DK1133269T3 - Kontrolleret afgivelsesindretning til indgift af terapeutika i det indre öre - Google Patents

Kontrolleret afgivelsesindretning til indgift af terapeutika i det indre öre

Info

Publication number
DK1133269T3
DK1133269T3 DK99965987T DK99965987T DK1133269T3 DK 1133269 T3 DK1133269 T3 DK 1133269T3 DK 99965987 T DK99965987 T DK 99965987T DK 99965987 T DK99965987 T DK 99965987T DK 1133269 T3 DK1133269 T3 DK 1133269T3
Authority
DK
Denmark
Prior art keywords
inner ear
therapeutic agents
drug delivery
ear
round window
Prior art date
Application number
DK99965987T
Other languages
English (en)
Inventor
Irving K Arenberg
Michael H Arenberg
Christine Lemke
John A Berglund
Felix Theeuwes
Original Assignee
Durect Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Durect Corp filed Critical Durect Corp
Application granted granted Critical
Publication of DK1133269T3 publication Critical patent/DK1133269T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0046—Ear
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F11/00—Methods or devices for treatment of the ears or hearing sense; Non-electric hearing aids; Methods or devices for enabling ear patients to achieve auditory perception through physiological senses other than hearing sense; Protective devices for the ears, carried on the body or in the hand
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Acoustics & Sound (AREA)
  • Biophysics (AREA)
  • Otolaryngology (AREA)
  • Psychology (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK99965987T 1998-12-04 1999-12-03 Kontrolleret afgivelsesindretning til indgift af terapeutika i det indre öre DK1133269T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/205,251 US8197461B1 (en) 1998-12-04 1998-12-04 Controlled release system for delivering therapeutic agents into the inner ear
PCT/US1999/028716 WO2000033775A1 (en) 1998-12-04 1999-12-03 Controlled release system for delivering therapeutic agents into the inner ear

Publications (1)

Publication Number Publication Date
DK1133269T3 true DK1133269T3 (da) 2007-06-11

Family

ID=22761443

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99965987T DK1133269T3 (da) 1998-12-04 1999-12-03 Kontrolleret afgivelsesindretning til indgift af terapeutika i det indre öre

Country Status (10)

Country Link
US (2) US8197461B1 (da)
EP (2) EP1133269B1 (da)
AT (1) ATE353615T1 (da)
AU (1) AU761837B2 (da)
CA (1) CA2350838C (da)
DE (1) DE69935155T2 (da)
DK (1) DK1133269T3 (da)
ES (1) ES2283146T3 (da)
PT (1) PT1133269E (da)
WO (1) WO2000033775A1 (da)

