DK1296951T3 - 5-chloro-3-(4-methansulfonylphenyl)-6'-methyl-[2,3']bipyridinyl i ren krystallinsk form og synteseproces - Google Patents

5-chloro-3-(4-methansulfonylphenyl)-6'-methyl-[2,3']bipyridinyl i ren krystallinsk form og synteseproces

Info

Publication number: DK1296951T3
Authority: DK; Denmark
Prior art keywords: methanesulfonylphenyl; bipyridinyl; chloro; methyl; crystalline form
Prior art date: 2000-05-26

Application number

DK01939267.9T

Other languages

English (en)

Inventor

Louis S Crocker

Ian W Davies

Richard G Osifchin

Andrew Kotliar

Original Assignee

Merck Sharp & Dohme

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-05-26

Filing date

2001-05-22

Publication date

2011-01-24

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22772880&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1296951(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2001-05-22 Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme

2011-01-24 Application granted granted Critical

2011-01-24 Publication of DK1296951T3 publication Critical patent/DK1296951T3/da

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/61—Halogen atoms or nitro radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

DK01939267.9T 2000-05-26 2001-05-22 5-chloro-3-(4-methansulfonylphenyl)-6'-methyl-[2,3']bipyridinyl i ren krystallinsk form og synteseproces DK1296951T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US20801700P	2000-05-26	2000-05-26
PCT/US2001/016566 WO2001092230A1 (en)	2000-05-26	2001-05-22	5-chloro-3-(4-methanesulfonylphenyl)-6'-methyl- [2,3']bipyridinyl in pure crystalline form and process for synthesis

Publications (1)

Publication Number	Publication Date
DK1296951T3 true DK1296951T3 (da)	2011-01-24

Family

ID=22772880

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK01939267.9T DK1296951T3 (da)	2000-05-26	2001-05-22	5-chloro-3-(4-methansulfonylphenyl)-6'-methyl-[2,3']bipyridinyl i ren krystallinsk form og synteseproces

Country Status (49)

