DK1270565T3 - 4-substitueret furan-2-sulfonamid og dets anvendelse i fremstillingen af sulfonylurinstofderivater - Google Patents
4-substitueret furan-2-sulfonamid og dets anvendelse i fremstillingen af sulfonylurinstofderivaterInfo
- Publication number
- DK1270565T3 DK1270565T3 DK02020749T DK02020749T DK1270565T3 DK 1270565 T3 DK1270565 T3 DK 1270565T3 DK 02020749 T DK02020749 T DK 02020749T DK 02020749 T DK02020749 T DK 02020749T DK 1270565 T3 DK1270565 T3 DK 1270565T3
- Authority
- DK
- Denmark
- Prior art keywords
- sulfonamide
- preparation
- substituted furan
- sulfonylurea derivatives
- sulfonylurea
- Prior art date
Links
- RHBMVXBGYGIDJN-UHFFFAOYSA-N furan-2-sulfonamide Chemical class NS(=O)(=O)C1=CC=CO1 RHBMVXBGYGIDJN-UHFFFAOYSA-N 0.000 title 1
- YROXIXLRRCOBKF-UHFFFAOYSA-N sulfonylurea Chemical class OC(=N)N=S(=O)=O YROXIXLRRCOBKF-UHFFFAOYSA-N 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/64—Sulfur atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
- C07C311/52—Y being a hetero atom
- C07C311/54—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
- C07C311/52—Y being a hetero atom
- C07C311/54—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea
- C07C311/57—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea having sulfur atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings
- C07C311/60—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea having sulfur atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings having nitrogen atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/14—Sulfones; Sulfoxides having sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/64—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton
- C07C323/67—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton containing sulfur atoms of sulfonamide groups, bound to the carbon skeleton
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/34—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US3697997P | 1997-01-29 | 1997-01-29 |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1270565T3 true DK1270565T3 (da) | 2004-10-04 |
Family
ID=21891776
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK02020749T DK1270565T3 (da) | 1997-01-29 | 1997-12-29 | 4-substitueret furan-2-sulfonamid og dets anvendelse i fremstillingen af sulfonylurinstofderivater |
DK97947201T DK0964849T3 (da) | 1997-01-29 | 1997-12-29 | Sulfonyl-urinstofderivater og deres anvendelse ved regulering af interleukin-1-aktivitet |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK97947201T DK0964849T3 (da) | 1997-01-29 | 1997-12-29 | Sulfonyl-urinstofderivater og deres anvendelse ved regulering af interleukin-1-aktivitet |
Country Status (40)
Country | Link |
---|---|
US (2) | US6166064A (fr) |
EP (1) | EP0964849B1 (fr) |
JP (1) | JP3573757B2 (fr) |
KR (1) | KR100324058B1 (fr) |
CN (1) | CN1127479C (fr) |
AP (1) | AP929A (fr) |
AR (1) | AR011093A1 (fr) |
AT (2) | ATE270285T1 (fr) |
AU (1) | AU723895B2 (fr) |
BG (1) | BG103597A (fr) |
BR (1) | BR9714328A (fr) |
CA (1) | CA2279186C (fr) |
CO (1) | CO4920230A1 (fr) |
CZ (1) | CZ293173B6 (fr) |
DE (2) | DE69722663T2 (fr) |
DK (2) | DK1270565T3 (fr) |
DZ (1) | DZ2407A1 (fr) |
EA (1) | EA001803B1 (fr) |
ES (2) | ES2198598T3 (fr) |
HR (1) | HRP980045B1 (fr) |
HU (1) | HUP0000567A3 (fr) |
ID (1) | ID22223A (fr) |
IL (1) | IL130855A0 (fr) |
IS (1) | IS5099A (fr) |
MA (1) | MA26468A1 (fr) |
NO (1) | NO313279B1 (fr) |
NZ (1) | NZ336248A (fr) |
OA (1) | OA11079A (fr) |
PA (1) | PA8444701A1 (fr) |
PE (1) | PE57898A1 (fr) |
PL (1) | PL335052A1 (fr) |
PT (2) | PT964849E (fr) |
SK (1) | SK283679B6 (fr) |
TN (1) | TNSN98017A1 (fr) |
TR (1) | TR199901816T2 (fr) |
