DE69935155D1 - Gesteuertes freisetzungssystem zur abgabe von therapeutika in den innenohrkanal - Google Patents

Gesteuertes freisetzungssystem zur abgabe von therapeutika in den innenohrkanal

Info

Publication number
DE69935155D1
DE69935155D1 DE69935155T DE69935155T DE69935155D1 DE 69935155 D1 DE69935155 D1 DE 69935155D1 DE 69935155 T DE69935155 T DE 69935155T DE 69935155 T DE69935155 T DE 69935155T DE 69935155 D1 DE69935155 D1 DE 69935155D1
Authority
DE
Germany
Prior art keywords
therapeutic agents
inner ear
drug delivery
round window
media material
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69935155T
Other languages
English (en)
Other versions
DE69935155T2 (de
Inventor
K Arenberg
H Arenberg
Christine Lemke
A Berglund
Felix Theeuwes
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Durect Corp
Original Assignee
Durect Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Durect Corp filed Critical Durect Corp
Application granted granted Critical
Publication of DE69935155D1 publication Critical patent/DE69935155D1/de
Publication of DE69935155T2 publication Critical patent/DE69935155T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0046—Ear
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F11/00—Methods or devices for treatment of the ears or hearing sense; Non-electric hearing aids; Methods or devices for enabling ear patients to achieve auditory perception through physiological senses other than hearing sense; Protective devices for the ears, carried on the body or in the hand
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physics & Mathematics (AREA)
  • Psychology (AREA)
  • Otolaryngology (AREA)
  • Biophysics (AREA)
  • Acoustics & Sound (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69935155T 1998-12-04 1999-12-03 Gesteuertes freisetzungssystem zur abgabe von therapeutika in den innenohrkanal Expired - Lifetime DE69935155T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US205251 1998-12-04
US09/205,251 US8197461B1 (en) 1998-12-04 1998-12-04 Controlled release system for delivering therapeutic agents into the inner ear
PCT/US1999/028716 WO2000033775A1 (en) 1998-12-04 1999-12-03 Controlled release system for delivering therapeutic agents into the inner ear

Publications (2)

Publication Number Publication Date
DE69935155D1 true DE69935155D1 (de) 2007-03-29
DE69935155T2 DE69935155T2 (de) 2007-10-31

Family

ID=22761443

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69935155T Expired - Lifetime DE69935155T2 (de) 1998-12-04 1999-12-03 Gesteuertes freisetzungssystem zur abgabe von therapeutika in den innenohrkanal

Country Status (10)

Country Link
US (2) US8197461B1 (de)
EP (2) EP1767175A1 (de)
AT (1) ATE353615T1 (de)
AU (1) AU761837B2 (de)
CA (1) CA2350838C (de)
DE (1) DE69935155T2 (de)
DK (1) DK1133269T3 (de)
ES (1) ES2283146T3 (de)
PT (1) PT1133269E (de)
WO (1) WO2000033775A1 (de)

