BR0215602A - ésteres de boronato - Google Patents

ésteres de boronato

Info

Publication number
BR0215602A
BR0215602A BR0215602-4A BR0215602A BR0215602A BR 0215602 A BR0215602 A BR 0215602A BR 0215602 A BR0215602 A BR 0215602A BR 0215602 A BR0215602 A BR 0215602A
Authority
BR
Brazil
Prior art keywords
boronate esters
aryl
hmb
pitavastatin
cerivastatin
Prior art date
Application number
BR0215602-4A
Other languages
English (en)
Inventor
Tom Thomas Puthiaprampil
Sumithra Srinath
Madhavan Sridharan
Sambasivam Ganesh
Original Assignee
Biocon Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biocon Ltd filed Critical Biocon Ltd
Publication of BR0215602A publication Critical patent/BR0215602A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pyrrole Compounds (AREA)

Abstract

"éSTERES DE BORONATO". A presente invenção refere-se a derivados de hexanoato de diidróxi oticamente ativos, ésteres de boronato da fórmula (IIa) que são intermediários úteis para a síntese de inibidores de enzima de HMB-CoA como atorvastatina, cerivastatina, rosuvastatina, pitavastatina, fluvastatina. Ar = arila ou heteroarila substituída ou não-substituída; R3 = alquila de 1 a 8 carbonos, arila ou aralquila; R4 = O, OH, CN ou um halogênio e a = ligação simples ou uma ligação dupla.
BR0215602-4A 2002-02-25 2002-02-25 ésteres de boronato BR0215602A (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IN2002/000032 WO2003070733A1 (en) 2002-02-25 2002-02-25 Novel boronate esters

Publications (1)

Publication Number Publication Date
BR0215602A true BR0215602A (pt) 2004-12-07

Family

ID=27742233

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0215602-4A BR0215602A (pt) 2002-02-25 2002-02-25 ésteres de boronato

Country Status (21)

