ES2192201T3 - Compuestos de piranona utiles para el tratamiento de infecciones retrovirales. - Google Patents
Compuestos de piranona utiles para el tratamiento de infecciones retrovirales.Info
- Publication number
- ES2192201T3 ES2192201T3 ES95918864T ES95918864T ES2192201T3 ES 2192201 T3 ES2192201 T3 ES 2192201T3 ES 95918864 T ES95918864 T ES 95918864T ES 95918864 T ES95918864 T ES 95918864T ES 2192201 T3 ES2192201 T3 ES 2192201T3
- Authority
- ES
- Spain
- Prior art keywords
- piranona
- treatment
- compounds useful
- onas
- retroviral infections
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 206010038997 Retroviral infections Diseases 0.000 title 1
- 241001430294 unidentified retrovirus Species 0.000 abstract 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/32—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/34—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D309/36—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
- C07D309/38—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms one oxygen atom in position 2 or 4, e.g. pyrones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/74—Benzo[b]pyrans, hydrogenated in the carbocyclic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Abstract
LA PRESENTE INVENCION SE REFIERE A COMPUESTOS DE FORMULAS (I) Y (II), QUE SON PIRAN-2-ONAS, 5,6-DIHIDROPIRAN-2-ONAS, 4-HIDROXIBENZOPIRAN-2-ONAS, 4-HIDROXI-CICLOALQUIL[B]PIRAN-2-ONAS, Y DERIVADOS DE LAS MISMAS, UTILES PARA INHIBIR UN RETROVIRUS EN UNA CELULA DE MAMIFERO INFECTADA POR DICHO RETROVIRUS, DONDE R{SUB,10} Y R{SUB,20} TOMADOS JUNTOS SON LAS FORMULAS (III) Y (IV).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US23881794A | 1994-05-06 | 1994-05-06 | |
US34936194A | 1994-12-02 | 1994-12-02 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2192201T3 true ES2192201T3 (es) | 2003-10-01 |
Family
ID=26931995
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES95918864T Expired - Lifetime ES2192201T3 (es) | 1994-05-06 | 1995-05-04 | Compuestos de piranona utiles para el tratamiento de infecciones retrovirales. |
Country Status (33)
Country | Link |
---|---|
US (2) | US5852195A (es) |
EP (1) | EP0758327B1 (es) |
JP (1) | JP3883206B2 (es) |
KR (1) | KR100445929B1 (es) |
CN (2) | CN1154642C (es) |
AT (1) | ATE236894T1 (es) |
AU (2) | AU701965B2 (es) |
BR (1) | BR9507615A (es) |
CA (2) | CA2187523C (es) |
CO (1) | CO4810313A1 (es) |
CZ (1) | CZ296515B6 (es) |
DE (2) | DE69530294T2 (es) |
DK (1) | DK0758327T3 (es) |
ES (1) | ES2192201T3 (es) |
FI (1) | FI117387B (es) |
FR (1) | FR05C0047I2 (es) |
HK (2) | HK1066796A1 (es) |
HU (1) | HU228057B1 (es) |
IL (3) | IL129871A (es) |
LU (1) | LU91220I2 (es) |
MX (1) | MX9605391A (es) |
MY (2) | MY127701A (es) |
NL (1) | NL300216I2 (es) |
NO (2) | NO315799B1 (es) |
NZ (1) | NZ285510A (es) |
PE (1) | PE23196A1 (es) |
PL (1) | PL190540B1 (es) |
PT (1) | PT758327E (es) |
RU (1) | RU2139284C1 (es) |
SI (1) | SI0758327T1 (es) |
SK (1) | SK284407B6 (es) |
TW (1) | TW504507B (es) |
WO (1) | WO1995030670A2 (es) |
