DK147484C - Fremgangsmaade til fremstilling af derivater af 4-desacetyl-vincaleucoblastin-c-3-carboxhydrazid - Google Patents

Fremgangsmaade til fremstilling af derivater af 4-desacetyl-vincaleucoblastin-c-3-carboxhydrazid

Info

Publication number: DK147484C
Authority: DK; Denmark
Prior art keywords: vincaleucoblastin; desacetyl; carbox; hydrazide; preparing derivatives
Prior art date: 1978-04-20

Application number

DK160679A

Other languages

Danish (da)

English (en)

Other versions

DK160679A (da

DK147484B (da

Inventor

George Joseph Cullinan

Koert Gerzon

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1978-04-20

Filing date

1979-04-19

Publication date

1985-03-25

1979-04-19 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

1979-10-21 Publication of DK160679A publication Critical patent/DK160679A/da

1983-01-14 Priority to DK14083A priority Critical patent/DK148510C/da

1983-01-14 Priority to DK13983A priority patent/DK148655C/da

1984-08-27 Publication of DK147484B publication Critical patent/DK147484B/da

1985-03-25 Application granted granted Critical

1985-03-25 Publication of DK147484C publication Critical patent/DK147484C/da

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Saccharide Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

DK160679A 1978-04-20 1979-04-19 Fremgangsmaade til fremstilling af derivater af 4-desacetyl-vincaleucoblastin-c-3-carboxhydrazid DK147484C (da)

Priority Applications (2)

Application Number	Priority Date	Filing Date	Title
DK14083A DK148510C (da)	1978-04-20	1983-01-14	Analogifremgangsmaade til fremstilling af derivater af 4-desacetyl-vincaleucoblastin-c-3-carboxhydrazid
DK13983A DK148655C (da)	1978-04-20	1983-01-14	Analogifremgangsmaade til fremstilling af derivater af 4-desacetyl-vincaleucoblastin-c-3-carboxhydrazid

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US05/899,032 US4166810A (en)	1978-04-20	1978-04-20	Derivatives of 4-desacetyl VLB C-3 carboxyhydrazide
US89903278		1978-04-20

Publications (3)

Publication Number	Publication Date
DK160679A DK160679A (da)	1979-10-21
DK147484B DK147484B (da)	1984-08-27
DK147484C true DK147484C (da)	1985-03-25

Family

ID=25410402

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK160679A DK147484C (da)	1978-04-20	1979-04-19	Fremgangsmaade til fremstilling af derivater af 4-desacetyl-vincaleucoblastin-c-3-carboxhydrazid

Country Status (32)