Country	Link
EP (1)	EP1296951B1 (da)
JP (2)	JP3665053B2 (da)
KR (1)	KR100757699B1 (da)
CN (1)	CN1227233C (da)
AR (1)	AR028577A1 (da)
AT (1)	ATE483687T1 (da)
AU (2)	AU6480401A (da)
BG (1)	BG65855B1 (da)
BR (1)	BRPI0111140B8 (da)
CA (1)	CA2410234C (da)
CR (1)	CR6606A (da)
CY (1)	CY1111440T1 (da)
CZ (1)	CZ20023888A3 (da)
DE (1)	DE60143197D1 (da)
DK (1)	DK1296951T3 (da)
EA (1)	EA004809B1 (da)
EE (1)	EE05242B1 (da)
EG (1)	EG24189A (da)
ES (1)	ES2351958T3 (da)
GC (1)	GC0000362A (da)
GE (1)	GEP20053492B (da)
GT (1)	GT200100091A (da)
HK (1)	HK1058932A1 (da)
HN (1)	HN2001000110A (da)
HR (1)	HRP20020934B1 (da)
HU (1)	HU228423B1 (da)
IL (1)	IL152582A0 (da)
IN (2)	IN2002CH02089A (da)
IS (1)	IS2806B (da)
JO (1)	JO2216B1 (da)
MA (1)	MA26919A1 (da)
ME (1)	ME00428B (da)
MX (1)	MX230696B (da)
MY (1)	MY123569A (da)
NO (1)	NO324495B1 (da)
NZ (1)	NZ522394A (da)
PA (1)	PA8516901A1 (da)
PE (1)	PE20011324A1 (da)
PH (1)	PH12001001175B1 (da)
PL (1)	PL358153A1 (da)
PT (1)	PT1296951E (da)
RS (1)	RS51541B (da)
SI (1)	SI1296951T1 (da)
SK (1)	SK287174B6 (da)
SV (1)	SV2002000462A (da)
TW (1)	TWI303634B (da)
UA (1)	UA73355C2 (da)
WO (1)	WO2001092230A1 (da)
ZA (1)	ZA200209558B (da)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6858631B1 (en)	1999-11-29	2005-02-22	Merck & Co., Inc.	Polymorphic, amorphous and hydrated forms of 5-chloro-3-(4-methanesulfonylphenyl)-6′-methyl-[2,3′]bipyridinyl
ATE320809T1 (de)	1999-11-29	2006-04-15	Merck Frosst Canada Inc	Polymorphe, amorphe und hydratisierte formen von 5-chlor-3-(methansulfonylphenyl)-6'-methyl-2, 3')bipyridinyl
US6521642B2 (en) *	2000-05-26	2003-02-18	Merck & Co., Inc.	5-chloro-3-(4-methanesulfonylphenyl)-6′-methyl-[2,3′]bipyridinyl in pure crystalline form and process for synthesis
DK2401253T3 (da)	2009-02-27	2016-04-18	Cadila Healthcare Ltd	Fremgangsmåde til fremstilling af etoricoxib
WO2012004677A1 (en)	2010-07-05	2012-01-12	Actavis Group Ptc Ehf	Solid state forms of etoricoxib salts
WO2012163839A1 (en)	2011-05-27	2012-12-06	Farma Grs, D.O.O.	A process for the preparation of polymorphic form i of etoricoxib
EP2773618A1 (en)	2011-11-03	2014-09-10	Cadila Healthcare Limited	An improved process for the preparation of etoricoxib and polymorphs thereof
WO2013075732A1 (en)	2011-11-21	2013-05-30	Synthon Bv	Process for making crystalline form i of etoricoxib
EP2601952A1 (en)	2011-12-07	2013-06-12	Zentiva, k.s.	Novel pharmaceutically acceptable salts and cocrystals of 5-chloro-3-(4-methanesulfonylphenyl)-6'-methyl-[2,3']bipyridinyl and their therapeutic uses
WO2014033526A1 (en)	2012-08-27	2014-03-06	Cadila Healthcare Limited	Pharmaceutical compositions of etoricoxib
WO2014041558A2 (en) *	2012-08-27	2014-03-20	Glenmark Pharmaceuticals Limited; Glenmark Generics Limited	Process for preparation of crystalline etoricoxib
CN104418799A (zh) *	2013-09-03	2015-03-18	天津药物研究院	一种依托考昔的晶型及其制备方法和应用
WO2015036550A1 (en)	2013-09-13	2015-03-19	Synthon B.V.	Process for making etoricoxib
CN106632003B (zh) *	2015-12-31	2019-02-12	上海博志研新药物技术有限公司	一种依托考昔的制备方法
CN108069896B (zh) *	2016-11-11	2022-08-12	昆明积大制药股份有限公司	一种依托考昔晶型的制备方法
CN107056691B (zh) *	2017-06-21	2020-03-10	四川尚锐生物医药有限公司	一种制备依托考昔晶型v的方法
CN107417599B (zh) *	2017-06-21	2020-06-09	四川尚锐生物医药有限公司	一种依托考昔晶型的制备方法
MX2017009660A (es)	2017-07-26	2017-11-23	Laboratorios Liomont S A De C V	Composicion farmaceutica con un rango de relacion entre el clorhidrato de tramadol y el etoricoxib para su administracion para el tratamiento del dolor.
CN107556231A (zh) *	2017-09-23	2018-01-09	江苏正大清江制药有限公司	一种依托考昔与对硝基苯甲酸形成的盐的晶型及制备方法
CN107417600A (zh) *	2017-09-26	2017-12-01	江苏正大清江制药有限公司	一种依托考昔与呋喃甲酸形成盐的新晶型及制备方法
CN107898787B (zh) *	2017-12-15	2018-11-30	扬子江药业集团上海海尼药业有限公司	一种药物组合物及其制剂和制备方法
MX2018013070A (es)	2017-12-29	2019-10-15	Gruenenthal Gmbh	Combinación farmacéutica que comprende clorhidrato de tramadol de liberación extendida y etoricoxib de liberación inmediata, y su uso para el tratamiento del dolor.
CN110143915A (zh) *	2019-06-03	2019-08-20	蚌埠学院	一种依托考昔与对甲苯磺酸形成盐的新晶型及制备方法

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US5593994A (en) *	1994-09-29	1997-01-14	The Dupont Merck Pharmaceutical Company	Prostaglandin synthase inhibitors
US5739166A (en) *	1994-11-29	1998-04-14	G.D. Searle & Co.	Substituted terphenyl compounds for the treatment of inflammation
CA2260016C (en) *	1996-07-18	2004-03-09	Merck Frosst Canada Inc.	Substituted pyridines as selective cyclooxygenase-2 inhibitors
US5861419A (en) *	1996-07-18	1999-01-19	Merck Frosst Canad, Inc.	Substituted pyridines as selective cyclooxygenase-2 inhibitors
CA2329193C (en) *	1998-04-24	2007-01-23	Merck & Co., Inc.	Process for synthesizing cox-2 inhibitors
ATE320809T1 (de) *	1999-11-29	2006-04-15	Merck Frosst Canada Inc	Polymorphe, amorphe und hydratisierte formen von 5-chlor-3-(methansulfonylphenyl)-6'-methyl-2, 3')bipyridinyl