Families Citing this family (94)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7963997B2 (en) * 2002-07-19 2011-06-21 Kensey Nash Corporation Device for regeneration of articular cartilage and other tissue
US8697108B2 (en) * 1994-05-13 2014-04-15 Kensey Nash Corporation Method for making a porous polymeric material
US8795242B2 (en) 1994-05-13 2014-08-05 Kensey Nash Corporation Resorbable polymeric device for localized drug delivery
US8197461B1 (en) 1998-12-04 2012-06-12 Durect Corporation Controlled release system for delivering therapeutic agents into the inner ear
US20070270579A1 (en) * 2001-05-18 2007-11-22 Sirna Therapeutics, Inc. RNA interference mediated inhibition of gene expression using short interfering nucleic acid (siNA)
US7517864B2 (en) * 2001-05-18 2009-04-14 Sirna Therapeutics, Inc. RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA)
US20050282188A1 (en) * 2001-05-18 2005-12-22 Sirna Therapeutics, Inc. RNA interference mediated inhibition of gene expression using short interfering nucleic acid (siNA)
US20080161256A1 (en) * 2001-05-18 2008-07-03 Sirna Therapeutics, Inc. RNA interference mediated inhibition of gene expression using short interfering nucleic acid (siNA)
US20050222066A1 (en) * 2001-05-18 2005-10-06 Sirna Therapeutics, Inc. RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA)
US20060241075A1 (en) * 2001-05-18 2006-10-26 Sirna Therapeutics, Inc. RNA interference mediated inhibition of desmoglein gene expression using short interfering nucleic acid (siNA)
US20070042983A1 (en) * 2001-05-18 2007-02-22 Sirna Therapeutics, Inc. RNA interference mediated inhibition of gene expression using short interfering nucleic acid (siNA)
ES2271278T3 (es) * 2001-06-18 2007-04-16 Durect Corporation Dispositivo para administrar microdosis de agentes en el oido.
US7206639B2 (en) * 2002-03-15 2007-04-17 Sarcos Investments Lc Cochlear drug delivery system and method
US7867193B2 (en) * 2004-01-29 2011-01-11 The Charles Stark Draper Laboratory, Inc. Drug delivery apparatus
EP1545551A4 (de) 2002-09-06 2008-10-22 Durect Corp Abgabe von modulatoren der glutamat-vermittelten neurotransmission an das innenohr
EP1438942A1 (de) * 2003-01-17 2004-07-21 Schering Oy Medikamentenabgabevorrichtung für das Mittelohr und Nase
DE10305349A1 (de) 2003-02-10 2004-08-26 Cell Center Cologne Gmbh Innenohr-Steckverbindung
US8940321B2 (en) 2003-12-12 2015-01-27 Otic Pharma Ltd. Compositions for treatment of ear disorders and methods of use thereof
ES2552936T3 (es) 2003-12-12 2015-12-03 Otic Pharma Ltd. Composiciones para el tratamiento del desordenes en el oído y métodos para el uso de los mismos
US7351246B2 (en) * 2004-01-20 2008-04-01 Epley John M Minimally invasive, sustained, intra-tympanic drug delivery system
US7867194B2 (en) 2004-01-29 2011-01-11 The Charles Stark Draper Laboratory, Inc. Drug delivery apparatus
US7668325B2 (en) 2005-05-03 2010-02-23 Earlens Corporation Hearing system having an open chamber for housing components and reducing the occlusion effect
CA2594963A1 (en) * 2005-01-24 2006-07-27 Neurosystec Corporation Apparatus and method for delivering therapeutic and/or other agents to the inner ear and to other tissues
US20070077270A1 (en) * 2005-03-28 2007-04-05 Clemson University Delivery devices and methods for long-term, targeted delivery of therapeutic agents to the eye and ear
US20100241219A1 (en) * 2005-06-20 2010-09-23 Abbeymoor Medical , Inc Medicament delivery article, accessory & system
US20070110788A1 (en) * 2005-11-14 2007-05-17 Hissong James B Injectable formulation capable of forming a drug-releasing device
US20110183348A1 (en) * 2010-01-22 2011-07-28 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Compositions and methods for therapeutic delivery with microorganisms
DK3326681T3 (da) * 2005-12-30 2019-09-30 Rdd Pharma Ltd Indretning til behandling af analsphincteren
US8267905B2 (en) * 2006-05-01 2012-09-18 Neurosystec Corporation Apparatus and method for delivery of therapeutic and other types of agents