Families Citing this family (68)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL129871A (en) * | 1994-05-06 | 2003-11-23 | Pharmacia & Upjohn Inc | Process for preparing 4-phenyl-substituted octanoyl-oxazolidin-2-one intermediates that are useful for preparing pyran-2-ones useful for treating retroviral infections |
US5914332A (en) | 1995-12-13 | 1999-06-22 | Abbott Laboratories | Retroviral protease inhibiting compounds |
WO1998000173A2 (en) * | 1996-07-03 | 1998-01-08 | Pharmacia & Upjohn Company | Targeted drug delivery using sulfonamide derivatives |
US5834506A (en) * | 1996-11-01 | 1998-11-10 | Warner-Lambert Company | Dihydropyrones with improved antiviral activity |
US6232333B1 (en) | 1996-11-21 | 2001-05-15 | Abbott Laboratories | Pharmaceutical composition |
DE69808463T2 (de) | 1997-07-29 | 2003-06-26 | Upjohn Co | Selbstemulgierende formulierung enthaltend saure lipophile verbindungen |
DE69804624T2 (de) * | 1997-07-29 | 2002-09-19 | Upjohn Co | Selbstemulgierende formulierung enthaltend lipophile verbindungen |
ES2219895T3 (es) * | 1997-07-29 | 2004-12-01 | PHARMACIA & UPJOHN COMPANY | Formulacion autoemulsionante para compuestos lipofilos. |
DK1015441T3 (da) * | 1997-09-11 | 2004-07-26 | Upjohn Co | Fremgangsmåde til fremstilling af 4-hydroxy-2-oxo-pyranderivater, der er nyttige som proteaseinhibitorer |
DE60000660T2 (de) * | 1999-03-18 | 2003-06-26 | Upjohn Co | Verbesserte verfahren fur assymmetrische hydrogenation |
US6956048B2 (en) * | 1999-03-31 | 2005-10-18 | Pharmacia & Upjohn Company | Pharmaceutical emulsions for retroviral protease inhibitors |
DK2269591T3 (en) | 2000-01-19 | 2018-07-16 | Abbvie Inc | IMPROVED PHARMACEUTICAL FORMULATIONS |
DE10108470A1 (de) * | 2001-02-22 | 2002-09-05 | Boehringer Ingelheim Pharma | Verfahren zur Herstellung optisch aktiver Dihydropyrone |
US6500963B2 (en) | 2001-02-22 | 2002-12-31 | Boehringer Ingelheim Pharma Kg | Process for preparing optically active dihydropyrones |
BR0307944A (pt) * | 2002-02-25 | 2005-02-01 | Kudos Pharm Ltd | Piranonas úteis como inibidores de atm |
BR0308856A (pt) * | 2002-04-01 | 2005-02-22 | Pfizer | Piranon e pirandion inibidores do rna polimerase dependente do rna do vìrus da hepatite c |
US8025899B2 (en) | 2003-08-28 | 2011-09-27 | Abbott Laboratories | Solid pharmaceutical dosage form |
US8377952B2 (en) | 2003-08-28 | 2013-02-19 | Abbott Laboratories | Solid pharmaceutical dosage formulation |
US8841326B2 (en) | 2004-02-12 | 2014-09-23 | Stc.Unm | Therapeutic curcumin derivatives |
IL161586A (en) * | 2004-04-22 | 2015-02-26 | Rafael Advanced Defense Sys | Irreplaceable energetic material and reactive shielding that uses it |
EP1812069A2 (en) * | 2004-11-08 | 2007-08-01 | Boehringer Ingelheim International GmbH | Method for treating hiv infection through co-administration of tipranavir and etravirine |
WO2006055455A1 (en) * | 2004-11-16 | 2006-05-26 | Boehringer Ingelheim International, Gmbh | Method for treating hiv infection through co-administration of tipranavir and darunavir |
WO2006055660A2 (en) * | 2004-11-19 | 2006-05-26 | Boehringer Ingelheim International Gmbh | Method for treating hiv infection through co-administration of tipranavir and uk-427, 857 |
