MXPA03001268A - Ariloxipiperidinas sin imidazol. - Google Patents

Ariloxipiperidinas sin imidazol.

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Publication number
MXPA03001268A
MXPA03001268A MXPA03001268A MXPA03001268A MXPA03001268A MX PA03001268 A MXPA03001268 A MX PA03001268A MX PA03001268 A MXPA03001268 A MX PA03001268A MX PA03001268 A MXPA03001268 A MX PA03001268A MX PA03001268 A MXPA03001268 A MX PA03001268A
Authority
MX
Mexico
Prior art keywords
imidazole
aryloxypiperidines
imidazole aryloxypiperidines
aryloxypiperidine
treat
Prior art date
Application number
MXPA03001268A
Other languages
English (en)
Inventor
R Shah Chandravadan
Original Assignee
Johnson & Johnson
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Johnson & Johnson filed Critical Johnson & Johnson
Publication of MXPA03001268A publication Critical patent/MXPA03001268A/es

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    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/325—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4402—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4465—Non condensed piperidines, e.g. piperocaine only substituted in position 4
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    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • C07C217/18—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted
    • C07C217/22—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted by carbon atoms having at least two bonds to oxygen atoms
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    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/24—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/25—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
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    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
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    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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Abstract

Se describen compuestos de ariloxipiperidinas sustituidas sin imidazol, composiciones que los contienen y metodos para elaborar y utilizarlos para tratar o evitar condiciones mediadas por histamina.
MXPA03001268A 2000-08-08 2001-08-06 Ariloxipiperidinas sin imidazol. MXPA03001268A (es)

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US22376800P 2000-08-08 2000-08-08
PCT/US2001/024660 WO2002012190A2 (en) 2000-08-08 2001-08-06 Non-imidazole aryloxypiperidines as h3 receptor ligands
US09/922,619 US7071191B2 (en) 2000-08-08 2001-08-06 Non-imidazole aryloxypiperidines

