CY1110666T1 - Πυραζολοπυριμιδινες καταλληλες για θεραπεια καρκινικων νοσων - Google Patents
Πυραζολοπυριμιδινες καταλληλες για θεραπεια καρκινικων νοσωνInfo
- Publication number
- CY1110666T1 CY1110666T1 CY20101100638T CY101100638T CY1110666T1 CY 1110666 T1 CY1110666 T1 CY 1110666T1 CY 20101100638 T CY20101100638 T CY 20101100638T CY 101100638 T CY101100638 T CY 101100638T CY 1110666 T1 CY1110666 T1 CY 1110666T1
- Authority
- CY
- Cyprus
- Prior art keywords
- compounds
- pyrazolopyrimidines
- disease treatment
- cancer disease
- methods
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
Στις πολλές πραγματοποιήσεις της, η παρούσα εφεύρεση παρέχει μια νέα τάξη ενώσεων pyrazolo[1,5-a]pyrimidine ως αναστολείς κυκλινο-εξαρτώμενων κινασών, μεθόδους παρασκευής τέτοιων ενώσεων, φαρμακευτικές συνθέσεις που περιλαμβάνουν μια ή περισσότερες τέτοιες ενώσεις, μεθόδους παρασκευής φαρμακευτικών συνθέσεων που περιλαμβάνουν μια ή περισσότερες τέτοιες ενώσεις, και μεθόδους θεραπείας, πρόληψης, καταστολής ή βελτίωσης μιας ή περισσοτέρων νόσων που σχετίζονται με τις CDKs χρησιμοποιώντας τέτοιες ενώσεις ή φαρμακευτικές συνθέσεις.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US40802702P | 2002-09-04 | 2002-09-04 | |
| US42195902P | 2002-10-29 | 2002-10-29 | |
| EP03794592A EP1537116B1 (en) | 2002-09-04 | 2003-09-03 | Pyrazolopyrimidines suitable for the treatment of cancer diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1110666T1 true CY1110666T1 (el) | 2015-06-11 |
Family
ID=31981560
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20101100638T CY1110666T1 (el) | 2002-09-04 | 2010-07-08 | Πυραζολοπυριμιδινες καταλληλες για θεραπεια καρκινικων νοσων |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP2194058B1 (el) |
| JP (1) | JP2010180234A (el) |
| AR (1) | AR041137A1 (el) |
| CY (1) | CY1110666T1 (el) |
| DE (1) | DE60332846D1 (el) |
| EC (2) | ECSP055642A (el) |
| ES (1) | ES2346204T3 (el) |
| MY (1) | MY138201A (el) |
| PL (1) | PL224879B1 (el) |
| PT (1) | PT1537116E (el) |
| RU (1) | RU2380369C9 (el) |
| TW (1) | TWI344468B (el) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2713722T3 (en) * | 2011-05-31 | 2017-07-03 | Celgene Int Ii Sarl | Newly known GLP-1 receptor stabilizers and modulators |
| JP6573604B2 (ja) | 2013-06-11 | 2019-09-11 | セルジーン インターナショナル ツー エスエーアールエル | 新規なｇｌｐ−１レセプターモジュレーター |
| AU2015360364B2 (en) | 2014-12-10 | 2020-04-30 | Receptos Llc | GLP-1 receptor modulators |
| WO2017035354A1 (en) | 2015-08-26 | 2017-03-02 | Blueprint Medicines Corporation | Compounds and compositions useful for treating disorders related to ntrk |
| MX2018006195A (es) | 2015-11-19 | 2018-09-05 | Blueprint Medicines Corp | Compuestos y composiciones utiles para el tratamiento de trastornos relacionados con ntrk. |
| CN116570594A (zh) | 2016-06-23 | 2023-08-11 | 马里兰大学巴尔的摩分校 | 选择性p38α特异性MAPK抑制剂 |
| MX2021006731A (es) | 2018-12-07 | 2021-09-23 | Univ Maryland | Inhibidores de proteínas quinasas activadas por mitógeno p38 en sitio no atp/catalítico. |
| WO2021236449A1 (en) | 2020-05-18 | 2021-11-25 | Gen1E Lifesciences Inc. | P38alpha mitogen-activated protein kinase inhibitors |
| EP4313959A1 (en) | 2021-03-23 | 2024-02-07 | GEN1E Lifesciences Inc. | Substituted naphthyl p38alpha mitogen-activated protein kinase inhibitors |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3907799A (en) | 1971-08-16 | 1975-09-23 | Icn Pharmaceuticals | Xanthine oxidase inhibitors |
| AU7997091A (en) | 1990-05-30 | 1991-12-31 | American Home Products Corporation | Substituted arylsulfonamides and benzamides |
| KR100191774B1 (ko) | 1991-04-22 | 1999-06-15 | 오스카 아끼히꼬 | 피라졸로[1,5-알파] 피리미딘 유도체 및 이것을 함유하는 항염증제 |
| EP0628559B1 (en) | 1993-06-10 | 2002-04-03 | Beiersdorf-Lilly GmbH | Pyrimidine compounds and their use as pharmaceuticals |
