DK1311482T3 - Ikke-imidazolaryloxypiperidiner som H3-receptorligander - Google Patents

Ikke-imidazolaryloxypiperidiner som H3-receptorligander

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Publication number
DK1311482T3
DK1311482T3 DK01959582T DK01959582T DK1311482T3 DK 1311482 T3 DK1311482 T3 DK 1311482T3 DK 01959582 T DK01959582 T DK 01959582T DK 01959582 T DK01959582 T DK 01959582T DK 1311482 T3 DK1311482 T3 DK 1311482T3
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DK
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Prior art keywords
imidazolaryloxypiperidines
receptor ligands
aryloxypiperidine
imidazole
treat
Prior art date
Application number
DK01959582T
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English (en)
Inventor
Richard Apodaca
Nicholas I Carruthers
Chandravadan R Shah
Curt A Dvorak
Wei Xiao
Original Assignee
Ortho Mcneil Pharm Inc
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Application filed by Ortho Mcneil Pharm Inc filed Critical Ortho Mcneil Pharm Inc
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Publication of DK1311482T3 publication Critical patent/DK1311482T3/da

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    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/325—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4402—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4465—Non condensed piperidines, e.g. piperocaine only substituted in position 4
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    • C07C217/22—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted by carbon atoms having at least two bonds to oxygen atoms
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EP1311482A2 (en) 2003-05-21
DE60126785D1 (de) 2007-04-05
HUP0302893A3 (en) 2006-04-28
AU2001281121B2 (en) 2007-08-23
KR20030048007A (ko) 2003-06-18
PL360373A1 (en) 2004-09-06
AU8112101A (en) 2002-02-18
ATE354568T1 (de) 2007-03-15
CZ2003686A3 (cs) 2003-08-13
WO2002012190A2 (en) 2002-02-14
EP1311482B1 (en) 2007-02-21
US7071191B2 (en) 2006-07-04
WO2002012190A3 (en) 2002-08-01
ES2282279T3 (es) 2007-10-16
CN100396668C (zh) 2008-06-25
CN1468221A (zh) 2004-01-14
US20050227979A1 (en) 2005-10-13
MXPA03001268A (es) 2004-09-06
KR100852362B1 (ko) 2008-08-14
US20020040024A1 (en) 2002-04-04
BR0113161A (pt) 2004-04-06
JP2004511438A (ja) 2004-04-15
US7241778B2 (en) 2007-07-10
HUP0302893A2 (hu) 2003-12-29
PT1311482E (pt) 2007-04-30
DE60126785T2 (de) 2007-10-25
CA2419036A1 (en) 2002-02-14

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