US20060128733A1 (en) * | 2004-11-19 | 2006-06-15 | Boehringer Ingelheim International Gmbh | Method for treating HIV infection through co-administration of tipranavir and reverset |
EP1819335A1 (en) * | 2004-12-01 | 2007-08-22 | Boehringer Ingelheim International Gmbh | Method for treating hiv infection through co-administration of tipranavir and sch-417690 |
CA2586501A1 (en) * | 2004-12-01 | 2006-06-08 | Boehringer Ingelheim International Gmbh | Method for treating hiv infection through co-administration of tipranavir and gw695634 |
JP2008521898A (ja) * | 2004-12-01 | 2008-06-26 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | チプラナビル及びgw873140を共に投与することを含むhiv感染症の治療方法 |
EP2131865B1 (en) | 2007-03-12 | 2014-12-17 | Nektar Therapeutics | Oligomer-protease inhibitor conjugates |
US20090062346A1 (en) * | 2007-08-29 | 2009-03-05 | Protia, Llc | Deuterium-enriched tipranavir |
WO2009042093A1 (en) * | 2007-09-25 | 2009-04-02 | Merck & Co., Inc. | Hiv protease inhibitors |
WO2009145814A2 (en) * | 2008-03-10 | 2009-12-03 | Vertex Pharmaceuticals Incorporated | Pyrimidines and pyridines useful as inhibitors of protein kinases |
WO2009114151A1 (en) | 2008-03-12 | 2009-09-17 | Nektar Therapeutics | Oligomer-amino acid and olgomer-atazanavir conjugates |
US8173621B2 (en) | 2008-06-11 | 2012-05-08 | Gilead Pharmasset Llc | Nucleoside cyclicphosphates |
SG194404A1 (en) | 2008-12-23 | 2013-11-29 | Gilead Pharmasset Llc | Synthesis of purine nucleosides |
WO2010075549A2 (en) | 2008-12-23 | 2010-07-01 | Pharmasset, Inc. | Nucleoside phosphoramidates |
US8551973B2 (en) | 2008-12-23 | 2013-10-08 | Gilead Pharmasset Llc | Nucleoside analogs |
EP2435037B1 (en) | 2009-05-27 | 2014-11-12 | Merck Sharp & Dohme Corp. | Hiv protease inhibitors |
EP2440249A2 (en) | 2009-06-12 | 2012-04-18 | Nektar Therapeutics | Covalent conjugates comprising a protease inhibitor, a water-soluble, non-peptidic oligomer and a lipophilic moiety |
RS55341B1 (sr) | 2009-06-17 | 2017-03-31 | Vertex Pharma | Inhibitori replikacije virusa gripa |
KR101466245B1 (ko) * | 2010-01-15 | 2014-12-01 | 한미사이언스 주식회사 | 테트라졸 메탄설폰산 염의 제조방법 및 이에 사용되는 신규 화합물 |
BR112012024884A2 (pt) | 2010-03-31 | 2016-10-18 | Gilead Pharmasset Llc | síntese estereosseletiva de ativos contendo fósforo |
US8772332B2 (en) * | 2010-09-09 | 2014-07-08 | Richard H. Ebright | Arylpropionyl-alpha-pyrone antibacterial agents |
US10800725B2 (en) | 2010-09-09 | 2020-10-13 | Richard H. Ebright | Arylpropionyl-triketone antibacterial agents |
WO2012037508A2 (en) | 2010-09-17 | 2012-03-22 | Rutgers, The State University Of New Jersey | Antibacterial agents: high-potency myxopyronin derivatives |
US9079834B2 (en) | 2010-10-28 | 2015-07-14 | Merck Canada Inc. | HIV protease inhibitors |
CN103492381A (zh) | 2010-12-16 | 2014-01-01 | 沃泰克斯药物股份有限公司 | 流感病毒复制的抑制剂 |
UA118010C2 (uk) | 2011-08-01 | 2018-11-12 | Вертекс Фармасьютікалз Інкорпорейтед | Інгібітори реплікації вірусів грипу |
EP2771332B1 (en) | 2011-10-26 | 2016-06-29 | Merck Canada Inc. | Thiophen and thiazol sulfonamid derivatives as HIV protease inhibitors for the treatment of AIDS |