Country Link
US (2) US7301046B2 (pt)
EP (1) EP1478650B1 (pt)
JP (1) JP4139334B2 (pt)
KR (1) KR100598079B1 (pt)
AT (1) ATE444299T1 (pt)
AU (1) AU2002241235B2 (pt)
BR (1) BR0215602A (pt)
CA (1) CA2475586C (pt)
CZ (1) CZ2004863A3 (pt)
DE (1) DE60233899D1 (pt)
DK (1) DK1478650T3 (pt)
ES (1) ES2332881T3 (pt)
HR (1) HRP20040888B1 (pt)
HU (1) HUP0500125A3 (pt)
IL (1) IL163333A (pt)
NO (1) NO20043223L (pt)
NZ (1) NZ534688A (pt)
PT (1) PT1478650E (pt)
RO (1) RO122095B1 (pt)
SK (1) SK288093B6 (pt)
WO (1) WO2003070733A1 (pt)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0011120D0 (en) * 2000-05-09 2000-06-28 Avecia Ltd Process
NL1015744C2 (nl) * 2000-07-19 2002-01-22 Dsm Nv Werkwijze voor de bereiding van 2-(6-gesubstitueerde-1,3-dioxan-4-yl) azijnzuurderivaten.
EP1323717A1 (en) * 2001-12-27 2003-07-02 Dsm N.V. Process for the preparation of 2-(6-Substituted-1,3-Dioxane-4-yL) acetic acid derivatives
DE60233899D1 (de) 2002-02-25 2009-11-12 Biocon Ltd Neue boronatester
EP2054518A2 (en) * 2006-07-19 2009-05-06 Board of Trustees of Michigan State University Microbial synthesis of d-1,2,4-butanetriol
WO2008042876A2 (en) 2006-10-02 2008-04-10 Codexis, Inc. Compositions and methods for producing stereoisomerically pure statins and synthetic intermediates therefor
KR100933172B1 (ko) 2007-11-30 2009-12-21 씨제이제일제당 (주) 아토르바스타틴 칼슘염의 개선된 제조방법
KR101339648B1 (ko) * 2012-05-10 2013-12-09 (주) 에프엔지리서치 신규한 아토바스타틴 중간체 및 이를 이용한 아토바스타틴의 제조 방법
KR101292743B1 (ko) * 2012-05-17 2013-08-02 (주) 에프엔지리서치 신규한 스타틴 중간체 및 이를 이용한 피타바스타틴, 로수바스타틴, 세리바스타틴 및 플루바스타틴의 제조 방법
KR101528359B1 (ko) * 2013-04-24 2015-06-15 (주) 성운파마코피아 스타틴 화합물 제조를 위한 신규한 보로네이트 에테르 화합물, 그 제조방법 및 상기 보로네이트 에테르 화합물을 이용한 스타틴 화합물 제조방법
CN108033899B (zh) * 2017-12-06 2020-04-10 浙江科技学院 一种(r)-6-氰基-5-羟基-3-羰基己酸叔丁酯的制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4474034A (en) 1982-09-23 1984-10-02 Avery Jr Richard J Refrigerant accumulator and charging apparatus and method for vapor-compression refrigeration system
DE3741509A1 (de) 1987-12-08 1989-06-22 Hoechst Ag Verfahren zur herstellung optisch aktiver 3-desmethylmevalonsaeurederivate sowie zwischenprodukte
DE69329221D1 (de) * 1992-06-10 2000-09-21 Chisso Corp Optisch aktives, 1,5-disubstituiertes 2,4-0-Isopropyliden-2,4-dihydroxypentan und ein Verfahren zu seiner Herstellung
SG44830A1 (en) * 1992-07-02 1997-12-19 Hoechst Ag Process for preparing tert-butyl 93R,5S) -6 Hydroxy-3,5-O-Isopropylidene-3, 5-Dihydroxyhexanoate
KR950005791A (ko) 1993-08-09 1995-03-20 후꾸야마 마사루 카르복실산 에스테르-유도체의 제조방법 및 그 방법에 사용되는 4- 플루오로비페닐 유도체
ES2176756T3 (es) * 1996-07-29 2002-12-01 Warner Lambert Co Proceso perfeccionado para la sintesis de los esteres protegidos del acido (s)-3,4-dihidroxibutirico.
JPH11171850A (ja) 1997-12-12 1999-06-29 Kanegafuchi Chem Ind Co Ltd 酪酸エステル誘導体の製造方法
AU2000254249A1 (en) 2000-03-28 2001-10-08 Biocon India Limited Synthesis of (r-(r*,r*))-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-
WO2002057229A1 (en) 2001-01-19 2002-07-25 Biocon India Limited FORM V CRYSTALLINE [R-(R*,R*)]-2-(4-FLUOROPHENYL)-ß,$G(D)-DIHYDROXY-5-(1-METHYLETHYL)-3-PHENYL-4-[(PHENYLAMINO)CARBONYL]-1H-PYRROLE-1- HEPTANOIC ACID HEMI CALCIUM SALT. (ATORVASTATIN)
DE60233899D1 (de) 2002-02-25 2009-11-12 Biocon Ltd Neue boronatester

Also Published As

Publication number Publication date
IL163333A (en) 2009-05-04
SK3052004A3 (sk) 2005-02-04
US7238826B2 (en) 2007-07-03
SK288093B6 (sk) 2013-07-02
EP1478650B1 (en) 2009-09-30
HRP20040888A2 (en) 2005-04-30
HUP0500125A2 (hu) 2005-04-28
WO2003070733A1 (en) 2003-08-28
KR100598079B1 (ko) 2006-07-07
NO20043223L (no) 2004-09-28
CZ2004863A3 (cs) 2004-12-15
EP1478650A1 (en) 2004-11-24
RO122095B1 (ro) 2008-12-30
DE60233899D1 (de) 2009-11-12
EP1478650A4 (en) 2008-02-13
PT1478650E (pt) 2010-01-04
US20060040898A1 (en) 2006-02-23
HUP0500125A3 (en) 2008-03-28
DK1478650T3 (da) 2010-01-25
AU2002241235A1 (en) 2003-09-09
AU2002241235B2 (en) 2009-04-23
JP4139334B2 (ja) 2008-08-27
NZ534688A (en) 2005-04-29
HRP20040888B1 (en) 2012-12-31
ATE444299T1 (de) 2009-10-15
US7301046B2 (en) 2007-11-27
JP2005518427A (ja) 2005-06-23
CA2475586A1 (en) 2003-08-28
CA2475586C (en) 2011-07-05
ES2332881T3 (es) 2010-02-15
US20050154213A1 (en) 2005-07-14
KR20040084915A (ko) 2004-10-06

