ATE234290T1 - Phenylalkyl-imidazole als h3-rezeptor- antagonisten - Google Patents

Phenylalkyl-imidazole als h3-rezeptor- antagonisten

Info

Publication number
ATE234290T1
ATE234290T1 AT95902442T AT95902442T ATE234290T1 AT E234290 T1 ATE234290 T1 AT E234290T1 AT 95902442 T AT95902442 T AT 95902442T AT 95902442 T AT95902442 T AT 95902442T AT E234290 T1 ATE234290 T1 AT E234290T1
Authority
AT
Austria
Prior art keywords
phenylalkyl
imidazole
receptor antagonists
imidazoles
alkyl
Prior art date
Application number
AT95902442T
Other languages
English (en)
Inventor
Robert G Aslanian
Michael J Green
Neng-Yang Shih
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Application granted granted Critical
Publication of ATE234290T1 publication Critical patent/ATE234290T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
AT95902442T 1993-11-15 1994-11-10 Phenylalkyl-imidazole als h3-rezeptor- antagonisten ATE234290T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15323193A 1993-11-15 1993-11-15
PCT/US1994/012717 WO1995014007A1 (en) 1993-11-15 1994-11-10 Phenyl-alkyl imidazoles as h3-receptor antagonists

Publications (1)

Publication Number Publication Date
ATE234290T1 true ATE234290T1 (de) 2003-03-15

Family

ID=22546320

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95902442T ATE234290T1 (de) 1993-11-15 1994-11-10 Phenylalkyl-imidazole als h3-rezeptor- antagonisten

Country Status (10)

Country Link
US (1) US5578616A (de)
EP (1) EP0729459B1 (de)
JP (1) JPH09505298A (de)
AT (1) ATE234290T1 (de)
AU (1) AU693142B2 (de)
DE (1) DE69432263T2 (de)
ES (1) ES2188649T3 (de)
HU (1) HUT74386A (de)
NZ (2) NZ276883A (de)
WO (1) WO1995014007A1 (de)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19615262A1 (de) * 1996-04-18 1997-10-23 Bayer Ag Heteroverknüpfte Phenylglycinolamide
SG72827A1 (en) * 1997-06-23 2000-05-23 Hoffmann La Roche Phenyl-and aminophenyl-alkylsulfonamide and urea derivatives
GB9715814D0 (en) * 1997-07-25 1997-10-01 Black James Foundation Histamine H3 receptor ligands
US6407132B1 (en) * 1997-07-25 2002-06-18 James Black Foundation Limited Substituted imidazole derivatives and their use as histamine H3 receptor ligands
GB2344588B (en) * 1997-07-25 2001-11-14 Black James Foundation 1H-4(5)-substituted imidazole derivatives their preparation and their use as histamine H 3 receptor ligands
NZ504124A (en) * 1997-11-07 2002-10-25 Schering Corp Phenyl-alkyl-imidazoles and use in treating inflammatory disease
DE69811110T2 (de) * 1997-11-07 2003-11-27 Schering Corp Phenyl-alkyl imidazole als h3 rezeptor antagonisten
US6034251A (en) * 1997-11-07 2000-03-07 Schering Corporation Phenyl-alkyl-imidazoles
US5990147A (en) * 1997-11-07 1999-11-23 Schering Corporation H3 receptor ligands of the phenyl-alkyl-imidazoles type
US6503935B1 (en) 1998-08-07 2003-01-07 Abbott Laboratories Imidazoles and related compounds as α1A agonists
US6133291A (en) * 1998-10-16 2000-10-17 Schering Corporation N-(imidazolylalkyl)substituted cyclic amines as histamine-H3 agonists or antagonists
US6100279A (en) * 1998-11-05 2000-08-08 Schering Corporation Imidazoylalkyl substituted with a five, six or seven membered heterocyclic ring containing one nitrogen atom
AU3033100A (en) 1999-01-18 2000-08-01 Boehringer Ingelheim International Gmbh Substituted imidazoles, their preparation and use
US6211182B1 (en) 1999-03-08 2001-04-03 Schering Corporation Imidazole compounds substituted with a six or seven membered heterocyclic ring containing two nitrogen atoms
US6908926B1 (en) 1999-04-16 2005-06-21 Novo Nordisk A/S Substituted imidazoles, their preparation and use
US6437147B1 (en) 2000-03-17 2002-08-20 Novo Nordisk Imidazole compounds
US6610721B2 (en) 2000-03-17 2003-08-26 Novo Nordisk A/S Imidazo heterocyclic compounds
AU8112101A (en) 2000-08-08 2002-02-18 Ortho Mcneil Pharm Inc Non-imidazole aryloxypiperidines
ATE319696T1 (de) 2000-08-08 2006-03-15 Ortho Mcneil Pharm Inc Nicht-imidazol aryloxyalkylamine als h3 rezeptor liganden
ES2261454T3 (es) 2000-08-08 2006-11-16 Ortho-Mcneil Pharmaceutical, Inc. Compuestos biciclicos como ligandos del receptor h3.
EP1318994B1 (de) 2000-09-20 2008-02-27 Schering Corporation Substituierte imidazole als duale histamin h1 und h3 agonisten oder antagonisten
AU2001291040A1 (en) 2000-09-20 2002-04-02 Schering Corporation Substituted imidazoles as dual histamine h1 and h3 agonists or antagonists
CA2422729A1 (en) 2000-09-20 2002-06-06 Schering Corporation Substituted imidazoles as dual histamine h1 and h3 agonists or antagonists
US6518287B2 (en) 2000-09-20 2003-02-11 Schering Corporation Substituted imidazoles as dual histamine H1 and H3 agonists or antagonists
PE20020507A1 (es) 2000-10-17 2002-06-25 Schering Corp Compuestos no-imidazoles como antagonistas del receptor histamina h3
AU2002256967A1 (en) * 2000-10-30 2002-09-12 Schering Corporation Treating or reducing the risk of cardiovascular disease
AU2002253929A1 (en) 2001-02-08 2002-09-24 Schering Corporation Use of dual h3/m2 antagonists with a bipiperidinic structure in the treatment of cognition deficit disorders
US6849621B2 (en) 2001-03-13 2005-02-01 Schering Corporation Piperidine compounds
US7880017B2 (en) * 2003-11-11 2011-02-01 Allergan, Inc. Process for the synthesis of imidazoles
US7183305B2 (en) * 2003-11-11 2007-02-27 Allergan, Inc. Process for the synthesis of imidazoles
EP1707203A1 (de) 2005-04-01 2006-10-04 Bioprojet Verwendung von Alkylaminen, die kein Imidazole enthalten, als Histamin H3 Rezeptor Liganden, zur Behandlung von Morbus Parkinson, obstruktiver Schlafapnoe, vaskularer Demenz, Demenz mit Lewy Korpen
EP1717235A3 (de) 2005-04-29 2007-02-28 Bioprojet Phenoxypropylpiperidine und -pyrrolidine und ihre Verwendung als Liganden für den Histamin H3-Rezeptor
EP1717233A1 (de) * 2005-04-29 2006-11-02 Bioprojet Liganden für den Histamin H3-Rezeptor und ihre therapeutische Anwendung
EP1931665A1 (de) 2005-09-20 2008-06-18 Schering Corporation Als histamin-h3-antagonist geeignetes 1-[[1-[(2-amin0-6-methyl-4-pyridinyl)methyl]-4-fluor-4-piperidinyl]carbonyl]-4-[2-(2-pyridinyl)-3h-imidazo[4,5-b]pyridin-3-yl]piperidin
US20080146523A1 (en) * 2006-12-18 2008-06-19 Guido Galley Imidazole derivatives
US8653123B2 (en) * 2010-09-16 2014-02-18 Allergan, Inc. Ester pro-drugs of [3-(1-(1H-imidazol-4-yl)ethyl)-2-methylphenyl] methanol for treating retinal diseases
WO2013078151A1 (en) 2011-11-21 2013-05-30 Allergan, Inc. Pharmaceutical compositions comprising 4-[1-(2,3-dimethylphenyl)ethyl]-3h-imidazole derivatives for treating retinal diseases
WO2014032755A2 (en) * 2012-08-29 2014-03-06 Merck Patent Gmbh Ddr2 inhibitors for the treatment of osteoarthritis