TW (1) | TW515788B (fr) |
UY (1) | UY24861A1 (fr) |
WO (1) | WO1998032733A1 (fr) |
YU (1) | YU33799A (fr) |
ZA (1) | ZA98685B (fr) |
Families Citing this family (73)
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EP1526383A3 (fr) * | 1998-08-31 | 2005-11-16 | Pfizer Products Inc. | Protéines de liaison pour diarylsulfonylurée |
IT1303249B1 (it) * | 1998-10-23 | 2000-11-06 | Dompe Spa | Alcune n-(2-aril-propionil)-solfonammidi e preparazionifarmaceutiche che le contengono. |
JP2003509378A (ja) * | 1999-09-14 | 2003-03-11 | ファイザー・プロダクツ・インク | IL−1raとIL−1プロセシング・放出阻害化合物の併用療法 |
US6808902B1 (en) | 1999-11-12 | 2004-10-26 | Amgen Inc. | Process for correction of a disulfide misfold in IL-1Ra Fc fusion molecules |
CA2369967A1 (fr) * | 2001-02-12 | 2002-08-12 | Joseph Anthony Cornicelli | Methodes de traitement de maladies et de troubles relies au facteur nucleaire-kappa b |
SG173211A1 (en) | 2001-06-26 | 2011-08-29 | Amgen Inc | Antibodies to opgl |
CA2459454A1 (fr) | 2001-09-14 | 2003-03-27 | Bayer Pharmaceuticals Corporation | Derives de benzofurane et de dihydrobenzofurane utiles comme agonistes du beta-3 adrenorecepteur |
WO2003045400A1 (fr) * | 2001-11-30 | 2003-06-05 | Pfizer Products Inc. | Combinaison d'un inhibiteur d'il-1/18 avec un inhibiteur de tnf pour le traitement d'inflammations |
US20030131370A1 (en) * | 2001-12-14 | 2003-07-10 | Pfizer Inc. | Disruption of the glutathione S-transferase-Omega-1 gene |
AU2003245989A1 (en) | 2002-07-09 | 2004-01-23 | Boehringer Ingelheim Pharma Gmbh And Co. Kg | Pharmaceutical compositions of anticholinergics and p38 kinase inhibitors in the treatment of respiratory diseases |
ES2449578T3 (es) | 2002-09-06 | 2014-03-20 | Amgen Inc. | Anticuerpo monoclonal anti-IL-1R1 humano terapéutico |
WO2004031777A1 (fr) * | 2002-10-03 | 2004-04-15 | Pfizer Products Inc. | Utilisation de gst-omega-2 en tant que cible therapeutique |
CL2004002015A1 (es) | 2003-08-06 | 2005-05-13 | Senomyx Inc | Derivados de amida, productos que las contienen, utiles para modificar el sabor de alimentos y medicamentos. |
WO2005090295A2 (fr) * | 2004-03-23 | 2005-09-29 | Dompe' Pha.R.Ma S.P.A. | Derives de l'acide 2-phenylpropionique et compositions pharmaceutiques contenant lesdits derives |
US20060045953A1 (en) * | 2004-08-06 | 2006-03-02 | Catherine Tachdjian | Aromatic amides and ureas and their uses as sweet and/or umami flavor modifiers, tastants and taste enhancers |
US20060035893A1 (en) | 2004-08-07 | 2006-02-16 | Boehringer Ingelheim International Gmbh | Pharmaceutical compositions for treatment of respiratory and gastrointestinal disorders |
PE20060777A1 (es) | 2004-12-24 | 2006-10-06 | Boehringer Ingelheim Int | Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas |
AU2006210513C1 (en) | 2005-02-04 | 2012-10-25 | Senomyx, Inc. | Compounds comprising linked heteroaryl moieties and their use as novel umami flavor modifiers, tastants and taste enhancers for comestible compositions |
WO2006090932A1 (fr) * | 2005-02-28 | 2006-08-31 | Eisai R & D Managemant Co., Ltd. | Marqueur de substitution pour compose de sulfonamide |
US7208526B2 (en) * | 2005-05-20 | 2007-04-24 | Hoffmann-La Roche Inc. | Styrylsulfonamides |
TW200715993A (en) | 2005-06-15 | 2007-05-01 | Senomyx Inc | Bis-aromatic amides and their uses as sweet flavor modifiers, tastants, and taste enhancers |
WO2007124152A2 (fr) | 2006-04-21 | 2007-11-01 | Senomyx, Inc. | Compositions comestibles comprenant des composes aromatisants a gout sale a potentiel eleve et leurs procedes de production |
EP1992344A1 (fr) | 2007-05-18 | 2008-11-19 | Institut Curie | P38 alpha comme cible therapeutique pour les maladies associées á une mutation de FGFR3 |