US20070264296A1 (en) * 2006-05-10 2007-11-15 Myntti Matthew F Biofilm extracellular polysachharide solvating system
US7976873B2 (en) * 2006-05-10 2011-07-12 Medtronic Xomed, Inc. Extracellular polysaccharide solvating system for treatment of bacterial ear conditions
US7993675B2 (en) * 2006-05-10 2011-08-09 Medtronic Xomed, Inc. Solvating system and sealant for medical use in the sinuses and nasal passages
US7959943B2 (en) * 2006-05-10 2011-06-14 Medtronics Xomed, Inc. Solvating system and sealant for medical use in the middle or inner ear
US7803148B2 (en) * 2006-06-09 2010-09-28 Neurosystec Corporation Flow-induced delivery from a drug mass
JP2010511595A (ja) * 2006-07-31 2010-04-15 ニューロシステック コーポレイション 遊離塩基ガシクリジンナノ粒子
WO2008094672A2 (en) 2007-01-31 2008-08-07 Charles Stark Draper Laboratory, Inc. Membrane-based fluid control in microfluidic devices
US8088095B2 (en) * 2007-02-08 2012-01-03 Medtronic Xomed, Inc. Polymeric sealant for medical use
US20090088844A1 (en) 2007-07-03 2009-04-02 Keegan Mark E Drug-eluting stapes prosthesis
WO2009049320A1 (en) 2007-10-12 2009-04-16 Earlens Corporation Multifunction system and method for integrated hearing and communiction with noise cancellation and feedback management
US7951393B2 (en) * 2007-11-14 2011-05-31 Canaan Vernon Lavelle Harris Keloid therapy
CN101264043B (zh) * 2008-01-14 2010-09-08 四川大学 耳穴定位粘药器
US20090181068A1 (en) 2008-01-14 2009-07-16 Dunn Richard L Low Viscosity Liquid Polymeric Delivery System
US11969501B2 (en) 2008-04-21 2024-04-30 Dompé Farmaceutici S.P.A. Auris formulations for treating otic diseases and conditions
CA2721927C (en) 2008-04-21 2014-01-28 Otonomy, Inc. Auris formulations for treating otic diseases and conditions
ES2759373T3 (es) 2008-06-12 2020-05-08 Medtronic Xomed Inc Producto para el tratamiento de heridas crónicas con un sistema extracelular de solvatación de sustancias poliméricas
WO2009155358A1 (en) 2008-06-17 2009-12-23 Earlens Corporation Optical electro-mechanical hearing devices with separate power and signal components
US8496957B2 (en) 2008-07-21 2013-07-30 Otonomy, Inc Controlled release auris sensory cell modulator compositions and methods for the treatment of otic disorders
DK2342905T3 (en) 2008-09-22 2019-04-08 Earlens Corp BALANCED Luminaire Fittings and Methods of Hearing
WO2010042427A2 (en) 2008-10-06 2010-04-15 Microbial Defense Systems, Llc Antimicrobial composition and methods of making and using same
US8808317B2 (en) * 2008-11-06 2014-08-19 Carl Braunagel Apparatus for cleaning a nasal cavity
US9078783B2 (en) * 2008-12-24 2015-07-14 Acclarent, Inc. Silent effusion removal
SE534532C2 (sv) * 2009-01-22 2011-09-27 Svante Syk-Eksell Expanderande propp avsedd för insättning i en näsborre/örongång och för distribuering av medicinska preparat
EP2445481B1 (de) * 2009-06-18 2017-03-22 Rdd Pharma Ltd. Verfahren und vorrichtungen zur freisetzung von arzneimitteln in körperöffnungen
EP2498763A4 (de) 2009-11-09 2015-10-07 Spotlight Technology Partners Llc Hydrogele auf polysaccharidbasis
US8795727B2 (en) 2009-11-09 2014-08-05 Spotlight Technology Partners Llc Fragmented hydrogels
WO2011107932A1 (en) * 2010-03-01 2011-09-09 Estimme Ltd. Drug delivery device
WO2012088187A2 (en) 2010-12-20 2012-06-28 SoundBeam LLC Anatomically customized ear canal hearing apparatus
EP2670456B1 (de) 2011-02-02 2019-12-18 The Charles Stark Draper Laboratory, Inc. Vorrichtung zur wirkstofffreisetzung
US8911424B2 (en) * 2011-02-09 2014-12-16 Ethicon, Inc. Methods and devices for preventing catheter related urinary tract infections
BR112013028673B1 (pt) 2011-05-10 2020-06-16 Next Science IP Holdings Pty Ltd Sólido antimicrobiano e métodos de fazer e usar o mesmo
DE102011107139A1 (de) * 2011-07-12 2013-01-17 Gerd Borkowski Hörgerät mit zumindest einem in den Gehörgang einzuführenden Abschnitt
WO2013022772A1 (en) 2011-08-05 2013-02-14 Unitract Syringe Pty Ltd Cannula with controlled depth of insertion