| US5571813A (en) | 1993-06-10 | 1996-11-05 | Beiersdorf-Lilly Gmbh | Fused pyrimidine compounds and their use as pharmaceuticals |
| EP0714898B1 (en) | 1994-06-21 | 2001-11-14 | Otsuka Pharmaceutical Factory, Inc. | PYRAZOLO [1,5-a]PYRIMIDINE DERIVATIVE |
| GB9716557D0 (en) | 1997-08-06 | 1997-10-08 | Glaxo Group Ltd | Benzylidene-1,3-dihydro-indol-2-one derivatives having anti-cancer activity |
| ES2281941T3 (es) | 1997-12-13 | 2007-10-01 | Bristol-Myers Squibb Company | Uso de pirazolo(3,4-b)piridina como inhibidores de quinasa dependiente de ciclina. |
| US6413974B1 (en) * | 1998-02-26 | 2002-07-02 | Aventis Pharmaceuticals Inc. | 6,9,-disubstituted 2-[trans-(4-aminocyclohexyl) amino] purines |
| DE19834047A1 (de) | 1998-07-29 | 2000-02-03 | Bayer Ag | Substituierte Pyrazolderivate |
| PT997474E (pt) | 1998-08-14 | 2004-01-30 | Pfizer | Agentes antitromboticos |
| AU752186B2 (en) | 1998-10-30 | 2002-09-12 | Merck & Co., Inc. | Thrombin inhibitors |
| CA2352505C (en) | 1998-12-22 | 2009-04-07 | Novartis Ag | Epothilone derivatives and their use as antitumor agents |
| DE1140938T1 (de) | 1999-01-11 | 2003-01-09 | Princeton University Princeton | Kinase-inhibitoren mit hoher affinität zur ziel detektion und ihre verwendung |
| IL147395A0 (en) | 1999-07-15 | 2002-08-14 | Pharmacopeia Inc | Bradykinin b1 receptor antagonists |
| EP1303513A1 (en) | 2000-07-26 | 2003-04-23 | Bristol-Myers Squibb Company | N-[5-[[[5-alkyl-2-oxazolyl]methyl]thio]-2-thiazolyl] carboxamide inhibitors of cyclin dependent kinases |
| AU2001290940A1 (en) | 2000-09-15 | 2002-03-26 | Vertex Pharmaceuticals Incorporated | Isoxazoles and their use as inhibitors of erk |
| PE20020507A1 (es) | 2000-10-17 | 2002-06-25 | Schering Corp | Compuestos no-imidazoles como antagonistas del receptor histamina h3 |
| US7067520B2 (en) | 2000-11-17 | 2006-06-27 | Ishihara Sangyo Kaisha, Ltd. | Preventive or therapeutic medicines for diabetes containing fused-heterocyclic compounds or their salts |
| JP2004516297A (ja) * | 2000-12-20 | 2004-06-03 | ソシエテ・ド・コンセイユ・ド・ルシエルシエ・エ・ダアツプリカーション・シヤンテイフイツク・（エス．セー．エール．アー．エス） | サイクリン依存性キナーゼ（ｃｄｋ）及びグリコーゲンシンターゼキナーゼ−３（ｇｓｋ−３）の阻害剤 |
| WO2002064211A1 (en) | 2001-02-09 | 2002-08-22 | Merck & Co., Inc. | Thrombin inhibitors |
-
2003
- 2003-09-03 TW TW092124347A patent/TWI344468B/zh not_active IP Right Cessation
- 2003-09-03 ES ES03794592T patent/ES2346204T3/es not_active Expired - Lifetime
- 2003-09-03 DE DE60332846T patent/DE60332846D1/de not_active Expired - Lifetime
- 2003-09-03 MY MYPI20033337A patent/MY138201A/en unknown
- 2003-09-03 PL PL375697A patent/PL224879B1/pl unknown
- 2003-09-03 EP EP10152446.0A patent/EP2194058B1/en not_active Expired - Lifetime
- 2003-09-03 PT PT03794592T patent/PT1537116E/pt unknown
- 2003-09-03 AR ARP030103192A patent/AR041137A1/es active IP Right Grant
- 2003-09-03 RU RU2005109543/04A patent/RU2380369C9/ru active
-
2005
- 2005-03-03 EC EC2005005642A patent/ECSP055642A/es unknown
-
2010
- 2010-04-06 JP JP2010088210A patent/JP2010180234A/ja not_active Withdrawn
- 2010-07-08 CY CY20101100638T patent/CY1110666T1/el unknown
-
2011
- 2011-09-01 EC EC2011005642A patent/ECSP11005642A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RU2380369C9 (ru) | 2011-07-10 |
| EP2194058B1 (en) | 2013-11-27 |
| PL224879B1 (pl) | 2017-02-28 |
| PL375697A1 (en) | 2005-12-12 |
| MY138201A (en) | 2009-05-29 |
| DE60332846D1 (de) | 2010-07-15 |
| ES2346204T3 (es) | 2010-10-13 |
| PT1537116E (pt) | 2010-09-03 |
| AR041137A1 (es) | 2005-05-04 |
| ECSP11005642A (es) | 2011-10-31 |
| ECSP055642A (es) | 2005-05-30 |
| RU2005109543A (ru) | 2006-05-10 |
| TW200410973A (en) | 2004-07-01 |
| JP2010180234A (ja) | 2010-08-19 |
| TWI344468B (en) | 2011-07-01 |
| EP2194058A1 (en) | 2010-06-09 |
| RU2380369C2 (ru) | 2010-01-27 |
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