US7973051B2 (en) * | 2007-11-30 | 2011-07-05 | Hoffman-La Roche Inc. | Aminothiazoles as FBPase inhibitors for diabetes |
WO2014078568A1 (fr) | 2012-11-14 | 2014-05-22 | The Johns Hopkins University | Méthodes et compositions pour le traitement de la schizophrénie |
WO2016025637A1 (fr) | 2014-08-12 | 2016-02-18 | Loyola University Of Chicago | Inhibiteurs indoline-sulfonamide de dape et ndm-1 et utilisation de ceux-ci |
MA56473A (fr) | 2015-02-16 | 2022-05-11 | The Provost Fellows Found Scholars And The Other Members Of Board Of The College Of The Holy & Undiv | Sulfonylurées, composés apparentés, et leur utilisation |
US10688077B2 (en) * | 2015-02-26 | 2020-06-23 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Inflammasome activation in myelodysplastic syndromes |
FR3046933B1 (fr) | 2016-01-25 | 2018-03-02 | Galderma Research & Development | Inhibiteurs nlrp3 pour le traitement des pathologies cutanees inflammatoires |
AU2017219204A1 (en) | 2016-02-16 | 2018-08-23 | The Provost, Fellows, Foundation Scholars, And The Other Members Of Board, Of The College Of The Holy And Undivided Trinity Of Queen Elizabeth Near Dublin | Sulfonylureas and related compounds and use of same |
MA44734A (fr) * | 2016-04-18 | 2021-05-19 | Novartis Ag | Composés et compositions destinés au traitement d'états associés à une activité de nlrp |
EP3445756B1 (fr) | 2016-04-18 | 2022-07-06 | Novartis AG | Composés et compositions pour traiter des états associés à une activité de nlrp |
EP3272739A1 (fr) * | 2016-07-20 | 2018-01-24 | NodThera Limited | Derives de sulfonyluree et leur application en matiere de regulation de l'activite de l'interleukine-1 |
US20220267260A1 (en) * | 2016-11-29 | 2022-08-25 | Epizyme, Inc. | Compounds containing a sulfonic group as kat inhibitors |
MY197636A (en) | 2017-01-23 | 2023-06-29 | Genentech Inc | Chemical compounds as inhibitors of interleukin-1 activity |
US11840543B2 (en) | 2017-05-24 | 2023-12-12 | The University Of Queensland | Compounds and uses |
US11236045B2 (en) | 2017-06-09 | 2022-02-01 | Cadila Healthcare Limited | Substituted sulfoximine compounds |
WO2019008029A1 (fr) | 2017-07-07 | 2019-01-10 | Inflazome Limited | Sulfonylurées et sulfonylthiourées en tant qu'inhibiteurs de nlrp3 |
RS62910B1 (sr) | 2017-07-07 | 2022-03-31 | Inflazome Ltd | Nova jedinjenja sulfonamid karboksamida |
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US11542255B2 (en) | 2017-08-15 | 2023-01-03 | Inflazome Limited | Sulfonylureas and sulfonylthioureas as NLRP3 inhibitors |
US11926600B2 (en) | 2017-08-15 | 2024-03-12 | Inflazome Limited | Sulfonylureas and sulfonylthioureas as NLRP3 inhibitors |
JP2020531448A (ja) | 2017-08-15 | 2020-11-05 | インフレイゾーム リミテッド | 新規なスルホンアミドカルボキサミド化合物 |
MA49903A (fr) | 2017-08-15 | 2020-06-24 | Inflazome Ltd | Sulfonylureés et sulfonylthioureés en tant qu'inhibiteurs de nlrp3 |
EP3668840A1 (fr) | 2017-08-15 | 2020-06-24 | Inflazome Limited | Nouveaux composés de sulfonamide carboxamide |
WO2019043610A1 (fr) | 2017-08-31 | 2019-03-07 | Cadila Healthcare Limited | Nouveaux dérivés de sulfonylurées substitués |
EP3692020A1 (fr) | 2017-10-03 | 2020-08-12 | Inflazome Limited | Nouveaux composés |
WO2019079119A1 (fr) | 2017-10-17 | 2019-04-25 | IFM Tre, Inc. | Sulfonamides et compositions associées pour le traitement d'états pathologiques associés à une activité de nlrp |
GB201721185D0 (en) | 2017-12-18 | 2018-01-31 | Nodthera Ltd | Sulphonyl urea derivatives |
CN108299256B (zh) * | 2018-01-09 | 2019-09-10 | 武汉大学 | 一类2,3,4-三羟基苯磺酰胺衍生物及其制备方法和应用 |
WO2019166628A1 (fr) | 2018-03-02 | 2019-09-06 | Inflazome Limited | Nouveaux composés |