Country	Link
US (1)	US4166810A (fr)
EP (1)	EP0005051B1 (fr)
JP (1)	JPS54141798A (fr)
AR (1)	AR228940A1 (fr)
AT (1)	AT369010B (fr)
AU (1)	AU527109B2 (fr)
BE (1)	BE875652A (fr)
BG (3)	BG33294A3 (fr)
CA (1)	CA1097629A (fr)
CH (1)	CH643269A5 (fr)
CS (3)	CS218585B2 (fr)
DD (1)	DD143075A5 (fr)
DE (1)	DE2964130D1 (fr)
DK (1)	DK147484C (fr)
EG (1)	EG14867A (fr)
ES (2)	ES479753A1 (fr)
FI (1)	FI791286A (fr)
FR (1)	FR2423495A1 (fr)
GB (1)	GB2019396B (fr)
GR (1)	GR69987B (fr)
HU (1)	HU181431B (fr)
IE (1)	IE48213B1 (fr)
IL (1)	IL57168A (fr)
LU (1)	LU81166A1 (fr)
NZ (1)	NZ190213A (fr)
PH (1)	PH14163A (fr)
PL (3)	PL119416B1 (fr)
PT (1)	PT69496A (fr)
RO (3)	RO81114A (fr)
SU (3)	SU1225490A3 (fr)
YU (1)	YU93179A (fr)
ZA (1)	ZA791856B (fr)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4322351A (en) *	1980-08-25	1982-03-30	Eli Lilly And Company	Antineoplastic 4'-formylamino and 4'-acetylamino VLB, and derivatives thereof
GR79898B (fr) *	1983-03-30	1984-10-31	Lilly Industries Ltd
US4667030A (en) *	1985-06-17	1987-05-19	Eli Lilly And Company	Hydrazide succinimide derivatives of antineoplastic indole-dihydroindole alkaloids
US4675400A (en) *	1985-06-17	1987-06-23	Eli Lilly And Company	Bifunctional derivatives of 4-desacetyl indole-dihydroindole alkaloids
US4801688A (en) *	1986-05-27	1989-01-31	Eli Lilly And Company	Hydrazone immunoglobulin conjugates
US5043340A (en) *	1990-04-03	1991-08-27	Eli Lilly And Company	Derivatives of 4-desacetyl VLB C-3 carboxhydrazide
US5043336A (en) *	1990-04-03	1991-08-27	Eli Lilly And Company	Cyclic imide derivatives of 4-desacetyl VLB c-3 carboxhydrazide
DE60231868D1 (de)	2001-04-24	2009-05-20	Purdue Research Foundation	Folat-mimetika und deren folatrezeptorbindende konjugate
AU2003243226A1 (en) *	2002-05-15	2003-12-02	Endocyte, Inc.	Vitamin-mitomycin conjugates
EP2529758A3 (fr)	2003-01-27	2013-01-02	Endocyte, Inc.	Conjugués d'administration de médicaments à liaison au récepteur de vitamines
WO2006012527A1 (fr)	2004-07-23	2006-02-02	Endocyte, Inc.	Groupes de liaison bivalents et conjugués de ceux-ci
US8044200B2 (en) *	2005-03-16	2011-10-25	Endocyte, Inc.	Synthesis and purification of pteroic acid and conjugates thereof
EP2382995A3 (fr)	2005-08-19	2013-09-25	Endocyte, Inc.	Conjugués de ligands d'alcaloïdes de Vinca, analogues et dérivés
CN103893779A (zh)	2005-08-19	2014-07-02	恩多塞特公司	多药物配体缀合物
WO2008100591A2 (fr) *	2007-02-14	2008-08-21	The General Hospital Corporation	Modulation de la signalisation de l'oxyde nitrique pour normaliser le système vasculaire tumoral
WO2008101231A2 (fr)	2007-02-16	2008-08-21	Endocyte, Inc.	Procédés et compositions de traitement et de diagnostic d'une maladie rénale
CA2680535C (fr) *	2007-03-14	2016-09-20	Endocyte, Inc.	Conjugues d'administration de medicament lies a un ligand de liaison de tubulysines
US9877965B2 (en)	2007-06-25	2018-01-30	Endocyte, Inc.	Vitamin receptor drug delivery conjugates for treating inflammation
WO2009002993A1 (fr)	2007-06-25	2008-12-31	Endocyte, Inc.	Conjugués contenant des lieurs espaceurs hydrophiles
AU2008316835B2 (en) *	2007-10-25	2015-07-16	Endocyte, Inc.	Tubulysins and processes for preparing
ES2574032T3 (es) *	2009-09-07	2016-06-14	Nipro Patch Co., Ltd.	Preparación absorbible por vía transdérmica
WO2013126797A1 (fr)	2012-02-24	2013-08-29	Purdue Research Foundation	Ciblage du récepteur de la cholécystokinine de type b pour imagerie et thérapie
US20140080175A1 (en)	2012-03-29	2014-03-20	Endocyte, Inc.	Processes for preparing tubulysin derivatives and conjugates thereof
WO2014062697A2 (fr)	2012-10-16	2014-04-24	Endocyte, Inc.	Conjugués d'administration de médicament contenant des acides aminés artificiels et procédés d'utilisation

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3097137A (en) *	1960-05-19	1963-07-09	Canadian Patents Dev	Vincaleukoblastine
US3205220A (en) *	1961-10-26	1965-09-07	Lilly Co Eli	Leurosidine and leurocristine and their production
US3392173A (en) *	1964-03-09	1968-07-09	Lilly Co Eli	Novel acyl derivatives of desacetyl-vincaleukoblastine and processes for their preparation
US3370057A (en) *	1964-04-27	1968-02-20	Lilly Co Eli	Leurosine
US3387001A (en) *	1964-10-19	1968-06-04	Lilly Co Eli	Novel aminoacyl esters of desacetyl vincaleukoblastine
US3887565A (en) *	1974-05-06	1975-06-03	Lilly Co Eli	Vincadioline
US3890325A (en) *	1974-05-15	1975-06-17	Lilly Co Eli	Leurocolombine
US3954773A (en) *	1974-11-21	1976-05-04	Eli Lilly And Company	4-Desacetoxyvinblastine
US3944554A (en) *	1975-01-09	1976-03-16	Eli Lilly And Company	4-Desacetoxy-3-hydroxyvinblastine
IL48685A (en) *	1975-01-09	1980-03-31	Lilly Co Eli	Amides of vincadioline and vinblastine
US4029663A (en) *	1975-07-10	1977-06-14	Eli Lilly And Company	Dimeric anhydro-vinca derivatives
US4115388A (en) *	1977-03-30	1978-09-19	Eli Lilly And Company	3'-Oxygenated derivatives of 4'-deoxy VLB "A" and "B" and related 1-formyl compounds