Families Citing this family (94)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7963997B2 (en) * 2002-07-19 2011-06-21 Kensey Nash Corporation Device for regeneration of articular cartilage and other tissue
US8697108B2 (en) * 1994-05-13 2014-04-15 Kensey Nash Corporation Method for making a porous polymeric material
US8795242B2 (en) 1994-05-13 2014-08-05 Kensey Nash Corporation Resorbable polymeric device for localized drug delivery
US8197461B1 (en) 1998-12-04 2012-06-12 Durect Corporation Controlled release system for delivering therapeutic agents into the inner ear
US20070270579A1 (en) * 2001-05-18 2007-11-22 Sirna Therapeutics, Inc. RNA interference mediated inhibition of gene expression using short interfering nucleic acid (siNA)
US20060241075A1 (en) * 2001-05-18 2006-10-26 Sirna Therapeutics, Inc. RNA interference mediated inhibition of desmoglein gene expression using short interfering nucleic acid (siNA)
US20080161256A1 (en) * 2001-05-18 2008-07-03 Sirna Therapeutics, Inc. RNA interference mediated inhibition of gene expression using short interfering nucleic acid (siNA)
US20050282188A1 (en) * 2001-05-18 2005-12-22 Sirna Therapeutics, Inc. RNA interference mediated inhibition of gene expression using short interfering nucleic acid (siNA)
US20070042983A1 (en) * 2001-05-18 2007-02-22 Sirna Therapeutics, Inc. RNA interference mediated inhibition of gene expression using short interfering nucleic acid (siNA)
US20050222066A1 (en) * 2001-05-18 2005-10-06 Sirna Therapeutics, Inc. RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA)
US7517864B2 (en) * 2001-05-18 2009-04-14 Sirna Therapeutics, Inc. RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA)
ATE342025T1 (de) * 2001-06-18 2006-11-15 Durect Corp Vorrichtung zur abgabe von mikrodosen eines medikaments in das ohr
US7206639B2 (en) * 2002-03-15 2007-04-17 Sarcos Investments Lc Cochlear drug delivery system and method
EP1545551A4 (en) 2002-09-06 2008-10-22 Durect Corp DISTRIBUTION OF MODULATORS OF THE GLUTAMAT-MEDIATED NEUROTRANSMISSION TO THE INNER EAR
EP1438942A1 (en) 2003-01-17 2004-07-21 Schering Oy An otorhinological drug delivery device
DE10305349A1 (de) 2003-02-10 2004-08-26 Cell Center Cologne Gmbh Innenohr-Steckverbindung
US8940321B2 (en) 2003-12-12 2015-01-27 Otic Pharma Ltd. Compositions for treatment of ear disorders and methods of use thereof
CA2548892C (en) 2003-12-12 2015-10-27 Eran Eilat Compositions for treatment of ear disorders and methods of use thereof
US7351246B2 (en) * 2004-01-20 2008-04-01 Epley John M Minimally invasive, sustained, intra-tympanic drug delivery system
US7867194B2 (en) 2004-01-29 2011-01-11 The Charles Stark Draper Laboratory, Inc. Drug delivery apparatus
WO2005072793A1 (en) * 2004-01-29 2005-08-11 The Charles Stark Draper Laboratory, Inc. Implantable drug delivery apparatus
US8401212B2 (en) 2007-10-12 2013-03-19 Earlens Corporation Multifunction system and method for integrated hearing and communication with noise cancellation and feedback management
US7668325B2 (en) 2005-05-03 2010-02-23 Earlens Corporation Hearing system having an open chamber for housing components and reducing the occlusion effect
US20060264897A1 (en) * 2005-01-24 2006-11-23 Neurosystec Corporation Apparatus and method for delivering therapeutic and/or other agents to the inner ear and to other tissues
US20070077270A1 (en) * 2005-03-28 2007-04-05 Clemson University Delivery devices and methods for long-term, targeted delivery of therapeutic agents to the eye and ear
WO2007001978A2 (en) * 2005-06-20 2007-01-04 Abbeymoor Medical, Inc. Self-adjusting endourethral device & methods of use
US20070110788A1 (en) * 2005-11-14 2007-05-17 Hissong James B Injectable formulation capable of forming a drug-releasing device
US20110183348A1 (en) * 2010-01-22 2011-07-28 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Compositions and methods for therapeutic delivery with microorganisms