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Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2282279T3 (es) * 2000-08-08 2007-10-16 Ortho-Mcneil Pharmaceutical, Inc. No-imidazol ariloxipiperidina como ligandos del receptor h3.
ATE319696T1 (de) * 2000-08-08 2006-03-15 Ortho Mcneil Pharm Inc Nicht-imidazol aryloxyalkylamine als h3 rezeptor liganden
CA2441080A1 (en) * 2001-03-23 2002-10-03 Eli Lilly And Company Non-imidazole aryl alkylamines compounds as histamine h3 receptor antagonists, preparation and therapeutic uses
US7208497B2 (en) 2001-07-02 2007-04-24 Novo Nordisk A/S Substituted piperazines and diazepanes
EP1430027B1 (en) 2001-09-14 2010-09-01 High Point Pharmaceuticals, LLC Novel aminoazetidine, -pyrrolidine and -piperidine derivatives
US7314937B2 (en) 2002-03-21 2008-01-01 Eli Lilly And Company Non-imidazole aryl alkylamines compounds as histamine H3 receptor antagonists, preparation and therapeutic uses
EP1795192A3 (en) * 2002-04-30 2008-05-07 Bayer Schering Pharma Aktiengesellschaft 1-(Pyridazin-3-yl)-imidazole derivatives as inhibitors of nitric oxide synthase (NOS)
US6982259B2 (en) * 2002-04-30 2006-01-03 Schering Aktiengesellschaft N-heterocyclic derivatives as NOS inhibitors
GB0224084D0 (en) * 2002-10-16 2002-11-27 Glaxo Group Ltd Novel compounds
GB0224083D0 (en) * 2002-10-16 2002-11-27 Glaxo Group Ltd Novel compounds
GB0224557D0 (en) * 2002-10-22 2002-11-27 Glaxo Group Ltd Novel compounds
WO2004037800A1 (en) * 2002-10-22 2004-05-06 Glaxo Group Limited Aryloxyalkylamine derivates as h3 receptor ligands
WO2004037257A1 (en) 2002-10-23 2004-05-06 Janssen Pharmaceutica, N.V. Phenylpiperidines and phenylpyrrolidines as histamine h3 receptor modulators
DK1558595T3 (da) 2002-10-23 2010-03-29 Janssen Pharmaceutica Nv Piperazinyl- og diazapanylbenzamider og -benzthioamider
GB0302094D0 (en) * 2003-01-29 2003-02-26 Pharmagene Lab Ltd EP4 receptor antagonists
GB0324159D0 (en) 2003-10-15 2003-11-19 Glaxo Group Ltd Novel compounds
GB0324269D0 (en) 2003-10-16 2003-11-19 Pharmagene Lab Ltd EP4 receptor antagonists
UA89226C2 (en) * 2004-03-25 2010-01-11 Янссен Фармацевтика Н.В. Imidazole compounds
EP1593679A1 (en) * 2004-05-07 2005-11-09 Warner-Lambert Company LLC 3- Or 4-monosubstituted phenol derivatives useful as H3 ligands
ATE472540T1 (de) * 2004-05-07 2010-07-15 Warner Lambert Co Als h3-liganden geeignete 3- oder 4- monosubstituierte phenol- und thiophenol-derivate
US7456164B2 (en) 2004-05-07 2008-11-25 Pfizer, Inc 3- or 4-monosubtituted phenol and thiophenol derivatives useful as H3 ligands
EP1595881A1 (en) 2004-05-12 2005-11-16 Pfizer Limited Tetrahydronaphthyridine derivates useful as histamine H3 receptor ligands
WO2006071750A1 (en) * 2004-12-23 2006-07-06 Athersys, Inc. 4-piperidinol tertiary amines as histamine 3 receptor inhibitors for the treatment of obesity and other cns disorders
EP2233470B1 (en) 2005-07-04 2011-12-07 High Point Pharmaceuticals, LLC Histamine H3 receptor antagonists
