DK1102762T3 - 2-substituerede-1-piperidylbenzimidazolforbindelser som ORL1-receptoragonister - Google Patents

2-substituerede-1-piperidylbenzimidazolforbindelser som ORL1-receptoragonister

Info

Publication number: DK1102762T3
Authority: DK; Denmark
Prior art keywords: piperidylbenzimidazole; substituted; compounds; receptor agonists; orl1 receptor
Prior art date: 1998-08-06

Application number

DK99926688T

Other languages

Danish (da)

English (en)

Inventor

Fumitaka Ito

Hirohide Noguchi

Hiroshi Kondo

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-08-06

Filing date

1999-07-05

Publication date

2002-12-16

1999-07-05 Application filed by Pfizer filed Critical Pfizer

2002-12-16 Application granted granted Critical

2002-12-16 Publication of DK1102762T3 publication Critical patent/DK1102762T3/da

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Psychiatry (AREA)
Anesthesiology (AREA)
Heart & Thoracic Surgery (AREA)
Addiction (AREA)
Cardiology (AREA)
Hospice & Palliative Care (AREA)
Toxicology (AREA)
Psychology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

DK99926688T 1998-08-06 1999-07-05 2-substituerede-1-piperidylbenzimidazolforbindelser som ORL1-receptoragonister DK1102762T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IBPCT/IB98/01206		1998-08-06
PCT/IB1999/001239 WO2000008013A2 (en)	1998-08-06	1999-07-05	2-substituted-1-piperidyl benzimidazole compounds as orl1-receptor agonists

Publications (1)

Publication Number	Publication Date
DK1102762T3 true DK1102762T3 (da)	2002-12-16

Family

ID=11004738

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK99926688T DK1102762T3 (da)	1998-08-06	1999-07-05	2-substituerede-1-piperidylbenzimidazolforbindelser som ORL1-receptoragonister

Country Status (44)

Country	Link
US (1)	US6172067B1 (zh)
EP (1)	EP1102762B1 (zh)
JP (1)	JP3367945B2 (zh)
CN (1)	CN1317968A (zh)
AP (1)	AP2001002063A0 (zh)
AR (1)	AR018686A1 (zh)
AT (1)	ATE227716T1 (zh)
AU (1)	AU749166B2 (zh)
BG (1)	BG105301A (zh)
BR (1)	BR9912778A (zh)
CA (1)	CA2339621C (zh)
CZ (1)	CZ2001397A3 (zh)
DE (1)	DE69903953T2 (zh)
DK (1)	DK1102762T3 (zh)
EA (1)	EA200100104A1 (zh)
EE (1)	EE200100075A (zh)
ES (1)	ES2185357T3 (zh)
GE (1)	GEP20033000B (zh)
GT (1)	GT199900125A (zh)
HK (1)	HK1040188A1 (zh)
HN (1)	HN1999000105A (zh)
HR (1)	HRP20010089B1 (zh)
HU (1)	HUP0103567A3 (zh)
ID (1)	ID27212A (zh)
IL (1)	IL141029A0 (zh)
IS (1)	IS5812A (zh)
MA (1)	MA26659A1 (zh)
NO (1)	NO20010603L (zh)
NZ (1)	NZ509299A (zh)
OA (1)	OA11590A (zh)
PA (1)	PA8477701A1 (zh)
PE (1)	PE20000868A1 (zh)
PL (1)	PL346211A1 (zh)
PT (1)	PT1102762E (zh)
SI (1)	SI1102762T1 (zh)
SK (1)	SK1602001A3 (zh)
SV (1)	SV1999000099A (zh)
TN (1)	TNSN99142A1 (zh)
TR (1)	TR200100403T2 (zh)
TW (1)	TW513424B (zh)
UY (1)	UY25659A1 (zh)
WO (1)	WO2000008013A2 (zh)
YU (1)	YU8201A (zh)
ZA (1)	ZA200100900B (zh)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6340681B1 (en) *	1999-07-16	2002-01-22	Pfizer Inc	2-benzimidazolylamine compounds as ORL-1-receptor agonists
SE9902987D0 (sv)	1999-08-24	1999-08-24	Astra Pharma Prod	Novel compounds
SE9903544D0 (sv)	1999-10-01	1999-10-01	Astra Pharma Prod	Novel compounds
EP1122257B1 (en) *	2000-01-05	2005-10-12	Pfizer Inc.	Benzimidazole compounds as ORL1-receptor agonists
GB2359078A (en) *	2000-02-11	2001-08-15	Astrazeneca Uk Ltd	Pharmaceutically active pyrimidine derivatives
GB2359081A (en)	2000-02-11	2001-08-15	Astrazeneca Uk Ltd	Pharmaceutically active thiazolopyrimidines
GB2359551A (en)	2000-02-23	2001-08-29	Astrazeneca Uk Ltd	Pharmaceutically active pyrimidine derivatives
GB0005642D0 (en)	2000-03-10	2000-05-03	Astrazeneca Uk Ltd	Chemical compounds
SE0003828D0 (sv)	2000-10-20	2000-10-20	Astrazeneca Ab	Novel compounds
AU2002224038B2 (en) *	2000-11-15	2006-03-09	Banyu Pharmaceutical Co., Ltd.	Benzimidazole derivatives
GB0104050D0 (en)	2001-02-19	2001-04-04	Astrazeneca Ab	Chemical compounds
GB0107228D0 (en)	2001-03-22	2001-05-16	Astrazeneca Ab	Chemical compounds
SE0101322D0 (sv)	2001-04-12	2001-04-12	Astrazeneca Ab	Novel compounds
IL158484A0 (en) *	2001-04-18	2004-05-12	Euro Celtique Sa	Nociceptin analogs
EP1385514B9 (en)	2001-04-18	2009-08-12	Euro-Celtique S.A.	Spiroindene and spiroindane compounds
AU2002338424B2 (en)	2001-04-18	2005-04-21	Euro-Celtique S.A.	Benzimidazolone compounds
IL158485A0 (en)	2001-04-18	2004-05-12	Euro Celtique Sa	Spiropyrazole compounds
BR0209128A (pt) *	2001-04-18	2005-11-01	Euro Celtique Sa	Compostos, composições farmacêuticas, métodos para o tratamento de dores, métodos para a modulação de uma resposta farmacológica e usos de compostos
WO2003004034A1 (en) *	2001-07-02	2003-01-16	Omeros Corporation	Method for inducing analgesia comprising administration alternatively of an opioid receptor agonist and an opioid receptor like receptor 1 agonist for and an implantable infusion pump
US20030040479A1 (en) *	2001-07-02	2003-02-27	Omeros Corporation	Rotational intrathecal analgesia method and device
SE0102716D0 (sv) *	2001-08-14	2001-08-14	Astrazeneca Ab	Novel compounds
SE0103818D0 (sv)	2001-11-15	2001-11-15	Astrazeneca Ab	Chemical compounds
AU2002360561A1 (en) *	2001-12-11	2003-06-23	Sepracor, Inc.	4-substituted piperidines, and methods of use thereof
US7566728B2 (en)	2002-03-29	2009-07-28	Mitsubishi Tanabe Pharma Corporation	Remedy for sleep disturbance
GB0221829D0 (en) *	2002-09-20	2002-10-30	Astrazeneca Ab	Novel compound
GB0221828D0 (en)	2002-09-20	2002-10-30	Astrazeneca Ab	Novel compound
DE10252666A1 (de) *	2002-11-11	2004-08-05	Grünenthal GmbH	N-Piperidyl-cyclohexan-Derivate
DE10252665A1 (de)	2002-11-11	2004-06-03	Grünenthal GmbH	4-Aminomethyl-1-aryl-cyclohexylamin-Derivate
GB0315203D0 (en) *	2003-06-28	2003-08-06	Celltech R&D Ltd	Chemical compounds
AR045939A1 (es)	2003-09-25	2005-11-16	Solvay Pharm Bv	Derivados de bencimidazolona y quinazolinona como agonistas de los receptores orl 1 humanos
GB0328243D0 (en) *	2003-12-05	2004-01-07	Astrazeneca Ab	Methods
US20050228023A1 (en) *	2003-12-19	2005-10-13	Sri International	Agonist and antagonist ligands of the nociceptin receptor
WO2006038738A1 (ja) *	2004-10-08	2006-04-13	Takeda Pharmaceutical Company Limited	受容体機能調節剤
JP2008526815A (ja)	2005-01-11	2008-07-24	ノイロサーチアクティーゼルスカブ	低コンダクタンスのカルシウム依存性カリウムチャネルのモジュレーターとしての新規２−アミノベンゾイミダゾール誘導体及びそれらの使用
US20090239880A1 (en) *	2006-07-03	2009-09-24	Ulrik Svane Sorensen	Combinations of monoamine reuptake inhibitors and potassium channel activators
KR101370434B1 (ko)	2007-01-16	2014-03-06	시오노기세이야쿠가부시키가이샤	Ｏｒｌ-1 리간드로서의 헤테로시클릭-치환 피페리딘
EP2433936A1 (en) *	2007-08-31	2012-03-28	Purdue Pharma LP	Substituted-quinoxaline-type-piperidine compounds and the uses thereof
US8119661B2 (en) *	2007-09-11	2012-02-21	Astrazeneca Ab	Piperidine derivatives and their use as muscarinic receptor modulators
KR101333660B1 (ko)	2008-07-21	2013-11-27	시오노기세이야쿠가부시키가이샤	치환-퀴녹살린-형 가교-피페리딘 화합물 및 그의 용도
MX2013001313A (es)	2010-08-05	2013-06-13	Amgen Inc	Compuestos de bencimidazol y azabencimidazol que inhiben la cinasa del linfoma anaplasico.
JP6007262B2 (ja)	2012-01-06	2016-10-12	ノーバス・インターナショナル・インコーポレイテッドＮｏｖｕｓＩｎｔｅｒｎａｔｉｏｎａｌ，Ｉｎｃ．	スルホキシドベース界面活性剤
EP2812313A4 (en)	2012-02-09	2015-09-30	Novus Int Inc	FUNCTIONALIZED POLYMERIC COMPOSITIONS
JO3300B1 (ar)	2012-06-06	2018-09-16	Novartis Ag	مركبات وتركيبات لتعديل نشاط egfr
EP3388056A1 (en)	2012-07-12	2018-10-17	Novus International Inc.	Matrix and layer compositions for protection of bioactives
US9085561B2 (en) *	2012-07-30	2015-07-21	Purdue Pharma L.P.	Cyclic urea- or lactam-substituted quinoxaline-type piperidines as ORL-1 modulators
US9090618B2 (en)	2012-12-27	2015-07-28	Purdue Pharma L.P.	Substituted benzimidazole-type piperidine compounds and uses thereof
US9656994B2 (en)	2013-03-22	2017-05-23	The Scripps Research Institute	Substituted benzimidazoles as nociceptin receptor modulators
DK3119762T3 (da)	2014-03-20	2021-08-30	Capella Therapeutics Inc	Benzimidazol-derivater som erbb-tyrosin-kinase-inhibitorer til behandlingen af kræft
WO2017083518A1 (en)	2015-11-12	2017-05-18	Novus International Inc.	Sulfur-containing compounds as solvents
US10584306B2 (en)	2017-08-11	2020-03-10	Board Of Regents Of The University Of Oklahoma	Surfactant microemulsions

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3318900A (en) *	1964-05-06	1967-05-09	Janssen Pharmaceutica Nv	Derivatives of benzimidazolinyl piperidine
JPS5297978A (en) *	1976-06-02	1977-08-17	Yoshitomi Pharmaceut Ind Ltd	Preparation of alicyclic derivatives
US5821219A (en)	1995-08-11	1998-10-13	Oregon Health Sciences University	Opioid antagonists and methods of their use
WO1997007208A1 (en)	1995-08-15	1997-02-27	Universite Libre De Bruxelles	Nucleic acid molecules encoding peptides having pronociceptive properties
US5866346A (en)	1995-09-27	1999-02-02	Indiana Unversity Foundation	Methods of using dynorphins as ligands for XOR1 receptor
EP0898568B1 (en) *	1996-04-19	2006-10-04	Neurosearch A/S	1-(4-piperidyl)-benzimidazoles having neurotrophic activity
EP0813065A3 (en)	1996-06-13	1998-07-22	F. Hoffmann-La Roche Ag	Modulation of LC132 (opioid-like) receptor function
EP0829481A1 (en) *	1996-09-16	1998-03-18	Pfizer Inc.	Morphinan hydroxamic acid compounds
US5718912A (en) *	1996-10-28	1998-02-17	Merck & Co., Inc.	Muscarine agonists
EP0990653B1 (en)	1997-05-30	2004-09-15	Banyu Pharmaceutical Co., Ltd.	2-oxoimidazole derivatives
AU8334298A (en)	1997-07-15	1999-02-10	Novo Nordisk A/S	Nociceptin analogues
US5929035A (en)	1998-04-14	1999-07-27	Regents Of The University Of Michigan	Methods of treating intestinal disorders
ID29137A (id)	1998-07-27	2001-08-02	Schering Corp	Ligan-ligan afinitas tinggi untuk reseptor nosiseptin orl-1

1999
- 1999-06-25 MA MA25646A patent/MA26659A1/fr unknown
- 1999-06-28 TW TW088110899A patent/TW513424B/zh not_active IP Right Cessation
- 1999-07-05 NZ NZ509299A patent/NZ509299A/en not_active Application Discontinuation
- 1999-07-05 CN CN99810857A patent/CN1317968A/zh active Pending
- 1999-07-05 TR TR2001/00403T patent/TR200100403T2/xx unknown
- 1999-07-05 JP JP2000563646A patent/JP3367945B2/ja not_active Expired - Fee Related
- 1999-07-05 SI SI9930151T patent/SI1102762T1/xx unknown
- 1999-07-05 TN TNTNSN99142A patent/TNSN99142A1/fr unknown
- 1999-07-05 ES ES99926688T patent/ES2185357T3/es not_active Expired - Lifetime
- 1999-07-05 EP EP99926688A patent/EP1102762B1/en not_active Expired - Lifetime
- 1999-07-05 AT AT99926688T patent/ATE227716T1/de not_active IP Right Cessation
- 1999-07-05 SK SK160-2001A patent/SK1602001A3/sk unknown
- 1999-07-05 PL PL99346211A patent/PL346211A1/xx not_active Application Discontinuation
- 1999-07-05 AP APAP/P/2001/002063A patent/AP2001002063A0/en unknown
- 1999-07-05 IL IL14102999A patent/IL141029A0/xx unknown
- 1999-07-05 DK DK99926688T patent/DK1102762T3/da active
- 1999-07-05 ID IDW20010284D patent/ID27212A/id unknown
- 1999-07-05 AU AU43859/99A patent/AU749166B2/en not_active Ceased
- 1999-07-05 HU HU0103567A patent/HUP0103567A3/hu unknown
- 1999-07-05 CA CA002339621A patent/CA2339621C/en not_active Expired - Fee Related
- 1999-07-05 BR BR9912778-4A patent/BR9912778A/pt not_active Application Discontinuation
- 1999-07-05 YU YU8201A patent/YU8201A/sh unknown
- 1999-07-05 HN HN1999000105A patent/HN1999000105A/es unknown
- 1999-07-05 CZ CZ2001397A patent/CZ2001397A3/cs unknown
- 1999-07-05 OA OA1200100031A patent/OA11590A/en unknown
- 1999-07-05 PT PT99926688T patent/PT1102762E/pt unknown
- 1999-07-05 EA EA200100104A patent/EA200100104A1/ru unknown
- 1999-07-05 GE GEAP19995740A patent/GEP20033000B/en unknown
- 1999-07-05 EE EEP200100075A patent/EE200100075A/xx unknown
- 1999-07-05 DE DE69903953T patent/DE69903953T2/de not_active Expired - Fee Related
- 1999-07-05 WO PCT/IB1999/001239 patent/WO2000008013A2/en not_active Application Discontinuation
- 1999-07-06 AR ARP990103264A patent/AR018686A1/es active IP Right Grant
- 1999-07-15 PE PE1999000717A patent/PE20000868A1/es not_active Application Discontinuation
- 1999-07-16 PA PA19998477701A patent/PA8477701A1/es unknown
- 1999-07-16 SV SV1999000099A patent/SV1999000099A/es not_active Application Discontinuation
- 1999-08-05 US US09/369,208 patent/US6172067B1/en not_active Expired - Fee Related
- 1999-08-06 GT GT199900125A patent/GT199900125A/es unknown
- 1999-08-13 UY UY25659A patent/UY25659A1/es not_active Application Discontinuation
2001
- 2001-01-16 IS IS5812A patent/IS5812A/is unknown
- 2001-02-01 ZA ZA200100900A patent/ZA200100900B/xx unknown
- 2001-02-02 HR HR970081A patent/HRP20010089B1/xx not_active IP Right Cessation
- 2001-02-05 NO NO20010603A patent/NO20010603L/no not_active Application Discontinuation
- 2001-03-01 BG BG105301A patent/BG105301A/xx unknown
2002
- 2002-02-26 HK HK02101444.8A patent/HK1040188A1/zh unknown

Also Published As

Publication number	Publication date
GT199900125A (es)	2001-01-27
YU8201A (sh)	2003-07-07
EE200100075A (et)	2002-06-17
CA2339621C (en)	2005-04-05
PE20000868A1 (es)	2000-08-31
NO20010603D0 (no)	2001-02-05
PA8477701A1 (es)	2000-09-29
AU4385999A (en)	2000-02-28
NO20010603L (no)	2001-04-05
DE69903953T2 (de)	2003-03-27
AP2001002063A0 (en)	2001-03-31
SV1999000099A (es)	2000-09-05
EP1102762A2 (en)	2001-05-30
PL346211A1 (en)	2002-01-28
ATE227716T1 (de)	2002-11-15
TR200100403T2 (tr)	2001-07-23
WO2000008013A2 (en)	2000-02-17
WO2000008013A3 (en)	2000-03-23
JP2002522431A (ja)	2002-07-23
CA2339621A1 (en)	2000-02-17
IL141029A0 (en)	2002-02-10
TW513424B (en)	2002-12-11
HUP0103567A3 (en)	2003-01-28
DE69903953D1 (de)	2002-12-19
TNSN99142A1 (fr)	2005-11-10
HRP20010089A2 (en)	2002-02-28
NZ509299A (en)	2003-05-30
GEP20033000B (en)	2003-06-25
PT1102762E (pt)	2003-02-28
EA200100104A1 (ru)	2001-08-27
US6172067B1 (en)	2001-01-09
ID27212A (id)	2001-03-08
BR9912778A (pt)	2001-09-25
SI1102762T1 (en)	2003-04-30
BG105301A (en)	2001-12-29
JP3367945B2 (ja)	2003-01-20
ES2185357T3 (es)	2003-04-16
CN1317968A (zh)	2001-10-17
EP1102762B1 (en)	2002-11-13
MA26659A1 (fr)	2004-12-20
UY25659A1 (es)	2000-02-23
AR018686A1 (es)	2001-11-28
AU749166B2 (en)	2002-06-20
SK1602001A3 (en)	2002-09-10
ZA200100900B (en)	2002-08-28
CZ2001397A3 (cs)	2002-05-15
HK1040188A1 (zh)	2002-05-31
HN1999000105A (es)	2000-11-11
HRP20010089B1 (en)	2003-04-30
IS5812A (is)	2001-01-16
OA11590A (en)	2004-08-18
HUP0103567A2 (hu)	2002-02-28

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