NO2006003I1 - ÄR-(RR)-N-Ä3-Ä1-Ä5,6-dihydro-4-hydroksy-2-okso-6-(2-fenyletyl)-6-propyl-2H-pyran-3-yl)ÜpropylÜfenylÜ5-(trifluormetyl)-2-pyridinsulfonamid eller et farmasoytisk salt derav = tipranavir eller et farmasoytisk salt derav - Google Patents

ÄR-(R*R*)-N-Ä3-Ä1-Ä5,6-dihydro-4-hydroksy-2-okso-6-(2-fenyletyl)-6-propyl-2H-pyran-3-yl)ÜpropylÜfenylÜ5-(trifluormetyl)-2-pyridinsulfonamid eller et farmasoytisk salt derav = tipranavir eller et farmasoytisk salt derav

Info

Publication number: NO2006003I1
Authority: NO; Norway
Prior art keywords: pharmaceutical salt; pyran; hydroxy; dihydro; tipranavir
Prior art date: 1994-05-06

Application number

NO2006003C

Other languages

English (en)

Other versions

NO2006003I2 (no

Original Assignee

Pharmacia & Upjohn Co Llc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-05-06

Filing date

2006-03-02

Publication date

2006-03-13

2006-03-02 Application filed by Pharmacia & Upjohn Co Llc filed Critical Pharmacia & Upjohn Co Llc

2006-03-13 Publication of NO2006003I1 publication Critical patent/NO2006003I1/no

2008-10-20 Publication of NO2006003I2 publication Critical patent/NO2006003I2/no

Links

150000003839 salts Chemical class 0.000 title 2
SUJUHGSWHZTSEU-UHFFFAOYSA-N Tipranavir Natural products C1C(O)=C(C(CC)C=2C=C(NS(=O)(=O)C=3N=CC(=CC=3)C(F)(F)F)C=CC=2)C(=O)OC1(CCC)CCC1=CC=CC=C1 SUJUHGSWHZTSEU-UHFFFAOYSA-N 0.000 title 1
SUJUHGSWHZTSEU-FYBSXPHGSA-N tipranavir Chemical compound C([C@@]1(CCC)OC(=O)C([C@H](CC)C=2C=C(NS(=O)(=O)C=3N=CC(=CC=3)C(F)(F)F)C=CC=2)=C(O)C1)CC1=CC=CC=C1 SUJUHGSWHZTSEU-FYBSXPHGSA-N 0.000 title 1
229960000838 tipranavir Drugs 0.000 title 1
241001430294 unidentified retrovirus Species 0.000 abstract 2
QBDAFARLDLCWAT-UHFFFAOYSA-N 2,3-dihydropyran-6-one Chemical class O=C1OCCC=C1 QBDAFARLDLCWAT-UHFFFAOYSA-N 0.000 abstract 1
ZPSJGADGUYYRKE-UHFFFAOYSA-N 2H-pyran-2-one Chemical class O=C1C=CC=CO1 ZPSJGADGUYYRKE-UHFFFAOYSA-N 0.000 abstract 1
VXIXUWQIVKSKSA-UHFFFAOYSA-N 4-hydroxycoumarin Chemical class C1=CC=CC2=C1OC(=O)C=C2O VXIXUWQIVKSKSA-UHFFFAOYSA-N 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
210000004962 mammalian cell Anatomy 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/32—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/34—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D309/36—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
- C07D309/38—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms one oxygen atom in position 2 or 4, e.g. pyrones
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/74—Benzo[b]pyrans, hydrogenated in the carbocyclic ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

NO2006003C 1994-05-06 2006-03-02 ÄR-(R*,R*)Ü-N-Ä3-Ä1-Ä5,6-dihydro-4-hydroksy-2-okso-6-(2-fenyletyl)-6-propyl-2H-pyran-3-ylÜpropylÜfenylÜ5-(trifluormetyl)-2-pyridinsulfonamid eller et farmasotisk salt derav= Tipranavir eller et farmasotisk salt derav NO2006003I2 (no)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US23881794A	1994-05-06	1994-05-06
US34936194A	1994-12-02	1994-12-02
PCT/US1995/005219 WO1995030670A2 (en)	1994-05-06	1995-05-04	Pyranone compounds useful to treat retroviral infections

Publications (2)

Publication Number	Publication Date
NO2006003I1 true NO2006003I1 (no)	2006-03-13
NO2006003I2 NO2006003I2 (no)	2008-10-20

Family

ID=26931995

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
NO19964676A NO315799B1 (no)	1994-05-06	1996-11-05	Pyranonforbindelser som er anvendbare for å behandle retrovirale infeksjoner
NO2006003C NO2006003I2 (no)	1994-05-06	2006-03-02	ÄR-(R,R)Ü-N-Ä3-Ä1-Ä5,6-dihydro-4-hydroksy-2-okso-6-(2-fenyletyl)-6-propyl-2H-pyran-3-ylÜpropylÜfenylÜ5-(trifluormetyl)-2-pyridinsulfonamid eller et farmasotisk salt derav= Tipranavir eller et farmasotisk salt derav

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
NO19964676A NO315799B1 (no)	1994-05-06	1996-11-05	Pyranonforbindelser som er anvendbare for å behandle retrovirale infeksjoner

Country Status (33)

Country	Link
US (2)	US5852195A (no)
EP (1)	EP0758327B1 (no)
JP (1)	JP3883206B2 (no)
KR (1)	KR100445929B1 (no)
CN (2)	CN1154642C (no)
AT (1)	ATE236894T1 (no)
AU (2)	AU701965B2 (no)
BR (1)	BR9507615A (no)
CA (2)	CA2560489C (no)
CO (1)	CO4810313A1 (no)
CZ (1)	CZ296515B6 (no)
DE (2)	DE69530294T2 (no)
DK (1)	DK0758327T3 (no)
ES (1)	ES2192201T3 (no)
FI (1)	FI117387B (no)
FR (1)	FR05C0047I2 (no)
HK (2)	HK1066796A1 (no)
HU (1)	HU228057B1 (no)
IL (3)	IL129871A (no)
LU (1)	LU91220I2 (no)
MX (1)	MX9605391A (no)
MY (2)	MY149862A (no)
NL (1)	NL300216I2 (no)
NO (2)	NO315799B1 (no)
NZ (1)	NZ285510A (no)
PE (1)	PE23196A1 (no)
PL (1)	PL190540B1 (no)
PT (1)	PT758327E (no)
RU (1)	RU2139284C1 (no)
SI (1)	SI0758327T1 (no)
SK (1)	SK284407B6 (no)
TW (1)	TW504507B (no)
WO (1)	WO1995030670A2 (no)

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1995
- 1995-05-01 IL IL12987195A patent/IL129871A/xx not_active IP Right Cessation
- 1995-05-04 NZ NZ285510A patent/NZ285510A/en not_active IP Right Cessation
- 1995-05-04 CN CNB951935534A patent/CN1154642C/zh not_active Expired - Lifetime
- 1995-05-04 EP EP95918864A patent/EP0758327B1/en not_active Expired - Lifetime
- 1995-05-04 HU HU9603074A patent/HU228057B1/hu active Protection Beyond IP Right Term
- 1995-05-04 SK SK1384-96A patent/SK284407B6/sk not_active IP Right Cessation
- 1995-05-04 PL PL95317061A patent/PL190540B1/pl unknown
- 1995-05-04 JP JP52901695A patent/JP3883206B2/ja not_active Expired - Lifetime
- 1995-05-04 DK DK95918864T patent/DK0758327T3/da active
- 1995-05-04 SI SI9530660T patent/SI0758327T1/xx unknown
- 1995-05-04 CA CA002560489A patent/CA2560489C/en not_active Expired - Lifetime
- 1995-05-04 WO PCT/US1995/005219 patent/WO1995030670A2/en active IP Right Grant
- 1995-05-04 PT PT95918864T patent/PT758327E/pt unknown
- 1995-05-04 KR KR1019960706245A patent/KR100445929B1/ko not_active IP Right Cessation
- 1995-05-04 AU AU24626/95A patent/AU701965B2/en not_active Expired
- 1995-05-04 BR BR9507615A patent/BR9507615A/pt active Search and Examination
- 1995-05-04 RU RU96123286A patent/RU2139284C1/ru active
- 1995-05-04 TW TW084104473A patent/TW504507B/zh not_active IP Right Cessation
- 1995-05-04 AT AT95918864T patent/ATE236894T1/de active
- 1995-05-04 US US08/809,224 patent/US5852195A/en not_active Expired - Lifetime
- 1995-05-04 CA CA002187523A patent/CA2187523C/en not_active Expired - Lifetime
- 1995-05-04 CN CNB2004100346805A patent/CN1329378C/zh not_active Expired - Lifetime
- 1995-05-04 DE DE69530294T patent/DE69530294T2/de not_active Expired - Lifetime
- 1995-05-04 MX MX9605391A patent/MX9605391A/es active IP Right Grant
- 1995-05-04 ES ES95918864T patent/ES2192201T3/es not_active Expired - Lifetime
- 1995-05-04 CZ CZ0317296A patent/CZ296515B6/cs not_active IP Right Cessation
- 1995-05-04 DE DE1995630294 patent/DE122006000014I2/de active Active
- 1995-05-05 MY MYPI20051072A patent/MY149862A/en unknown
- 1995-05-05 MY MYPI95001195A patent/MY127701A/en unknown
- 1995-05-05 CO CO95018810A patent/CO4810313A1/es unknown
- 1995-05-08 PE PE1995268036A patent/PE23196A1/es not_active IP Right Cessation
1996
- 1996-05-01 IL IL11356796A patent/IL113567A/xx not_active IP Right Cessation
- 1996-11-05 FI FI964441A patent/FI117387B/fi not_active IP Right Cessation
- 1996-11-05 NO NO19964676A patent/NO315799B1/no not_active IP Right Cessation
1998
- 1998-11-09 US US09/188,998 patent/US6169181B1/en not_active Expired - Lifetime
1999
- 1999-04-09 AU AU23686/99A patent/AU718117B2/en not_active Expired
- 1999-05-10 IL IL12987199A patent/IL129871A0/xx unknown
2004
- 2004-12-07 HK HK04109663A patent/HK1066796A1/xx not_active IP Right Cessation
2005
- 2005-12-22 FR FR05C0047C patent/FR05C0047I2/fr active Active
2006
- 2006-01-20 NL NL300216C patent/NL300216I2/nl unknown
- 2006-02-08 LU LU91220C patent/LU91220I2/fr unknown
- 2006-03-02 NO NO2006003C patent/NO2006003I2/no unknown
- 2006-04-25 HK HK06104885.4A patent/HK1084667A1/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
CN1150424A (zh)	1997-05-21
AU718117B2 (en)	2000-04-06
FI964441A (fi)	1996-11-05
DK0758327T3 (da)	2003-07-28
SK284407B6 (sk)	2005-03-04
AU2368699A (en)	1999-06-03
PT758327E (pt)	2003-08-29
JP3883206B2 (ja)	2007-02-21
FR05C0047I1 (no)	2006-03-10
NO2006003I2 (no)	2008-10-20
DE122006000014I2 (de)	2007-03-29
HK1066796A1 (en)	2005-04-01
DE69530294D1 (de)	2003-05-15
DE69530294T2 (de)	2003-12-24
CA2560489C (en)	2010-01-12
CA2187523C (en)	2006-11-21
CA2187523A1 (en)	1995-11-16
PL317061A1 (en)	1997-03-03
EP0758327A1 (en)	1997-02-19
CA2560489A1 (en)	1995-11-16
WO1995030670A2 (en)	1995-11-16
BR9507615A (pt)	1997-09-09
PE23196A1 (es)	1996-06-07
PL190540B1 (pl)	2005-12-30
HU9603074D0 (en)	1997-01-28
ES2192201T3 (es)	2003-10-01
NO964676L (no)	1997-01-06
EP0758327B1 (en)	2003-04-09
NO964676D0 (no)	1996-11-05
CN1539825A (zh)	2004-10-27
KR100445929B1 (ko)	2005-09-30
NZ285510A (en)	1998-03-25
IL129871A0 (en)	2000-02-29
LU91220I2 (fr)	2006-04-10
CN1154642C (zh)	2004-06-23
IL113567A (en)	2003-05-29
JPH09512821A (ja)	1997-12-22
FI964441A0 (fi)	1996-11-05
SI0758327T1 (en)	2003-08-31
WO1995030670A3 (en)	1996-04-25
DE122006000014I1 (de)	2006-11-16
TW504507B (en)	2002-10-01
KR970702858A (ko)	1997-06-10
HUT77601A (hu)	1998-06-29
MY127701A (en)	2006-12-29
AU701965B2 (en)	1999-02-11
MX9605391A (es)	1997-12-31
CZ296515B6 (cs)	2006-04-12
FI117387B (fi)	2006-09-29
CZ317296A3 (en)	1997-04-16
SK138496A3 (en)	1997-06-04
CO4810313A1 (es)	1999-06-30
US6169181B1 (en)	2001-01-02
FR05C0047I2 (no)	2007-10-19
CN1329378C (zh)	2007-08-01
NO315799B1 (no)	2003-10-27
IL129871A (en)	2003-11-23
AU2462695A (en)	1995-11-29
HK1084667A1 (en)	2006-08-04
NL300216I2 (nl)	2006-06-01
HU228057B1 (en)	2012-09-28
MY149862A (en)	2013-10-31
NL300216I1 (nl)	2006-04-03
US5852195A (en)	1998-12-22
ATE236894T1 (de)	2003-04-15
RU2139284C1 (ru)	1999-10-10

Publication	Publication Date	Title
NO2006003I2 (no)	2008-10-20	ÄR-(R,R)Ü-N-Ä3-Ä1-Ä5,6-dihydro-4-hydroksy-2-okso-6-(2-fenyletyl)-6-propyl-2H-pyran-3-ylÜpropylÜfenylÜ5-(trifluormetyl)-2-pyridinsulfonamid eller et farmasotisk salt derav= Tipranavir eller et farmasotisk salt derav
ATE200669T1 (de)	2001-05-15	4-hydroxy-benzopyran-2-one und 4-hydroxy- zykloalkyl(b) - pyran--2-one verwendbarfuer die behandlung von retroviralen infectionen
CA2145661A1 (en)	1994-05-26	Pyran-2-ones and 5,6-dihydropyran-2-ones useful for treating hiv and other retroviruses
TR199700844T1 (xx)	1998-01-21	Pirazolil-Benzoil T�revleri.
TR199902326T2 (xx)	2000-05-22	Anti-hiperkolesterinemikler olarak ikameli piridinler ve bifeniller.
BR9810021A (pt)	2000-09-19	Derivados 9-oxima-eritromicina
DE3067201D1 (en)	1984-04-26	Quinazoline derivatives, processes for their preparation and pharmaceutical compositions containing them
ES2055235T3 (es)	1994-08-16	Composicion anti-inflamatoria y/o antialergica que comprende derivados de glutation.
BR0011246A (pt)	2002-03-05	Processos para o preparo de novos derivados de propenona substituìda
TR199800814T2 (xx)	1998-07-21	3-(1-piperazinil)-1,2-Benzizotiazol haz�rlamak i�in i�lemler ve ara �r�nler.
ATE293635T1 (de)	2005-05-15	Streptograminderivate, ihre herstellung und sie enthaltende zubereitungen
TR199801366T2 (en)	1998-10-21	�zooksasefem t�revleri.

NO2006003I1 - ÄR-(R*R*)-N-Ä3-Ä1-Ä5,6-dihydro-4-hydroksy-2-okso-6-(2-fenyletyl)-6-propyl-2H-pyran-3-yl)ÜpropylÜfenylÜ5-(trifluormetyl)-2-pyridinsulfonamid eller et farmasoytisk salt derav = tipranavir eller et farmasoytisk salt derav - Google Patents