US9517994B2 (en) | 2012-01-05 | 2016-12-13 | Rutgers, The State University Of New Jersey | Antibacterial agents: phloroglucinol derivatives |
AR092489A1 (es) | 2012-09-11 | 2015-04-22 | Merck Sharp & Dohme | Inhibidores de proteasa del vih |
US9227990B2 (en) | 2012-10-29 | 2016-01-05 | Cipla Limited | Antiviral phosphonate analogues and process for preparation thereof |
WO2015013835A1 (en) | 2013-07-31 | 2015-02-05 | Merck Sharp & Dohme Corp. | Piperazine derivatives as hiv protease inhibitors |
DK3421468T3 (da) | 2013-11-13 | 2021-01-11 | Vertex Pharma | Fremgangsmåder til fremstilling af inhibitorer af re-plikation af influenzavira |
NZ719729A (en) | 2013-11-13 | 2022-04-29 | Vertex Pharma | Inhibitors of influenza viruses replication |
EP3083609B1 (en) | 2013-12-19 | 2018-08-15 | Merck Sharp & Dohme Corp. | Hiv protease inhibitors |
EP3082822B1 (en) | 2013-12-19 | 2020-01-15 | Merck Sharp & Dohme Corp. | Hiv protease inhibitors |
WO2015134366A1 (en) | 2014-03-06 | 2015-09-11 | Merck Sharp & Dohme Corp. | Hiv protease inhibitors |
US10138255B2 (en) | 2014-03-10 | 2018-11-27 | Merck Sharp & Dohme Corp. | Piperazine derivatives as HIV protease inhibitors |
EP3212196A4 (en) | 2014-10-29 | 2018-07-11 | Wisconsin Alumni Research Foundation | Boronic acid inhibitors of hiv protease |
EP3294735B8 (en) | 2015-05-13 | 2022-01-05 | Vertex Pharmaceuticals Incorporated | Inhibitors of influenza viruses replication |
WO2016183116A1 (en) | 2015-05-13 | 2016-11-17 | Vertex Pharmaceuticals Incorporated | Methods of preparing inhibitors of influenza viruses replication |
US10450292B2 (en) | 2015-12-10 | 2019-10-22 | Rutgers, The State University of New Jersesy | Inhibitors of bacterial RNA polymerase: arylpropanoyl, arylpropenoyl, and arylcyclopropanecarboxyl phloroglucinols |
WO2017156458A1 (en) | 2016-03-11 | 2017-09-14 | University Of South Florida | Beta-lactamase inhibitors, formulations, and uses thereof |
US20210246125A1 (en) * | 2016-12-04 | 2021-08-12 | 712 North, Inc. | Pyranone compounds useful to modulate oma1 protease |
CN112118837A (zh) | 2018-02-13 | 2020-12-22 | 罗格斯新泽西州立大学 | 抗菌剂:o-烷基氘化派洛宁 |
WO2019173507A1 (en) | 2018-03-06 | 2019-09-12 | Rutgers, The State University Of New Jersey | Antibacterial agents : arylalkylcarboxamido phloroglucinols |
CN110551090B (zh) * | 2019-10-21 | 2021-06-18 | 扬州工业职业技术学院 | 一种超声波提取中药狗脊中抗肿瘤活性成分的方法 |
US20230218644A1 (en) | 2020-04-16 | 2023-07-13 | Som Innovation Biotech, S.A. | Compounds for use in the treatment of viral infections by respiratory syndrome-related coronavirus |
Family Cites Families (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB193507A (en) | 1921-11-25 | 1923-02-26 | English Electric Co Ltd | Improvements in and connected with hydraulic impulse turbines |
NL80964C (es) * | 1952-03-08 | |||
NL82169C (es) * | 1952-05-16 | |||
US2723277A (en) * | 1952-08-26 | 1955-11-08 | Hoffmann La Roche | Malonic acid derivatives and process for the manufacture thereof |
US2872457A (en) * | 1956-04-19 | 1959-02-03 | Wisconsin Alumni Res Found | Process for the preparation of 4-hydroxycoumarin derivatives |
GB836740A (en) * | 1956-04-25 | 1960-06-09 | Bayer Ag | Coumarin derivatives and their production |
FR1276654A (fr) * | 1958-10-01 | 1961-11-24 | Nouveaux dérivés de l'hydroxy-4-alpha-2-pyrone | |
FR1463767A (fr) * | 1963-04-03 | 1966-07-22 | Clin Byla Ets | Dérivés de la coumarine et leur préparation |
BE674997A (es) * | 1965-01-13 | 1966-07-12 | ||
FR1559595A (es) * | 1966-12-13 | 1969-03-14 | ||
US3489774A (en) * | 1967-04-24 | 1970-01-13 | Dow Chemical Co | 3-(beta-aryl-beta-(arylthio) (or arylseleno) propionyl)-coumarin products |
US3493586A (en) * | 1969-01-23 | 1970-02-03 | Dow Chemical Co | 3-(beta-aryl-beta-(arylthio) (or arylseleno)-propionyl)pyrone products |
JPS4823942B1 (es) * | 1969-02-14 | 1973-07-17 | ||
US3764693A (en) * | 1969-11-21 | 1973-10-09 | Lipha | A rodenticidal compositions containing 4-hydroxy coumarins |
US3835161A (en) * | 1972-10-24 | 1974-09-10 | Realisations Scient S E Res C | 3-substituted-4-hydroxy-coumarins |
JPS53147073A (en) * | 1977-05-24 | 1978-12-21 | Sankyo Co Ltd | Mevalonolactone derivatives |
IL60751A (en) * | 1979-08-17 | 1985-04-30 | Merck & Co Inc | 6-(2'-((substituted phenyl)ethyl and-ethenyl)-4-hydroxy-tetrahydro-2h-pyran-2-one derivatives,their preparation and pharmaceutical compositions containing them |
CA1171424A (en) * | 1981-06-17 | 1984-07-24 | Alvin K. Willard | ( )-(4r, 6s) - (e)-6-[2-(4'fluro-3,3', 5-trimethyl- [l,l'-biphenyl]-2-yl)ethenyl]-3,4,5,6- tetrahydro-4-hydroxy-2h-pyran-2-one |
JPS634652A (ja) * | 1986-06-25 | 1988-01-09 | Hitachi Ltd | 半導体装置 |
WO1988004652A1 (en) | 1986-12-17 | 1988-06-30 | Nippon Soda Co., Ltd. | Heterocyclic compounds having triketo skeleton |
US4900754A (en) * | 1987-12-21 | 1990-02-13 | Rorer Pharmaceutical Corp. | HMG-COA reductase inhibitors |
WO1989007939A2 (en) * | 1988-03-01 | 1989-09-08 | The Upjohn Company | Coumarins to inhibit reverse transcriptase in humans |
DE3929913A1 (de) * | 1989-09-08 | 1991-04-04 | Hoechst Ag | 4-hydroxytetrahydropyran-2-one sowie die entsprechenden dihydroxycarbonsaeurederivate, salze und ester, verfahren zu ihrer herstellung, ihre verwendung als arzneimittel, pharmazeutische praeparate sowie vorprodukte |
JPH05503073A (ja) * | 1989-09-26 | 1993-05-27 | オクタマー,インコーポレイテッド | ウイルス性疾患の治療に有用な6―アミノ―1,2―ベンゾピロン |
JPH05501879A (ja) * | 1989-10-27 | 1993-04-08 | ジ・アップジョン・カンパニー | Hivおよび他のレトロウイルスを処理する方法およびそれに有用な化合物 |
JPH03227923A (ja) | 1990-01-30 | 1991-10-08 | Sawai Seiyaku Kk | ひと免疫不全ウイルス疾患処置剤 |
SE9000624D0 (sv) * | 1990-02-22 | 1990-02-22 | Pharmacia Ab | New use |
CA2035972C (en) * | 1990-02-23 | 2006-07-11 | Martin Karpf | Process for the preparation of oxetanones |
ATE161252T1 (de) * | 1990-09-07 | 1998-01-15 | Schering Corp | Antivirale und antihypertensive verbindungen |
AU8612491A (en) * | 1990-09-07 | 1992-03-30 | Schering Corporation | Antiviral compounds |
EP0550464A1 (en) * | 1990-09-07 | 1993-07-14 | Schering Corporation | Antiviral compounds and antihypertensive compounds |
US5484951A (en) * | 1990-10-19 | 1996-01-16 | Octamer, Incorporated | 5-iodo-6-amino-6-nitroso-1,2-benzopyrones useful as cytostatic and antiviral agents |
WO1992017490A1 (en) * | 1991-04-04 | 1992-10-15 | The Upjohn Company | Phosphorus containing compounds as inhibitors of retroviruses |
EP0607334B1 (en) * | 1991-10-11 | 1997-07-30 | The Du Pont Merck Pharmaceutical Company | Cyclic ureas and analogues useful as retroviral protease inhibitiors |
AU676992B2 (en) * | 1991-10-22 | 1997-04-10 | Emory University | Adenosine diphosphoribose polymerase binding nitroso aromatic compounds useful as anti-tumor and anti-retroviral agents |
DE4308451A1 (de) * | 1992-09-10 | 1994-04-14 | Bayer Ag | 3-Aryl-pyron-Derivate |
ZA938019B (en) * | 1992-11-13 | 1995-04-28 | Upjohn Co | Pyran-2-ones and 5,6-dihydropyran-2-ones useful for treating HIV and other retroviruses |
IL108459A0 (en) * | 1993-02-05 | 1994-04-12 | Opjohn Company | 4-Hydroxy-benzopyran-2-ones and 4-hydroxy-cycloalkyl [B] pyran-2-ones useful for treating infections due to hiv and other retroviruses |
IL129871A (en) * | 1994-05-06 | 2003-11-23 | Pharmacia & Upjohn Inc | Process for preparing 4-phenyl-substituted octanoyl-oxazolidin-2-one intermediates that are useful for preparing pyran-2-ones useful for treating retroviral infections |
-
1995
- 1995-05-01 IL IL12987195A patent/IL129871A/xx not_active IP Right Cessation
- 1995-05-04 SK SK1384-96A patent/SK284407B6/sk not_active IP Right Cessation
- 1995-05-04 BR BR9507615A patent/BR9507615A/pt active Search and Examination
- 1995-05-04 NZ NZ285510A patent/NZ285510A/en not_active IP Right Cessation
- 1995-05-04 HU HU9603074A patent/HU228057B1/hu active Protection Beyond IP Right Term
- 1995-05-04 JP JP52901695A patent/JP3883206B2/ja not_active Expired - Lifetime
- 1995-05-04 DK DK95918864T patent/DK0758327T3/da active
- 1995-05-04 MX MX9605391A patent/MX9605391A/es active IP Right Grant
- 1995-05-04 WO PCT/US1995/005219 patent/WO1995030670A2/en active IP Right Grant
- 1995-05-04 CN CNB951935534A patent/CN1154642C/zh not_active Expired - Lifetime
- 1995-05-04 ES ES95918864T patent/ES2192201T3/es not_active Expired - Lifetime
- 1995-05-04 AU AU24626/95A patent/AU701965B2/en not_active Expired
- 1995-05-04 AT AT95918864T patent/ATE236894T1/de active
- 1995-05-04 PL PL95317061A patent/PL190540B1/pl unknown
- 1995-05-04 DE DE69530294T patent/DE69530294T2/de not_active Expired - Lifetime
- 1995-05-04 CA CA002187523A patent/CA2187523C/en not_active Expired - Lifetime
- 1995-05-04 TW TW084104473A patent/TW504507B/zh not_active IP Right Cessation
- 1995-05-04 CZ CZ0317296A patent/CZ296515B6/cs not_active IP Right Cessation
- 1995-05-04 CN CNB2004100346805A patent/CN1329378C/zh not_active Expired - Lifetime
- 1995-05-04 DE DE1995630294 patent/DE122006000014I2/de active Active
- 1995-05-04 EP EP95918864A patent/EP0758327B1/en not_active Expired - Lifetime
- 1995-05-04 US US08/809,224 patent/US5852195A/en not_active Expired - Lifetime
- 1995-05-04 RU RU96123286A patent/RU2139284C1/ru active
- 1995-05-04 PT PT95918864T patent/PT758327E/pt unknown
- 1995-05-04 SI SI9530660T patent/SI0758327T1/xx unknown
- 1995-05-04 KR KR1019960706245A patent/KR100445929B1/ko not_active IP Right Cessation
- 1995-05-04 CA CA002560489A patent/CA2560489C/en not_active Expired - Lifetime
- 1995-05-05 CO CO95018810A patent/CO4810313A1/es unknown
- 1995-05-05 MY MYPI95001195A patent/MY127701A/en unknown