2001
- 2001-05-15 PH PH12001001175A patent/PH12001001175B1/en unknown
- 2001-05-16 AR ARP010102327A patent/AR028577A1/es unknown
- 2001-05-16 TW TW090111718A patent/TWI303634B/zh not_active IP Right Cessation
- 2001-05-16 GC GCP20011369 patent/GC0000362A/en active
- 2001-05-17 PE PE2001000443A patent/PE20011324A1/es not_active Application Discontinuation
- 2001-05-18 MY MYPI20012375 patent/MY123569A/en unknown
- 2001-05-21 GT GT200100091A patent/GT200100091A/es unknown
- 2001-05-22 AT AT01939267T patent/ATE483687T1/de active
- 2001-05-22 BR BRPI0111140-0 patent/BRPI0111140B8/pt not_active IP Right Cessation
- 2001-05-22 UA UA20021210537A patent/UA73355C2/uk unknown
- 2001-05-22 AU AU6480401A patent/AU6480401A/xx active Pending
- 2001-05-22 JO JO200179A patent/JO2216B1/en active
- 2001-05-22 SK SK1670-2002A patent/SK287174B6/sk not_active IP Right Cessation
- 2001-05-22 AU AU2001264804A patent/AU2001264804B2/en not_active Expired
- 2001-05-22 MX MXPA02011619 patent/MX230696B/es active IP Right Grant
- 2001-05-22 JP JP2002500844A patent/JP3665053B2/ja not_active Expired - Lifetime
- 2001-05-22 ME MEP-2008-638A patent/ME00428B/me unknown
- 2001-05-22 CZ CZ20023888A patent/CZ20023888A3/cs unknown
- 2001-05-22 EG EG20010540A patent/EG24189A/xx active
- 2001-05-22 PL PL01358153A patent/PL358153A1/xx not_active Application Discontinuation
- 2001-05-22 GE GE5012A patent/GEP20053492B/en unknown
- 2001-05-22 KR KR20027015871A patent/KR100757699B1/ko active Protection Beyond IP Right Term
- 2001-05-22 PT PT01939267T patent/PT1296951E/pt unknown
- 2001-05-22 DE DE60143197T patent/DE60143197D1/de not_active Expired - Lifetime
- 2001-05-22 DK DK01939267.9T patent/DK1296951T3/da active
- 2001-05-22 HU HU0302336A patent/HU228423B1/hu unknown
- 2001-05-22 ES ES01939267T patent/ES2351958T3/es not_active Expired - Lifetime
- 2001-05-22 EA EA200201264A patent/EA004809B1/ru not_active IP Right Cessation
- 2001-05-22 PA PA20018516901A patent/PA8516901A1/es unknown
- 2001-05-22 RS YUP-894/02A patent/RS51541B/sr unknown
- 2001-05-22 CA CA002410234A patent/CA2410234C/en not_active Expired - Lifetime
- 2001-05-22 NZ NZ522394A patent/NZ522394A/en not_active IP Right Cessation
- 2001-05-22 EE EEP200200655A patent/EE05242B1/xx unknown
- 2001-05-22 IL IL15258201A patent/IL152582A0/xx active IP Right Grant
- 2001-05-22 SI SI200130982T patent/SI1296951T1/sl unknown
- 2001-05-22 CN CNB018101372A patent/CN1227233C/zh not_active Ceased
- 2001-05-22 EP EP01939267A patent/EP1296951B1/en not_active Expired - Lifetime
- 2001-05-22 WO PCT/US2001/016566 patent/WO2001092230A1/en active IP Right Grant
- 2001-05-23 SV SV2001000462A patent/SV2002000462A/es active IP Right Grant
- 2001-05-23 HN HN2001000110A patent/HN2001000110A/es unknown
2002
- 2002-03-08 CR CR6606A patent/CR6606A/es unknown
- 2002-10-31 BG BG107237A patent/BG65855B1/bg unknown
- 2002-11-20 IS IS6630A patent/IS2806B/is unknown
- 2002-11-25 HR HR20020934A patent/HRP20020934B1/xx not_active IP Right Cessation
- 2002-11-25 ZA ZA200209558A patent/ZA200209558B/en unknown
- 2002-11-26 NO NO20025674A patent/NO324495B1/no not_active IP Right Cessation
- 2002-12-16 IN IN2089CH2002 patent/IN2002CH02089A/en unknown
- 2002-12-23 MA MA26971A patent/MA26919A1/fr unknown
2004
- 2004-03-10 HK HK04101751A patent/HK1058932A1/xx not_active IP Right Cessation
- 2004-09-10 JP JP2004263913A patent/JP4142621B2/ja not_active Expired - Lifetime
2007
- 2007-11-12 IN IN5103CH2007 patent/IN2007CH05103A/en unknown
2011
- 2011-01-04 CY CY20111100010T patent/CY1111440T1/el unknown

