DK1478650T3 - Nye boronatestere - Google Patents
Nye boronatestereInfo
- Publication number
- DK1478650T3 DK1478650T3 DK02707083.8T DK02707083T DK1478650T3 DK 1478650 T3 DK1478650 T3 DK 1478650T3 DK 02707083 T DK02707083 T DK 02707083T DK 1478650 T3 DK1478650 T3 DK 1478650T3
- Authority
- DK
- Denmark
- Prior art keywords
- new
- boronate esters
- pitavastatin
- cerivastatin
- rosuvastatin
- Prior art date
Links
- ZADPBFCGQRWHPN-UHFFFAOYSA-N boronic acid Chemical class OBO ZADPBFCGQRWHPN-UHFFFAOYSA-N 0.000 title abstract 2
- FJLGEFLZQAZZCD-MCBHFWOFSA-N (3R,5S)-fluvastatin Chemical compound C12=CC=CC=C2N(C(C)C)C(\C=C\[C@@H](O)C[C@@H](O)CC(O)=O)=C1C1=CC=C(F)C=C1 FJLGEFLZQAZZCD-MCBHFWOFSA-N 0.000 abstract 1
- CABVTRNMFUVUDM-VRHQGPGLSA-N (3S)-3-hydroxy-3-methylglutaryl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)C[C@@](O)(CC(O)=O)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 CABVTRNMFUVUDM-VRHQGPGLSA-N 0.000 abstract 1
- XUKUURHRXDUEBC-KAYWLYCHSA-N Atorvastatin Chemical compound C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CC[C@@H](O)C[C@@H](O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-KAYWLYCHSA-N 0.000 abstract 1
- XUKUURHRXDUEBC-UHFFFAOYSA-N Atorvastatin Natural products C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CCC(O)CC(O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-UHFFFAOYSA-N 0.000 abstract 1
- 229960005370 atorvastatin Drugs 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 229960005110 cerivastatin Drugs 0.000 abstract 1
- SEERZIQQUAZTOL-ANMDKAQQSA-N cerivastatin Chemical compound COCC1=C(C(C)C)N=C(C(C)C)C(\C=C\[C@@H](O)C[C@@H](O)CC(O)=O)=C1C1=CC=C(F)C=C1 SEERZIQQUAZTOL-ANMDKAQQSA-N 0.000 abstract 1
- 239000002532 enzyme inhibitor Substances 0.000 abstract 1
- 229960003765 fluvastatin Drugs 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 229960002797 pitavastatin Drugs 0.000 abstract 1
- VGYFMXBACGZSIL-MCBHFWOFSA-N pitavastatin Chemical compound OC(=O)C[C@H](O)C[C@H](O)\C=C\C1=C(C2CC2)N=C2C=CC=CC2=C1C1=CC=C(F)C=C1 VGYFMXBACGZSIL-MCBHFWOFSA-N 0.000 abstract 1
- 229960000672 rosuvastatin Drugs 0.000 abstract 1
- BPRHUIZQVSMCRT-VEUZHWNKSA-N rosuvastatin Chemical compound CC(C)C1=NC(N(C)S(C)(=O)=O)=NC(C=2C=CC(F)=CC=2)=C1\C=C\[C@@H](O)C[C@@H](O)CC(O)=O BPRHUIZQVSMCRT-VEUZHWNKSA-N 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Pyrrole Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP02707083A EP1478650B1 (en) | 2002-02-25 | 2002-02-25 | Novel boronate esters |
PCT/IN2002/000032 WO2003070733A1 (en) | 2002-02-25 | 2002-02-25 | Novel boronate esters |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1478650T3 true DK1478650T3 (da) | 2010-01-25 |
Family
ID=27742233
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK02707083.8T DK1478650T3 (da) | 2002-02-25 | 2002-02-25 | Nye boronatestere |
Country Status (21)
Country | Link |
---|---|
US (2) | US7301046B2 (da) |
EP (1) | EP1478650B1 (da) |
JP (1) | JP4139334B2 (da) |
KR (1) | KR100598079B1 (da) |
AT (1) | ATE444299T1 (da) |
AU (1) | AU2002241235B2 (da) |
