DK0502690T3 - Cyclopropanderivat - Google Patents

Cyclopropanderivat

Info

Publication number
DK0502690T3
DK0502690T3 DK92301802T DK92301802T DK0502690T3 DK 0502690 T3 DK0502690 T3 DK 0502690T3 DK 92301802 T DK92301802 T DK 92301802T DK 92301802 T DK92301802 T DK 92301802T DK 0502690 T3 DK0502690 T3 DK 0502690T3
Authority
DK
Denmark
Prior art keywords
cyclopropane derivative
independently
cyclopropane
derivative
purine
Prior art date
Application number
DK92301802T
Other languages
Danish (da)
English (en)
Inventor
Satoshi Central Resear Hatsuya
Takaaki Sekiyama
Takashi Tsuji
Satoshi Iwayama
Masahiko Okunishi
Original Assignee
Ajinomoto Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ajinomoto Kk filed Critical Ajinomoto Kk
Application granted granted Critical
Publication of DK0502690T3 publication Critical patent/DK0502690T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D473/00Heterocyclic compounds containing purine ring systems
    • C07D473/02Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D473/00Heterocyclic compounds containing purine ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/20Antivirals for DNA viruses
    • A61P31/22Antivirals for DNA viruses for herpes viruses
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52Two oxygen atoms
    • C07D239/54Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK92301802T 1991-03-05 1992-03-03 Cyclopropanderivat DK0502690T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP12323991 1991-03-05
JP18470991 1991-07-24

Publications (1)

Publication Number Publication Date
DK0502690T3 true DK0502690T3 (da) 2000-05-22

Family

ID=26460224

Family Applications (1)

Application Number Title Priority Date Filing Date
DK92301802T DK0502690T3 (da) 1991-03-05 1992-03-03 Cyclopropanderivat

Country Status (9)