EP3326681B1 (en) * 2005-12-30 2019-06-26 RDD Pharma Ltd. Device for treating the anal sphincter
US8267905B2 (en) * 2006-05-01 2012-09-18 Neurosystec Corporation Apparatus and method for delivery of therapeutic and other types of agents
US20070264296A1 (en) * 2006-05-10 2007-11-15 Myntti Matthew F Biofilm extracellular polysachharide solvating system
US7993675B2 (en) 2006-05-10 2011-08-09 Medtronic Xomed, Inc. Solvating system and sealant for medical use in the sinuses and nasal passages
US7976873B2 (en) * 2006-05-10 2011-07-12 Medtronic Xomed, Inc. Extracellular polysaccharide solvating system for treatment of bacterial ear conditions
US7959943B2 (en) * 2006-05-10 2011-06-14 Medtronics Xomed, Inc. Solvating system and sealant for medical use in the middle or inner ear
US7803148B2 (en) * 2006-06-09 2010-09-28 Neurosystec Corporation Flow-induced delivery from a drug mass
WO2008016602A2 (en) * 2006-07-31 2008-02-07 Neurosystec Corporation Free base gacyclidine nanoparticles
US9046192B2 (en) * 2007-01-31 2015-06-02 The Charles Stark Draper Laboratory, Inc. Membrane-based fluid control in microfluidic devices
US8088095B2 (en) * 2007-02-08 2012-01-03 Medtronic Xomed, Inc. Polymeric sealant for medical use
US20090088844A1 (en) * 2007-07-03 2009-04-02 Keegan Mark E Drug-eluting stapes prosthesis
US7951393B2 (en) * 2007-11-14 2011-05-31 Canaan Vernon Lavelle Harris Keloid therapy
US20090181068A1 (en) 2008-01-14 2009-07-16 Dunn Richard L Low Viscosity Liquid Polymeric Delivery System
CN101264043B (zh) * 2008-01-14 2010-09-08 四川大学 耳穴定位粘药器
RU2499592C2 (ru) * 2008-04-21 2013-11-27 Отономи, Инк. Фармацевтическая композиция для лечения ушных заболеваний
US11969501B2 (en) 2008-04-21 2024-04-30 Dompé Farmaceutici S.P.A. Auris formulations for treating otic diseases and conditions
CA2727432C (en) 2008-06-12 2016-10-11 Medtronic Xomed, Inc. Method for treating chronic wounds with an extracellular polymeric substance solvating system
CN102124757B (zh) 2008-06-17 2014-08-27 依耳乐恩斯公司 传输音频信号及利用其刺激目标的***、装置和方法
US8496957B2 (en) 2008-07-21 2013-07-30 Otonomy, Inc Controlled release auris sensory cell modulator compositions and methods for the treatment of otic disorders
WO2010033932A1 (en) 2008-09-22 2010-03-25 Earlens Corporation Transducer devices and methods for hearing
WO2010042427A2 (en) 2008-10-06 2010-04-15 Microbial Defense Systems, Llc Antimicrobial composition and methods of making and using same
US8808317B2 (en) * 2008-11-06 2014-08-19 Carl Braunagel Apparatus for cleaning a nasal cavity
US9078783B2 (en) * 2008-12-24 2015-07-14 Acclarent, Inc. Silent effusion removal
SE534532C2 (sv) * 2009-01-22 2011-09-27 Svante Syk-Eksell Expanderande propp avsedd för insättning i en näsborre/örongång och för distribuering av medicinska preparat
US8715706B2 (en) * 2009-06-18 2014-05-06 RDD Pharma, Ltd. Methods and devices for delivery of pharmaceutical agents within orifices of the body
JP5864429B2 (ja) 2009-11-09 2016-02-17 スポットライト テクノロジー パートナーズ エルエルシーＳｐｏｔｌｉｇｈｔ Ｔｅｃｈｎｏｌｏｇｙ Ｐａｒｔｎｅｒｓ Ｌｌｃ 架橋ヒドロゲル組成物、ヒドロゲル組成物の形成方法、及びキット
EP2498764B1 (en) 2009-11-09 2017-09-06 Spotlight Technology Partners LLC Fragmented hydrogels
WO2011107932A1 (en) * 2010-03-01 2011-09-09 Estimme Ltd. Drug delivery device
DK2656639T3 (da) 2010-12-20 2020-06-29 Earlens Corp Anatomisk tilpasset øregangshøreapparat
CA2825757C (en) 2011-02-02 2019-09-03 The Charles Stark Draper Laboratory, Inc. Drug delivery apparatus
US8911424B2 (en) * 2011-02-09 2014-12-16 Ethicon, Inc. Methods and devices for preventing catheter related urinary tract infections
JP6463629B2 (ja) 2011-05-10 2019-02-06 ネクスト サイエンス アイピー ホールディングス ピーティワイ エルティーディ 抗菌性固体およびその製造方法
DE102011107139A1 (de) * 2011-07-12 2013-01-17 Gerd Borkowski Hörgerät mit zumindest einem in den Gehörgang einzuführenden Abschnitt
CA2843904A1 (en) 2011-08-05 2013-02-14 Unitract Syringe Pty Ltd Cannula with controlled depth of insertion
