DK146489D0 - Fremgangsmaade til fremstilling af 2',3'-dideoxy-2',3'-didehydronucleosider - Google Patents

Fremgangsmaade til fremstilling af 2',3'-dideoxy-2',3'-didehydronucleosider

Info

Publication number
DK146489D0
DK146489D0 DK146489A DK146489A DK146489D0 DK 146489 D0 DK146489 D0 DK 146489D0 DK 146489 A DK146489 A DK 146489A DK 146489 A DK146489 A DK 146489A DK 146489 D0 DK146489 D0 DK 146489D0
Authority
DK
Denmark
Prior art keywords
didehydronucleosides
dideoxy
preparing
Prior art date
Application number
DK146489A
Other languages
English (en)
Other versions
DK146489A (da
Inventor
Jr John E Starrett
Muzammil M Mansuri
John C Martin
Carl E Fuller
Henry G Howell
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of DK146489D0 publication Critical patent/DK146489D0/da
Publication of DK146489A publication Critical patent/DK146489A/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/056—Triazole or tetrazole radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK146489A 1988-03-24 1989-03-22 Fremgangsmaade til fremstilling af 2',3'-dideoxy-2',3'-didehydronucleosider DK146489A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/173,473 US4904770A (en) 1988-03-24 1988-03-24 Production of 2',3'-dideoxy-2',3'-didehydronucleosides

Publications (2)

Publication Number Publication Date
DK146489D0 true DK146489D0 (da) 1989-03-22
DK146489A DK146489A (da) 1989-09-25

Family

ID=22632190

Family Applications (1)

Application Number Title Priority Date Filing Date
DK146489A DK146489A (da) 1988-03-24 1989-03-22 Fremgangsmaade til fremstilling af 2',3'-dideoxy-2',3'-didehydronucleosider

Country Status (14)