WO2019166627A1 (fr) | 2018-03-02 | 2019-09-06 | Inflazome Limited | Nouveaux composés |
EP3759077A1 (fr) | 2018-03-02 | 2021-01-06 | Inflazome Limited | Nouveaux composés |
WO2019166632A1 (fr) | 2018-03-02 | 2019-09-06 | Inflazome Limited | Nouveaux composés |
JP2021529187A (ja) | 2018-07-03 | 2021-10-28 | ノバルティス アーゲー | Nlrpモジュレータ |
CA3104199A1 (fr) | 2018-07-20 | 2020-01-23 | F. Hoffmann-La Roche Ag | Composes de sulfonyluree en tant qu'inhibiteurs de l'activite de l'interleukine 1 |
US20210236599A1 (en) | 2018-08-13 | 2021-08-05 | Iltoo Pharma | Combination of interleukin-2 with an interleukin 1 inhibitor, conjugates and therapeutic uses thereof |
JP2022505525A (ja) | 2018-10-24 | 2022-01-14 | ノバルティス アーゲー | Nlrp活性に関連する状態を治療するための化合物及び組成物 |
EA202191968A1 (ru) | 2019-01-14 | 2021-11-16 | Кадила Хелзкэр Лимитед | Новые замещенные производные сульфонилмочевины |
WO2020254697A1 (fr) | 2019-06-21 | 2020-12-24 | Ac Immune Sa | 1,2-thiazoles et 1,2 thiazines fusionnés qui agissent en tant que modulateurs de nl3p3 |
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KR20230028425A (ko) | 2020-06-19 | 2023-02-28 | 에이씨 이뮨 에스에이 | Nlrp3 인플라마좀 경로를 조절하는 디하이드로옥사졸 및 티오우레아 또는 우레아 유도체 |
WO2022022646A1 (fr) * | 2020-07-29 | 2022-02-03 | 南京明德新药研发有限公司 | Composé cyclique hétéroaromatique à cinq chaînons contenant du sélénium |
EP4208459A1 (fr) | 2020-09-04 | 2023-07-12 | Nodthera Limited | Dérivés sulfamoyl-urée contenant une fraction alkyl-oxacycloalkyle et leurs utilisations |
ES2948511A1 (es) * | 2021-09-08 | 2023-09-13 | Fundacion Para La Investigacion Biomedica Del Hospital Univ De La Princesa | Derivados de n-sulfonilureas y su uso terapeutico |
WO2023098612A1 (fr) * | 2021-12-03 | 2023-06-08 | 南京明德新药研发有限公司 | Forme saline et forme cristalline de dérivé de diméthyl sulfoximine |
WO2023118521A1 (fr) | 2021-12-22 | 2023-06-29 | Ac Immune Sa | Composés dérivés de dihydro-oxazol |
WO2023156311A1 (fr) * | 2022-02-15 | 2023-08-24 | F. Hoffmann-La Roche Ag | Procédés pour la préparation de dérivés de 1,2,3,5,6,7-hexahydro-s-indacène |
WO2023222565A1 (fr) | 2022-05-16 | 2023-11-23 | Institut National de la Santé et de la Recherche Médicale | Procédés d'évaluation de l'épuisement de cellules souches hématopoïétiques induites par une inflammation chronique |
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US4586950A (en) * | 1982-05-31 | 1986-05-06 | E. I. Du Pont De Nemours & Company | Novel phenyl-substituted sulfonamides |
US4780125A (en) * | 1982-09-01 | 1988-10-25 | Ciba-Geigy Corporation | N-phenylsulfonyl-N'-triazinylureas |
DE3927369A1 (de) * | 1989-08-19 | 1991-02-21 | Bayer Ag | Substituierte n-(chinolin-2-yl-methoxy)benzyl-sulfonyl-harnstoffe |
US5064851A (en) * | 1990-07-24 | 1991-11-12 | Pfizer Inc. | 3-(1-substituted-pyrazoyl)-2-oxindole derivatives, compositions and use |
US5254589A (en) * | 1991-10-15 | 1993-10-19 | Warner-Lambert Company | Sulfonyl urea and carbamate ACAT inhibitors |
DE4344957A1 (de) * | 1993-12-30 | 1995-07-06 | Hoechst Ag | Substituierte Benzolsulfonylharnstoffe und -thioharnstoffe, Herstellungsverfahren und Verwendungsmöglichkeiten pharmazeutischer Präparate auf Basis dieser Verbindungen |
CN1038679C (zh) * | 1994-12-07 | 1998-06-10 | 南开大学 | 磺酰脲类化合物及其除草用途 |
HU226462B1 (en) * | 1995-02-17 | 2008-12-29 | Hoechst Ag | Substituted benzol-sulfonyl-ureas and -thioureas, process for producing them, pharmaceutical compositions containing them, and their use |
WO1998044799A1 (fr) * | 1997-04-10 | 1998-10-15 | Eli Lilly And Company | Urees diarylsulfonyle servant au traitement de la diarrhee secretoire |
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