EP2755546A4 (de) * 2011-09-15 2015-08-12 Yoseph Yaacobi Systeme und verfahren zur behandlung von ohrerkrankungen
US8685106B2 (en) 2011-11-15 2014-04-01 Abraham Lin Method of a pharmaceutical delivery system for use within a joint replacement
US20140309597A1 (en) * 2012-10-15 2014-10-16 Jeremiah Joseph Lowney Applicator for delivering a single dose of medicine to an inner canal of an ear
US10821276B2 (en) 2012-12-14 2020-11-03 The Trustees Of Columbia University In The City Of New York System and method to locally deliver therapeutic agent to inner ear
EP2931196A4 (de) * 2012-12-14 2016-07-13 Univ Columbia System und verfahren zur lokalen verabreichung eines therapeutikums in das innenohr
US20150182382A1 (en) * 2013-12-27 2015-07-02 Custom Protect Ear, Inc. Pre-lubricated earplugs and the method of production thereof
US10034103B2 (en) 2014-03-18 2018-07-24 Earlens Corporation High fidelity and reduced feedback contact hearing apparatus and methods
US9616207B2 (en) * 2014-06-26 2017-04-11 Cochlear Limited Treatment of the ear
EP3169396B1 (de) 2014-07-14 2021-04-21 Earlens Corporation Gleitende vorspannung und spitzenunterdrückung für optische hörgeräte
US9924276B2 (en) 2014-11-26 2018-03-20 Earlens Corporation Adjustable venting for hearing instruments
MX2018001571A (es) * 2015-08-05 2018-09-06 Childrens Medical Center Composiciones con potenciadores de permeacion para suministro de farmacos.
WO2017059240A1 (en) * 2015-10-02 2017-04-06 Earlens Corporation Drug delivery customized ear canal apparatus
US11350226B2 (en) 2015-12-30 2022-05-31 Earlens Corporation Charging protocol for rechargeable hearing systems
US10492010B2 (en) 2015-12-30 2019-11-26 Earlens Corporations Damping in contact hearing systems
US10306381B2 (en) 2015-12-30 2019-05-28 Earlens Corporation Charging protocol for rechargable hearing systems
US11213430B2 (en) 2016-05-26 2022-01-04 Cochlear Limited Inner ear plug
AU2017281086A1 (en) 2016-06-22 2019-02-07 Mass Eye And Ear Infirmary A system for inner ear drug delivery via trans-round window membrane injection
JP2019527571A (ja) * 2016-08-05 2019-10-03 タスカー メディカル，インコーポレイテッド 治療物質を中耳及び／又は内耳へ送達するためのシステム、装置及び方法
CN112738700A (zh) 2016-09-09 2021-04-30 伊尔兰斯公司 智能镜***和方法
WO2018093733A1 (en) 2016-11-15 2018-05-24 Earlens Corporation Improved impression procedure
US20180221208A1 (en) * 2017-02-08 2018-08-09 Tusker Medical, Inc. Systems, apparatus, and methods for delivery of therapeutic substance to the tympanic membrane
WO2019073348A2 (en) * 2017-10-12 2019-04-18 Cochlear Limited AUTOMATED CLINICAL ADMINISTRATION OF INTERNAL EAR TREATMENT MATERIALS
WO2019136133A1 (en) 2018-01-03 2019-07-11 The Trustees Of Columbia University In The City Of New York Microneedle for local delivery of therapeutic agent
JP7273830B2 (ja) 2018-01-16 2023-05-15 タスカー メディカル，インコーポレイテッド 耳下手術のための可視化デバイス
WO2019173470A1 (en) 2018-03-07 2019-09-12 Earlens Corporation Contact hearing device and retention structure materials
WO2019199680A1 (en) 2018-04-09 2019-10-17 Earlens Corporation Dynamic filter
EP3781102A1 (de) 2018-04-19 2021-02-24 Spiral Therapeutics, Inc. Innenohrarzneimittelabgabevorrichtungen und verfahren zur verwendung
CN112469466A (zh) * 2018-08-24 2021-03-09 科利耳有限公司 哺乳动物内部的质量输送
WO2020115674A1 (en) * 2018-12-05 2020-06-11 Cochlear Limited Therapeutic substance storage and delivery
WO2021150887A1 (en) 2020-01-24 2021-07-29 Spiral Therapeutics Inc. Visualization devices, systems, and methods for otology and other uses
WO2022081955A1 (en) * 2020-10-15 2022-04-21 The Board Of Trustees Of The Leland Stanford Junior University Method and system for ototopical delivery using nanoparticles for ear infection diagnosis and treatment
EP4183380A1 (de) * 2021-11-22 2023-05-24 Medizinische Hochschule Hannover Patientenspezifisches, arzneimittelfreisetzendes, komprimierbares implantat mit integriertem handgriff zum einsetzen in eine körperhöhle und verfahren zu seiner herstellung

