SI0758327T1 - Pyranone compounds useful to treat retroviral infections - Google Patents
Pyranone compounds useful to treat retroviral infectionsInfo
- Publication number
- SI0758327T1 SI0758327T1 SI9530660T SI9530660T SI0758327T1 SI 0758327 T1 SI0758327 T1 SI 0758327T1 SI 9530660 T SI9530660 T SI 9530660T SI 9530660 T SI9530660 T SI 9530660T SI 0758327 T1 SI0758327 T1 SI 0758327T1
- Authority
- SI
- Slovenia
- Prior art keywords
- compounds useful
- retroviral infections
- ones
- pyranone compounds
- treat retroviral
- Prior art date
Links
- ZPSJGADGUYYRKE-UHFFFAOYSA-N 2H-pyran-2-one Chemical class O=C1C=CC=CO1 ZPSJGADGUYYRKE-UHFFFAOYSA-N 0.000 title abstract 2
- 206010038997 Retroviral infections Diseases 0.000 title 1
- 241001430294 unidentified retrovirus Species 0.000 abstract 2
- QBDAFARLDLCWAT-UHFFFAOYSA-N 2,3-dihydropyran-6-one Chemical class O=C1OCCC=C1 QBDAFARLDLCWAT-UHFFFAOYSA-N 0.000 abstract 1
- VXIXUWQIVKSKSA-UHFFFAOYSA-N 4-hydroxycoumarin Chemical class C1=CC=CC2=C1OC(=O)C=C2O VXIXUWQIVKSKSA-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 210000004962 mammalian cell Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/32—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/34—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D309/36—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
- C07D309/38—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms one oxygen atom in position 2 or 4, e.g. pyrones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/74—Benzo[b]pyrans, hydrogenated in the carbocyclic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US23881794A | 1994-05-06 | 1994-05-06 | |
US34936194A | 1994-12-02 | 1994-12-02 | |
PCT/US1995/005219 WO1995030670A2 (en) | 1994-05-06 | 1995-05-04 | Pyranone compounds useful to treat retroviral infections |
EP95918864A EP0758327B1 (en) | 1994-05-06 | 1995-05-04 | Pyranone compounds useful to treat retroviral infections |
Publications (1)
Publication Number | Publication Date |
---|---|
SI0758327T1 true SI0758327T1 (en) | 2003-08-31 |
Family
ID=26931995
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI9530660T SI0758327T1 (en) | 1994-05-06 | 1995-05-04 | Pyranone compounds useful to treat retroviral infections |
Country Status (33)
Country | Link |
---|---|
US (2) | US5852195A (xx) |
EP (1) | EP0758327B1 (xx) |
JP (1) | JP3883206B2 (xx) |
KR (1) | KR100445929B1 (xx) |
CN (2) | CN1154642C (xx) |
AT (1) | ATE236894T1 (xx) |
AU (2) | AU701965B2 (xx) |
BR (1) | BR9507615A (xx) |
CA (2) | CA2560489C (xx) |
CO (1) | CO4810313A1 (xx) |
CZ (1) | CZ296515B6 (xx) |
DE (2) | DE122006000014I2 (xx) |
DK (1) | DK0758327T3 (xx) |
ES (1) | ES2192201T3 (xx) |
FI (1) | FI117387B (xx) |
FR (1) | FR05C0047I2 (xx) |
HK (2) | HK1066796A1 (xx) |
HU (1) | HU228057B1 (xx) |
IL (3) | IL129871A (xx) |
LU (1) | LU91220I2 (xx) |
MX (1) | MX9605391A (xx) |
MY (2) | MY149862A (xx) |
NL (1) | NL300216I2 (xx) |
NO (2) | NO315799B1 (xx) |