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU518569B2 (en) * 1979-08-07 1981-10-08 Farmos-Yhtyma Oy 4-benzyl- and 4-benzoyl imidazole derivatives
GB8626287D0 (en) * 1986-11-04 1986-12-03 Ucb Sa Substituted 1h-imidazoles
JPH01242571A (ja) * 1988-03-22 1989-09-27 Mitsui Petrochem Ind Ltd イミダゾール誘導体の製造方法
GB8810067D0 (en) * 1988-04-28 1988-06-02 Ucb Sa Substituted 1-(1h-imidazol-4-yl)alkyl-benzamides
GB8916947D0 (en) * 1989-07-25 1989-09-13 Smith Kline French Lab Medicaments
GB9115740D0 (en) * 1991-07-20 1991-09-04 Smithkline Beecham Plc Medicaments
FR2686084B1 (fr) * 1992-01-10 1995-12-22 Bioprojet Soc Civ Nouveaux derives de l'imidazole, leur preparation et leurs applications therapeutiques.

Also Published As

Publication number Publication date
NZ330898A (en) 2000-01-28
DE69432263T2 (de) 2003-12-04
EP0729459A1 (de) 1996-09-04
EP0729459B1 (de) 2003-03-12
DE69432263D1 (de) 2003-04-17
WO1995014007A1 (en) 1995-05-26
AU693142B2 (en) 1998-06-25
JPH09505298A (ja) 1997-05-27
HUT74386A (en) 1996-12-30
NZ276883A (en) 1998-08-26
US5578616A (en) 1996-11-26
HU9601282D0 (en) 1996-07-29
ES2188649T3 (es) 2003-07-01
AU1171295A (en) 1995-06-06

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Legal Events

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RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties