DK0758327T3 - Pyranonforbindelser, der er nyttige til behandling af retrovirale infektioner - Google Patents

Pyranonforbindelser, der er nyttige til behandling af retrovirale infektioner

Info

Publication number: DK0758327T3
Authority: DK; Denmark
Prior art keywords: treatment; compounds useful; retroviral infections; ones; pyranone compounds
Prior art date: 1994-05-06

Application number

DK95918864T

Other languages

Danish (da)

English (en)

Inventor

Joel Morris

Gordon L Bundy

Harvey Irving Skulnick

Ronald B Gammill

David John Anderson

Joseph Walter Strohbach

Steven Ronald Turner

Paul Adrian Aristoff

Paul D Johnson

Karen Rene Romines

Suvit Thaisrivongs

Theresa M Schwartz

Ruben A Tommasi

Louis L Skaletzki

George P Luke

Original Assignee

Upjohn Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-05-06

Filing date

1995-05-04

Publication date

2003-07-28

1995-05-04 Application filed by Upjohn Co filed Critical Upjohn Co

2003-07-28 Application granted granted Critical

2003-07-28 Publication of DK0758327T3 publication Critical patent/DK0758327T3/da

Links

ZPSJGADGUYYRKE-UHFFFAOYSA-N 2H-pyran-2-one Chemical class O=C1C=CC=CO1 ZPSJGADGUYYRKE-UHFFFAOYSA-N 0.000 title abstract 2
206010038997 Retroviral infections Diseases 0.000 title 1
241001430294 unidentified retrovirus Species 0.000 abstract 2
QBDAFARLDLCWAT-UHFFFAOYSA-N 2,3-dihydropyran-6-one Chemical class O=C1OCCC=C1 QBDAFARLDLCWAT-UHFFFAOYSA-N 0.000 abstract 1
VXIXUWQIVKSKSA-UHFFFAOYSA-N 4-hydroxycoumarin Chemical class C1=CC=CC2=C1OC(=O)C=C2O VXIXUWQIVKSKSA-UHFFFAOYSA-N 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
210000004962 mammalian cell Anatomy 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/32—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/34—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D309/36—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
- C07D309/38—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms one oxygen atom in position 2 or 4, e.g. pyrones
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/74—Benzo[b]pyrans, hydrogenated in the carbocyclic ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Virology (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Oncology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Communicable Diseases (AREA)
Molecular Biology (AREA)
Tropical Medicine & Parasitology (AREA)
AIDS & HIV (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

DK95918864T 1994-05-06 1995-05-04 Pyranonforbindelser, der er nyttige til behandling af retrovirale infektioner DK0758327T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US23881794A	1994-05-06	1994-05-06
US34936194A	1994-12-02	1994-12-02
PCT/US1995/005219 WO1995030670A2 (en)	1994-05-06	1995-05-04	Pyranone compounds useful to treat retroviral infections

Publications (1)

Publication Number	Publication Date
DK0758327T3 true DK0758327T3 (da)	2003-07-28

Family

ID=26931995

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK95918864T DK0758327T3 (da)	1994-05-06	1995-05-04	Pyranonforbindelser, der er nyttige til behandling af retrovirale infektioner

Country Status (33)

Country	Link
US (2)	US5852195A (es)
EP (1)	EP0758327B1 (es)
JP (1)	JP3883206B2 (es)
KR (1)	KR100445929B1 (es)
CN (2)	CN1154642C (es)
AT (1)	ATE236894T1 (es)
AU (2)	AU701965B2 (es)
BR (1)	BR9507615A (es)
CA (2)	CA2560489C (es)
CO (1)	CO4810313A1 (es)
CZ (1)	CZ296515B6 (es)
DE (2)	DE122006000014I2 (es)
DK (1)	DK0758327T3 (es)
ES (1)	ES2192201T3 (es)
FI (1)	FI117387B (es)
FR (1)	FR05C0047I2 (es)
HK (2)	HK1066796A1 (es)
HU (1)	HU228057B1 (es)
IL (3)	IL129871A (es)
LU (1)	LU91220I2 (es)
MX (1)	MX9605391A (es)
MY (2)	MY149862A (es)
NL (1)	NL300216I2 (es)
NO (2)	NO315799B1 (es)
NZ (1)	NZ285510A (es)
PE (1)	PE23196A1 (es)
PL (1)	PL190540B1 (es)
PT (1)	PT758327E (es)
RU (1)	RU2139284C1 (es)
SI (1)	SI0758327T1 (es)
SK (1)	SK284407B6 (es)
TW (1)	TW504507B (es)
WO (1)	WO1995030670A2 (es)