NZ (1) | NZ285510A (xx) |
PE (1) | PE23196A1 (xx) |
PL (1) | PL190540B1 (xx) |
PT (1) | PT758327E (xx) |
RU (1) | RU2139284C1 (xx) |
SI (1) | SI0758327T1 (xx) |
SK (1) | SK284407B6 (xx) |
TW (1) | TW504507B (xx) |
WO (1) | WO1995030670A2 (xx) |
Families Citing this family (68)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL129871A (en) * | 1994-05-06 | 2003-11-23 | Pharmacia & Upjohn Inc | Process for preparing 4-phenyl-substituted octanoyl-oxazolidin-2-one intermediates that are useful for preparing pyran-2-ones useful for treating retroviral infections |
US5914332A (en) | 1995-12-13 | 1999-06-22 | Abbott Laboratories | Retroviral protease inhibiting compounds |
ATE249842T1 (de) * | 1996-07-03 | 2003-10-15 | Upjohn Co | Zielgerichte arzneimittel abgabe für zulphonamide-derivate |
US5834506A (en) * | 1996-11-01 | 1998-11-10 | Warner-Lambert Company | Dihydropyrones with improved antiviral activity |
US6232333B1 (en) | 1996-11-21 | 2001-05-15 | Abbott Laboratories | Pharmaceutical composition |
DK0989851T3 (da) * | 1997-07-29 | 2003-01-27 | Upjohn Co | Selvemulgerende formulering indeholdende sure lipofile forbindelser |
EP0999838B1 (en) | 1997-07-29 | 2002-04-03 | PHARMACIA & UPJOHN COMPANY | Self-emulsifying formulation for lipophilic compounds |
CA2294031E (en) * | 1997-07-29 | 2012-04-03 | Pharmacia & Upjohn Company | Self-emulsifying formulation for lipophilic compounds |
NZ503338A (en) * | 1997-09-11 | 2002-03-01 | Upjohn Co | Process to produce 4-hydroxy-2-oxo-pyrane derivatives |
WO2000055150A1 (en) * | 1999-03-18 | 2000-09-21 | Pharmacia & Upjohn Company | Improved process for asymmetric hydrogenation |
US6956048B2 (en) * | 1999-03-31 | 2005-10-18 | Pharmacia & Upjohn Company | Pharmaceutical emulsions for retroviral protease inhibitors |
JP4769400B2 (ja) | 2000-01-19 | 2011-09-07 | アボット・ラボラトリーズ | 改良された医薬配合物 |
DE10108470A1 (de) * | 2001-02-22 | 2002-09-05 | Boehringer Ingelheim Pharma | Verfahren zur Herstellung optisch aktiver Dihydropyrone |
US6500963B2 (en) | 2001-02-22 | 2002-12-31 | Boehringer Ingelheim Pharma Kg | Process for preparing optically active dihydropyrones |
AU2003209990B8 (en) * | 2002-02-25 | 2008-10-30 | Kudos Pharmaceuticals Ltd | Pyranones useful as ATM inhibitors |
CA2480583C (en) * | 2002-04-01 | 2008-07-15 | Pfizer Inc. | Pyranon and pyrandion inhibitors of hepatitis c virus rna-dependent rna polymerase |
US8025899B2 (en) | 2003-08-28 | 2011-09-27 | Abbott Laboratories | Solid pharmaceutical dosage form |
US8377952B2 (en) | 2003-08-28 | 2013-02-19 | Abbott Laboratories | Solid pharmaceutical dosage formulation |
US8841326B2 (en) | 2004-02-12 | 2014-09-23 | Stc.Unm | Therapeutic curcumin derivatives |
IL161586A (en) * | 2004-04-22 | 2015-02-26 | Rafael Advanced Defense Sys | Irreplaceable energetic material and reactive shielding that uses it |
JP2008519073A (ja) * | 2004-11-08 | 2008-06-05 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | チプラナビル及びエトラビリンの同時投与によるhiv感染症の治療法 |