Country Link
US (1) US4904770A (da)
EP (1) EP0334368A3 (da)
JP (1) JPH02149595A (da)
KR (2) KR0140889B1 (da)
AU (1) AU622439B2 (da)
CA (1) CA1339448C (da)
DK (1) DK146489A (da)
EG (1) EG18661A (da)
FI (1) FI93111C (da)
IL (2) IL89693A (da)
NO (1) NO171367C (da)
NZ (1) NZ228390A (da)
PT (1) PT90099B (da)
ZA (1) ZA892166B (da)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5455339A (en) * 1986-05-01 1995-10-03 University Of Georgia Research Foundation, Inc. Method for the preparation of 2',3'-dideoxy and 2',3'-dideoxydide-hydro nucleosides
US5384396A (en) * 1988-02-23 1995-01-24 The University Of Georgia Research Foundation, Inc. Process for the deoxygenation of nucleosides
JPH02152976A (ja) * 1988-05-06 1990-06-12 Bristol Myers Co ２´，３´―ジデヒドロ―２´，３´―ジデオキシヌクレオシドのプロドラッグ
SE464168B (sv) * 1989-07-19 1991-03-18 Bo Fredrik Oeberg Antiviral komposition bestaaende av en 3'-fluoro-2',3'-dideoxynukleosidfoerening och en 2',3'-dideoxynukleosidfoerening (exempelvis azt)
US5200514A (en) * 1990-01-19 1993-04-06 University Of Georgia Research Foundation, Inc. Synthesis of 2'-deoxypyrimidine nucleosides
WO1992002516A1 (fr) * 1990-07-27 1992-02-20 Japan Tobacco Inc. Procede de production de 2',3'-didesoxy-2',3'-dideshydronucleoside
US5166327A (en) * 1990-07-31 1992-11-24 Yuki Gosei Kogyo Co., Ltd. Process for producing 3'-deoxy-3-'-fluorothymidine
JP3042073B2 (ja) * 1991-06-19 2000-05-15 味の素株式会社 ヌクレオシド誘導体とその製造方法
EP0550714B1 (en) * 1991-06-21 1996-02-28 Acic (Canada) Inc. Processes for production of zidovudine
FR2688003B1 (fr) * 1992-02-28 1995-06-30 Univ Limoges Derives de nucleosides, leur preparation et leurs applications biologiques.
US5506349A (en) * 1992-05-13 1996-04-09 Ribozyme Pharmaceuticals, Inc. Chemical synthesis of 2', 3'-dideoxycytidine
US5539099A (en) * 1993-11-15 1996-07-23 Bristol-Myers Squibb Company Process for large-scale preparation of 2',3'-didehydro-2',3'-dideoxynucleosides
US5608049A (en) * 1995-03-10 1997-03-04 Bristol-Myers Squibb Company Preparation of d4T from 5-methyluridine
US5608048A (en) * 1995-06-05 1997-03-04 Bristol-Myers Squibb Company d4 T polymorphic Form 1 process
US6635753B1 (en) 1998-09-30 2003-10-21 Brantford Chemicals Inc. Process for the preparation of substantially pure stavudine and related intermediates useful in the preparation thereof
US7638496B2 (en) 2000-02-15 2009-12-29 Valeant Pharmaceuticals North America Nucleoside analogs with carboxamidine modified monocyclic base
IT1318463B1 (it) * 2000-04-12 2003-08-25 Archimica S P A Ora Clariant L Procedimento per la preparazione di 5'-acetilstavudina.
US6927291B2 (en) * 2001-03-01 2005-08-09 Pharmasset, Ltd. Method for the synthesis of 2′,3′-dideoxy-2′,3′-didehydronucleosides
US20050131224A1 (en) * 2003-12-15 2005-06-16 Cti Pet Systems, Inc. Method for preparing radiolabeled thymidine
US7160537B2 (en) * 2003-12-15 2007-01-09 Siemens Medical Solutions Usa, Inc. Method for preparing radiolabeled thymidine having low chromophoric byproducts
EP1550665A1 (en) * 2003-12-26 2005-07-06 Ajinomoto Co., Inc. A process for the production of purine nucleoside compounds
US7250416B2 (en) 2005-03-11 2007-07-31 Supergen, Inc. Azacytosine analogs and derivatives
KR101294467B1 (ko) 2005-07-25 2013-09-09 인터뮨, 인크. Ｃ형 간염 바이러스 복제의 신규 거대고리형 억제제
US7700567B2 (en) 2005-09-29 2010-04-20 Supergen, Inc. Oligonucleotide analogues incorporating 5-aza-cytosine therein
CN101029068B (zh) * 2007-04-09 2010-06-23 陆咏 一种2',3'-二脱氢-3'-脱氧胸苷的合成方法
AU2012302051B2 (en) 2011-08-30 2017-04-27 Astex Pharmaceuticals, Inc. Decitabine derivative formulations
EP2986602A1 (en) * 2013-04-16 2016-02-24 Bristol-Myers Squibb Company Method for producing festinavir using 5-methyluridine as starting material
JP6768722B2 (ja) 2015-07-02 2020-10-14 大塚製薬株式会社 凍結乾燥医薬組成物
JP2020529409A (ja) 2017-08-03 2020-10-08 大塚製薬株式会社 薬物化合物およびその精製方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3322747A (en) * 1965-04-01 1967-05-30 Merck & Co Inc Thionocarbonate nucleosides
US3539550A (en) * 1967-01-23 1970-11-10 Syntex Corp Process for the preparation of 2'-halo-2'-deoxy pyrimidine nucleosides
US3792040A (en) * 1970-03-19 1974-02-12 Syntex Corp Acyl derivatives of o2,2'-anhydro-1-(beta-d-arabinofuranosyl)-cytosines and methods of preparing

Also Published As

Publication number Publication date
KR0142109B1 (en) 1998-07-01
FI891338A0 (fi) 1989-03-21
DK146489A (da) 1989-09-25
FI93111C (fi) 1995-02-27
AU3167389A (en) 1989-09-28
AU622439B2 (en) 1992-04-09
CA1339448C (en) 1997-09-09
PT90099A (pt) 1989-11-10
EP0334368A3 (en) 1991-12-27
FI93111B (fi) 1994-11-15
EG18661A (en) 1993-10-30
PT90099B (pt) 1994-07-29
NO171367B (no) 1992-11-23
KR890014528A (ko) 1989-10-24
NO891208D0 (no) 1989-03-20
KR0140889B1 (en) 1998-06-15
NO891208L (no) 1989-09-25
IL89693A0 (en) 1989-09-28
NO171367C (no) 1993-03-03
IL89693A (en) 1994-08-26
EP0334368A2 (en) 1989-09-27
FI891338A (fi) 1989-09-25
US4904770A (en) 1990-02-27
IL105573A (en) 1994-04-12
NZ228390A (en) 1991-12-23
JPH02149595A (ja) 1990-06-08
ZA892166B (en) 1992-02-26

Similar Documents

Publication Publication Date Title
DK146489D0 (da) Fremgangsmaade til fremstilling af 2',3'-dideoxy-2',3'-didehydronucleosider
DK142989D0 (da) Fremgangsmaade til fremstilling af 2ae'-o-demethyltylosin
DK390D0 (da) Fremgangsmaade til fremstilling af hydroxylapatit
DE68923387T2 (de) 2',3'-Dideoxy-2',2'-difluornucleoside.
DK379985A (da) Fremgangsmaade til fremstilling af 6-chlor-n-methyl-2,3,4,5-tetrahydro-lh-benzazepin
DK157855C (da) Fremgangsmaade til fremstilling af 2,3-dichlor-5-trichlormethylpyridin
DK97889A (da) Fremgangsmaade til fremstilling af 4,4'-dibrombiphenyl
NO863756D0 (no) Metode for fremstilling av celleplast.
DK154207C (da) Fremgangsmaade til fremstilling af 1,8-dihydroxy-10-acyl-9-anthroner
DK113483A (da) Fremgangsmaade til fremstilling af 3,4-diphenyl-5-methylpyrazolderivater
DK687188D0 (da) Fremgangsmaade til fremstilling af 2,2'-oxodisuccinat
DK433987A (da) Fremgangsmaade til fremstilling af 1,12-dodecandisyre ii
KR860005812A (ko) 4,4-디알킬-2-아제티디논의 제조 방법
DK417787D0 (da) Fremgangsmaade til fremstilling af 7-oxo-4-thia-1-azabicyclo-(3,2,0)hept-2-en-derivater
DK700688A (da) Fremgangsmaade til fremstilling af 2,4- eller 2,4,5,-substituerede 6-hydroxypyrimidiner
DK231987D0 (da) Fremgangsmaade til fremstilling af 2,3-epoxyamider
DK389484D0 (da) Fremgangsmaade til fremstilling af 2,3-dihydrobenzopyranonderivater
DK413787D0 (da) Fremgangsmaade til fremstilling af 2,4-diamino-5-benzylpyrimidiner
DK84987D0 (da) Kontinuerlig fremgangsmaade til fremstilling af o,o-di-la-vere-alkylchlorthiophosphat
DK157999C (da) Fremgangsmaade til fremstilling af 5,11-dihydro-6h-pyridooe2,3-baaoe1,4aabenzodiazepin-6-oner
DK35688A (da) Fremgangsmaade til fremstilling af 5-aryl-2,4-diakyl-3h-1,2,4-triazol-3-thioner
KR900009518A (ko) 4,4'-비스비페닐의 제조방법
DK433689D0 (da) Fremgangsmaade til fremstilling af 2-n-propyl-4-amino-5-methoxy-methylpyrimidin
DK3289D0 (da) Fremgangsmaade til fremstilling af 5,8,13,14-tetrahydrobenz-(5,6)-isoindolo(2,1-b)-isoquinolin-8,13-dionderivater
DK135589D0 (da) Fremgangsmaade til fremstilling af 1-substituerede 5-amino-1h-imidazol-4-carboxamider

Legal Events

Date Code Title Description
AHB Application shelved due to non-payment