1978
- 1978-04-20 US US05/899,032 patent/US4166810A/en not_active Expired - Lifetime
1979
- 1979-04-17 JP JP4715279A patent/JPS54141798A/ja active Granted
- 1979-04-17 PH PH23391A patent/PH14163A/en unknown
- 1979-04-17 PT PT69496A patent/PT69496A/pt unknown
- 1979-04-18 GR GR58950A patent/GR69987B/el unknown
- 1979-04-18 RO RO79102376A patent/RO81114A/fr unknown
- 1979-04-18 EP EP79300638A patent/EP0005051B1/fr not_active Expired
- 1979-04-18 RO RO7997290A patent/RO80084A/fr unknown
- 1979-04-18 NZ NZ190213A patent/NZ190213A/xx unknown
- 1979-04-18 LU LU81166A patent/LU81166A1/fr unknown
- 1979-04-18 DE DE7979300638T patent/DE2964130D1/de not_active Expired
- 1979-04-18 EG EG238/79A patent/EG14867A/xx active
- 1979-04-18 RO RO79102377A patent/RO81037A/fr unknown
- 1979-04-18 AT AT0291279A patent/AT369010B/de not_active IP Right Cessation
- 1979-04-18 BE BE1/9358A patent/BE875652A/fr unknown
- 1979-04-18 AU AU46097/79A patent/AU527109B2/en not_active Ceased
- 1979-04-18 GB GB7913460A patent/GB2019396B/en not_active Expired
- 1979-04-18 YU YU00931/79A patent/YU93179A/xx unknown
- 1979-04-19 FR FR7909874A patent/FR2423495A1/fr active Granted
- 1979-04-19 CS CS807546A patent/CS218585B2/cs unknown
- 1979-04-19 HU HU79EI850A patent/HU181431B/hu not_active IP Right Cessation
- 1979-04-19 CS CS807545A patent/CS218584B2/cs unknown
- 1979-04-19 ZA ZA791856A patent/ZA791856B/xx unknown
- 1979-04-19 CA CA325,844A patent/CA1097629A/fr not_active Expired
- 1979-04-19 PL PL1979215011A patent/PL119416B1/pl unknown
- 1979-04-19 CS CS792678A patent/CS218583B2/cs unknown
- 1979-04-19 PL PL21591179A patent/PL215911A1/xx unknown
- 1979-04-19 PL PL1979230538A patent/PL125470B1/pl unknown
- 1979-04-19 FI FI791286A patent/FI791286A/fi not_active Application Discontinuation
- 1979-04-19 ES ES479753A patent/ES479753A1/es not_active Expired
- 1979-04-19 DK DK160679A patent/DK147484C/da not_active IP Right Cessation
- 1979-04-19 CH CH370779A patent/CH643269A5/fr not_active IP Right Cessation
- 1979-04-19 ES ES479754A patent/ES479754A1/es not_active Expired
- 1979-04-20 BG BG7943323A patent/BG33294A3/xx unknown
- 1979-04-20 BG BG8256470A patent/BG33297A3/xx unknown
- 1979-04-20 SU SU792925606A patent/SU1225490A3/ru active
- 1979-04-20 SU SU792759650A patent/SU893135A3/ru active
- 1979-04-20 DD DD79212369A patent/DD143075A5/de unknown
- 1979-04-20 BG BG8256469A patent/BG33296A3/xx unknown
- 1979-04-20 AR AR276248A patent/AR228940A1/es active
- 1979-04-29 IL IL57168A patent/IL57168A/xx unknown
- 1979-08-08 IE IE795/79A patent/IE48213B1/en unknown
1980
- 1980-05-26 SU SU802925605A patent/SU1061698A3/ru active

Also Published As

Publication number	Publication date
YU93179A (en)	1983-01-21
RO81037A (fr)	1983-02-01
GR69987B (fr)	1982-07-22
RO81114B (ro)	1983-01-30
RO81114A (fr)	1983-02-01
CA1097629A (fr)	1981-03-17
DE2964130D1 (en)	1983-01-05
ATA291279A (de)	1982-04-15
HU181431B (en)	1983-07-28
CS218583B2 (en)	1983-02-25
IL57168A0 (en)	1979-07-25
AU4609779A (en)	1979-10-25
AU527109B2 (en)	1983-02-17
CS218585B2 (en)	1983-02-25
GB2019396B (en)	1982-09-15
IL57168A (en)	1983-10-31
GB2019396A (en)	1979-10-31
RO80084A (fr)	1983-02-01
BG33294A3 (en)	1983-01-14
PL119416B1 (en)	1981-12-31
FR2423495B1 (fr)	1983-02-11
RO80084B (ro)	1983-01-30
PH14163A (en)	1981-03-19
RO81037B (ro)	1983-01-30
JPS6245873B2 (fr)	1987-09-29
FR2423495A1 (fr)	1979-11-16
FI791286A (fi)	1979-10-21
IE48213B1 (en)	1984-10-31
BE875652A (fr)	1979-10-18
CS218584B2 (en)	1983-02-25
DK160679A (da)	1979-10-21
ES479754A1 (es)	1980-08-16
AT369010B (de)	1982-11-25
PL125470B1 (en)	1983-05-31
DK147484B (da)	1984-08-27
EP0005051B1 (fr)	1982-12-01
EG14867A (en)	1986-09-30
DD143075A5 (de)	1980-07-30
PT69496A (en)	1979-05-01
AR228940A1 (es)	1983-05-13
BG33297A3 (en)	1983-01-14
ZA791856B (en)	1980-11-26
BG33296A3 (en)	1983-01-14
CH643269A5 (fr)	1984-05-30
SU1061698A3 (ru)	1983-12-15
NZ190213A (en)	1982-12-21
LU81166A1 (fr)	1979-09-07
PL215911A1 (fr)	1980-03-24
JPS54141798A (en)	1979-11-05
SU1225490A3 (ru)	1986-04-15
US4166810A (en)	1979-09-04
ES479753A1 (es)	1980-08-16
SU893135A3 (ru)	1981-12-23
EP0005051A1 (fr)	1979-10-31
IE790795L (en)	1979-10-20

Legal Events

Date	Code	Title	Description
1995-11-27	PBP	Patent lapsed

Publication	Publication Date	Title
DK147484C (da)	1985-03-25	Fremgangsmaade til fremstilling af derivater af 4-desacetyl-vincaleucoblastin-c-3-carboxhydrazid
DK158679C (da)	1990-12-03	Fremgangsmaade til fremstilling af ethanol
DK251079A (da)	1979-12-21	Fremgangsmaade til fremstilling af phenylpiperazinderivater
DK520679A (da)	1980-06-09	Fremgangsmaade til fremstilling af 3-quinolincarboxulsyrederivater
DK584777A (da)	1978-07-01	Fremgangsmaade til fremstilling af sterolinforbindelser
DK70979A (da)	1979-08-22	Fremgangsmaade til fremstilling af phthalocyaninpigmeneter
DK232080A (da)	1980-12-01	Fremgangsmaade til fremstilling af hydroxyaminoeburnanderivater
DK300781A (da)	1981-07-07	Fremgangsmaade til fremstilling af halogenfenylpyridyllylamin-derivater
DK152752C (da)	1988-09-26	Fremgangsmaade til fremstilling af l-sulpirid
DK226579A (da)	1979-12-09	Fremgangsmaade til fremstilling af metaboliter
DK160312C (da)	1991-07-29	Fremgangsmaade til fremstilling af derivater af 7-aminothiazolylacetamidocephalosporansyre
DK159153C (da)	1991-03-11	Analogifremgangsmaade til fremstilling af penicillinforbindelser
DK152579A (da)	1979-10-14	Fremgangsmaade til fremstilling af androstaner
DK183880A (da)	1980-10-31	Fremgangsmaade til fremstilling af hydroxyderivater af isopropyrimidin
DK36379A (da)	1979-07-31	Fremgangsmaade til fremstilling af n-ethylethylendiamin
DK172779A (da)	1979-10-29	Fremgangsmaade til fremstilling af cyklopropanderivater
DK208677A (da)	1977-11-14	Fremgangsmade til fremstilling af maphthylforbindelser
DK143107C (da)	1981-11-09	Fremgangsmaade til fremstilling af 2-isopropylaminopyrimidin
DK178279A (da)	1979-11-03	Fremgangsmaade til fremstilling af tetrapeptidhydrazidderivater
DK147420C (da)	1985-02-18	Fremgangsmaade til fremstilling af acylcyanider
DK195979A (da)	1979-11-13	Fremgangsmaade til fremstilling af d-homosteroider
DK335479A (da)	1980-02-12	Fremgangsmaade til fremstilling af oligomere af pyridocarbazoler
DK545280A (da)	1981-06-22	Fremgangsmaade til fremstilling af nitrothiazolinforbindelser
DK304479A (da)	1980-01-21	Fremgangsmaade til fremstilling af 20-methyl13,14-didehydro-pg12-derivater
DK149853C (da)	1987-06-29	Fremgangsmaade til fremstilling af s-alkyl-sulfonimidoylxanthonderivater