WO2006055455A1 (en) * | 2004-11-16 | 2006-05-26 | Boehringer Ingelheim International, Gmbh | Method for treating hiv infection through co-administration of tipranavir and darunavir |
EP1814549A2 (en) * | 2004-11-19 | 2007-08-08 | Boehringer Ingelheim International GmbH | Method for treating hiv infection through co-administration of tipranavir and uk-427, 857 |
US20060128733A1 (en) * | 2004-11-19 | 2006-06-15 | Boehringer Ingelheim International Gmbh | Method for treating HIV infection through co-administration of tipranavir and reverset |
US20060135563A1 (en) * | 2004-12-01 | 2006-06-22 | Boehringer Ingelheim International Gmbh | Method for treating HIV infection through co-administration of tipranavir and SCH-417690 |
CA2586501A1 (en) * | 2004-12-01 | 2006-06-08 | Boehringer Ingelheim International Gmbh | Method for treating hiv infection through co-administration of tipranavir and gw695634 |
EP1819333A1 (en) * | 2004-12-01 | 2007-08-22 | Boehringer Ingelheim International Gmbh | Method for treating hiv infection through co-administration of tipranavir and gw873140 |
CN101631568B (zh) | 2007-03-12 | 2012-08-22 | 尼克塔治疗公司 | 低聚物-蛋白酶抑制剂偶联物 |
US20090062346A1 (en) * | 2007-08-29 | 2009-03-05 | Protia, Llc | Deuterium-enriched tipranavir |
CA2700132A1 (en) * | 2007-09-25 | 2009-04-02 | Merck Sharp & Dohme Corp. | Hiv protease inhibitors |
JP2011513483A (ja) * | 2008-03-10 | 2011-04-28 | バーテックス ファーマシューティカルズ インコーポレイテッド | タンパク質キナーゼの阻害剤として有用なピリミジンおよびピリジン |
WO2009114151A1 (en) | 2008-03-12 | 2009-09-17 | Nektar Therapeutics | Oligomer-amino acid and olgomer-atazanavir conjugates |
US8173621B2 (en) | 2008-06-11 | 2012-05-08 | Gilead Pharmasset Llc | Nucleoside cyclicphosphates |
AU2009329867B2 (en) | 2008-12-23 | 2015-01-29 | Gilead Pharmasset Llc | Nucleoside phosphoramidates |
TW201031675A (en) | 2008-12-23 | 2010-09-01 | Pharmasset Inc | Synthesis of purine nucleosides |
US8551973B2 (en) | 2008-12-23 | 2013-10-08 | Gilead Pharmasset Llc | Nucleoside analogs |
WO2010138338A1 (en) | 2009-05-27 | 2010-12-02 | Merck Sharp & Dohme Corp. | Hiv protease inhibitors |
US20120108501A1 (en) | 2009-06-12 | 2012-05-03 | Nektar Therapeutics | Protease Inhibitors |
EP3141252B8 (en) | 2009-06-17 | 2019-03-13 | Vertex Pharmaceuticals Incorporated | Inhibitors of influenza viruses replication |
KR101466245B1 (ko) * | 2010-01-15 | 2014-12-01 | 한미사이언스 주식회사 | 테트라졸 메탄설폰산 염의 제조방법 및 이에 사용되는 신규 화합물 |
HUE026235T2 (en) | 2010-03-31 | 2016-06-28 | Gilead Pharmasset Llc | Crystalline (S) -isopropyl 2 - (((S) - (((2R, 3R, 4R, 5R) -5- (2,4-dioxo-3,4-dihydropyrimidin-1 (2H) -IL) - 4-Fluoro-3-hydroxy-4-methyltetrahydrofuran-2-IL) methoxy) (phenoxy) phosphoryl) amino) propanoate |
WO2012033815A1 (en) * | 2010-09-09 | 2012-03-15 | Rutgers, The State University Of New Jersey | Arylpropionyl-alpha-pyrone antibacterial agents |