US7687499B2 (en) 2005-09-16 2010-03-30 Janssen Pharmaceutica Nv Cyclopropyl amines as modulators of the histamine H3 receptor
JP2009528976A (ja) 2005-09-23 2009-08-13 株式会社エムズサイエンス ピペリジン誘導体及びピペラジン誘導体
AR056690A1 (es) * 2005-10-14 2007-10-17 Athersys Inc Derivados de indol como inhibidores de indol como inhibidores del receptor 3 de histamina para el tartamiento de trastornos del sueno y cognitivos obesidad y otros trastornos de snc
EP1954287B2 (en) * 2005-10-31 2016-02-24 Merck Sharp & Dohme Corp. Cetp inhibitors
EP1945639A1 (en) * 2005-11-04 2008-07-23 Pfizer Limited Tetrahydronaphthyridine derivative
ES2663496T3 (es) 2005-11-29 2018-04-13 Nihon Medi-Physics Co., Ltd. Compuesto precursor de compuesto orgánico marcado con halógeno radiactivo
CN101448503B (zh) 2006-01-27 2011-04-13 株式会社爱慕知科学 哌啶和哌嗪衍生物
MX2008014766A (es) 2006-05-29 2009-03-06 High Point Pharmaceuticals Llc 3-(1,3-benzodioxol-5-il)-6-(4-ciclopropilpiperazin-1-il)-piperazi na, sus sales y solvatos y su uso como antagonista del receptor de h3 histamina.
WO2007138431A2 (en) * 2006-05-30 2007-12-06 Pfizer Products Inc. Azabicyclic ether histamine-3 antagonists
MX2009000884A (es) 2006-07-25 2009-06-05 Cephalon Inc Derivados de piridizinona.
KR20090031786A (ko) * 2006-08-23 2009-03-27 화이자 프로덕츠 인코포레이티드 피페리딘 유도체
WO2008072703A1 (ja) * 2006-12-14 2008-06-19 Taisho Pharmaceutical Co., Ltd. ビフェニルアミド誘導体
WO2008072724A1 (ja) * 2006-12-14 2008-06-19 Taisho Pharmaceutical Co., Ltd. ピラゾール誘導体
EP2014656A3 (en) 2007-06-11 2011-08-24 High Point Pharmaceuticals, LLC New heteocyclic h3 antagonists
AU2008294708B2 (en) 2007-09-06 2012-03-15 Glaxo Group Limited Piperazine derivative having affinity for the histamine H3 receptor
SI2221298T1 (sl) 2007-11-13 2013-12-31 Taisho Pharmaceutical Co., Ltd. Derivati fenilpirazola
CA2712897A1 (en) 2008-01-30 2009-08-06 Pharmacopeia, Inc. Substituted spirocyclic piperidine derivatives as histamine-3 (h3) receptor ligands
EP2271619A1 (en) * 2008-04-07 2011-01-12 Irm Llc Compounds and compositions as modulators of gpr119 activity
RS54248B1 (en) * 2011-02-23 2016-02-29 Suven Life Sciences Limited NEW UNITS AS LISTS OF HISTAMINE H3 RECEPTORS
GB201114448D0 (en) * 2011-08-22 2011-10-05 Takeda Pharmaceutical Compounds and their use
US9284324B2 (en) 2011-12-08 2016-03-15 Taisho Pharmaceutical Co., Ltd Phenylpyrrole derivative
TW201343636A (zh) * 2011-12-27 2013-11-01 大正製藥股份有限公司 苯基***衍生物
WO2013151982A1 (en) 2012-04-03 2013-10-10 Arena Pharmaceuticals, Inc. Methods and compounds useful in treating pruritus, and methods for identifying such compounds
HUP1300139A2 (en) * 2013-03-06 2014-09-29 Richter Gedeon Nyrt Phenoxypiperidine h3 antagonists
HUP1900190A1 (hu) * 2019-05-31 2020-12-28 Richter Gedeon Nyrt Szelektív hisztamin H3 receptor antagonisták autizmus spektrum betegség kezelésére
CN114466845A (zh) * 2019-09-25 2022-05-10 昂科艾伦迪治疗法公司 制备5-(4-((2s,5s)-5-(4-氯苄基)-2-甲基吗啉代)哌啶-1-基)-1h-1,2,4-***-3-胺的方法