CN103796573A (zh) * 2011-09-15 2014-05-14 优瑟夫·雅阿科比 一种治疗耳病的***和方法
US8685106B2 (en) 2011-11-15 2014-04-01 Abraham Lin Method of a pharmaceutical delivery system for use within a joint replacement
US20140309597A1 (en) * 2012-10-15 2014-10-16 Jeremiah Joseph Lowney Applicator for delivering a single dose of medicine to an inner canal of an ear
US10821276B2 (en) 2012-12-14 2020-11-03 The Trustees Of Columbia University In The City Of New York System and method to locally deliver therapeutic agent to inner ear
CA2932540A1 (en) * 2012-12-14 2014-06-19 The Trustees Of Columbia University In The City Of New York System and method to locally deliver therapeutic agent to inner ear
US20150182382A1 (en) * 2013-12-27 2015-07-02 Custom Protect Ear, Inc. Pre-lubricated earplugs and the method of production thereof
US10034103B2 (en) 2014-03-18 2018-07-24 Earlens Corporation High fidelity and reduced feedback contact hearing apparatus and methods
US9616207B2 (en) * 2014-06-26 2017-04-11 Cochlear Limited Treatment of the ear
WO2016011044A1 (en) 2014-07-14 2016-01-21 Earlens Corporation Sliding bias and peak limiting for optical hearing devices
US9924276B2 (en) 2014-11-26 2018-03-20 Earlens Corporation Adjustable venting for hearing instruments
AU2016304585B2 (en) * 2015-08-05 2023-04-06 Children's Medical Center Corporation Compositions with permeation enhancers for drug delivery
WO2017059218A1 (en) * 2015-10-02 2017-04-06 Earlens Corporation Wearable customized ear canal apparatus
US10492010B2 (en) 2015-12-30 2019-11-26 Earlens Corporations Damping in contact hearing systems
US20170195806A1 (en) 2015-12-30 2017-07-06 Earlens Corporation Battery coating for rechargable hearing systems
US11350226B2 (en) 2015-12-30 2022-05-31 Earlens Corporation Charging protocol for rechargeable hearing systems
US11213430B2 (en) 2016-05-26 2022-01-04 Cochlear Limited Inner ear plug
JP2019522539A (ja) 2016-06-22 2019-08-15 ザ チャールズ スターク ドレイパー ラボラトリー， インク．Ｔｈｅ Ｃｈａｒｌｅｓ Ｓｔａｒｋ Ｄｒａｐｅｒ Ｌａｂｏｒａｔｏｒｙ， Ｉｎｃ． 経正円窓膜注入による内耳薬物送達用のシステム
EP3493779A1 (en) * 2016-08-05 2019-06-12 Tusker Medical, Inc. Systems, apparatus, and methods for delivery of therapeutic substance to the middle and/or inner ear
US20180077504A1 (en) 2016-09-09 2018-03-15 Earlens Corporation Contact hearing systems, apparatus and methods
WO2018093733A1 (en) 2016-11-15 2018-05-24 Earlens Corporation Improved impression procedure
US20180221208A1 (en) * 2017-02-08 2018-08-09 Tusker Medical, Inc. Systems, apparatus, and methods for delivery of therapeutic substance to the tympanic membrane
EP3694579A4 (en) * 2017-10-12 2021-07-07 Cochlear Limited CLINICAL-BASED AUTOMATED DELIVERY OF TREATMENT SUBSTANCES TO THE INTERNAL EAR
US11844919B2 (en) 2018-01-03 2023-12-19 The Trustees Of Columbia University In The City Of New York Microneedle for local delivery of therapeutic agent
EP3740111A1 (en) 2018-01-16 2020-11-25 Tusker Medical, Inc. Visualization devices and methods for otologic procedures
WO2019173470A1 (en) 2018-03-07 2019-09-12 Earlens Corporation Contact hearing device and retention structure materials
WO2019199680A1 (en) 2018-04-09 2019-10-17 Earlens Corporation Dynamic filter
CN112702983B (zh) * 2018-04-19 2023-06-30 斯皮拉尔诊疗有限公司 内耳药物递送装置和使用方法
EP3840827A4 (en) * 2018-08-24 2022-05-18 Cochlear Limited MASS TRANSPORT WITHIN MAMMALS
US20220032020A1 (en) * 2018-12-05 2022-02-03 Cochlear Limited Therapeutic substance storage and delivery
EP4093352A4 (en) 2020-01-24 2024-02-21 Spiral Therapeutics, Inc. OTOLOGY DEVICES, SYSTEMS AND METHODS
WO2022081955A1 (en) * 2020-10-15 2022-04-21 The Board Of Trustees Of The Leland Stanford Junior University Method and system for ototopical delivery using nanoparticles for ear infection diagnosis and treatment
EP4183380A1 (en) * 2021-11-22 2023-05-24 Medizinische Hochschule Hannover Patient-specific, drug releasing, compressible implant with in-tegrated handle for insertion into a body cavity and method for its manufacture