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE850341C (de) 1950-04-15 1952-09-25 Gazzoni & Co A Vorrichtung zum Benetzen des aeusseren Gehoerganges mit einer schmerzstillenden Fluessigkeit
GB1204117A (en) 1966-09-08 1970-09-03 Syntex Corp Devices and methods for administering pharmaceutical preparations
US3982545A (en) 1974-08-22 1976-09-28 Herbert Silverstein Middle ear aeration and implant
US4034759A (en) 1975-08-27 1977-07-12 Xomed, Inc. Moisture-expandable prosthesis
US4141973A (en) 1975-10-17 1979-02-27 Biotrics, Inc. Ultrapure hyaluronic acid and the use thereof
US4159719A (en) 1977-05-09 1979-07-03 Xomed, Inc. Moisture-expandable ear wick
GB2042888B (en) 1979-03-05 1983-09-28 Teijin Ltd Preparation for administration to the mucosa of the oral or nasal cavity
US4360019A (en) 1979-02-28 1982-11-23 Andros Incorporated Implantable infusion device
US4343931A (en) 1979-12-17 1982-08-10 Minnesota Mining And Manufacturing Company Synthetic absorbable surgical devices of poly(esteramides)
US4297748A (en) 1980-01-02 1981-11-03 Moloy Peter J Middle ear balloon
US4692147A (en) 1980-04-02 1987-09-08 Medtronic, Inc. Drug administration device
US5166331A (en) 1983-10-10 1992-11-24 Fidia, S.P.A. Hyaluronics acid fractions, methods for the preparation thereof, and pharmaceutical compositions containing same
US4487603A (en) 1982-11-26 1984-12-11 Cordis Corporation Implantable microinfusion pump system
US4472394A (en) * 1983-09-19 1984-09-18 G. D. Searle & Co. Method for increasing weight in domestic animals
US4784640A (en) * 1984-08-20 1988-11-15 Johnson Ronald F Apparatus for implanting implants in cattle
US4725852A (en) 1985-05-09 1988-02-16 Burlington Industries, Inc. Random artificially perturbed liquid apparatus and method
US4851402A (en) * 1987-02-27 1989-07-25 International Minerals & Chemical Corp. Estriol growth promotant
US4874368A (en) 1988-07-25 1989-10-17 Micromedics, Inc. Fibrin glue delivery system
US5350580A (en) 1990-03-05 1994-09-27 Minnesota Mining And Manufacturing Company Device and method for extended delivery of pharmacologically active agents to the ear
US5236413B1 (en) 1990-05-07 1996-06-18 Andrew J Feiring Method and apparatus for inducing the permeation of medication into internal tissue
US5344411A (en) 1991-02-27 1994-09-06 Leonard Bloom Method and device for inhibiting HIV, hepatitis B and other viruses and germs when using a catheter in a medical environment
US5437656A (en) 1991-02-27 1995-08-01 Leonard Bloom Method and device for inhibiting H.I.V. hepatitis B and other viruses and germs when using a needle, scalpel and other sharp instrument in a medical environment
US5695458A (en) 1991-02-27 1997-12-09 Maryland Biopolymer Technologies, Llc Anti-infective polymer-iodine coating for blood collection and delivery systems
AU1579092A (en) 1991-02-27 1992-10-06 Nova Pharmaceutical Corporation Anti-infective and anti-inflammatory releasing systems for medical devices
US5304134A (en) 1992-01-17 1994-04-19 Danforth Biomedical, Inc. Lubricious yet bondable catheter channel sleeve for over-the-wire catheters
US5461140A (en) 1992-04-30 1995-10-24 Pharmaceutical Delivery Systems Bioerodible polymers for solid controlled release pharmaceutical compositions
US5419312A (en) 1993-04-20 1995-05-30 Wildflower Communications, Inc. Multi-function endoscope apparatus
US5421818A (en) 1993-10-18 1995-06-06 Inner Ear Medical Delivery Systems, Inc. Multi-functional inner ear treatment and diagnostic system
DE19509029C2 (de) 1994-06-06 1999-11-11 Ford Werke Ag Verfahren zur Herstellung einer katalytischen Behandlungsvorrichtung
US6239116B1 (en) 1994-07-15 2001-05-29 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
US5572594A (en) 1994-09-27 1996-11-05 Devoe; Lambert Ear canal device holder
US5736524A (en) 1994-11-14 1998-04-07 Merck & Co.,. Inc. Polynucleotide tuberculosis vaccine
DE19549506C2 (de) * 1995-03-07 1998-07-30 Richard Prof Dr Sueverkruep Darreichungsform zur äußerlichen Applikation und Verfahren zur Herstellung derselben
WO1997000067A1 (en) 1995-06-15 1997-01-03 University Of Victoria Innovation And Development Mycobacterium tuberculosis dna sequences encoding immunostimulatory peptides
WO1997038698A1 (en) 1996-04-18 1997-10-23 University Technology Corporation Methods for treating middle and inner ear disorders
US5954682A (en) 1996-09-25 1999-09-21 Advanced Medical Instruments Therapeutic applicator apparatus and method
US6045528A (en) 1997-06-13 2000-04-04 Intraear, Inc. Inner ear fluid transfer and diagnostic system
EP1011650A1 (de) * 1997-09-24 2000-06-28 Amgen Inc., Methode zur verhinderung und behandlung von gehörverlust unter verwendung von sensorneurotrophen stoffen
US6177434B1 (en) * 1997-12-16 2001-01-23 The United States Of America As Represented By The Secretary Of The Navy Prevention or reversal of sensorineural hearing loss (SNHL) through biologic mechanisms
US6440102B1 (en) 1998-07-23 2002-08-27 Durect Corporation Fluid transfer and diagnostic system for treating the inner ear
US8197461B1 (en) 1998-12-04 2012-06-12 Durect Corporation Controlled release system for delivering therapeutic agents into the inner ear