WO2012033846A1 (en) | 2010-09-09 | 2012-03-15 | Rutgers, The State University Of New Jersey | Arylpropionyl-triketone antibacterial agents |
US9133155B2 (en) | 2010-09-17 | 2015-09-15 | Rutgers, The State University Of New Jersey | Antibacterial agents: high-potency myxopyronin derivatives |
WO2012055031A1 (en) | 2010-10-28 | 2012-05-03 | Merck Canada Inc. | Hiv protease inhibitors |
CN103492381A (zh) | 2010-12-16 | 2014-01-01 | 沃泰克斯药物股份有限公司 | 流感病毒复制的抑制剂 |
UA118010C2 (uk) | 2011-08-01 | 2018-11-12 | Вертекс Фармасьютікалз Інкорпорейтед | Інгібітори реплікації вірусів грипу |
EP2771332B1 (en) | 2011-10-26 | 2016-06-29 | Merck Canada Inc. | Thiophen and thiazol sulfonamid derivatives as HIV protease inhibitors for the treatment of AIDS |
WO2013103969A1 (en) | 2012-01-05 | 2013-07-11 | Rutgers, The State University Of New Jersey | Antibacterial agents: phloroglucinol derivatives |
KR20150053971A (ko) | 2012-09-11 | 2015-05-19 | 머크 샤프 앤드 돔 코포레이션 | Hiv 프로테아제 억제제 |
JP2015536940A (ja) | 2012-10-29 | 2015-12-24 | シプラ・リミテッド | 抗ウイルス性ホスホネート類似体及びその製造方法 |
WO2015013835A1 (en) | 2013-07-31 | 2015-02-05 | Merck Sharp & Dohme Corp. | Piperazine derivatives as hiv protease inhibitors |
EP3851437A3 (en) | 2013-11-13 | 2021-11-03 | Vertex Pharmaceuticals Incorporated | Methods of preparing 1h-pyrrolo[2,3-b]pyridine derivates |
AU2014348840B2 (en) | 2013-11-13 | 2019-06-06 | Vertex Pharmaceuticals Incorporated | Inhibitors of influenza viruses replication |
WO2015095276A1 (en) | 2013-12-19 | 2015-06-25 | Merck Sharp & Dohme Corp. | Hiv protease inhibitors |
EP3083609B1 (en) | 2013-12-19 | 2018-08-15 | Merck Sharp & Dohme Corp. | Hiv protease inhibitors |
US9994587B2 (en) | 2014-03-06 | 2018-06-12 | Merck Sharp & Dohme Corp. | HIV protease inhibitors |
EP3116862B1 (en) | 2014-03-10 | 2019-04-17 | Merck Sharp & Dohme Corp. | Piperazine derivatives as hiv protease inhibitors |
WO2016069955A1 (en) | 2014-10-29 | 2016-05-06 | Wisconsin Alumni Research Foundation | Boronic acid inhibitors of hiv protease |
WO2016183120A1 (en) | 2015-05-13 | 2016-11-17 | Vertex Pharmaceuticals Incorporated | Inhibitors of influenza viruses replication |
WO2016183116A1 (en) | 2015-05-13 | 2016-11-17 | Vertex Pharmaceuticals Incorporated | Methods of preparing inhibitors of influenza viruses replication |
US10450292B2 (en) | 2015-12-10 | 2019-10-22 | Rutgers, The State University of New Jersesy | Inhibitors of bacterial RNA polymerase: arylpropanoyl, arylpropenoyl, and arylcyclopropanecarboxyl phloroglucinols |
WO2017156458A1 (en) * | 2016-03-11 | 2017-09-14 | University Of South Florida | Beta-lactamase inhibitors, formulations, and uses thereof |
US11993590B2 (en) * | 2016-12-04 | 2024-05-28 | 712 North Inc. | Pyranone compounds useful to modulate OMA1 protease |
US11685723B2 (en) | 2018-02-13 | 2023-06-27 | Rutgers, The State University Of New Jersey | Antibacterial agents: O-alkyl-deuterated pyronins |
US11572337B2 (en) | 2018-03-06 | 2023-02-07 | Rutgers, The State University Of New Jersey | Antibacterial agents: arylalkylcarboxamido phloroglucinols |
CN110551090B (zh) * | 2019-10-21 | 2021-06-18 | 扬州工业职业技术学院 | 一种超声波提取中药狗脊中抗肿瘤活性成分的方法 |
US20230218644A1 (en) | 2020-04-16 | 2023-07-13 | Som Innovation Biotech, S.A. | Compounds for use in the treatment of viral infections by respiratory syndrome-related coronavirus |
Family Cites Families (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB193507A (en) | 1921-11-25 | 1923-02-26 | English Electric Co Ltd | Improvements in and connected with hydraulic impulse turbines |
NL80964C (xx) * | 1952-03-08 | |||
NL83407C (xx) * | 1952-05-16 | |||
US2723277A (en) * | 1952-08-26 | 1955-11-08 | Hoffmann La Roche | Malonic acid derivatives and process for the manufacture thereof |
US2872457A (en) * | 1956-04-19 | 1959-02-03 | Wisconsin Alumni Res Found | Process for the preparation of 4-hydroxycoumarin derivatives |
GB836740A (en) * | 1956-04-25 | 1960-06-09 | Bayer Ag | Coumarin derivatives and their production |
FR1276654A (fr) * | 1958-10-01 | 1961-11-24 | Nouveaux dérivés de l'hydroxy-4-alpha-2-pyrone | |
FR1463767A (fr) * | 1963-04-03 | 1966-07-22 | Clin Byla Ets | Dérivés de la coumarine et leur préparation |
BE674997A (xx) * | 1965-01-13 | 1966-07-12 | ||
FR1559595A (xx) * | 1966-12-13 | 1969-03-14 | ||
US3489774A (en) * | 1967-04-24 | 1970-01-13 | Dow Chemical Co | 3-(beta-aryl-beta-(arylthio) (or arylseleno) propionyl)-coumarin products |
US3493586A (en) * | 1969-01-23 | 1970-02-03 | Dow Chemical Co | 3-(beta-aryl-beta-(arylthio) (or arylseleno)-propionyl)pyrone products |
JPS4823942B1 (xx) * | 1969-02-14 | 1973-07-17 | ||
US3764693A (en) * | 1969-11-21 | 1973-10-09 | Lipha | A rodenticidal compositions containing 4-hydroxy coumarins |
US3835161A (en) * | 1972-10-24 | 1974-09-10 | Realisations Scient S E Res C | 3-substituted-4-hydroxy-coumarins |
JPS53147073A (en) * | 1977-05-24 | 1978-12-21 | Sankyo Co Ltd | Mevalonolactone derivatives |
NZ194557A (en) * | 1979-08-17 | 1984-09-28 | Merck & Co Inc | Substituted pyranone derivatives;dihydroxy acids therefrom;pharmaceutical compositions |
CA1171424A (en) * | 1981-06-17 | 1984-07-24 | Alvin K. Willard | ( )-(4r, 6s) - (e)-6-[2-(4'fluro-3,3', 5-trimethyl- [l,l'-biphenyl]-2-yl)ethenyl]-3,4,5,6- tetrahydro-4-hydroxy-2h-pyran-2-one |
JPS634652A (ja) * | 1986-06-25 | 1988-01-09 | Hitachi Ltd | 半導体装置 |
WO1988004652A1 (en) | 1986-12-17 | 1988-06-30 | Nippon Soda Co., Ltd. | Heterocyclic compounds having triketo skeleton |
US4900754A (en) * | 1987-12-21 | 1990-02-13 | Rorer Pharmaceutical Corp. | HMG-COA reductase inhibitors |
AU4074789A (en) * | 1988-03-01 | 1989-09-22 | Upjohn Company, The | Coumarins to inhibit reverse transcriptase in humans |
DE3929913A1 (de) * | 1989-09-08 | 1991-04-04 | Hoechst Ag | 4-hydroxytetrahydropyran-2-one sowie die entsprechenden dihydroxycarbonsaeurederivate, salze und ester, verfahren zu ihrer herstellung, ihre verwendung als arzneimittel, pharmazeutische praeparate sowie vorprodukte |
WO1991004663A1 (en) * | 1989-09-26 | 1991-04-18 | The Regents Of The University Of California | 6-amino-1,2-benzopyrones useful for treatment of viral diseases |
EP0497835A1 (en) * | 1989-10-27 | 1992-08-12 | The Upjohn Company | Method for treating hiv and other retroviruses and compounds useful therefor |
JPH03227923A (ja) | 1990-01-30 | 1991-10-08 | Sawai Seiyaku Kk | ひと免疫不全ウイルス疾患処置剤 |
SE9000624D0 (sv) * | 1990-02-22 | 1990-02-22 | Pharmacia Ab | New use |
CA2035972C (en) * | 1990-02-23 | 2006-07-11 | Martin Karpf | Process for the preparation of oxetanones |
AU8665991A (en) * | 1990-09-07 | 1992-03-30 | Schering Corporation | Antiviral compounds and antihypertensive compounds |
WO1992004326A1 (en) * | 1990-09-07 | 1992-03-19 | Schering Corporation | Antiviral compounds |
CA2091173A1 (en) * | 1990-09-07 | 1992-03-08 | Adriano Afonso | Antiviral compounds and antihypertensive compounds |
US5484951A (en) * | 1990-10-19 | 1996-01-16 | Octamer, Incorporated | 5-iodo-6-amino-6-nitroso-1,2-benzopyrones useful as cytostatic and antiviral agents |
JPH06506463A (ja) * | 1991-04-04 | 1994-07-21 | ジ・アップジョン・カンパニー | Hivおよび他のレトロウイルスの治療に有用な化合物 |
HU221816B1 (hu) * | 1991-10-11 | 2003-01-28 | Bristol-Myers Squibb Pharma Company | Gyűrűs karbonil vegyületek, és ezeket tartalmazó gyógyászati készítmények |
WO1993007868A1 (en) * | 1991-10-22 | 1993-04-29 | Octamer, Inc. | Adenosine diphosphoribose polymerase binding nitroso aromatic compounds useful as anti-tumor and anti-retroviral agents |
DE4308451A1 (de) * | 1992-09-10 | 1994-04-14 | Bayer Ag | 3-Aryl-pyron-Derivate |
ZA938019B (en) * | 1992-11-13 | 1995-04-28 | Upjohn Co | Pyran-2-ones and 5,6-dihydropyran-2-ones useful for treating HIV and other retroviruses |
IL108459A0 (en) * | 1993-02-05 | 1994-04-12 | Opjohn Company | 4-Hydroxy-benzopyran-2-ones and 4-hydroxy-cycloalkyl [B] pyran-2-ones useful for treating infections due to hiv and other retroviruses |
IL129871A (en) * | 1994-05-06 | 2003-11-23 | Pharmacia & Upjohn Inc | Process for preparing 4-phenyl-substituted octanoyl-oxazolidin-2-one intermediates that are useful for preparing pyran-2-ones useful for treating retroviral infections |
-
1995
- 1995-05-01 IL IL12987195A patent/IL129871A/xx not_active IP Right Cessation
- 1995-05-04 AT AT95918864T patent/ATE236894T1/de active
- 1995-05-04 SI SI9530660T patent/SI0758327T1/xx unknown
- 1995-05-04 MX MX9605391A patent/MX9605391A/es active IP Right Grant
- 1995-05-04 ES ES95918864T patent/ES2192201T3/es not_active Expired - Lifetime
- 1995-05-04 JP JP52901695A patent/JP3883206B2/ja not_active Expired - Lifetime
- 1995-05-04 CN CNB951935534A patent/CN1154642C/zh not_active Expired - Lifetime
- 1995-05-04 WO PCT/US1995/005219 patent/WO1995030670A2/en active IP Right Grant
- 1995-05-04 KR KR1019960706245A patent/KR100445929B1/ko not_active IP Right Cessation