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE850341C (de) 1950-04-15 1952-09-25 Gazzoni & Co A Vorrichtung zum Benetzen des aeusseren Gehoerganges mit einer schmerzstillenden Fluessigkeit
GB1204117A (en) 1966-09-08 1970-09-03 Syntex Corp Devices and methods for administering pharmaceutical preparations
US3982545A (en) 1974-08-22 1976-09-28 Herbert Silverstein Middle ear aeration and implant
US4034759A (en) 1975-08-27 1977-07-12 Xomed, Inc. Moisture-expandable prosthesis
US4141973A (en) 1975-10-17 1979-02-27 Biotrics, Inc. Ultrapure hyaluronic acid and the use thereof
US4159719A (en) 1977-05-09 1979-07-03 Xomed, Inc. Moisture-expandable ear wick
GB2042888B (en) 1979-03-05 1983-09-28 Teijin Ltd Preparation for administration to the mucosa of the oral or nasal cavity
US4360019A (en) 1979-02-28 1982-11-23 Andros Incorporated Implantable infusion device
US4343931A (en) 1979-12-17 1982-08-10 Minnesota Mining And Manufacturing Company Synthetic absorbable surgical devices of poly(esteramides)
US4297748A (en) 1980-01-02 1981-11-03 Moloy Peter J Middle ear balloon
US4692147A (en) 1980-04-02 1987-09-08 Medtronic, Inc. Drug administration device
US5166331A (en) 1983-10-10 1992-11-24 Fidia, S.P.A. Hyaluronics acid fractions, methods for the preparation thereof, and pharmaceutical compositions containing same
US4487603A (en) 1982-11-26 1984-12-11 Cordis Corporation Implantable microinfusion pump system
US4472394A (en) * 1983-09-19 1984-09-18 G. D. Searle & Co. Method for increasing weight in domestic animals
US4784640A (en) * 1984-08-20 1988-11-15 Johnson Ronald F Apparatus for implanting implants in cattle
US4725852A (en) 1985-05-09 1988-02-16 Burlington Industries, Inc. Random artificially perturbed liquid apparatus and method
US4851402A (en) * 1987-02-27 1989-07-25 International Minerals & Chemical Corp. Estriol growth promotant
US4874368A (en) 1988-07-25 1989-10-17 Micromedics, Inc. Fibrin glue delivery system
US5350580A (en) 1990-03-05 1994-09-27 Minnesota Mining And Manufacturing Company Device and method for extended delivery of pharmacologically active agents to the ear
US5236413B1 (en) 1990-05-07 1996-06-18 Andrew J Feiring Method and apparatus for inducing the permeation of medication into internal tissue
US5344411A (en) 1991-02-27 1994-09-06 Leonard Bloom Method and device for inhibiting HIV, hepatitis B and other viruses and germs when using a catheter in a medical environment
AU1579092A (en) 1991-02-27 1992-10-06 Nova Pharmaceutical Corporation Anti-infective and anti-inflammatory releasing systems for medical devices
US5437656A (en) 1991-02-27 1995-08-01 Leonard Bloom Method and device for inhibiting H.I.V. hepatitis B and other viruses and germs when using a needle, scalpel and other sharp instrument in a medical environment
US5695458A (en) 1991-02-27 1997-12-09 Maryland Biopolymer Technologies, Llc Anti-infective polymer-iodine coating for blood collection and delivery systems
US5304134A (en) 1992-01-17 1994-04-19 Danforth Biomedical, Inc. Lubricious yet bondable catheter channel sleeve for over-the-wire catheters
US5461140A (en) 1992-04-30 1995-10-24 Pharmaceutical Delivery Systems Bioerodible polymers for solid controlled release pharmaceutical compositions
US5419312A (en) 1993-04-20 1995-05-30 Wildflower Communications, Inc. Multi-function endoscope apparatus
US5421818A (en) 1993-10-18 1995-06-06 Inner Ear Medical Delivery Systems, Inc. Multi-functional inner ear treatment and diagnostic system
DE19509029C2 (de) 1994-06-06 1999-11-11 Ford Werke Ag Verfahren zur Herstellung einer katalytischen Behandlungsvorrichtung
US6239116B1 (en) 1994-07-15 2001-05-29 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
US5572594A (en) 1994-09-27 1996-11-05 Devoe; Lambert Ear canal device holder
US5736524A (en) 1994-11-14 1998-04-07 Merck & Co.,. Inc. Polynucleotide tuberculosis vaccine
DE19508029C2 (de) 1995-03-07 1997-10-09 Richard Prof Dr Sueverkruep Darreichungsform zur äußerlichen Applikation von ophthalmischen Arzneistoffen und Verfahren zur Herstellung derselben
AU6280596A (en) 1995-06-15 1997-01-15 University Of Victoria Innovation And Development Corporation Mycobacterium tuberculosis dna sequences encoding immunostimlatory peptides
AU2676397A (en) 1996-04-18 1997-11-07 University Technology Corporation Methods for treating middle and inner ear disorders
US5954682A (en) 1996-09-25 1999-09-21 Advanced Medical Instruments Therapeutic applicator apparatus and method
US6045528A (en) 1997-06-13 2000-04-04 Intraear, Inc. Inner ear fluid transfer and diagnostic system
AU742040C (en) * 1997-09-24 2003-10-02 Amgen, Inc. Method for preventing and treating hearing loss using sensorineurotrophic compounds
US6177434B1 (en) * 1997-12-16 2001-01-23 The United States Of America As Represented By The Secretary Of The Navy Prevention or reversal of sensorineural hearing loss (SNHL) through biologic mechanisms
US6440102B1 (en) 1998-07-23 2002-08-27 Durect Corporation Fluid transfer and diagnostic system for treating the inner ear
US8197461B1 (en) 1998-12-04 2012-06-12 Durect Corporation Controlled release system for delivering therapeutic agents into the inner ear

Also Published As

Publication number Publication date
AU2164600A (en) 2000-06-26
EP1767175A1 (en) 2007-03-28
PT1133269E (pt) 2007-05-31
US8197461B1 (en) 2012-06-12
ES2283146T3 (es) 2007-10-16
ATE353615T1 (de) 2007-03-15
US6685697B1 (en) 2004-02-03
DE69935155T2 (de) 2007-10-31
AU761837B2 (en) 2003-06-12
WO2000033775A1 (en) 2000-06-15
DE69935155D1 (de) 2007-03-29
CA2350838C (en) 2008-12-02
CA2350838A1 (en) 2000-06-15
EP1133269A1 (en) 2001-09-19
EP1133269B1 (en) 2007-02-14

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