DE602004028493D1 - Isochinolinon-kaliumkanalinhibitoren - Google Patents
Isochinolinon-kaliumkanalinhibitorenInfo
- Publication number
- DE602004028493D1 DE602004028493D1 DE602004028493T DE602004028493T DE602004028493D1 DE 602004028493 D1 DE602004028493 D1 DE 602004028493D1 DE 602004028493 T DE602004028493 T DE 602004028493T DE 602004028493 T DE602004028493 T DE 602004028493T DE 602004028493 D1 DE602004028493 D1 DE 602004028493D1
- Authority
- DE
- Germany
- Prior art keywords
- potassium channel
- channel inhibitors
- isoquinolinone
- isoquinolinone potassium
- inhibitors
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US50521503P | 2003-09-23 | 2003-09-23 | |
| PCT/US2004/030484 WO2005030726A1 (en) | 2003-09-23 | 2004-09-17 | Isoquinolinone potassium channel inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE602004028493D1 true DE602004028493D1 (de) | 2010-09-16 |
Family
ID=34392991
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE602004028493T Active DE602004028493D1 (de) | 2003-09-23 | 2004-09-17 | Isochinolinon-kaliumkanalinhibitoren |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7741322B2 (de) |
| EP (1) | EP1667976B1 (de) |
| JP (1) | JP4717815B2 (de) |
| CN (1) | CN1856472A (de) |
| AT (1) | ATE476419T1 (de) |
| AU (1) | AU2004276238B2 (de) |
| CA (1) | CA2539729C (de) |
| DE (1) | DE602004028493D1 (de) |
| WO (1) | WO2005030726A1 (de) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005030727A1 (en) * | 2003-09-23 | 2005-04-07 | Merck & Co., Inc. | Isoquinolinone potassium channel inhibitors |
| CA2539853C (en) * | 2003-09-23 | 2011-04-19 | Merck & Co., Inc. | Isoquinolinone potassium channel inhibitors |
| AU2004276236B2 (en) * | 2003-09-23 | 2008-01-24 | Merck Sharp & Dohme Corp. | Isoquinolinone potassium channel inhibitors |
| EP1667981A4 (de) * | 2003-09-23 | 2008-08-13 | Merck & Co Inc | Isochinoline als kaliumkanalinhibitoren |
| US7569589B2 (en) | 2004-07-29 | 2009-08-04 | Merck & Co., Inc. | Potassium channel inhibitors |
| AU2005267884B2 (en) | 2004-07-29 | 2011-04-21 | Merck Sharp & Dohme Corp. | Potassium channel inhibitors |
| CN101277939A (zh) | 2005-09-09 | 2008-10-01 | 布里斯托尔-迈尔斯斯奎布公司 | 无环ikur抑制剂 |
| WO2007109577A1 (en) * | 2006-03-17 | 2007-09-27 | Kalypsys, Inc. | Alkylamine-substituted bicyclic aryl compounds useful as modulators of ppar |
| DE102006019589A1 (de) * | 2006-04-27 | 2007-10-31 | Sanofi-Aventis Deutschland Gmbh | Inhibitoren des TASK-1 und Task-3 Ionenkanals |
| BRPI0806371A2 (pt) | 2007-01-22 | 2011-09-13 | Gtx Inc | agentes ligação de receptor nuclear |
| US9623021B2 (en) * | 2007-01-22 | 2017-04-18 | Gtx, Inc. | Nuclear receptor binding agents |
| US9604931B2 (en) | 2007-01-22 | 2017-03-28 | Gtx, Inc. | Nuclear receptor binding agents |
| US11098018B2 (en) * | 2017-08-14 | 2021-08-24 | Acesion Pharma Aps | Potassium channel inhibitors |
| CN110670090B (zh) * | 2019-11-13 | 2021-06-29 | 广西师范大学 | 一种基于电化学合成异喹啉酮类化合物的方法 |