- 1995-05-04 CZ CZ0317296A patent/CZ296515B6/cs not_active IP Right Cessation
- 1995-05-04 TW TW084104473A patent/TW504507B/zh not_active IP Right Cessation
- 1995-05-04 HU HU9603074A patent/HU228057B1/hu active Protection Beyond IP Right Term
- 1995-05-04 RU RU96123286A patent/RU2139284C1/ru active
- 1995-05-04 NZ NZ285510A patent/NZ285510A/en not_active IP Right Cessation
- 1995-05-04 DE DE1995630294 patent/DE122006000014I2/de active Active
- 1995-05-04 PL PL95317061A patent/PL190540B1/pl unknown
- 1995-05-04 CA CA002560489A patent/CA2560489C/en not_active Expired - Lifetime
- 1995-05-04 CA CA002187523A patent/CA2187523C/en not_active Expired - Lifetime
- 1995-05-04 DE DE69530294T patent/DE69530294T2/de not_active Expired - Lifetime
- 1995-05-04 AU AU24626/95A patent/AU701965B2/en not_active Expired
- 1995-05-04 US US08/809,224 patent/US5852195A/en not_active Expired - Lifetime
- 1995-05-04 DK DK95918864T patent/DK0758327T3/da active
- 1995-05-04 PT PT95918864T patent/PT758327E/pt unknown
- 1995-05-04 EP EP95918864A patent/EP0758327B1/en not_active Expired - Lifetime
- 1995-05-04 BR BR9507615A patent/BR9507615A/pt active Search and Examination
- 1995-05-04 SK SK1384-96A patent/SK284407B6/sk not_active IP Right Cessation
- 1995-05-04 CN CNB2004100346805A patent/CN1329378C/zh not_active Expired - Lifetime
- 1995-05-05 CO CO95018810A patent/CO4810313A1/es unknown
- 1995-05-05 MY MYPI20051072A patent/MY149862A/en unknown
- 1995-05-05 MY MYPI95001195A patent/MY127701A/en unknown
- 1995-05-08 PE PE1995268036A patent/PE23196A1/es not_active IP Right Cessation
-
1996
- 1996-05-01 IL IL11356796A patent/IL113567A/xx not_active IP Right Cessation
- 1996-11-05 FI FI964441A patent/FI117387B/fi not_active IP Right Cessation
- 1996-11-05 NO NO19964676A patent/NO315799B1/no not_active IP Right Cessation
-
1998
- 1998-11-09 US US09/188,998 patent/US6169181B1/en not_active Expired - Lifetime
-
1999
- 1999-04-09 AU AU23686/99A patent/AU718117B2/en not_active Expired
- 1999-05-10 IL IL12987199A patent/IL129871A0/xx unknown
-
2004
- 2004-12-07 HK HK04109663A patent/HK1066796A1/xx not_active IP Right Cessation
-
2005
- 2005-12-22 FR FR05C0047C patent/FR05C0047I2/fr active Active
-
2006
- 2006-01-20 NL NL300216C patent/NL300216I2/nl unknown
- 2006-02-08 LU LU91220C patent/LU91220I2/fr unknown
- 2006-03-02 NO NO2006003C patent/NO2006003I2/no unknown
- 2006-04-25 HK HK06104885.4A patent/HK1084667A1/xx not_active IP Right Cessation
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HK1084667A1 (en) | Pyranone compounds useful to treat retroviral infections | |
MY119031A (en) | Pyran-2-ones and 5,6-dihydropyran-2-ones useful for treating hiv and other retroviruses | |
NO953070D0 (no) | 4-hydroksy-benzopyran-2-oner og 4-hydroksysykloalkyl[BÅpyran-2-oner anvendbare for behandling av retrovirusinfeksjoner | |
ECSP951440A (es) | Compuestos utiles para tratar infecciones por retrovirus |