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US5484951A (en) *	1990-10-19	1996-01-16	Octamer, Incorporated	5-iodo-6-amino-6-nitroso-1,2-benzopyrones useful as cytostatic and antiviral agents
JPH06506463A (ja) *	1991-04-04	1994-07-21	ジ・アップジョン・カンパニー	Ｈｉｖおよび他のレトロウイルスの治療に有用な化合物
HU221816B1 (hu) *	1991-10-11	2003-01-28	Bristol-Myers Squibb Pharma Company	Gyűrűs karbonil vegyületek, és ezeket tartalmazó gyógyászati készítmények
WO1993007868A1 (en) *	1991-10-22	1993-04-29	Octamer, Inc.	Adenosine diphosphoribose polymerase binding nitroso aromatic compounds useful as anti-tumor and anti-retroviral agents
DE4308451A1 (de) *	1992-09-10	1994-04-14	Bayer Ag	3-Aryl-pyron-Derivate
ZA938019B (en) *	1992-11-13	1995-04-28	Upjohn Co	Pyran-2-ones and 5,6-dihydropyran-2-ones useful for treating HIV and other retroviruses
IL108459A0 (en) *	1993-02-05	1994-04-12	Opjohn Company	4-Hydroxy-benzopyran-2-ones and 4-hydroxy-cycloalkyl [B] pyran-2-ones useful for treating infections due to hiv and other retroviruses
IL129871A (en) *	1994-05-06	2003-11-23	Pharmacia & Upjohn Inc	Process for preparing 4-phenyl-substituted octanoyl-oxazolidin-2-one intermediates that are useful for preparing pyran-2-ones useful for treating retroviral infections