- 1995-05-05 MY MYPI20051072A patent/MY149862A/en unknown
- 1995-05-08 PE PE1995268036A patent/PE23196A1/es not_active IP Right Cessation
-
1996
- 1996-05-01 IL IL11356796A patent/IL113567A/xx not_active IP Right Cessation
- 1996-11-05 NO NO19964676A patent/NO315799B1/no not_active IP Right Cessation
- 1996-11-05 FI FI964441A patent/FI117387B/fi not_active IP Right Cessation
-
1998
- 1998-11-09 US US09/188,998 patent/US6169181B1/en not_active Expired - Lifetime
-
1999
- 1999-04-09 AU AU23686/99A patent/AU718117B2/en not_active Expired
- 1999-05-10 IL IL12987199A patent/IL129871A0/xx unknown
-
2004
- 2004-12-07 HK HK04109663A patent/HK1066796A1/xx not_active IP Right Cessation
-
2005
- 2005-12-22 FR FR05C0047C patent/FR05C0047I2/fr active Active
-
2006
- 2006-01-20 NL NL300216C patent/NL300216I2/nl unknown
- 2006-02-08 LU LU91220C patent/LU91220I2/fr unknown
- 2006-03-02 NO NO2006003C patent/NO2006003I2/no unknown
- 2006-04-25 HK HK06104885.4A patent/HK1084667A1/xx not_active IP Right Cessation
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2192201T3 (es) | Compuestos de piranona utiles para el tratamiento de infecciones retrovirales. | |
DK0558673T3 (da) | Retrovirale proteaseinhibitorer | |
NL1002835A1 (nl) | Synergistisch stabilisatormengsel. | |
ES2114056T3 (es) | Uso de derivados nor y homo de acidos biliares como potenciadores de absorcion para medicamentos. | |
ES2174992T3 (es) | Productos intermediarios para la obtencion de compuestos inhibidores de proteasas retrovirales. | |
ATE267164T1 (de) | 9-(substituiertes glycyl)amido-6-(substituiert)-5-hydroxy-6-deoxy etracycline | |
ES2173341T3 (es) | Compuestos inhibidores de proteasa retroviral. | |
GT199900067A (es) | Nuevas 4-fenilpiperidinas para el tratamiento dedermatosis prurìtica. | |
ES2098140T3 (es) | Liosferas que contienen gonadotropina. | |
ES2037013T3 (es) | Procedimiento para preparar tieno-1,4-diazepinas. | |
DE59709414D1 (de) | Oxyiminopregnancarbolactone | |
ES2183331T3 (es) | Inhibidores de sulfamida-metaloproteasa. | |
DE69126987T2 (de) | Retrovirale protease-inhibitoren | |
AR019496A1 (es) | Azalidas de 13 miembros, composiciones farmaceuticas, uso en la preparacion de medicamentos y preparacion de los mismos | |
ES2190471T3 (es) | Procedimiento para producir derivados de guanidina, intermedios de dichos compuestos y su produccion. | |
ES2179476T3 (es) | Procedimiento para preparar derivados de pirazol. | |
ES2159054T3 (es) | Compuestos di-terc-butil-fenolicos que contienen azufre utiles como agentes antiinflamatorios. | |
ES2166900T3 (es) | Derivados de ara-c. | |
ES2173586T3 (es) | Derivados de ciclohexandiol. | |
BR9807785A (pt) | Processo para a preparação do composto, e, composto | |
DK0579939T3 (da) | Phospholipidderivater | |
SE9602416D0 (sv) | New forms of an organic salt of N'N-diacetylcystine | |
CO4180473A1 (es) | Derivados tiazoles como novedosos compuestos antivirales | |
AR006452A1 (es) | Derivados de oxazolidina, proceso para su produccion y agentes farmaceuticos que los contienen | |
OA09519A (fr) | D-acide aspartique b-hydroxamate en tant que medicament |