Country Link
US (2) US5342840A (de)
EP (1) EP0502690B1 (de)
JP (1) JP2923933B2 (de)
KR (1) KR100232619B1 (de)
AT (1) ATE187173T1 (de)
CA (1) CA2062299C (de)
DE (1) DE69230349T2 (de)
DK (1) DK0502690T3 (de)
ES (1) ES2139588T3 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR950011530A (ko) * 1993-10-21 1995-05-15 도바 다다스 사이클로프로판 유도체 및 이를 함유하는 항바이러스제
TW282470B (de) * 1993-11-18 1996-08-01 Ajinomoto Kk
JP3769737B2 (ja) * 1994-03-30 2006-04-26 味の素株式会社 シクロプロパン誘導体及びその製造法
EP0845454A1 (de) * 1996-12-02 1998-06-03 Ajinomoto Co., Inc. Verfahren zur Herstellung von optisch aktiver Cyclopropan-Derivaten
JPH1129572A (ja) * 1997-07-10 1999-02-02 Ajinomoto Co Inc 核酸誘導体の精製法
JPH11255768A (ja) * 1998-03-09 1999-09-21 Ajinomoto Co Inc 抗ウイルス剤の製造方法
MY141789A (en) * 2001-01-19 2010-06-30 Lg Chem Investment Ltd Novel acyclic nucleoside phosphonate derivatives, salts thereof and process for the preparation of the same.
JP4397691B2 (ja) 2001-10-30 2010-01-13 コンフォーマ・セラピューティクス・コーポレイション Hsp90阻害活性を有するプリン類似体
JP2004026695A (ja) * 2002-06-24 2004-01-29 M's Science Corp 水性点眼用製剤
US7138401B2 (en) 2003-09-18 2006-11-21 Conforma Therapeutics Corporation 2-aminopurine analogs having HSP90-inhibiting activity
FR2864901B1 (fr) * 2004-01-09 2007-10-05 Philippe Perovitch Composition pour le traitement au contact des hyposialies, incluant de la pilocarpine et a effets multiples
NZ561939A (en) 2005-03-30 2011-03-31 Conforma Therapeutics Corp Alkynyl pyrrolopyrimidines and related analogs as HSP90-inhibitors
DE102005053153B4 (de) * 2005-11-04 2007-07-19 Helmut Ristl Ristl-Getriebe
GB0814065D0 (en) * 2008-08-01 2008-09-10 Univ Leuven Kath Use of nucleoside analogs as anti-koi herpes virus molecules
WO2013059215A1 (en) 2011-10-17 2013-04-25 Biotheryx, Inc. Substituted biaryl alkyl amides
US9040699B2 (en) 2011-11-10 2015-05-26 Aratana Therapeutics Nv Method for preparing cyclopropane derivatives
US9107943B2 (en) 2012-01-20 2015-08-18 Aratana Therapeutics Nv Eye drop composition
CN104447749B (zh) * 2014-11-21 2016-06-01 河南师范大学 一种通过嘌呤对乙烯基环丙烷的选择性开环构建非环核苷的方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4016267A (en) * 1974-06-19 1977-04-05 Hoffmann-La Roche Inc. Sulfacytosine derivatives
US3923792A (en) * 1974-06-19 1975-12-02 Hoffmann La Roche Sulfacytosine derivatives
US4065480A (en) * 1975-06-12 1977-12-27 The Procter & Gamble Company Process for preparing substituted cyclopropycarbinyl compounds
CA1150299A (en) * 1978-08-17 1983-07-19 Pieter A. Verbrugge Intermediates in the preparation of cyclopropane-carboxylate esters and process for their manufacture
SE7810947L (sv) * 1978-10-20 1980-04-21 Draco Ab 3-alkylxanthines
US4617304A (en) * 1984-04-10 1986-10-14 Merck & Co., Inc. Purine derivatives
US4859680A (en) * 1984-04-10 1989-08-22 Merck & Co., Inc. Pyrimidine derivatives as antiviral compounds
US4714777A (en) * 1984-06-21 1987-12-22 University Of Pittsburgh Cyclopropanone hydrate derivatives
US4782062A (en) * 1987-05-11 1988-11-01 Merck & Co., Inc. 9-(2-hydroxymethyl)cycloalkylmethyl) guanines
DE3869299D1 (de) * 1987-09-24 1992-04-23 Mitsubishi Chem Ind Verfahren zur herstellung eines cycloalkanols.
US5126345A (en) * 1988-03-30 1992-06-30 E. R. Squibb & Sons, Inc. Bis (hydroxymethyl) cyclobutyl triazolopyrimidines
US5208388A (en) * 1988-07-19 1993-05-04 Bayer Aktiengesellschaft 2,2-difluorocyclopropyl derivatives
DE3824432A1 (de) * 1988-07-19 1990-03-22 Bayer Ag 2,2-difluorcyclopropyl-derivate
US4918075A (en) * 1988-12-20 1990-04-17 E. R. Squibb & Sons, Inc. Purinyl and pyrimidinyl cyclobutanes and their use as antiviral agents
US4988703A (en) * 1989-05-22 1991-01-29 Abbott Laboratories Carbocyclic nucleoside analogs with antiviral activity
US5064961A (en) * 1989-12-18 1991-11-12 E. R. Squibb & Sons, Inc. Process for preparing an optically active cyclobutane nucleoside
US5095136A (en) * 1990-08-27 1992-03-10 E. R. Squibb & Sons, Inc. Method for preparing isoprenoid cyclopropane 1,1-dicarboxylates and derivatives thereof and novel intermediates
DE4222497A1 (de) * 1992-07-09 1994-01-13 Huels Chemische Werke Ag Verfahren zur Herstellung von chlorfreiem Cyclopropancarbonsäuremethylester

Also Published As

Publication number Publication date
ES2139588T3 (es) 2000-02-16
CA2062299C (en) 1999-05-25
EP0502690B1 (de) 1999-12-01
ATE187173T1 (de) 1999-12-15
DE69230349T2 (de) 2000-07-27
JP2923933B2 (ja) 1999-07-26
US5449840A (en) 1995-09-12
KR920018052A (ko) 1992-10-21
CA2062299A1 (en) 1992-09-06
DE69230349D1 (de) 2000-01-05
US5342840A (en) 1994-08-30
EP0502690A2 (de) 1992-09-09
JPH0578357A (ja) 1993-03-30
EP0502690A3 (en) 1992-12-09
KR100232619B1 (ko) 1999-12-01

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