1995
- 1995-05-01 IL IL12987195A patent/IL129871A/xx not_active IP Right Cessation
- 1995-05-04 AT AT95918864T patent/ATE236894T1/de active
- 1995-05-04 SI SI9530660T patent/SI0758327T1/xx unknown
- 1995-05-04 MX MX9605391A patent/MX9605391A/es active IP Right Grant
- 1995-05-04 ES ES95918864T patent/ES2192201T3/es not_active Expired - Lifetime
- 1995-05-04 JP JP52901695A patent/JP3883206B2/ja not_active Expired - Lifetime
- 1995-05-04 CN CNB951935534A patent/CN1154642C/zh not_active Expired - Lifetime
- 1995-05-04 WO PCT/US1995/005219 patent/WO1995030670A2/en active IP Right Grant
- 1995-05-04 KR KR1019960706245A patent/KR100445929B1/ko not_active IP Right Cessation
- 1995-05-04 CZ CZ0317296A patent/CZ296515B6/cs not_active IP Right Cessation
- 1995-05-04 TW TW084104473A patent/TW504507B/zh not_active IP Right Cessation
- 1995-05-04 HU HU9603074A patent/HU228057B1/hu active Protection Beyond IP Right Term
- 1995-05-04 RU RU96123286A patent/RU2139284C1/ru active
- 1995-05-04 NZ NZ285510A patent/NZ285510A/en not_active IP Right Cessation
- 1995-05-04 DE DE1995630294 patent/DE122006000014I2/de active Active
- 1995-05-04 PL PL95317061A patent/PL190540B1/pl unknown
- 1995-05-04 CA CA002560489A patent/CA2560489C/en not_active Expired - Lifetime
- 1995-05-04 CA CA002187523A patent/CA2187523C/en not_active Expired - Lifetime
- 1995-05-04 DE DE69530294T patent/DE69530294T2/de not_active Expired - Lifetime
- 1995-05-04 AU AU24626/95A patent/AU701965B2/en not_active Expired
- 1995-05-04 US US08/809,224 patent/US5852195A/en not_active Expired - Lifetime
- 1995-05-04 DK DK95918864T patent/DK0758327T3/da active
- 1995-05-04 PT PT95918864T patent/PT758327E/pt unknown
- 1995-05-04 EP EP95918864A patent/EP0758327B1/en not_active Expired - Lifetime
- 1995-05-04 BR BR9507615A patent/BR9507615A/pt active Search and Examination
- 1995-05-04 SK SK1384-96A patent/SK284407B6/sk not_active IP Right Cessation
- 1995-05-04 CN CNB2004100346805A patent/CN1329378C/zh not_active Expired - Lifetime
- 1995-05-05 CO CO95018810A patent/CO4810313A1/es unknown
- 1995-05-05 MY MYPI20051072A patent/MY149862A/en unknown
- 1995-05-05 MY MYPI95001195A patent/MY127701A/en unknown
- 1995-05-08 PE PE1995268036A patent/PE23196A1/es not_active IP Right Cessation
1996
- 1996-05-01 IL IL11356796A patent/IL113567A/xx not_active IP Right Cessation
- 1996-11-05 FI FI964441A patent/FI117387B/fi not_active IP Right Cessation
- 1996-11-05 NO NO19964676A patent/NO315799B1/no not_active IP Right Cessation
1998
- 1998-11-09 US US09/188,998 patent/US6169181B1/en not_active Expired - Lifetime
1999
- 1999-04-09 AU AU23686/99A patent/AU718117B2/en not_active Expired
- 1999-05-10 IL IL12987199A patent/IL129871A0/xx unknown
2004
- 2004-12-07 HK HK04109663A patent/HK1066796A1/xx not_active IP Right Cessation
2005
- 2005-12-22 FR FR05C0047C patent/FR05C0047I2/fr active Active
2006
- 2006-01-20 NL NL300216C patent/NL300216I2/nl unknown
- 2006-02-08 LU LU91220C patent/LU91220I2/fr unknown
- 2006-03-02 NO NO2006003C patent/NO2006003I2/no unknown
- 2006-04-25 HK HK06104885.4A patent/HK1084667A1/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
FI117387B (fi)	2006-09-29
MX9605391A (es)	1997-12-31
MY127701A (en)	2006-12-29
JP3883206B2 (ja)	2007-02-21
CZ317296A3 (en)	1997-04-16
BR9507615A (pt)	1997-09-09
CN1329378C (zh)	2007-08-01
TW504507B (en)	2002-10-01
FI964441A0 (fi)	1996-11-05
CA2560489A1 (en)	1995-11-16
KR970702858A (ko)	1997-06-10
SI0758327T1 (en)	2003-08-31
CA2187523A1 (en)	1995-11-16
MY149862A (en)	2013-10-31
ES2192201T3 (es)	2003-10-01
FR05C0047I1 (es)	2006-03-10
HK1084667A1 (en)	2006-08-04
HU9603074D0 (en)	1997-01-28
FR05C0047I2 (es)	2007-10-19
JPH09512821A (ja)	1997-12-22
AU718117B2 (en)	2000-04-06
AU2368699A (en)	1999-06-03
WO1995030670A3 (en)	1996-04-25
DE122006000014I1 (de)	2006-11-16
HUT77601A (hu)	1998-06-29
EP0758327B1 (en)	2003-04-09
FI964441A (fi)	1996-11-05
CZ296515B6 (cs)	2006-04-12
KR100445929B1 (ko)	2005-09-30
AU701965B2 (en)	1999-02-11
HU228057B1 (en)	2012-09-28
RU2139284C1 (ru)	1999-10-10
CN1154642C (zh)	2004-06-23
NO2006003I2 (no)	2008-10-20
SK284407B6 (sk)	2005-03-04
IL129871A0 (en)	2000-02-29
CO4810313A1 (es)	1999-06-30
PE23196A1 (es)	1996-06-07
US6169181B1 (en)	2001-01-02
DE69530294T2 (de)	2003-12-24
EP0758327A1 (en)	1997-02-19
AU2462695A (en)	1995-11-29
LU91220I2 (fr)	2006-04-10
IL129871A (en)	2003-11-23
NO315799B1 (no)	2003-10-27
PL190540B1 (pl)	2005-12-30
CA2187523C (en)	2006-11-21
CA2560489C (en)	2010-01-12
CN1539825A (zh)	2004-10-27
ATE236894T1 (de)	2003-04-15
NZ285510A (en)	1998-03-25
NO2006003I1 (no)	2006-03-13
WO1995030670A2 (en)	1995-11-16
DE69530294D1 (de)	2003-05-15
IL113567A (en)	2003-05-29
SK138496A3 (en)	1997-06-04
CN1150424A (zh)	1997-05-21
NO964676D0 (no)	1996-11-05
PL317061A1 (en)	1997-03-03
NL300216I1 (nl)	2006-04-03
US5852195A (en)	1998-12-22
HK1066796A1 (en)	2005-04-01
DE122006000014I2 (de)	2007-03-29
NL300216I2 (nl)	2006-06-01
NO964676L (no)	1997-01-06
PT758327E (pt)	2003-08-29

Publication	Publication Date	Title
DK0758327T3 (da)	2003-07-28	Pyranonforbindelser, der er nyttige til behandling af retrovirale infektioner
DK0682663T3 (da)	2001-06-18	4-Hydroxybenzopyran-2-oner og 4-hydroxycycloalkyl[b]pyran-2-oner, der er nyttige til behandling af retrovirale infektioner
MY119031A (en)	2005-03-31	Pyran-2-ones and 5,6-dihydropyran-2-ones useful for treating hiv and other retroviruses
ES2059296T3 (es)	1996-07-16	Inhibidores de proteasas retrovirales.
TR199700844T1 (xx)	1998-01-21	Pirazolil-Benzoil T�revleri.
TR200800474T2 (tr)	2008-04-21	Florfenikole aracı maddelerin hazırlanmasına ilişkin işlem.
HK1026691A1 (en)	2000-12-22	Substituted benzimidazoles and their use for treating retroviral infection
YU194691A (sh)	1994-01-20	Benzodiazepinoni
ECSP951440A (es)	1996-07-16	Compuestos utiles para tratar infecciones por retrovirus