BG103597A - Сулфонилурейни производни и тяхното използване при контролиране активността на интерлевкин-1 - Google Patents
Сулфонилурейни производни и тяхното използване при контролиране активността на интерлевкин-1 Download PDFInfo
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- BG103597A BG103597A BG103597A BG10359799A BG103597A BG 103597 A BG103597 A BG 103597A BG 103597 A BG103597 A BG 103597A BG 10359799 A BG10359799 A BG 10359799A BG 103597 A BG103597 A BG 103597A
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- Prior art keywords
- alkyl
- hydroxy
- hydrogen
- urea
- halo
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- 125000003170 phenylsulfonyl group Chemical group C1(=CC=CC=C1)S(=O)(=O)* 0.000 claims description 5
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- GOJUJUVQIVIZAV-UHFFFAOYSA-N 2-amino-4,6-dichloropyrimidine-5-carbaldehyde Chemical group NC1=NC(Cl)=C(C=O)C(Cl)=N1 GOJUJUVQIVIZAV-UHFFFAOYSA-N 0.000 claims description 4
- RZNNEQHIXCRCKM-UHFFFAOYSA-N 4-(2-hydroxypropan-2-yl)furan-2-sulfonamide Chemical compound CC(C)(O)C1=COC(S(N)(=O)=O)=C1 RZNNEQHIXCRCKM-UHFFFAOYSA-N 0.000 claims description 4
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- YRSBLSHMKVQWHP-UHFFFAOYSA-N 1-[4-chloro-2,6-di(propan-2-yl)phenyl]-3-[3-(2-hydroxypropan-2-yl)phenyl]sulfonylurea Chemical compound CC(C)C1=CC(Cl)=CC(C(C)C)=C1NC(=O)NS(=O)(=O)C1=CC=CC(C(C)(C)O)=C1 YRSBLSHMKVQWHP-UHFFFAOYSA-N 0.000 claims description 3
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- NMPXFRKPFCOTDU-UHFFFAOYSA-N 1-[4-chloro-2,6-di(propan-2-yl)phenyl]-3-[(5-fluoro-1h-indol-6-yl)sulfonyl]urea Chemical compound CC(C)C1=CC(Cl)=CC(C(C)C)=C1NC(=O)NS(=O)(=O)C(C(=C1)F)=CC2=C1C=CN2 NMPXFRKPFCOTDU-UHFFFAOYSA-N 0.000 claims description 2
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- UTUTZQKQYZYYKW-UHFFFAOYSA-N 1-[4-fluoro-2,6-di(propan-2-yl)phenyl]-3-[3-(2-hydroxypropan-2-yl)phenyl]sulfonylurea Chemical compound CC(C)C1=CC(F)=CC(C(C)C)=C1NC(=O)NS(=O)(=O)C1=CC=CC(C(C)(C)O)=C1 UTUTZQKQYZYYKW-UHFFFAOYSA-N 0.000 claims 1
- KHBQMWCZKVMBLN-UHFFFAOYSA-N Benzenesulfonamide Chemical compound NS(=O)(=O)C1=CC=CC=C1 KHBQMWCZKVMBLN-UHFFFAOYSA-N 0.000 claims 1
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- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07C323/64—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton
- C07C323/67—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton containing sulfur atoms of sulfonamide groups, bound to the carbon skeleton
-
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/34—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US3697997P | 1997-01-29 | 1997-01-29 | |
PCT/IB1997/001603 WO1998032733A1 (fr) | 1997-01-29 | 1997-12-29 | Derives de sulfonyluree et leur application en matiere de regulation de l'activite de l'interleukine-1 |
Publications (1)
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BG103597A true BG103597A (bg) | 2000-02-29 |
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BG103597A BG103597A (bg) | 1997-01-29 | 1999-07-22 | Сулфонилурейни производни и тяхното използване при контролиране активността на интерлевкин-1 |
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US (2) | US6166064A (fr) |
EP (1) | EP0964849B1 (fr) |
JP (1) | JP3573757B2 (fr) |
KR (1) | KR100324058B1 (fr) |
CN (1) | CN1127479C (fr) |
AP (1) | AP929A (fr) |
AR (1) | AR011093A1 (fr) |
AT (2) | ATE270285T1 (fr) |
AU (1) | AU723895B2 (fr) |
BG (1) | BG103597A (fr) |
BR (1) | BR9714328A (fr) |
CA (1) | CA2279186C (fr) |
CO (1) | CO4920230A1 (fr) |
CZ (1) | CZ293173B6 (fr) |
DE (2) | DE69722663T2 (fr) |
DK (2) | DK1270565T3 (fr) |
DZ (1) | DZ2407A1 (fr) |
EA (1) | EA001803B1 (fr) |
ES (2) | ES2198598T3 (fr) |
HR (1) | HRP980045B1 (fr) |
HU (1) | HUP0000567A3 (fr) |
ID (1) | ID22223A (fr) |
IL (1) | IL130855A0 (fr) |
IS (1) | IS5099A (fr) |
MA (1) | MA26468A1 (fr) |
NO (1) | NO313279B1 (fr) |
NZ (1) | NZ336248A (fr) |
OA (1) | OA11079A (fr) |
PA (1) | PA8444701A1 (fr) |
PE (1) | PE57898A1 (fr) |
PL (1) | PL335052A1 (fr) |
PT (2) | PT964849E (fr) |
SK (1) | SK283679B6 (fr) |
TN (1) | TNSN98017A1 (fr) |
TR (1) | TR199901816T2 (fr) |
TW (1) | TW515788B (fr) |
UY (1) | UY24861A1 (fr) |
WO (1) | WO1998032733A1 (fr) |
YU (1) | YU33799A (fr) |
ZA (1) | ZA98685B (fr) |
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1997
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- 1997-12-29 CA CA002279186A patent/CA2279186C/fr not_active Expired - Fee Related
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- 1997-12-29 EP EP97947201A patent/EP0964849B1/fr not_active Expired - Lifetime
- 1997-12-29 WO PCT/IB1997/001603 patent/WO1998032733A1/fr active IP Right Grant
- 1997-12-29 HU HU0000567A patent/HUP0000567A3/hu unknown
- 1997-12-29 ID IDW990764A patent/ID22223A/id unknown
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1998
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- 1998-01-20 UY UY24861A patent/UY24861A1/es unknown
- 1998-01-23 PE PE1998000051A patent/PE57898A1/es not_active Application Discontinuation
- 1998-01-26 TW TW087101087A patent/TW515788B/zh not_active IP Right Cessation
- 1998-01-27 DZ DZ980017A patent/DZ2407A1/fr active
- 1998-01-27 AR ARP980100358A patent/AR011093A1/es not_active Application Discontinuation
- 1998-01-27 HR HR980045A patent/HRP980045B1/xx not_active IP Right Cessation
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- 1998-01-28 MA MA24947A patent/MA26468A1/fr unknown
- 1998-01-28 TN TNTNSN98017A patent/TNSN98017A1/fr unknown
- 1998-01-29 CO CO98004326A patent/CO4920230A1/es unknown
- 1998-01-29 AP APAP/P/1998/001190A patent/AP929A/en active
-
1999
- 1999-06-29 IS IS5099A patent/IS5099A/is unknown
- 1999-07-22 BG BG103597A patent/BG103597A/bg unknown
- 1999-07-23 OA OA9900165A patent/OA11079A/en unknown
- 1999-07-28 NO NO19993658A patent/NO313279B1/no not_active IP Right Cessation
-
2000
- 2000-10-31 US US09/703,142 patent/US6433009B1/en not_active Expired - Fee Related
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