Also Published As

Publication number Publication date
EP1133269A1 (de) 2001-09-19
CA2350838C (en) 2008-12-02
WO2000033775A1 (en) 2000-06-15
US8197461B1 (en) 2012-06-12
EP1767175A1 (de) 2007-03-28
ES2283146T3 (es) 2007-10-16
DK1133269T3 (da) 2007-06-11
DE69935155T2 (de) 2007-10-31
CA2350838A1 (en) 2000-06-15
ATE353615T1 (de) 2007-03-15
AU2164600A (en) 2000-06-26
US6685697B1 (en) 2004-02-03
EP1133269B1 (de) 2007-02-14
AU761837B2 (en) 2003-06-12
PT1133269E (pt) 2007-05-31

Similar Documents

Publication Publication Date Title
DE69935155D1 (de) Gesteuertes freisetzungssystem zur abgabe von therapeutika in den innenohrkanal
HUP9802773A2 (en) Transcorneal drug-release system
DK0862416T3 (da) Ikke-polymert indgivelsessystem med forhalet frigørelse
WO2004010975A3 (en) Controlled drug delivery
BRPI0411924A8 (pt) Métodos e dispositivos para oclusão de lúmens de corpo e/ou para fornecimento de agentes terapêuticos
MXPA03006825A (es) Dispositivos vasculares revestidos.
NO20034684L (no) Mikroprojeksjonsanordning med belegg inneholdende et fordelaktig middel
HUP0300491A2 (en) Improvements in or relating to the delivery of oral drugs
EP1262206A3 (de) Kontrastmittelabgabesystem mit patientenspezifischer Dosierung
ATE344063T1 (de) Beschichtete medizinische geräte
WO2003077972A3 (en) Implantable drug delivery system
PT737066E (pt) Dispositivo transdermico contendo polivinilpirrolidona como potenciador de solubilidade
MY133883A (en) Gastrointestinal drug delivery system
ATE444768T1 (de) Wirkstoffabgabesysteme
DE69803360D1 (de) Anwendungsformen zur behandlung der männlichen erektilen dysfunktion
CY1108665T1 (el) Διαταξεις χορηγησης φαρμακων παρατεταμενης απελευθερωσης, μεθοδοι χρησης και μεθοδοι κατασκευης αυτων
WO2001043749A3 (en) Pharmaceutical implant containing immediate-release and sustained-release components and method of administration
IL195723A (en) Use of p53 inhibitors for the preparation of medicament
HUP0203590A2 (hu) Gyógyszerkészítmény a csonttömeg csökkenésével járó betegségek kezelésére
EP1139746A4 (de) Verbindungen und verfahren zur behandlung von atemwegserkrankungen sowie zur verabreichung von arzneistoffen für die atmewege
DE60143964D1 (de) Arzneimittel zur behandlung von osteonekrose und zur versorgung von patienten mit risiko für die entstehung von osteonekrose
DE60112777D1 (de) Beschichtete medizinische geräte und verfahren zur sterilisation
ATE308328T1 (de) Pharmazeutische zusammensetzung enthaltend clindamycin und clotrimazol, zur behandlung vaginaler infektionen
AR034493A1 (es) Combinacion de principios activos para el tratamiento medico de toxicomanias.
HUP0203908A2 (hu) Ozmotikus adagolórendszer és eljárás elsősorban gyógyszer adagolására

Legal Events

Date Code Title Description
8364 No opposition during term of opposition