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2566360A (en) * 1948-08-30 1951-09-04 Schering Corp Aminoalkyl ethers of pyridyl alkylene aryl compounds
GB1096441A (en) * 1964-01-15 1967-12-29 Bristol Myers Co Ethers of benzyl phenols and a process for the preparation thereof
US3919231A (en) 1974-06-17 1975-11-11 Morton Norwich Products Inc Series of 5-aryl-2-furamidines
US5182291A (en) * 1986-02-14 1993-01-26 Sanofi Pyrozala-pyridyl aminoabkoxyphenol compounds
US4833149A (en) 1986-09-22 1989-05-23 Ortho Pharmaceutical Corporation 2- or 3-aryl substituted imidazo[1,2-a]pyridines
JP3280040B2 (ja) * 1990-03-26 2002-04-30 武田薬品工業株式会社 アミノベンゼン化合物
US5580883A (en) * 1990-03-26 1996-12-03 Takeda Chemical Industries, Ltd. Aminobenzene compounds to prevent nerve cell degradation
US5352707A (en) * 1992-03-26 1994-10-04 Harbor Branch Oceanographic Institution, Inc. Method for treating airway congestion
US5217986A (en) 1992-03-26 1993-06-08 Harbor Branch Oceanographic Institution, Inc. Anti-allergy agent
BR9306190A (pt) 1992-04-01 1998-06-23 Univ Toledo Composto composiçao farmacéutica e processo para tratar um indivíduo sofrendo de um distúrbio cognitivo ou uma deficiéncia na atençao ou estímulo
US5242924A (en) * 1992-07-02 1993-09-07 Sterling Winthrop Inc. Tetrazolyl-(phenoxy and phenoxyalkyl)-piperidinylpyridazines as antiviral agents
US5840746A (en) 1993-06-24 1998-11-24 Merck Frosst Canada, Inc. Use of inhibitors of cyclooxygenase in the treatment of neurodegenerative diseases
FR2708609B1 (fr) 1993-07-29 1995-10-20 Sanofi Elf Dérivés de méthylguanidine, leurs procédés de préparation ainsi que les compositions en contenant.
WO1995014007A1 (en) 1993-11-15 1995-05-26 Schering Corporation Phenyl-alkyl imidazoles as h3-receptor antagonists
US5580523A (en) 1994-04-01 1996-12-03 Bard; Allen J. Integrated chemical synthesizers
AUPN037195A0 (en) * 1995-01-03 1995-01-27 Australian Nuclear Science & Technology Organisation Piperidine-based sigma receptor ligands
IL117149A0 (en) * 1995-02-23 1996-06-18 Schering Corp Muscarinic antagonists
EP0871614A1 (en) * 1995-05-08 1998-10-21 Hoechst Marion Roussel, Inc. Alpha-(substituted alkylphenyl)-4-(hydroxydiphenylmethyl)-1-piperidine butanol derivatives, their preparation and their use as anti-histamines, anti-allergy agents and bronchodilators
JP4263240B2 (ja) 1995-11-09 2009-05-13 サノフィ−アベンティス ５−フェニル−３−（ピペリジン−４−イル）−１，３，４−オキサジアゾール−２（３ｈ）−オン誘導体、及びその５−ｈｔ４又はｈ３レセプターリガンドとしての用途
TW486475B (en) * 1996-12-26 2002-05-11 Ube Industries Acid addition salt of optically active piperidine compound and process for preparing the same
EP0986540B1 (en) * 1997-04-22 2005-02-16 Euro-Celtique S.A. The use of carbocyclic and heterocyclic substituted semicarbazones and thiosemicarbazones as sodium channel blockers
US6200536B1 (en) 1997-06-26 2001-03-13 Battelle Memorial Institute Active microchannel heat exchanger
US5869479A (en) 1997-08-14 1999-02-09 Schering Corporation Treatment of upper airway allergic responses
GB9803536D0 (en) 1998-02-19 1998-04-15 Black James Foundation Histamine H,receptor ligands
ZA991315B (en) 1998-02-20 2000-11-20 Ortho Mcneil Pharm Inc Novel substituted pyridino arylpiperazines useful in the treatment of benign prostatic hyperplasia.
EP0982300A3 (en) 1998-07-29 2000-03-08 Societe Civile Bioprojet Non-imidazole alkylamines as histamine H3 - receptor ligands and their therapeutic applications
EP0978512A1 (en) * 1998-07-29 2000-02-09 Societe Civile Bioprojet Non-imidazole aryloxy (or arylthio) alkylamines as histamine H3-receptor antagonists and their therapeutic applications
DE19920161A1 (de) 1998-11-06 2000-05-25 Atotech Deutschland Gmbh Verfahren zum Herstellen von Mikrobauteilen mit Strömungskanälen
DE60017702T2 (de) 1999-03-03 2006-04-06 Symyx Technologies, Inc., Santa Clara Chemische verfahrensmikrosysteme zur evaluierung heterogener katalysatoren und ihre verwendung
KR20020063888A (ko) 1999-11-04 2002-08-05 바실리어 파마슈티카 아게 치환된 5-벤질-2,4-디아미노피리미딘
EP1286761A2 (en) 2000-05-24 2003-03-05 Cellular Process Chemistry Inc. Modular chemical production system incorporating a microreactor
ES2282279T3 (es) * 2000-08-08 2007-10-16 Ortho-Mcneil Pharmaceutical, Inc. No-imidazol ariloxipiperidina como ligandos del receptor h3.
ATE323076T1 (de) 2000-08-08 2006-04-15 Ortho Mcneil Pharm Inc Bicyclische verbindungen als h3 rezeptor liganden

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PL360373A1 (en) 2004-09-06
CZ2003686A3 (cs) 2003-08-13
KR20030048007A (ko) 2003-06-18
CN100396668C (zh) 2008-06-25
EP1311482B1 (en) 2007-02-21
US20050227979A1 (en) 2005-10-13
ATE354568T1 (de) 2007-03-15
CA2419036A1 (en) 2002-02-14
US7241778B2 (en) 2007-07-10
AU8112101A (en) 2002-02-18
ES2282279T3 (es) 2007-10-16
DE60126785T2 (de) 2007-10-25
EP1311482A2 (en) 2003-05-21
US7071191B2 (en) 2006-07-04
HUP0302893A3 (en) 2006-04-28
KR100852362B1 (ko) 2008-08-14
US20020040024A1 (en) 2002-04-04
WO2002012190A2 (en) 2002-02-14
JP2004511438A (ja) 2004-04-15
PT1311482E (pt) 2007-04-30
CN1468221A (zh) 2004-01-14
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AU2001281121B2 (en) 2007-08-23
DK1311482T3 (da) 2007-05-07

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