Also Published As

Publication number	Publication date
NO324495B1 (no)	2007-10-29
CN1443168A (zh)	2003-09-17
AU2001264804B2 (en)	2006-04-06
MY123569A (en)	2006-05-31
BG107237A (bg)	2003-05-30
BRPI0111140B8 (pt)	2021-05-25
PA8516901A1 (es)	2002-04-25
MXPA02011619A (es)	2003-03-27
CY1111440T1 (el)	2015-08-05
NO20025674L (no)	2002-11-26
ME00428B (me)	2011-10-10
SI1296951T1 (sl)	2011-01-31
BR0111140A (pt)	2005-01-11
HU228423B1 (en)	2013-03-28
KR100757699B1 (ko)	2007-09-13
AR028577A1 (es)	2003-05-14
ATE483687T1 (de)	2010-10-15
TWI303634B (en)	2008-12-01
EP1296951A1 (en)	2003-04-02
CA2410234C (en)	2008-05-13
EA200201264A1 (ru)	2003-04-24
KR20030003762A (ko)	2003-01-10
IN2007CH05103A (da)	2008-08-27
SK16702002A3 (sk)	2003-05-02
GC0000362A (en)	2007-03-31
JP2004501116A (ja)	2004-01-15
GT200100091A (es)	2001-12-28
PT1296951E (pt)	2010-12-07
UA73355C2 (en)	2005-07-15
CZ20023888A3 (cs)	2003-02-12
WO2001092230A1 (en)	2001-12-06
PL358153A1 (en)	2004-08-09
PE20011324A1 (es)	2002-01-28
MA26919A1 (fr)	2004-12-20
CA2410234A1 (en)	2001-12-06
IS2806B (is)	2012-09-15
JP4142621B2 (ja)	2008-09-03
AU6480401A (en)	2001-12-11
SK287174B6 (sk)	2010-02-08
YU89402A (sh)	2005-11-28
HRP20020934A2 (en)	2005-02-28
HK1058932A1 (en)	2004-06-11
NO20025674D0 (no)	2002-11-26
BRPI0111140B1 (pt)	2018-03-13
HUP0302336A2 (hu)	2003-11-28
GEP20053492B (en)	2005-04-25
IL152582A0 (en)	2003-05-29
PH12001001175B1 (en)	2006-08-10
ZA200209558B (en)	2003-10-28
EA004809B1 (ru)	2004-08-26
ES2351958T3 (es)	2011-02-14
EE05242B1 (et)	2009-12-15
SV2002000462A (es)	2002-03-08
IS6630A (is)	2002-11-20
IN2002CH02089A (da)	2005-02-25
EE200200655A (et)	2004-08-16
EG24189A (en)	2008-10-08
CN1227233C (zh)	2005-11-16
JP3665053B2 (ja)	2005-06-29
RS51541B (sr)	2011-06-30
JP2005047927A (ja)	2005-02-24
NZ522394A (en)	2004-05-28
HRP20020934B1 (en)	2012-01-31
CR6606A (es)	2006-02-06
MX230696B (es)	2005-09-19
JO2216B1 (en)	2004-10-07
HN2001000110A (es)	2002-03-06
EP1296951B1 (en)	2010-10-06
BG65855B1 (bg)	2010-03-31
DE60143197D1 (de)	2010-11-18

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IL154240A0 (en)	2003-07-31	4-pyrimidinamine derivatives, pharmaceutical compositions and related methods
HUP0302429A3 (en)	2004-01-28	4-amino-quinazolines, process for producing them, pharmaceutical compositions containing them and their use
EE200300060A (et)	2004-12-15	Polaarsete rühmadega perfluoroalküülrühma sisaldavad kompleksid, nende valmistamismeetod ja kasutamine
AU2002223766A1 (en)	2002-05-21	Single crystals, method for making single crystals by growth in solution and uses
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EP1372594A4 (en)	2004-04-07	KOJINIC ACID DERIVATIVES STABLE IN WATER AND METHOD FOR THE PRODUCTION THEREOF, AND THE LIGHTENING COSMETIC COMPOSITIONS CONTAINING THE SAME
IL156160A0 (en)	2003-12-23	Klainetins and their derivatives, method for their preparation and use thereof
NO20023845L (no)	2002-10-10	Pluraflaviner og derivater derav, fremgangsmåte for fremstilling av disse og deres anvendelse
IL159514A0 (en)	2004-06-01	A new process for the synthesis of torsemide, in particular of pure and stable form ii
DK1200446T3 (da)	2005-10-24	Oxathiepino[6,5-b]dihydropyridiner og beslægtede forbindelser og fremgangsmåder
AU2001241047A1 (en)	2001-09-17	Pyridonecarboxylic acid derivatives
SI1347965T1 (sl)	2006-06-30	Nove soli desloratadina, postopek za njihovo sintezo in njihovi farmacevtski sestavki
SI1252150T1 (en)	2003-10-31	Heterocyclic derivatives, preparation method and pharmaceutical compositions containing same