BR (1) | BR0215602A (da) |
CA (1) | CA2475586C (da) |
CZ (1) | CZ2004863A3 (da) |
DE (1) | DE60233899D1 (da) |
DK (1) | DK1478650T3 (da) |
ES (1) | ES2332881T3 (da) |
HR (1) | HRP20040888B1 (da) |
HU (1) | HUP0500125A3 (da) |
IL (1) | IL163333A (da) |
NO (1) | NO20043223L (da) |
NZ (1) | NZ534688A (da) |
PT (1) | PT1478650E (da) |
RO (1) | RO122095B1 (da) |
SK (1) | SK288093B6 (da) |
WO (1) | WO2003070733A1 (da) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0011120D0 (en) * | 2000-05-09 | 2000-06-28 | Avecia Ltd | Process |
NL1015744C2 (nl) * | 2000-07-19 | 2002-01-22 | Dsm Nv | Werkwijze voor de bereiding van 2-(6-gesubstitueerde-1,3-dioxan-4-yl) azijnzuurderivaten. |
EP1323717A1 (en) * | 2001-12-27 | 2003-07-02 | Dsm N.V. | Process for the preparation of 2-(6-Substituted-1,3-Dioxane-4-yL) acetic acid derivatives |
DK1478650T3 (da) | 2002-02-25 | 2010-01-25 | Biocon Ltd | Nye boronatestere |
KR20090039738A (ko) * | 2006-07-19 | 2009-04-22 | 보드 오브 트러스티즈 오브 미시건 스테이트 유니버시티 | D-1,2,4-부탄트리올의 미생물 합성 |
US7879585B2 (en) | 2006-10-02 | 2011-02-01 | Codexis, Inc. | Ketoreductase enzymes and uses thereof |
KR100933172B1 (ko) | 2007-11-30 | 2009-12-21 | 씨제이제일제당 (주) | 아토르바스타틴 칼슘염의 개선된 제조방법 |
KR101339648B1 (ko) * | 2012-05-10 | 2013-12-09 | (주) 에프엔지리서치 | 신규한 아토바스타틴 중간체 및 이를 이용한 아토바스타틴의 제조 방법 |
KR101292743B1 (ko) * | 2012-05-17 | 2013-08-02 | (주) 에프엔지리서치 | 신규한 스타틴 중간체 및 이를 이용한 피타바스타틴, 로수바스타틴, 세리바스타틴 및 플루바스타틴의 제조 방법 |
KR101528359B1 (ko) * | 2013-04-24 | 2015-06-15 | (주) 성운파마코피아 | 스타틴 화합물 제조를 위한 신규한 보로네이트 에테르 화합물, 그 제조방법 및 상기 보로네이트 에테르 화합물을 이용한 스타틴 화합물 제조방법 |
CN108033899B (zh) * | 2017-12-06 | 2020-04-10 | 浙江科技学院 | 一种(r)-6-氰基-5-羟基-3-羰基己酸叔丁酯的制备方法 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4474034A (en) | 1982-09-23 | 1984-10-02 | Avery Jr Richard J | Refrigerant accumulator and charging apparatus and method for vapor-compression refrigeration system |
DE3741509A1 (de) | 1987-12-08 | 1989-06-22 | Hoechst Ag | Verfahren zur herstellung optisch aktiver 3-desmethylmevalonsaeurederivate sowie zwischenprodukte |
EP0579370B1 (en) | 1992-06-10 | 2000-08-16 | Chisso Corporation | An optically active 1,5-disubstituted-2,4-0-isoproylidene-2,4-dihydroxypentane and a process for producing the same |
DK0577040T3 (da) | 1992-07-02 | 1998-02-02 | Hoechst Ag | Fremgangsmåde til fremstilling af (3R,5S)6-hydroxy-3,,5-O-isopropyliden-3,5-dihydroxyhexansyre-tert.-butylester |
EP0643054A3 (en) | 1993-08-09 | 1995-05-03 | Fujirebio Kk | Process for the preparation of carbonic acid ester derivatives and intermediates. |
AU3515497A (en) | 1996-07-29 | 1998-02-20 | Warner-Lambert Company | Improved process for the synthesis of protected esters of (s)-3,4-dihydroxybutyric acid |
JPH11171850A (ja) | 1997-12-12 | 1999-06-29 | Kanegafuchi Chem Ind Co Ltd | 酪酸エステル誘導体の製造方法 |
AU2000254249A1 (en) * | 2000-03-28 | 2001-10-08 | Biocon India Limited | Synthesis of (r-(r*,r*))-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1- |
WO2002057229A1 (en) | 2001-01-19 | 2002-07-25 | Biocon India Limited | FORM V CRYSTALLINE [R-(R*,R*)]-2-(4-FLUOROPHENYL)-ß,$G(D)-DIHYDROXY-5-(1-METHYLETHYL)-3-PHENYL-4-[(PHENYLAMINO)CARBONYL]-1H-PYRROLE-1- HEPTANOIC ACID HEMI CALCIUM SALT. (ATORVASTATIN) |
DK1478650T3 (da) | 2002-02-25 | 2010-01-25 | Biocon Ltd | Nye boronatestere |
-
2002
- 2002-02-25 DK DK02707083.8T patent/DK1478650T3/da active
- 2002-02-25 RO ROA200400728A patent/RO122095B1/ro unknown
- 2002-02-25 US US10/505,528 patent/US7301046B2/en not_active Expired - Fee Related
- 2002-02-25 WO PCT/IN2002/000032 patent/WO2003070733A1/en active IP Right Grant
- 2002-02-25 HU HU0500125A patent/HUP0500125A3/hu unknown
- 2002-02-25 CA CA2475586A patent/CA2475586C/en not_active Expired - Fee Related
- 2002-02-25 KR KR1020047012639A patent/KR100598079B1/ko not_active IP Right Cessation
- 2002-02-25 DE DE60233899T patent/DE60233899D1/de not_active Expired - Lifetime
- 2002-02-25 NZ NZ534688A patent/NZ534688A/en not_active IP Right Cessation
- 2002-02-25 ES ES02707083T patent/ES2332881T3/es not_active Expired - Lifetime
- 2002-02-25 BR BR0215602-4A patent/BR0215602A/pt not_active Application Discontinuation
- 2002-02-25 EP EP02707083A patent/EP1478650B1/en not_active Expired - Lifetime
- 2002-02-25 PT PT02707083T patent/PT1478650E/pt unknown
- 2002-02-25 AT AT02707083T patent/ATE444299T1/de not_active IP Right Cessation
- 2002-02-25 JP JP2003569640A patent/JP4139334B2/ja not_active Expired - Fee Related
- 2002-02-25 AU AU2002241235A patent/AU2002241235B2/en not_active Ceased
- 2002-02-25 SK SK305-2004A patent/SK288093B6/sk not_active IP Right Cessation
- 2002-02-25 CZ CZ2004863A patent/CZ2004863A3/cs unknown
-
2004
- 2004-07-29 NO NO20043223A patent/NO20043223L/no not_active Application Discontinuation
- 2004-08-03 IL IL163333A patent/IL163333A/en not_active IP Right Cessation
- 2004-08-23 US US10/923,934 patent/US7238826B2/en not_active Expired - Fee Related
- 2004-09-24 HR HR20040888 patent/HRP20040888B1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
BR0215602A (pt) | 2004-12-07 |
CZ2004863A3 (cs) | 2004-12-15 |
NO20043223L (no) | 2004-09-28 |
US7301046B2 (en) | 2007-11-27 |
RO122095B1 (ro) | 2008-12-30 |
CA2475586A1 (en) | 2003-08-28 |
IL163333A (en) | 2009-05-04 |
ES2332881T3 (es) | 2010-02-15 |
HUP0500125A2 (hu) | 2005-04-28 |
HRP20040888A2 (en) | 2005-04-30 |
EP1478650A1 (en) | 2004-11-24 |
JP4139334B2 (ja) | 2008-08-27 |
HRP20040888B1 (en) | 2012-12-31 |
CA2475586C (en) | 2011-07-05 |
EP1478650B1 (en) | 2009-09-30 |
HUP0500125A3 (en) | 2008-03-28 |
US20050154213A1 (en) | 2005-07-14 |
PT1478650E (pt) | 2010-01-04 |
EP1478650A4 (en) | 2008-02-13 |
AU2002241235A1 (en) | 2003-09-09 |
DE60233899D1 (de) | 2009-11-12 |
WO2003070733A1 (en) | 2003-08-28 |
AU2002241235B2 (en) | 2009-04-23 |
KR20040084915A (ko) | 2004-10-06 |
SK3052004A3 (sk) | 2005-02-04 |
US7238826B2 (en) | 2007-07-03 |
US20060040898A1 (en) | 2006-02-23 |
SK288093B6 (sk) | 2013-07-02 |
KR100598079B1 (ko) | 2006-07-07 |
JP2005518427A (ja) | 2005-06-23 |
ATE444299T1 (de) | 2009-10-15 |
NZ534688A (en) | 2005-04-29 |
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