| WO2023156386A2 (en) * | 2022-02-16 | 2023-08-24 | Duke Street Bio Limited | Pharmaceutical compound |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3594380A (en) * | 1969-02-18 | 1971-07-20 | American Home Prod | Isoquinolin-1(2h)-ones |
| DE69315920T2 (de) | 1992-09-04 | 1998-06-10 | Takeda Chemical Industries Ltd | Kondensierte heterozyklische Verbindungen, deren Herstellung und Verwendung |
| EP0634402A1 (de) * | 1993-07-14 | 1995-01-18 | Takeda Chemical Industries, Ltd. | Isochinolinon-Derivate, ihre Herstellung und Verwendung |
| US5387685A (en) | 1993-07-16 | 1995-02-07 | American Cyanamid Co | MDR reversal agents |
| CA2421819C (en) | 2000-09-20 | 2010-03-09 | Merck & Co., Inc. | Isoquinolinone potassium channel inhibitors |
| EP1396488A1 (de) * | 2001-05-23 | 2004-03-10 | Mitsubishi Pharma Corporation | Kondensierte heterocyclische verbindung und deren medizinische verwendung |
| US7402595B2 (en) * | 2002-02-13 | 2008-07-22 | Takeda Pharmaceutical Company Limited | JNK inhibitor |
| EP1667981A4 (de) * | 2003-09-23 | 2008-08-13 | Merck & Co Inc | Isochinoline als kaliumkanalinhibitoren |
| AU2004276236B2 (en) * | 2003-09-23 | 2008-01-24 | Merck Sharp & Dohme Corp. | Isoquinolinone potassium channel inhibitors |
| CA2539853C (en) * | 2003-09-23 | 2011-04-19 | Merck & Co., Inc. | Isoquinolinone potassium channel inhibitors |
| WO2005030727A1 (en) * | 2003-09-23 | 2005-04-07 | Merck & Co., Inc. | Isoquinolinone potassium channel inhibitors |
-
2004
- 2004-09-17 CA CA2539729A patent/CA2539729C/en not_active Expired - Fee Related
- 2004-09-17 WO PCT/US2004/030484 patent/WO2005030726A1/en active Application Filing
- 2004-09-17 CN CNA2004800273770A patent/CN1856472A/zh active Pending
- 2004-09-17 US US10/571,858 patent/US7741322B2/en not_active Expired - Fee Related
- 2004-09-17 DE DE602004028493T patent/DE602004028493D1/de active Active
- 2004-09-17 JP JP2006527053A patent/JP4717815B2/ja not_active Expired - Fee Related
- 2004-09-17 AU AU2004276238A patent/AU2004276238B2/en not_active Ceased
- 2004-09-17 AT AT04784368T patent/ATE476419T1/de not_active IP Right Cessation
- 2004-09-17 EP EP04784368A patent/EP1667976B1/de active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP1667976A1 (de) | 2006-06-14 |
| JP2007506679A (ja) | 2007-03-22 |
| EP1667976A4 (de) | 2008-02-13 |
| US20060281743A1 (en) | 2006-12-14 |
| AU2004276238B2 (en) | 2010-10-28 |
| ATE476419T1 (de) | 2010-08-15 |
| CA2539729A1 (en) | 2005-04-07 |
| US7741322B2 (en) | 2010-06-22 |
| JP4717815B2 (ja) | 2011-07-06 |
| CN1856472A (zh) | 2006-11-01 |
| CA2539729C (en) | 2010-09-07 |
| WO2005030726A1 (en) | 2005-04-07 |
| EP1667976B1 (de) | 2010-08-04 |
| AU2004276238A1 (en) | 2005-04-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| R081 | Change of applicant/patentee |
Ref document number: 1667976 Country of ref document: EP Owner name: SCHERING CORPORATION, US Free format text: FORMER OWNER: MERCK SHARP & DOHME CORP., RAHWAY, US Effective date: 20121213 |
|
| R082 | Change of representative |
Ref document number: 1667976 Country of ref document: EP Representative=s name: ABITZ & PARTNER, DE Effective date: 20121213 |