Similar Documents

Publication Publication Date Title
DE69912581D1 (de) Biarylessigsäure-derivate und ihre verwendung als cox-2 inhibitoren
BR0215602A (pt) ésteres de boronato
TW200736221A (en) Novel pharmaceutical salts and polymorphs of a Factor Xa inhibitor
TR200302281T2 (tr) Statinlerin kalsiyum tuzu formlarını hazırlamak için işlemler
DE60304059D1 (de) 3-(2-hydroxy-phenyl)-1h-pyrazol-4-carbonsäureamid derivate als hsp90 inhibitoren zur behandlung von krebs
ATE449099T1 (de) Derivate des 2-trifluormethyl-6-aminopurins als phosphodiesterase 4 inhibitoren
ATE360627T1 (de) Pyrrolidindion-substituierte piperidin- phthalazone als pde4-inhibitoren
BR0307801A (pt) Processo para a fabricação de derivados de ácido mevalÈnico inibidores da hmg-coa reductase
ATE404536T1 (de) Substituierte chinolinderivate als inhibitoren von mitotischem kinesin
NO20065148L (no) Monocykliske heterocykler som kinase inhibitorer
CY1109006T1 (el) Παραγωγα πουρινης ως αναστολεις κινασης
TR200201506T2 (tr) Terapötik maddeler olarak kinaz inhibitörleri
MX2009006630A (es) Derivados de 4-imidazolil-1,2,3,4-tetrahidro-quinola y su uso como inhibidores de aldosterona / 11-beta-hidroxilasa.
RU2004139029A (ru) Применение замещенных цианопирролидинов и содержащих их комбинированных препаратов для лечения гиперлипидемии и ассоциированных заболеваний
WO2004046122A3 (en) Benzoxazole, benzthiazole and benzimidazole acid derivatives and their use as heparanase inhibitors
PE20060184A1 (es) Derivados de imidazoles como inhibidores de la sintesis del colesterol
SE0103710D0 (sv) Compounds
ATE496025T1 (de) Magnesiumsalze von hmg-coa-reduktase-hemmern
PE20070603A1 (es) COMPOSICION FARMACEUTICA QUE COMPRENDE UN INHIBIDOR DE ESCUALENO SINTASA Y UN INHIBIDOR DE 3-HIDROXI-3-METILGLUTARIL-CoA-REDUCTASA (HMG-CoA)
HK1078854A1 (en) Method for producing a 3,5-dihydroxy-6-heptenoate
AU2003281220A1 (en) N-benzyl-3-phenyl-3-heterocyclyl-propionamide compounds as tachykinin and/ or serotonin reuptake inhibitors
AR033651A1 (es) Derivados de pirimidina-2,4,6-triona, composiciones farmaceuticas que contienen dichos compuestos y el empleo de los mismos para la manufactura de un medicamento
ECSP066740A (es) ß-HIDROXI ÉSTERES HETEROAROMÁTICOS ÓPTIMAMENTE ACTIVOS, PROCESOS PARA SU PREPARACIÓN A PARTIR DE ß-CETO ÉSTERES Y PROCESOS PARA LA PREPARACIÓN DE DICHOS ß-CETO ÉSTERES
NZ512207A (en) Process for producing quinolinecarbaldehyde
ATE542812T1 (de) Substituierte indolylalkylaminoderivate als neue inhibitoren von histondeacetylase

Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B15K Others concerning applications: alteration of classification

Free format text: PARA: INT. CL. C07F 5/04; C07B 61/00

Ipc: C07F 5/04 (2011.01), C07B 61/00 (2011.01)

B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07G Grant request does not fulfill article 229-c lpi (prior consent of anvisa) [chapter 7.7 patent gazette]

Free format text: NOTIFICACAO DE DEVOLUCAO DO PEDIDO POR NAO SE ENQUADRAR NO ART. 229-C DA LPI.

B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements