研究院有限公司 | 一种小分子免疫化合物的晶型、其制备方法和含有其的药物组合物 |
JP7500438B2 (ja) * | 2018-06-01 | 2024-06-17 | ビヨンドスプリング ファーマシューティカルズ,インコーポレイテッド | Egfr変異に関連する癌の治療組成物及び治療方法 |
CN109030642B (zh) * | 2018-06-26 | 2021-03-09 | 深圳海王医药科技研究院有限公司 | 一种脱氢苯基阿夕斯丁类似物及其异构体的测定方法 |
CN111840291B (zh) * | 2020-07-14 | 2021-12-21 | 深圳海王医药科技研究院有限公司 | 一种在肿瘤治疗中具有增效作用的化合物的应用 |
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US7919497B2 (en) | 2002-08-02 | 2011-04-05 | Nereus Pharmaceuticals, Inc. | Analogs of dehydrophenylahistins and their therapeutic use |
KR101049100B1 (ko) | 2002-08-02 | 2011-07-15 | 니리어스 파마슈티컬즈, 인코퍼레이션 | 데하이드로페닐아히스틴 및 그의 동족체, 및 이들의 합성방법 |
KR101228104B1 (ko) | 2004-02-04 | 2013-02-01 | 니리어스 파마슈티컬즈, 인코퍼레이션 | 데하이드로페닐아히스틴 및 그의 동족체, 및 이들의합성방법 |
US8129527B2 (en) * | 2006-11-03 | 2012-03-06 | Nereus Pharmacuticals, Inc. | Analogs of dehydrophenylahistins and their therapeutic use |
-
2003
- 2003-08-01 KR KR1020057001947A patent/KR101049100B1/ko active IP Right Grant
- 2003-08-01 AU AU2003302721A patent/AU2003302721B2/en not_active Expired
- 2003-08-01 CA CA2494049A patent/CA2494049C/en not_active Expired - Lifetime
- 2003-08-01 DE DE60316688T patent/DE60316688T2/de not_active Expired - Lifetime
- 2003-08-01 MX MXPA05001217A patent/MXPA05001217A/es active IP Right Grant
- 2003-08-01 DK DK03811651T patent/DK1529044T5/da active
- 2003-08-01 US US10/632,531 patent/US7064201B2/en not_active Expired - Lifetime
- 2003-08-01 BR BR0313363-0A patent/BR0313363A/pt not_active Application Discontinuation
- 2003-08-01 CN CNB038234645A patent/CN100540548C/zh not_active Expired - Lifetime
- 2003-08-01 BR BRPI0313363A patent/BRPI0313363A8/pt unknown
- 2003-08-01 NZ NZ538433A patent/NZ538433A/en not_active IP Right Cessation
- 2003-08-01 JP JP2004560278A patent/JP4616649B2/ja not_active Expired - Lifetime
- 2003-08-01 EP EP03811651A patent/EP1529044B1/en not_active Expired - Lifetime
- 2003-08-01 PT PT03811651T patent/PT1529044E/pt unknown
- 2003-08-01 IL IL16662803A patent/IL166628A0/xx unknown
- 2003-08-01 ES ES03811651T patent/ES2295695T3/es not_active Expired - Lifetime
- 2003-08-01 WO PCT/US2003/024232 patent/WO2004054498A2/en active IP Right Grant
- 2003-08-01 AT AT03811651T patent/ATE374767T1/de active
- 2003-08-01 KR KR1020117006692A patent/KR101184374B1/ko active IP Right Grant
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2005
- 2005-02-01 IL IL166628A patent/IL166628A/en active IP Right Grant
- 2005-02-24 ZA ZA2005/01616A patent/ZA200501616B/en unknown
- 2005-02-28 CO CO05018564A patent/CO5721010A2/es active IP Right Grant
- 2005-11-11 HK HK05110096A patent/HK1078080A1/xx not_active IP Right Cessation
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2006
- 2006-04-18 HK HK06104593.7A patent/HK1084388A1/xx not_active IP Right Cessation
- 2006-06-07 US US11/448,924 patent/US7956058B2/en active Active
- 2006-06-07 US US11/448,948 patent/US7674903B2/en active Active
- 2006-06-07 US US11/448,283 patent/US20060223822A1/en not_active Abandoned
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